KEGG ORTHOLOGY: K07514

ORTHOLOGY: K07514

Entry

K07514                      KO

Symbol

EHHADH

Name

enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]

Pathway

map00071

Fatty acid degradation

map00280

Valine, leucine and isoleucine degradation

map00310

Lysine degradation

map00380

Tryptophan metabolism

map00410

beta-Alanine metabolism

map00627

Aminobenzoate degradation

map00640

Propanoate metabolism

map00650

Butanoate metabolism

map00930

Caprolactam degradation

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01120

Microbial metabolism in diverse environments

map01212

Fatty acid metabolism

map03320

PPAR signaling pathway

map04146

Peroxisome

Module

M00032

Lysine degradation, lysine => saccharopine => acetoacetyl-CoA

M00087

beta-Oxidation

Reaction

R01975

(S)-3-hydroxybutanoyl-CoA:NAD+ oxidoreductase

R03026

(S)-3-hydroxybutanoyl-CoA hydro-lyase

R03045

3-hydroxypropionyl-CoA hydro-lyase

R04137

3-hydroxyisovaleryl-CoA hydro-lyase

R04170

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

R04203

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase

R04204

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

R04224

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

R04737

(S)-3-hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase

R04738

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

R04739

(S)-3-hydroxytetradecanoyl-CoA:NAD+ oxidoreductase

R04740

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

R04741

(S)-3-hydroxydodecanoyl-CoA:NAD+ oxidoreductase

R04743

(S)-hydroxydecanoyl-CoA:NAD+ oxidoreductase

R04744

(S)-hydroxydecanoyl-CoA hydro-lyase

R04745

(S)-hydroxyoctanoyl-CoA:NAD+ oxidoreductase

R04746

(S)-hydroxyoctanoyl-CoA hydro-lyase

R04748

(S)-hydroxyhexanoyl-CoA:NAD+ oxidoreductase

R04749

(S)-hydroxyhexanoyl-CoA hydro-lyase

R04756

cis,cis-3,6-dodecadienoyl-CoA delta3-cis-delta2-trans-isomerase

R05595

R06941

(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase

R06942

(3S)-3-hydroxyacyl-CoA hydro-lyase

Disease

H01198

Fanconi renotubular syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00650 Butanoate metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00310 Lysine degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00380 Tryptophan metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09111 Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00930 Caprolactam degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35  3-hydroxyacyl-CoA dehydrogenase
     K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17  enoyl-CoA hydratase
     K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.8  Delta3-Delta2-enoyl-CoA isomerase
     K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase

Other DBs

GO:	0004300 0003857 0004165

Genes

HSA:	1962(EHHADH)

PTR:	460996(EHHADH)

PPS:	100985141(EHHADH)

GGO:	101130472(EHHADH)

PON:	100174685(EHHADH)

NLE:	100586768(EHHADH)

HMH:	116479922(EHHADH)

MCC:	701193(EHHADH)

MCF:	102118537(EHHADH)

MTHB:

126948446

MNI:	105480141(EHHADH)

CSAB:

103221115(EHHADH)

CATY:

105573959(EHHADH)

PANU:

100997048(EHHADH)

TGE:	112619647(EHHADH)

MLEU:

105541035(EHHADH)

RRO:	104672740(EHHADH)

RBB:	108525336(EHHADH)

TFN:	117083838(EHHADH)

PTEH:

111523217(EHHADH)

CANG:

105514476(EHHADH)

CJC:	100395397(EHHADH)

SBQ:	101049266(EHHADH)

CIMI:

108311091(EHHADH)

CSYR:

103253098

MMUR:

105863069(EHHADH)

LCAT:

123630345(EHHADH)

PCOQ:

105808288(EHHADH)

OGA:	100965096(EHHADH)

MMU:	74147(Ehhadh)

MCAL:

110311920(Ehhadh)

MPAH:

110330110(Ehhadh)

RNO:	171142(Ehhadh)

MCOC:

116085740(Ehhadh)

ANU:	117702132 117717517(Ehhadh)

MUN:	110561900(Ehhadh)

CGE:	100754698(Ehhadh)

MAUA:

101832275(Ehhadh)

PROB:

127226986(Ehhadh)

PLEU:

114684255(Ehhadh) 114684664 114687893

MORG:

121465101(Ehhadh)

MFOT:

126504179

AAMP:

119825175(Ehhadh)

NGI:	103732668(Ehhadh)

HGL:	101699730(Ehhadh)

CPOC:

100135519 100732696

CCAN:

109695163

DORD:

105999704 105999705

DSP:	122097828 122097848

PLOP:

NCAR:

MMMA:

OCU:

OPI:	101522356(EHHADH)

TUP:	102502891(EHHADH)

GVR:	103591460(EHHADH)

CFA:	488110(EHHADH)

CLUD:

112662628(EHHADH)

VVP:	112926276(EHHADH)

VLG:	121477417(EHHADH)

NPO:	129498716(EHHADH)

AML:	100468058(EHHADH)

UMR:	103676178(EHHADH)

UAH:	113254101(EHHADH)

UAR:	123778934(EHHADH)

ELK:

111150208

LLV:

125101702

MPUF:

101685945(EHHADH)

MNP:	132011971(EHHADH)

MLK:	131824775(EHHADH)

NVS:	122908770(EHHADH)

ORO:	101370722(EHHADH)

EJU:	114207180(EHHADH)

ZCA:	113918332(EHHADH)

MLX:	118006911(EHHADH)

NSU:	110582430(EHHADH)

LWW:	102732268(EHHADH)

FCA:	101083876(EHHADH)

PYU:	121034100(EHHADH)

PCOO:

112850204(EHHADH)

PBG:	122491648(EHHADH)

PVIV:

125175562(EHHADH)

LRUF:

124526811

PTG:	102965690(EHHADH)

PPAD:

109275245(EHHADH)

PUC:

125921106

AJU:

106967987

HHV:	120238074(EHHADH)

BTA:	518852(EHHADH)

BOM:	102285943(EHHADH)

BIU:	109557289(EHHADH)

BBUB:

102404255(EHHADH)

BBIS:

104998607(EHHADH)

CHX:	102179598(EHHADH)

OAS:	101117635(EHHADH)

BTAX:

128054724(EHHADH)

ODA:	120872222(EHHADH)

CCAD:

122444841(EHHADH)

MBEZ:

129544984(EHHADH)

SSC:	448846(EHHADH)

CFR:	102519802(EHHADH)

CBAI:

105072312(EHHADH)

CDK:	105085864(EHHADH)

VPC:	102535563(EHHADH)

BACU:

102997304(EHHADH)

BMUS:

118894255(EHHADH)

LVE:	103073756(EHHADH)

OOR:	101277611(EHHADH)

DLE:	111173099(EHHADH)

PCAD:

102985760(EHHADH)

PSIU:

116753374(EHHADH)

NASI:

112415146(EHHADH)

ECB:	100067714(EHHADH)

EPZ:	103565918(EHHADH)

EAI:	106834502(EHHADH)

MYB:	102240784(EHHADH)

MYD:	102771761(EHHADH)

MMYO:

118676759(EHHADH)

MLF:	102438879(EHHADH)

PKL:	118723609(EHHADH)

EFUS:

103300660(EHHADH)

MNA:	107527318(EHHADH)

DRO:	112308135(EHHADH)

SHON:

119004236(EHHADH)

AJM:	119038747(EHHADH)

PDIC:

114490871(EHHADH)

PHAS:

123827199(EHHADH)

MMF:	118617797(EHHADH)

PPAM:

129079845(EHHADH)

HAI:	109396830(EHHADH)

RFQ:	117036016(EHHADH)

PALE:

102880064(EHHADH)

PGIG:

120592913(EHHADH)

PVP:	105306896(EHHADH)

RAY:	107518255(EHHADH)

TOD:	119257360(EHHADH)

SARA:

101544136(EHHADH)

SETR:

126012106(EHHADH)

LAV:	100677184(EHHADH)

TMU:

101352903

ETF:	101653713(EHHADH)

DNM:	101423565(EHHADH)

MDO:	100026751(EHHADH)

GAS:	123244682(EHHADH)

