KEGG   ORTHOLOGY: K07281Help
Entry
K07281                      KO                                     

Name
ipct
Definition
1L-myo-inositol 1-phosphate cytidylyltransferase [EC:2.7.7.74]
Pathway
Inositol phosphate metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K07281  ipct; 1L-myo-inositol 1-phosphate cytidylyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.74  1L-myo-inositol 1-phosphate cytidylyltransferase
     K07281  ipct; 1L-myo-inositol 1-phosphate cytidylyltransferase
BRITE hierarchy
Other DBs
RN: 
COG: 
Genes
MTHD: 
ENM: 
NAR: 
STAX: 
GBE: 
GDI: 
GDI0629(hasC)
GDJ: 
NTR: 
TMR: 
TPZ: 
RXY: 
Rxyl_1212
TTR: 
Tter_0472
RMR: 
Rmar_1196
RMG: 
Rhom172_1617
AAE: 
aq_1367(spsI)
PMX: 
PERMA_1921
TTK: 
TST_0884
TID: 
Thein_0126
MIF: 
Metin_0454
MIG: 
Metig_1787
AFU: 
AF_0263
AFG: 
AFULGI_00002550
APO: 
Arcpr_0766
AVE: 
Arcve_2013
AST: 
Asulf_00859
FPL: 
Ferp_0148
GAC: 
GACE_2065
GAH: 
GAH_01161
PHO: 
PH1219(PH1219)
PAB: 
PAB2433
PFU: 
PF1058
PFI: 
PFC_04525
PYN: 
PNA2_1704
PYA: 
PYCH_00120
PYS: 
Py04_1010
PYC: 
TQ32_04290
TKO: 
TK2279
TON: 
TON_1248
TGA: 
TGAM_1853
TSI: 
TSIB_1010
TBA: 
TERMP_01130
THE: 
GQS_09430
THA: 
TAM4_5
THM: 
CL1_1475
TLT: 
OCC_08385
THS: 
TES1_1181
TNU: 
BD01_1626
TEU: 
TEU_00190
TCH: 
CHITON_0904
TPEP: 
A0127_03970
PPAC: 
PAP_05835
APE: 
APE_1514.1
ACJ: 
ACAM_0951
IAG: 
Igag_0487
HBU: 
Hbut_0150
PFM: 
Pyrfu_0046
PDL: 
Pyrde_0746
TPE: 
Tpen_1250
THB: 
N186_00105
KCR: 
Kcr_0184
BARC: 
AOA65_0707
LOKI: 
Lokiarch_24620 Lokiarch_51830
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H
  Title
Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.
  Journal
J Bacteriol 189:5405-12 (2007)
DOI:10.1128/JB.00465-07
  Sequence
[rxy:Rxyl_1212]
KEGG   ENZYME: 2.7.7.74Help
Entry
EC 2.7.7.74                 Enzyme                                 

Name
1L-myo-inositol 1-phosphate cytidylyltransferase;
CTP:inositol-1-phosphate cytidylyltransferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
IPCT (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
L-myo-inositol-1-phosphate cytidylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:1L-myo-inositol 1-phosphate cytidylyltransferase
Reaction(IUBMB)
CTP + 1L-myo-inositol 1-phosphate = diphosphate + CDP-1L-myo-inositol [RN:R09669]
Reaction(KEGG)
Substrate
CTP [CPD:C00063];
1L-myo-inositol 1-phosphate [CPD:C04006]
Product
diphosphate [CPD:C00013];
CDP-1L-myo-inositol [CPD:C19794]
Comment
In many organisms this activity is catalysed by a bifunctional enzyme. The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments.
History
EC 2.7.7.74 created 2011
Pathway
Inositol phosphate metabolism
Orthology
K07281  
1L-myo-inositol 1-phosphate cytidylyltransferase
Genes
MTHD: 
ENM: 
NAR: 
STAX: 
GBE: 
GDI: 
GDI0629(hasC)
GDJ: 
NTR: 
TMR: 
TPZ: 
RXY: 
Rxyl_1212
TTR: 
Tter_0472
RMR: 
Rmar_1196
RMG: 
Rhom172_1617
AAE: 
aq_1367(spsI)
PMX: 
PERMA_1921
TTK: 
TST_0884
TID: 
Thein_0126
MIF: 
Metin_0454
MIG: 
Metig_1787
AFU: 
AF_0263
AFG: 
AFULGI_00002550
APO: 
Arcpr_0766
AVE: 
Arcve_2013
AST: 
Asulf_00859
FPL: 
Ferp_0148
GAC: 
GACE_2065
GAH: 
GAH_01161
PHO: 
PH1219(PH1219)
PAB: 
PAB2433
PFU: 
PF1058
PFI: 
PFC_04525
PYN: 
PNA2_1704
PYA: 
PYCH_00120
PYS: 
Py04_1010
PYC: 
TQ32_04290
TKO: 
TK2279
TON: 
TON_1248
TGA: 
TGAM_1853
TSI: 
TSIB_1010
TBA: 
TERMP_01130
THE: 
GQS_09430
THA: 
TAM4_5
THM: 
CL1_1475
TLT: 
OCC_08385
THS: 
TES1_1181
TNU: 
BD01_1626
TEU: 
TEU_00190
TCH: 
CHITON_0904
TPEP: 
A0127_03970
PPAC: 
PAP_05835
APE: 
APE_1514.1
ACJ: 
ACAM_0951
IAG: 
Igag_0487
HBU: 
Hbut_0150
PFM: 
Pyrfu_0046
PDL: 
Pyrde_0746
TPE: 
Tpen_1250
THB: 
N186_00105
KCR: 
Kcr_0184
BARC: 
AOA65_0707
LOKI: 
Lokiarch_24620 Lokiarch_51830
 » show all
Taxonomy
Reference
1  [PMID:17526717]
  Authors
Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H
  Title
Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.
  Journal
J. Bacteriol. 189 (2007) 5405-12.
  Sequence
[aae:aq_1367] [afu:AF_0263] [pfu:PF1058][rxy:Rxyl_1212] [tko:TK2279]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
KEGG   REACTION: R09669Help
Entry
R09669                      Reaction                               

Name
CTP:1L-myo-inositol 1-phosphate cytidylyltransferase
Definition
CTP + 1D-myo-Inositol 3-phosphate <=> Diphosphate + CDP-1L-myo-inositol
Equation
Reaction class
C04006_C19794
Enzyme
Pathway
Inositol phosphate metabolism
Orthology
K07281  
1L-myo-inositol 1-phosphate cytidylyltransferase [EC:2.7.7.74]
Other DBs
RHEA: 
DBGET integrated database retrieval system