KEGG   ORTHOLOGY: K03937Help
Entry
K03937                      KO                                     

Name
NDUFS4
Definition
NADH dehydrogenase (ubiquinone) Fe-S protein 4
Pathway
ko00190  Oxidative phosphorylation
ko01100  Metabolic pathways
ko04714  Thermogenesis
ko04723  Retrograde endocannabinoid signaling
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05010  Alzheimer's disease
ko05012  Parkinson's disease
ko05016  Huntington's disease
Module
M00143  NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria
Disease
H00473  Mitochondrial respiratory chain deficiencies (MRCD)
H01354  Leigh syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Energy metabolism
   00190 Oxidative phosphorylation
    K03937  NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4
 Organismal Systems
  Nervous system
   04723 Retrograde endocannabinoid signaling
    K03937  NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4
  Environmental adaptation
   04714 Thermogenesis
    K03937  NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K03937  NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4
   05012 Parkinson's disease
    K03937  NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4
   05016 Huntington's disease
    K03937  NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K03937  NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4
KEGG modules [BR:ko00002]
 Structural complex
  Energy metabolism
   ATP synthesis
    M00143  NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria
     K03937  NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4
BRITE hierarchy
Other DBs
TC: 3.D.1.6
Genes
HSA: 4724(NDUFS4)
PTR: 461878(NDUFS4)
PPS: 100980708(NDUFS4)
GGO: 101125075(NDUFS4)
PON: 100172316(NDUFS4)
NLE: 100590696(NDUFS4)
MCC: 704137(NDUFS4)
MCF: 102137128(NDUFS4)
CSAB: 103221350(NDUFS4)
RRO: 104672473(NDUFS4)
RBB: 108516683(NDUFS4)
CJC: 100412322(NDUFS4)
SBQ: 101039247(NDUFS4)
MMU: 17993(Ndufs4)
RNO: 499529(Ndufs4)
CGE: 100773999(Ndufs4)
NGI: 103734046(Ndufs4)
HGL: 101699557(Ndufs4)
CCAN: 109691798(Ndufs4)
OCU: 100344233(NDUFS4)
TUP: 102473387(NDUFS4) 102474234
CFA: 479335(NDUFS4)
AML: 100467769(NDUFS4)
UMR: 103664628(NDUFS4)
ORO: 101378518(NDUFS4)
FCA: 101089240(NDUFS4)
PTG: 102954909(NDUFS4)
AJU: 106987822(NDUFS4)
BTA: 327680(NDUFS4)
BOM: 102275372(NDUFS4)
BIU: 109574960(NDUFS4)
PHD: 102339443(NDUFS4)
CHX: 102170635(NDUFS4)
OAS: 101118899(NDUFS4)
SSC: 100516161(NDUFS4)
CFR: 102524104(NDUFS4)
CDK: 105087155(NDUFS4)
BACU: 103018097(NDUFS4)
LVE: 103084967(NDUFS4)
OOR: 101281506(NDUFS4)
ECB: 100063168(NDUFS4)
EPZ: 103558133(NDUFS4)
EAI: 106843348(NDUFS4)
MYB: 102243749(NDUFS4)
MYD: 102760641(NDUFS4)
HAI: 109382110(NDUFS4)
RSS: 109449703(NDUFS4)
PALE: 102897677(NDUFS4)
LAV: 100665872(NDUFS4)
TMU: 101349133
MDO: 100031559(NDUFS4)
SHR: 100930936(NDUFS4)
OAA: 100075551(NDUFS4)
GGA: 374122(NDUFS4)
MGP: 100549240(NDUFS4)
CJO: 107305993(NDUFS4)
APLA: 101803070(NDUFS4)
ACYG: 106035587(NDUFS4)
TGU: 100190761(NDUFS4)
GFR: 102037942(NDUFS4)
FAB: 101819987(NDUFS4)
PHI: 102105765(NDUFS4)
PMAJ: 107216357(NDUFS4)
CCW: 104686662(NDUFS4)
FPG: 101915592(NDUFS4)
