KEGG ORTHOLOGY: K03868

ORTHOLOGY: K03868

Entry

K03868 KO

Name

RBX1, ROC1

Definition

RING-box protein 1

Pathway

ko03420	Nucleotide excision repair
ko04066	HIF-1 signaling pathway
ko04110	Cell cycle
ko04111	Cell cycle - yeast
ko04114	Oocyte meiosis
ko04120	Ubiquitin mediated proteolysis
ko04141	Protein processing in endoplasmic reticulum
ko04310	Wnt signaling pathway
ko04350	TGF-beta signaling pathway
ko04710	Circadian rhythm
ko05200	Pathways in cancer
ko05211	Renal cell carcinoma

Module

M00379	SCF-MET30 complex
M00380	SCF-BTRC complex
M00381	SCF-SKP2 complex
M00382	SCF-FBS complex
M00383	ECV complex
M00384	Cul3-SPOP complex
M00385	Cul4-DDB1-DDB2 complex
M00386	Cul4-DDB1-CSA complex
M00387	SCF-FBW7 complex
M00407	SCF-CDC4 complex
M00411	SCF-GRR1 complex

Brite

KEGG Orthology (KO) [BR:ko00001]
Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K03868  RBX1, ROC1; RING-box protein 1
   04120 Ubiquitin mediated proteolysis
    K03868  RBX1, ROC1; RING-box protein 1
  Replication and repair
   03420 Nucleotide excision repair
    K03868  RBX1, ROC1; RING-box protein 1
Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K03868  RBX1, ROC1; RING-box protein 1
   04350 TGF-beta signaling pathway
    K03868  RBX1, ROC1; RING-box protein 1
   04066 HIF-1 signaling pathway
    K03868  RBX1, ROC1; RING-box protein 1
Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K03868  RBX1, ROC1; RING-box protein 1
   04111 Cell cycle - yeast
    K03868  RBX1, ROC1; RING-box protein 1
   04114 Oocyte meiosis
    K03868  RBX1, ROC1; RING-box protein 1
Organismal Systems
  Environmental adaptation
   04710 Circadian rhythm
    K03868  RBX1, ROC1; RING-box protein 1
Human Diseases
  Cancers
   05200 Pathways in cancer
    K03868  RBX1, ROC1; RING-box protein 1
   05211 Renal cell carcinoma
    K03868  RBX1, ROC1; RING-box protein 1
KEGG pathway modules [BR:ko00002]
Structural complex
  Genetic information processing
   Ubiquitin system
    M00379  SCF-MET30 complex [BR:ko04121]
     K03868  RBX1, ROC1; RING-box protein 1
    M00380  SCF-BTRC complex [BR:ko04121]
     K03868  RBX1, ROC1; RING-box protein 1
    M00381  SCF-SKP2 complex [BR:ko04121]
     K03868  RBX1, ROC1; RING-box protein 1
    M00382  SCF-FBS complex [BR:ko04121]
     K03868  RBX1, ROC1; RING-box protein 1
    M00407  SCF-CDC4 complex [BR:ko04121]
     K03868  RBX1, ROC1; RING-box protein 1
    M00411  SCF-GRR1 complex [BR:ko04121]
     K03868  RBX1, ROC1; RING-box protein 1
    M00383  ECV complex [BR:ko04121]
     K03868  RBX1, ROC1; RING-box protein 1
    M00384  Cul3-SPOP complex [BR:ko04121]
     K03868  RBX1, ROC1; RING-box protein 1
    M00385  Cul4-DDB1-DDB2 complex [BR:ko04121 ko03400]
     K03868  RBX1, ROC1; RING-box protein 1
    M00386  Cul4-DDB1-CSA complex [BR:ko04121 ko03400]
     K03868  RBX1, ROC1; RING-box protein 1
    M00387  SCF-FBW7 complex [BR:ko04121]
     K03868  RBX1, ROC1; RING-box protein 1
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  UBL E3 ligases
   K03868  RBX1, ROC1; RING-box protein 1
  multi subunit Ring-finger type E3
   SCF complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   ECV complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   Cul3 complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   Cul4 complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   Cul7 complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic Type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    GGR (global genome repair) factors
     Cul4-DDB2 complex
      K03868  RBX1, ROC1; RING-box protein 1
    TCR (transcription coupled repair) factors
     Cul4-CSA complex
      K03868  RBX1, ROC1; RING-box protein 1

