KEGG   ORTHOLOGY: K03084Help
Entry
K03084                      KO                                     

Name
SHIP1, INPP5D
Definition
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
Pathway
Inositol phosphate metabolism
Phosphatidylinositol signaling system
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
 Environmental Information Processing
  Signal transduction
   04070 Phosphatidylinositol signaling system
    K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
 Organismal Systems
  Immune system
   04662 B cell receptor signaling pathway
    K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
   04664 Fc epsilon RI signaling pathway
    K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
   04666 Fc gamma R-mediated phagocytosis
    K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.86  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
     K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
HSA: 
3635(INPP5D)
PTR: 
470683(INPP5D)
PPS: 
100988546(INPP5D)
GGO: 
101142949(INPP5D)
PON: 
100446045(INPP5D)
NLE: 
100598985(INPP5D)
MCC: 
717832(INPP5D)
MCF: 
CSAB: 
103218100(INPP5D)
RRO: 
104654059(INPP5D)
CJC: 
100400043(INPP5D)
SBQ: 
101051962(INPP5D)
MMU: 
16331(Inpp5d)
RNO: 
54259(Inpp5d)
CGE: 
100764735(Inpp5d)
NGI: 
103738235(Inpp5d)
HGL: 
101711777(Inpp5d)
CCAN: 
109695964(Inpp5d)
OCU: 
103347299 103352489(INPP5D)
TUP: 
102487042(INPP5D)
CFA: 
100688270(INPP5D)
AML: 
100464150(INPP5D)
UMR: 
103662839(INPP5D)
FCA: 
101100500(INPP5D)
PTG: 
102971986(INPP5D)
AJU: 
106975888(INPP5D)
BTA: 
507329(INPP5D)
BOM: 
102266365(INPP5D)
BIU: 
109556542 109556923
PHD: 
102315017(INPP5D)
CHX: 
102170935(INPP5D)
OAS: 
101112941(INPP5D)
SSC: 
100526019(INPP5D)
CFR: 
102506956(INPP5D)
BACU: 
103008465(INPP5D)
LVE: 
103091136(INPP5D)
ECB: 
100064896(INPP5D)
MYB: 
102240810(INPP5D)
MYD: 
102769498(INPP5D)
HAI: 
109375054(INPP5D)
RSS: 
109451485(INPP5D)
PALE: 
102882532(INPP5D)
LAV: 
100664012(INPP5D)
MDO: 
100021361(INPP5D)
SHR: 
100916136(INPP5D)
OAA: 
100092282(INPP5D)
GGA: 
424745(INPP5D)
MGP: 
100549631(INPP5D)
CJO: 
107317932(INPP5D)
APLA: 
101797866(INPP5D)
ACYG: 
106040262(INPP5D)
TGU: 
100219581(INPP5D)
GFR: 
102043433(INPP5D)
FAB: 
101809542(INPP5D)
PHI: 
102105757(INPP5D)
CCW: 
104683678(INPP5D)
FPG: 
101923853(INPP5D)
FCH: 
102056843(INPP5D)
CLV: 
102095796(INPP5D)
AAM: 
106484450(INPP5D)
ASN: 
102380530(INPP5D)
AMJ: 
102572303(INPP5D)
PSS: 
102462454(INPP5D)
CMY: 
102935566(INPP5D)
CPIC: 
101950741(INPP5D)
ACS: 
100561031(inpp5d)
PBI: 
103050036(INPP5D) 103055569
GJA: 
107123574(INPP5D)
XLA: 
108718174(inpp5d.S) 399051(inpp5d.L)
XTR: 
100497417(inpp5d)
NPR: 
108796209(INPP5D)
DRE: 
559103(inpp5d)
SRX: 
107717933 107752650
SANH: 
107694111 107696774
SGH: 
107552268 107590654
IPU: 
108272096(inpp5d)
TRU: 
101079472(inpp5d)
TNG: 
GSTEN00025747G001
LCO: 
104925824(inpp5d)
NCC: 
104965434 104965435
MZE: 
101476435(inpp5d)
OLA: 
101163652(inpp5d)
XMA: 
102221920(inpp5d)
CSEM: 
103399950(inpp5d)
LCF: 
108878870(inpp5d)
SASA: 
100380693(ship1) 106560606
ELS: 
105029544(inpp5d)
SFM: 
108937425(inpp5d)
LCM: 
102365596(INPP5D)
CMK: 
103185799(inpp5d)
DPP: 
DICPUDRAFT_156222
DFA: 
DFA_08125(Dd5P1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8769125
  Authors
Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C
  Title
Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.
