KEGG ORTHOLOGY: K05296

ORTHOLOGY: K05296

Entry

K05296 KO

Name

E1.1.1.51

Definition

3(or 17)beta-hydroxysteroid dehydrogenase [EC:1.1.1.51]

Pathway

ko00140	Steroid hormone biosynthesis
ko00984	Steroid degradation

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    K05296  E1.1.1.51; 3(or 17)beta-hydroxysteroid dehydrogenase
  Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K05296  E1.1.1.51; 3(or 17)beta-hydroxysteroid dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     K05296  E1.1.1.51; 3(or 17)beta-hydroxysteroid dehydrogenase

Other DBs

RN:

R01836 R01838 R02352 R02353 R03406 R03407 R09956 R09957

GO:

0030283

Genes

PRE:	PCA10_43660
PPUU:	PputUW4_01679
PKC:	PKB_4320
PFZ:	AV641_10575
PPSY:	AOC04_07875
SPL:	Spea_2173
SHL:	Shal_2144
ZAL:	AZF00_07095
HJA:	BST95_16580
RIN:	ACS15_4335 ACS15_4391
REU:	Reut_A1545 Reut_A1552
REH:	H16_B0642(h16_B0642) H16_B0649(h16_B0649)
CNC:	CNE_2c05880 CNE_2c05960
CTI:	RALTA_B0491
CBW:	RR42_s2341
BUR:	Bcep18194_B1514
BCT:	GEM_4149
BCEP:	APZ15_31395
BPYR:	ABD05_28030
BCON:	NL30_04370
BDF:	WI26_20980
BTEI:	WS51_05535
BFN:	OI25_4612
PVE:	UC34_06900
CTT:	CtCNB1_1764
CTES:	O987_11065
AZI:	AzCIB_1461
THU:	AC731_008840
GME:	Gmet_2217
AEX:	Astex_2504
NPP:	PP1Y_Mpl5490
NRE:	BES08_24625
SYB:	TZ53_04155
SPHR:	BSY17_3924
SINB:	SIDU_16905
SPHG:	AZE99_02220 AZE99_05050
ELQ:	Ga0102493_111116
CMAN:	A9D14_16350
PORL:	BG023_11268

» show all

Reference

PMID:193845

Authors

Schultz RM, Groman EV, Engel LL

Title

3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms.

Journal

J Biol Chem 252:3775-83 (1977)

Reference

PMID:20554032

Authors

Horinouchi M, Kurita T, Hayashi T, Kudo T

Title

Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Delta4(5)-isomerase and 3alpha- and 3beta-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot.

Journal

J Steroid Biochem Mol Biol 122:253-63 (2010)
DOI:10.1016/j.jsbmb.2010.06.002

All links

Ontology (3)   
   KEGG BRITE (2)   
   GO (1)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (11)   
   KEGG ENZYME (1)   
   KEGG REACTION (8)   
   KEGG RCLASS (2)   
Gene (47)   
   KEGG GENES (44)   
   OC (3)   
Protein sequence (37)   
   UniProt (37)   
Literature (2)   
   PubMed (2)   
All databases (108)   

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ENZYME: 1.1.1.51

Entry

EC 1.1.1.51 Enzyme

Name

3(or 17)beta-hydroxysteroid dehydrogenase;
beta-hydroxy steroid dehydrogenase;
17-ketoreductase;
17beta-hydroxy steroid dehydrogenase;
3beta-hydroxysteroid dehydrogenase;
3beta-hydroxy steroid dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase

Reaction(IUBMB)

testosterone + NAD(P)+ = androstenedione + NAD(P)H + H+ [RN:R01836 R01838]

Reaction(KEGG)

R01836 R01838;
(other) R02352 R02353 R03406 R03407 R09956 R09957

Substrate

testosterone [CPD:C00535];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

androstenedione [CPD:C00280];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Also acts on other 3beta- or 17beta-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase.

History

EC 1.1.1.51 created 1961

Pathway

ec00140	Steroid hormone biosynthesis
ec00984	Steroid degradation
ec01100	Metabolic pathways
ec01120	Microbial metabolism in diverse environments

Orthology

K04119	aldo-keto reductase family 1 member C3
K05296	3(or 17)beta-hydroxysteroid dehydrogenase