Other DBs

COG:

COG5194

Genes

HSA:	9978(RBX1)
PTR:	458860(RBX1)
PPS:	100970959 100981636(RBX1)
GGO:	101151577(RBX1)
PON:	100441665(RBX1)
MCC:	710252
MMU:	100043674(Gm9840) 56438(Rbx1)
RNO:	300084(Rbx1)
CFA:	474494(RBX1)
AML:	100469702
FCA:	101087758(RBX1)
BTA:	518880(RBX1) 780968
ECB:	100055581
MDO:	100013521
SHR:	100918404(RBX1)
OAA:	100076928
GGA:	418001(RBX1)
MGP:	100543550
TGU:	100190092
ACS:	100566553
XTR:	100379935(rbx1)
DRE:	449846(rbx1)
TRU:	101079814
OLA:	101170590
BFO:	BRAFLDRAFT_113519
CIN:	100182516
SPU:	591601
DME:	Dmel_CG16982(Roc1a) Dmel_CG16988(Roc1b)
DPO:	Dpse_GA14260 Dpse_GA22841
DAN:	Dana_GF13953 Dana_GF22186 Dana_GF24894
DER:	Dere_GG12803 Dere_GG14721
DPE:	Dper_GL13357 Dper_GL22584
DSE:	Dsec_GM14339 Dsec_GM19082
DSI:	Dsim_GD11014 Dsim_GD16520
DWI:	Dwil_GK13170 Dwil_GK16427
DYA:	Dyak_GE16630 Dyak_GE21084
DGR:	Dgri_GH15458 Dgri_GH17811
DMO:	Dmoj_GI16422 Dmoj_GI16738
DVI:	Dvir_GJ12485 Dvir_GJ15825
AGA:	AgaP_AGAP005202
AAG:	AaeL_AAEL004691
CQU:	CpipJ_CPIJ012886
AME:	408691(Roc1a)
NVI:	100115578(NV14787)
TCA:	655935
API:	100162035
PHU:	Phum_PHUM087130
ISC:	IscW_ISCW018511
CEL:	CELE_ZK287.5(rbx-1)
CBR:	CBG19342(Cbr-rbx-1)
BMY:	Bm1_05985
NVE:	NEMVE_v1g169697
HMG:	100204043
TAD:	TRIADDRAFT_50330
AQU:	100636037
ATH:	AT3G42830 AT5G20570(RBX1)
ALY:	ARALYDRAFT_488960(RBX1)
GMX:	100526919 100789570 100798515
MTR:	MTR_2g088570
CSV:	101209538 101209687 101228252 101231169
RCU:	RCOM_0083800
POP:	POPTR_584115 POPTR_645824 POPTR_836177
VVI:	100259489
OSA:	4326152 4330476
DOSA:	Os01t0106800-01(Os01g0106800) Os02t0708300-01(Os02g0708300)
BDI:	100826136 100841533
SBI:	SORBI_03g008660(SORBIDRAFT_03g008660) SORBI_04g030370(SORBIDRAFT_04g030370)
ZMA:	100192928(Rbx1)
SMO:	SELMODRAFT_269625 SELMODRAFT_269937
PPP:	PHYPADRAFT_122839 PHYPADRAFT_216076
CRE:	CHLREDRAFT_79815(RBX1)
VCN:	VOLCADRAFT_75918
OLU:	OSTLU_119493(Rbx1)
OTA:	Ot02g00670(rbx1)
CME:	CMQ353C
SCE:	YOL133W(HRT1)
AGO:	AGOS_ADL181W
ERC:	Ecym_2029
KLA:	KLLA0E07151g
LTH:	KLTH0F19228g
PPA:	PAS_chr4_0436
VPO:	Kpol_1014p16
ZRO:	ZYRO0C03058g
NCS:	NCAS_0C04480(NCAS0C04480)
NDI:	NDAI_0G03860(NDAI0G03860)
TPF:	TPHA_0P01470(TPHA0P01470)
TBL:	TBLA_0B08710(TBLA0B08710)
TDL:	TDEL_0A00470(TDEL0A00470)
KAF:	KAFR_0C01780(KAFR0C01780)
DHA:	DEHA2F17666g
PIC:	PICST_37145(HRT1)
LEL:	LELG_02061
CTP:	CTRG_02424
CDU:	CD36_82410