  Journal
Biochem Biophys Res Commun 225:243-9 (1996)
DOI:10.1006/bbrc.1996.1161
  Sequence
[hsa:3635]
KEGG   ORTHOLOGY: K15909Help
Entry
K15909                      KO                                     

Name
SHIP2, INPPL1
Definition
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
Pathway
Inositol phosphate metabolism
Phosphatidylinositol signaling system
B cell receptor signaling pathway
Fc gamma R-mediated phagocytosis
Insulin signaling pathway
Disease
H01828  
Opsismodysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
 Environmental Information Processing
  Signal transduction
   04070 Phosphatidylinositol signaling system
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
 Organismal Systems
  Immune system
   04662 B cell receptor signaling pathway
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
   04666 Fc gamma R-mediated phagocytosis
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
  Endocrine system
   04910 Insulin signaling pathway
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.86  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
     K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Inositol 5-phosphatases
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
HSA: 
3636(INPPL1)
PTR: 
451403(INPPL1)
PPS: 
100992766(INPPL1)
GGO: 
101127569(INPPL1)
PON: 
100450015(INPPL1)
NLE: 
100596562(INPPL1)
MCC: 
718421(INPPL1)
MCF: 
102115401(INPPL1)
CSAB: 
103247996(INPPL1)
RRO: 
104665152(INPPL1)
CJC: 
100396447(INPPL1)
SBQ: 
101029956(INPPL1)
MMU: 
16332(Inppl1)
RNO: 
65038(Inppl1)
CGE: 
100772102(Inppl1)
NGI: 
103750804(Inppl1)
HGL: 
101698814(Inppl1)
CCAN: 
109693012(Inppl1)
OCU: 
100339369(INPPL1)
TUP: 
102485077(INPPL1)
CFA: 
485209(INPPL1)
AML: 
100482460(INPPL1)
UMR: 
103678107(INPPL1)
FCA: 
101095611(INPPL1)
PTG: 
102956183(INPPL1)
AJU: 
106970927(INPPL1)
BTA: 
783833(INPPL1)
BOM: 
102278222(INPPL1)
BIU: 
109569627(INPPL1)
PHD: 
102326290(INPPL1)
CHX: 
102178924(INPPL1)
OAS: 
101121707(INPPL1)
SSC: 
100462718(INPPL1)
CFR: 
102509164(INPPL1)
BACU: 
102999607(INPPL1)
LVE: 
103078405(INPPL1)
ECB: 
100066037(INPPL1)
MYB: 
102248134(INPPL1)
MYD: 
102755641(INPPL1)
HAI: 
109372436(INPPL1)
RSS: 
109454033(INPPL1)
PALE: 
102890098(INPPL1)
LAV: 
100673994(INPPL1)
MDO: 
100015500(INPPL1)
SHR: 
100930081(INPPL1)
OAA: 
100088229
GGA: 
428692(INPPL1)
MGP: 
100540799
CJO: 
107312645
APLA: 
101792254
ACYG: 
106042953(INPPL1)
TGU: 
100222691
GFR: 
102032471(INPPL1) 102036900
FAB: 
101807549(INPPL1) 101820739
PHI: 
102101537 102102439(INPPL1)
CCW: 
104687164(INPPL1) 104691345
FPG: 
101918373(INPPL1) 101919963
FCH: 
102048151 102056978(INPPL1)
CLV: 
102083667(INPPL1) 102085697
AAM: 
106486171(INPPL1)
ASN: 
102375443 102388319(INPPL1)
AMJ: 
102563685(INPPL1) 102576763
PSS: 
102448035(INPPL1) 102448772
CMY: 
102929300 102929354(INPPL1)
CPIC: 
101932232(INPPL1) 101951468
ACS: 
100556812(inppl1)
PBI: 
