| Entry |
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| Name |
RPB1, POLR2A
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| Definition |
DNA-directed RNA polymerase II subunit RPB1 [EC: 2.7.7.6]
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| Pathway |
| Purine metabolism | | Pyrimidine metabolism | | RNA polymerase | | Huntington's disease | | Herpes simplex infection | | Epstein-Barr virus infection |
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| Module |
| RNA polymerase II, eukaryotes |
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| Brite |
KEGG Orthology (KO) [BR:ko00001]
Metabolism
Nucleotide metabolism
00230 Purine metabolism
K03006 RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1
00240 Pyrimidine metabolism
K03006 RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1
Genetic Information Processing
Transcription
03020 RNA polymerase
K03006 RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1
Human Diseases
Neurodegenerative diseases
05016 Huntington's disease
K03006 RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1
Infectious diseases
05168 Herpes simplex infection
K03006 RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1
05169 Epstein-Barr virus infection
K03006 RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1
KEGG pathway modules [BR:ko00002]
Structural complex
Genetic information processing
RNA polymerase
M00180 RNA polymerase II, eukaryotes [BR:ko03021 ko03400]
K03006 RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1
Enzymes [BR:ko01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.7 Nucleotidyltransferases
2.7.7.6 DNA-directed RNA polymerase
K03006 RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1
Transcription machinery [BR:ko03021]
Eukaryotic type
RNA polymerase II system
RNA polymerase II
Core subunits
K03006 RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic Type
SSBR (single strand breaks repair)
NER (nucleotide excision repair)
TCR (transcription coupled repair) factors
DNA-directed RNA polymerase II complex
K03006 RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1
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| Other DBs |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | ACS: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | CQU: | | AME: | | NVI: | | TCA: | | API: | | PHU: | | ISC: | | CBR: | | BMY: | | TSP: | | SMM: | | NVE: | | HMG: | | TAD: | | AQU: | | ATH: | | ALY: | | GMX: | | MTR: | | CSV: | | RCU: | | VVI: | | OSA: | | DOSA: | | BDI: | | SBI: | | SMO: | | PPP: | | CRE: | | VCN: | | OLU: | | OTA: | | CME: | | SCE: | | AGO: | | ERC: | | KLA: | | LTH: | | PPA: | | VPO: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TBL: | | TDL: | | KAF: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | VAL: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | ZTR: | | TML: | | SPO: | | CNE: | | CNB: | | CGI: | | PPL: | | LBC: | | MPR: | | CCI: | | SCM: | | UMA: | | MGL: | | PGR: | | ECU: | | EIN: | | EHE: | | NCE: | | MBR: | | NGR: | | DDI: | | DPP: | | EHI: | | EDI: | | PFA: | | PFD: | | PFH: | | PYO: | | PCB: | | PKN: | | PVX: | | PCY: | | TAN: | | TPV: | | BBO: | | CPV: | | CHO: | | TGO: | | TET: | | PTM: | | TBR: | | TCR: | | LMA: | | LIF: | | LDO: | | LMI: | | LBZ: | | GLA: | | TVA: | | PTI: | | TPS: | | PIF: | |
» show all
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| Reference |
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| Authors |
Cramer P, Bushnell DA, Kornberg RD |
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| Title |
Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. |
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| Journal |
Science 292:1863-76 (2001) |
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| Reference |
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| Authors |
Kershnar E, Wu SY, Chiang CM |
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| Title |
Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. |
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| Journal |
J Biol Chem 273:34444-53 (1998) |
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