COT:	CORT_0B04130
YLI:	YALI0B17358g
CLU:	CLUG_04212
SMP:	SMAC_07095
PAN:	PODANSg5275
MTM:	MYCTH_2304045
MGR:	MGG_08844
FGR:	FG02497.1
NHE:	NECHADRAFT_42915
VAL:	VDBG_08639
SSL:	SS1G_00027
BFU:	BC1G_11671
ANI:	AN8844.2
NFI:	NFIA_037330
AFM:	AFUA_5G05790
AOR:	AOR_1_1150184(AO090009000684)
ANG:	ANI_1_294154(An17g02100)
AFV:	AFLA_048270
ACT:	ACLA_009060
PCS:	Pc20g00850
CIM:	CIMG_06244
CPW:	CPC735_027760
PBL:	PAAG_07371
URE:	UREG_04145
ABE:	ARB_07022
TVE:	TRV_07648
AJE:	HCAG_03036
PNO:	SNOG_09105
PTE:	PTT_16968
ZTR:	MYCGRDRAFT_46230
TML:	GSTUM_00002417001
SPO:	SPAC23H4.18c(rbx1)
CNE:	CNB03140
CNB:	CNBB2560
CGI:	CGB_A3220W
LBC:	LACBIDRAFT_317013
CCI:	CC1G_08674
SCM:	SCHCODRAFT_77263
UMA:	UM05744.1
MGL:	MGL_0788
PGR:	PGTG_18192
ECU:	ECU01_1095
EIN:	Eint_011010
EHE:	EHEL_010980
NCE:	NCER_101168
MBR:	MONBRDRAFT_18418
NGR:	NAEGRDRAFT_5552
DDI:	DDB_G0287629(rbx1)
DPP:	DICPUDRAFT_88388
EHI:	EHI_151630(2.t00108)
EDI:	EDI_254030
PFA:	PFC0845c
PFD:	PFDG_02979
PFH:	PFHG_00876
PYO:	PY00969
PCB:	PC000269.01.0
PBE:	PB300235.00.0
PKN:	PKH_082220
PVX:	PVX_095280
PCY:	PCYB_083070
TAN:	TA10565
TPV:	TP04_0669
BBO:	BBOV_III007590(17.m07664)
CPV:	cgd8_930
CHO:	Chro.80112
TGO:	TGME49_013690
TET:	TTHERM_00313710
PTM:	GSPATT00005494001 GSPATT00024170001
TBR:	Tb10.70.6035
TCR:	503965.20 506495.9
LMA:	LMJF_21_0023
LIF:	LINJ_21_0040
LDO:	LDBPK_210040
LMI:	LMXM_21_0023
LBZ:	LBRM_21_0040
TVA:	TVAG_104530 TVAG_399840
PTI:	PHATRDRAFT_39090(Rbx1)
TPS:	THAPSDRAFT_40817
PIF:	PITG_01524

» show all

Reference

PMID:15688063

Authors

Petroski MD, Deshaies RJ.

Title

Function and regulation of cullin-RING ubiquitin ligases.

Journal

Nat Rev Mol Cell Biol 6:9-20 (2005)

Reference

PMID:15520277

Authors

Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW.

Title

Systematic analysis and nomenclature of mammalian F-box proteins.

Journal

Genes Dev 18:2573-80 (2004)

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Ontology (5)   
   KEGG BRITE (4)   
   COG (1)   
Pathway (671)   
   KEGG PATHWAY (24)   
   KEGG MODULE (647)   
Gene (464)   
   KEGG GENES (206)   
   KEGG DGENES (23)   
   KEGG EGENES (228)   
   KEGG MGENES (7)   
Protein sequence (171)   
   UniProt (171)   
Literature (2)   
   PubMed (2)   
All databases (1313)   

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