103051579(INPPL1)
GJA: 
107108467 107117873
XLA: 
108698315 108708768(inppl1.L)
XTR: 
100485745(inppl1)
NPR: 
108785616 108799086 108801007(INPPL1)
DRE: 
325179(inppl1a)
SRX: 
107710497 107731861 107738283(inppl1) 107744521 107751986
SANH: 
107658108 107665445 107679436(inppl1) 107701601
SGH: 
107550733 107557639(inppl1) 107561253 107568462
IPU: 
108261207(SHIP-2) 108268863(inppl1b) 108277646(inppl1)
TRU: 
101065901(inppl1) 101069844
TNG: 
GSTEN00010186G001 GSTEN00031238G001
LCO: 
104920140(inppl1) 104923483
NCC: 
104958004 104968285(inppl1)
MZE: 
101483507(inppl1) 101484941
OLA: 
101165747(inppl1) 101168299
XMA: 
102222770 102228371(inppl1)
CSEM: 
103378565(inppl1) 103390762
LCF: 
108872540 108886606(inppl1)
SASA: 
106581340 106581406 106591049 106604736 106611739 106613219(inppl1)
ELS: 
105029104(inppl1) 105029605
SFM: 
108923188 108932224(inppl1)
LCM: 
102351582 102361839(INPPL1)
CMK: 
103172441 103172958 103179101(inppl1) 103190809
SPU: 
584901
HRO: 
HELRODRAFT_192166
CRG: 
105320686
OBI: 
106880499
ADF: 
107355719
HMG: 
100212864
AQU: 
100641488
SRE: 
PTSG_07791
ACAN: 
ACA1_083100 ACA1_267300
SPAR: 
SPRG_05175
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9660833
  Authors
Habib T, Hejna JA, Moses RE, Decker SJ
  Title
Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein.
  Journal
J Biol Chem 273:18605-9 (1998)
DOI:10.1074/jbc.273.29.18605
  Sequence
[hsa:3636]
KEGG   ENZYME: 3.1.3.86Help
Entry
EC 3.1.3.86                 Enzyme                                 

Name
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase;
SHIP1;
SHIP2;
SHIP;
p150Ship
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate [RN:R09827]
Reaction(KEGG)
Substrate
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [CPD:C05981];
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate [CPD:C11554];
phosphate [CPD:C00009]
Comment
This enzyme hydroylses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4) [5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects.
History
EC 3.1.3.86 created 2011
Pathway
Inositol phosphate metabolism
Orthology
K03084  
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
K15909  
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Genes
HSA: 
3635(INPP5D) 3636(INPPL1)
PTR: 
451403(INPPL1) 470683(INPP5D)
PPS: 
100988546(INPP5D) 100992766(INPPL1)
GGO: 
101127569(INPPL1) 101142949(INPP5D)
PON: 
100446045(INPP5D) 100450015(INPPL1)
NLE: 
100596562(INPPL1) 100598985(INPP5D)
MCC: 
717832(INPP5D) 718421(INPPL1)
MCF: 
102115401(INPPL1) 102125377 102134197(INPP5D)
CSAB: 
103218100(INPP5D) 103247996(INPPL1)
RRO: 
104654059(INPP5D) 104665152(INPPL1)
CJC: 
100396447(INPPL1) 100400043(INPP5D)
SBQ: 
101029956(INPPL1) 101051962(INPP5D)
MMU: 
16331(Inpp5d) 16332(Inppl1)
RNO: 
54259(Inpp5d) 65038(Inppl1)
CGE: 
100764735(Inpp5d) 100772102(Inppl1)
NGI: 
103738235(Inpp5d) 103750804(Inppl1)
HGL: 
101698814(Inppl1) 101711777(Inpp5d)