Genes

HSA:	8644(AKR1C3)
PTR:	100612718(AKR1C3)
PPS:	100986388(AKR1C3)
GGO:	101144878
PON:	100174617(AKR1C3)
NLE:	100604844(AKR1C3)
MCC:	711440(AKR1C3)
MCF:	102142023(HSD17B5)
SBQ:	101041594
CFA:	497070(AKR1C3)
FCA:	100510801(AKR1C3)
PTG:	102963188
AJU:	106988139
BTA:	100139386(20ALPHA-HSD) 100337056 107131313 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 619029 782884 785762 785996
BOM:	102269337
SSC:	733634(AKR1C1)
BACU:	103002145 103003050
LVE:	103069218
ECB:	100070616
MYB:	102255491
MYD:	102751586
OAA:	100085065
PSS:	102446010
XLA:	100049750(LOC100490956.L) 443571(akr1c3.L)
XTR:	105946859 779627(akr1c3)
PRE:	PCA10_43660
PPUU:	PputUW4_01679
PKC:	PKB_4320
PFZ:	AV641_10575
PPSY:	AOC04_07875
SPL:	Spea_2173
SHL:	Shal_2144
ZAL:	AZF00_07095
HJA:	BST95_16580
RIN:	ACS15_4335 ACS15_4391
REU:	Reut_A1545 Reut_A1552
REH:	H16_B0642(h16_B0642) H16_B0649(h16_B0649)
CNC:	CNE_2c05880 CNE_2c05960
CTI:	RALTA_B0491
CBW:	RR42_s2341
BUR:	Bcep18194_B1514
BCT:	GEM_4149
BCEP:	APZ15_31395
BPYR:	ABD05_28030
BCON:	NL30_04370
BDF:	WI26_20980
BTEI:	WS51_05535
BFN:	OI25_4612
PVE:	UC34_06900
CTT:	CtCNB1_1764
CTES:	O987_11065
AZI:	AzCIB_1461
THU:	AC731_008840
GME:	Gmet_2217
AEX:	Astex_2504
NPP:	PP1Y_Mpl5490
NRE:	BES08_24625
SYB:	TZ53_04155
SPHR:	BSY17_3924
SINB:	SIDU_16905
SPHG:	AZE99_02220 AZE99_05050
ELQ:	Ga0102493_111116
CMAN:	A9D14_16350
PORL:	BG023_11268

» show all

Reference

1 [PMID:14214322]

Authors

DAHM K, BREUER H.

Title

[PRECIPITATION OF A 17-BETA-HYDROXYSTEROID:NAD(P) OXIDOREDUCTASE FROM THE RAT ADRENAL GLAND.]

Journal

Hoppe. Seylers. Z. Physiol. Chem. 336 (1964) 63-8.

Reference

2 [PMID:13549484]

Authors

LYNN WS Jr, BROWN RH.

Title

The conversion of progesterone to androgens by testes.

Journal

J. Biol. Chem. 232 (1958) 1015-30.

Reference

3 [PMID:13295221]

Authors

MARCUS PI, TALALAY P.

Title

Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.

Journal

J. Biol. Chem. 218 (1956) 661-74.

Reference

4 [PMID:193845]

Authors

Schultz RM, Groman EV, Engel LL.

Title

3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms.

Journal

J. Biol. Chem. 252 (1977) 3775-83.

Reference

5 [PMID:13129261]

Authors

TALALAY P, DOBSON MM.

Title

Purification and properties of a beta-hydroxysteroid dehydrogenase.

Journal

J. Biol. Chem. 205 (1953) 823-37.

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.51

IUBMB Enzyme Nomenclature:

1.1.1.51

ExPASy - ENZYME nomenclature database:

1.1.1.51

UM-BBD (Biocatalysis/Biodegradation Database):

1.1.1.51

BRENDA, the Enzyme Database:

1.1.1.51

CAS:

9015-81-0

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Pathway (8)   
   KEGG PATHWAY (8)   
Chemical substance (14)   
   KEGG COMPOUND (14)   
Chemical reaction (10)   
   KEGG REACTION (8)   
   KEGG RCLASS (2)   
Gene (85)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (83)   
Protein sequence (113)   
   UniProt (85)   
   SWISS-PROT (6)   
   RefSeq(pep) (15)   
   PDBSTR (4)   
   PMD (3)   
DNA sequence (108)   
   RefSeq(nuc) (19)   
   GenBank (46)   
   EMBL (43)   
3D Structure (1)   
   PDB (1)   
Protein domain (1)   
   PROSITE(DOC) (1)   
Enzyme (1)   
   UMBBD-EC (1)   
All databases (341)   

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REACTION: R09957

Entry

R09957 Reaction

Name

dehydroepiandrosterone:NAD+ oxidoreductase

Definition

Dehydroepiandrosterone + NAD+ <=> 5-Androstene-3,17-dione + NADH + H+

Equation

C01227 + C00003 <=> C20252 + C00004 + C00080

Reaction class

RC00001	C00003_C00004
RC00144	C01227_C20252

Enzyme

1.1.1.51

Pathway

rn00984	Steroid degradation
rn01120	Microbial metabolism in diverse environments

Orthology

K05296

3(or 17)beta-hydroxysteroid dehydrogenase [EC:1.1.1.51]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (45)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (44)   
All databases (58)   

Download RDF

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