FCH: 102056336(NDUFS4)
CLV: 102092216(NDUFS4)
EGZ: 104134688(NDUFS4)
ASN: 102379648(NDUFS4)
AMJ: 102562322(NDUFS4)
PSS: 102454700(NDUFS4)
CMY: 102932784(NDUFS4)
CPIC: 101935861(NDUFS4)
ACS: 100558063(ndufs4)
PVT: 110073922(NDUFS4)
PBI: 103053933(NDUFS4)
GJA: 107117035(NDUFS4)
XLA: 108718389 447172(ndufs4.L)
XTR: 100125122(ndufs4)
NPR: 108792526(NDUFS4)
DRE: 573689(ndufs4)
SANH: 107661235 107681229(ndufs4)
IPU: 108256051(ndufs4)
AMEX: 103027100(ndufs4)
TRU: 101065318(ndufs4)
LCO: 104922977(ndufs4) 109141694
NCC: 104961572(ndufs4)
MZE: 101487339(ndufs4)
OLA: 111947944(ndufs4)
XMA: 102230631(ndufs4)
PRET: 103469994(ndufs4)
NFU: 107394290(ndufs4)
CSEM: 103397738(ndufs4)
LCF: 108881449(ndufs4)
HCQ: 109526781(ndufs4)
BPEC: 110154825(ndufs4)
SASA: 106570923(ndufs4)
ELS: 105014557(ndufs4)
SFM: 108938476(ndufs4)
LCM: 102353812(NDUFS4)
CMK: 103177881(ndufs4)
CIN: 100182853
SPU: 100888952
APLC: 110987093
SKO: 100374479
DME: Dmel_CG12203(ND-18)
DSI: Dsimw501_GD17444(Dsim_GD17444)
MDE: 101897644
AAG: 5578538
AME: 727599(Ndufs4)
BIM: 100746354
BTER: 100649862
SOC: 105193622
AEC: 105154162
ACEP: 105622697
PBAR: 105424880
HST: 105187591
CFO: 105256684
LHU: 105679668
PGC: 109860272
NVI: 100116901(Ndufs4)
TCA: 664573(Ndufs4)
NVL: 108561567
BMOR: 101739007
PMAC: 106715792
PRAP: 110994455
API: 100164295(Ndufs4)
DNX: 107172061
ZNE: 110837943
FCD: 110861122
CEL: CELE_ZK973.10(lpd-5)
CBR: CBG23930(Cbr-lpd-5)
BMY: Bm1_55425
TSP: Tsp_03499
CRG: 105328413
MYI: 110445591
OBI: 106883740
LAK: 106150948
EPA: 110243047
ADF: 107353348
HMG: 100212472
ATH: AT5G67590(FRO1)
CRB: 17874698
TCC: 18611298
EGR: 104418437
VRA: 106765762
VAR: 108330849
CCAJ: 109814913
CAM: 101504736
LJA: Lj5g3v2302920.1(Lj5g3v2302920.1)
ZJU: 107424932
RCU: 8283373
SLY: 101264166
SPEN: 107008721
SOT: 102590838
CANN: 107860179
NTO: 104117599
BVG: 104901946
SOE: 110776589
OSA: 4343746
DOSA: Os07t0585800-01(Os07g0585800)
OBR: 102719600
BDI: 100833859
ATS: 109754459(LOC109754459)
SBI: 8078970
ZMA: 100193844 100281028(pco104752)
SITA: 101773438
PDA: 103722770
EGU: 105057959
DCT: 110096607
ATR: 18446994
VCN: VOLCADRAFT_77953(nuoS4)
APRO: F751_6773
PIC: PICST_62206(NUO21.2)
CAL: CAALFM_C101010WA(CaO19.3290)
CAUR: QG37_03561
SLB: AWJ20_607
NCR: NCU05221(nuo21)
NTE: NEUTE1DRAFT80538(NEUTE1DRAFT_80538)
MGR: MGG_04136
MAW: MAC_08174
MAJ: MAA_02733
CMT: CCM_00415
MBE: MBM_00729
ANI: AN7497.2
ANG: ANI_1_1174094(An11g09390)
ABE: ARB_03885
TVE: TRV_06626
PTE: PTT_08515
CNE: CNM01810
CNB: CNBM1690
ABP: AGABI1DRAFT85329(NdufS4)
ABV: AGABI2DRAFT193877(NdufS4)
SLA: SERLADRAFT_470186(NdufS4)
MGL: MGL_1562
DDI: DDB_G0295657(ndufs4)
DFA: DFA_11402(ndufs4)
SPAR: SPRG_02418
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9463323
  Authors
van den Heuvel L, Ruitenbeek W, Smeets R, Gelman-Kohan Z, Elpeleg O, Loeffen J, Trijbels F, Mariman E, de Bruijn D, Smeitink J
  Title
Demonstration of a new pathogenic mutation in human complex I deficiency: a 5-bp duplication in the nuclear gene encoding the 18-kD (AQDQ) subunit.
  Journal
Am J Hum Genet 62:262-8 (1998)
DOI:10.1086/301716
  Sequence
[hsa:4724]

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