CCAN: 
109693012(Inppl1) 109695964(Inpp5d)
OCU: 
100339369(INPPL1) 103347299 103352489(INPP5D)
TUP: 
102485077(INPPL1) 102487042(INPP5D)
CFA: 
100688270(INPP5D) 485209(INPPL1)
AML: 
100464150(INPP5D) 100482460(INPPL1)
UMR: 
103662839(INPP5D) 103678107(INPPL1)
FCA: 
101095611(INPPL1) 101100500(INPP5D)
PTG: 
102956183(INPPL1) 102971986(INPP5D)
AJU: 
106970927(INPPL1) 106975888(INPP5D)
BTA: 
507329(INPP5D) 783833(INPPL1)
BOM: 
102266365(INPP5D) 102278222(INPPL1)
BIU: 
109556542 109556923 109569627(INPPL1)
PHD: 
102315017(INPP5D) 102326290(INPPL1)
CHX: 
102170935(INPP5D) 102178924(INPPL1)
OAS: 
101112941(INPP5D) 101121707(INPPL1)
SSC: 
100462718(INPPL1) 100526019(INPP5D)
CFR: 
102506956(INPP5D) 102509164(INPPL1)
BACU: 
102999607(INPPL1) 103008465(INPP5D)
LVE: 
103078405(INPPL1) 103091136(INPP5D)
ECB: 
100064896(INPP5D) 100066037(INPPL1)
MYB: 
102240810(INPP5D) 102248134(INPPL1)
MYD: 
102755641(INPPL1) 102769498(INPP5D)
HAI: 
109372436(INPPL1) 109375054(INPP5D)
RSS: 
109451485(INPP5D) 109454033(INPPL1)
PALE: 
102882532(INPP5D) 102890098(INPPL1)
LAV: 
100664012(INPP5D) 100673994(INPPL1)
MDO: 
100015500(INPPL1) 100021361(INPP5D)
SHR: 
100916136(INPP5D) 100930081(INPPL1)
OAA: 
100088229 100092282(INPP5D)
GGA: 
424745(INPP5D) 428692(INPPL1)
MGP: 
100540799 100549631(INPP5D)
CJO: 
107312645 107317932(INPP5D)
APLA: 
101792254 101797866(INPP5D)
ACYG: 
106040262(INPP5D) 106042953(INPPL1)
TGU: 
100219581(INPP5D) 100222691
GFR: 
102032471(INPPL1) 102036900 102043433(INPP5D)
FAB: 
101807549(INPPL1) 101809542(INPP5D) 101820739
PHI: 
102101537 102102439(INPPL1) 102105757(INPP5D)
CCW: 
104683678(INPP5D) 104687164(INPPL1) 104691345
FPG: 
101918373(INPPL1) 101919963 101923853(INPP5D)
FCH: 
102048151 102056843(INPP5D) 102056978(INPPL1)
CLV: 
102083667(INPPL1) 102085697 102095796(INPP5D)
AAM: 
106484450(INPP5D) 106486171(INPPL1)
ASN: 
102375443 102380530(INPP5D) 102388319(INPPL1)
AMJ: 
102563685(INPPL1) 102572303(INPP5D) 102576763
PSS: 
102448035(INPPL1) 102448772 102462454(INPP5D)
CMY: 
102929300 102929354(INPPL1) 102935566(INPP5D)
CPIC: 
101932232(INPPL1) 101950741(INPP5D) 101951468
ACS: 
100556812(inppl1) 100561031(inpp5d)
PBI: 
103050036(INPP5D) 103051579(INPPL1) 103055569
GJA: 
107108467 107117873 107123574(INPP5D)
XLA: 
108698315 108708768(inppl1.L) 108718174(inpp5d.S) 399051(inpp5d.L)
XTR: 
100485745(inppl1) 100497417(inpp5d)
NPR: 
108785616 108796209(INPP5D) 108799086 108801007(INPPL1)
DRE: 
325179(inppl1a) 559103(inpp5d)
SRX: 
107710497 107717933 107731861 107738283(inppl1) 107744521 107751986 107752650
SANH: 
107658108 107665445 107679436(inppl1) 107694111 107696774 107701601
SGH: 
107550733 107552268 107557639(inppl1) 107561253 107568462 107590654
IPU: 
108261207(SHIP-2) 108268863(inppl1b) 108272096(inpp5d) 108277646(inppl1)
TRU: 
101065901(inppl1) 101069844 101079472(inpp5d)
TNG: 
GSTEN00010186G001 GSTEN00025747G001 GSTEN00031238G001
LCO: 
104920140(inppl1) 104923483 104925824(inpp5d)
NCC: 
104958004 104965434 104965435 104968285(inppl1)
MZE: 
101476435(inpp5d) 101483507(inppl1) 101484941
OLA: 
101163652(inpp5d) 101165747(inppl1) 101168299
XMA: 
102221920(inpp5d) 102222770 102228371(inppl1)
CSEM: 
103378565(inppl1) 103390762 103399950(inpp5d)
LCF: 
108872540 108878870(inpp5d) 108886606(inppl1)
SASA: 
100380693(ship1) 106560606 106581340 106581406 106591049 106604736 106611739 106613219(inppl1)
ELS: 
105029104(inppl1) 105029544(inpp5d) 105029605
SFM: 
108923188 108932224(inppl1) 108937425(inpp5d)
LCM: 
102351582 102361839(INPPL1) 102365596(INPP5D)
CMK: 
103172441 103172958 103179101(inppl1) 103185799(inpp5d) 103190809
SPU: 
584901
HRO: 
HELRODRAFT_192166
CRG: 
105320686
OBI: 
106880499
ADF: 
107355719
HMG: 
100212864
AQU: 
100641488
SRE: 
PTSG_07791
DPP: 
DICPUDRAFT_156222
DFA: 
DFA_08125(Dd5P1)
ACAN: 
ACA1_083100 ACA1_267300
SPAR: 
SPRG_05175
 » show all
Taxonomy
Reference
1  [PMID:8654924]
  Authors
Lioubin MN, Algate PA, Tsai S, Carlberg K, Aebersold A, Rohrschneider LR
  Title
p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.
  Journal
Genes. Dev. 10 (1996) 1084-95.
  Sequence
[mmu:16331]
Reference
2  [PMID:8643691]
  Authors
Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G
  Title
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 1689-93.
  Sequence
[mmu:16331]
Reference
3  [PMID:9341117]
  Authors
Giuriato S, Payrastre B, Drayer AL, Plantavid M, Woscholski R, Parker P, Erneux C, Chap H
  Title
Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets.
  Journal
J. Biol. Chem. 272 (1997) 26857-63.
Reference
4  [PMID:8769125]
  Authors
Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C
  Title
Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.
  Journal
Biochem. Biophys. Res. Commun. 225 (1996) 243-9.
  Sequence
[hsa:3635]
Reference
5  [PMID:9824312]
  Authors
Pesesse X, Moreau C, Drayer AL, Woscholski R, Parker P, Erneux C
  Title
The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity.
  Journal
FEBS. Lett. 437 (1998) 301-3.
  Sequence
[hsa:3636]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
KEGG   REACTION: R09827Help
Entry
R09827                      Reaction                               

Name
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase
Definition
Phosphatidylinositol-3,4,5-trisphosphate + H2O <=> 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate + Orthophosphate
Equation
Reaction class
C05981_C11554
Enzyme
3.1.3.36        3.1.3.86
Pathway
Inositol phosphate metabolism
Orthology
K01099  
inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
K03084  
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
K15909  
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
K20278  
inositol polyphosphate 5-phosphatase INPP5E [EC:3.1.3.36]
K20279  
synaptojanin [EC:3.1.3.36]
Other DBs
RHEA: 
DBGET integrated database retrieval system