SHR:	100913272(EHHADH)

AFZ:

127563515

PCW:	110221285(EHHADH)

OAA:	100082172(EHHADH)

GGA:	424877(EHHADH)

PCOC:

116231030(EHHADH)

MGP:	100551164(EHHADH)

CJO:	107317934(EHHADH)

TPAI:

128082767(EHHADH)

LMUT:

125697493(EHHADH)

NMEL:

110398159(EHHADH)

APLA:

101795970(EHHADH)

ACYG:

106039208(EHHADH)

CATA:

118246948(EHHADH)

AFUL:

116492724(EHHADH)

TGU:	100229171(EHHADH)

LSR:	110474075(EHHADH)

SCAN:

103815479(EHHADH)

PMOA:

120496450(EHHADH)

OTC:	121342163(EHHADH)

PRUF:

121364038(EHHADH)

GFR:	102040622(EHHADH)

FAB:	101818793(EHHADH)

OMA:	130256565(EHHADH)

PHI:	102112202(EHHADH)

PMAJ:

107208675(EHHADH)

CCAE:

111945334(EHHADH)

CCW:	104696695(EHHADH)

CBRC:

103612410(EHHADH)

ETL:	114054815(EHHADH)

ZAB:	102060514(EHHADH)

ACHL:

103804661(EHHADH)

SVG:	106849693(EHHADH)

MMEA:

130581492(EHHADH)

HRT:	120757095(EHHADH)

FPG:	101918474(EHHADH)

FCH:	102057870(EHHADH)

CLV:	102091542(EHHADH)

EGZ:	104131306(EHHADH)

NNI:	104010666(EHHADH)

PCRI:

104035898(EHHADH)

PLET:

104621252(EHHADH)

EHS:	104515039(EHHADH)

PCAO:

104052498(EHHADH)

ACUN:

113483679(EHHADH)

TALA:

104358391(EHHADH)

PADL:

103916934(EHHADH)

AFOR:

103903731(EHHADH)

ACHC:

115347400(EHHADH)

HALD:

104317864(EHHADH)

HLE:	104827863(EHHADH)

AGEN:

126039798

GCL:

127020128

CCRI:

104166182(EHHADH)

CSTI:

104558711(EHHADH)

CMAC:

104474898(EHHADH)

MUI:	104546147(EHHADH)

BREG:

104634099(EHHADH)

FGA:	104075194(EHHADH)

GSTE:

104256732(EHHADH)

LDI:	104342572(EHHADH)

MNB:	103776383(EHHADH)

OHA:	104335115(EHHADH)

NNT:	104409816(EHHADH)

SHAB:

115611825(EHHADH)

DPUB:

104305530(EHHADH)

PGUU:

104463689(EHHADH)

ACAR:

104519549(EHHADH)

CPEA:

104385120(EHHADH)

AVIT:

104269201(EHHADH)

CVF:	104288562(EHHADH)

RTD:	128911683(EHHADH)

CUCA:

104066360(EHHADH)

TEO:	104380371(EHHADH)

BRHI:

104495582(EHHADH)

AAM:	106493091(EHHADH)

AROW:

112970787(EHHADH)

NPD:	112946774(EHHADH)

TGT:	104565507(EHHADH)

DNE:	112983448(EHHADH)

SCAM:

104154206(EHHADH)

ASN:	102381971(EHHADH)

AMJ:	102558567(EHHADH)

CPOO:

109315316(EHHADH)

GGN:	109287805(EHHADH)

PSS:	102453335(EHHADH)

CMY:	102939101(EHHADH)

CCAY:

125642408(EHHADH)

DCC:	119861746(EHHADH)

CPIC:

101941626(EHHADH)

TST:	117882621(EHHADH)

CABI:

116815340(EHHADH)

MRV:	120372509(EHHADH)

ACS:	100558466(ehhadh)

ASAO:

132770771(EHHADH)

PVT:	110075819(EHHADH)

SUND:

121927038(EHHADH)

PBI:	103052873(EHHADH)

PMUR:

107285887(EHHADH)

CTIG:

120313906(EHHADH)

TSR:	106540162(EHHADH)

PGUT:

117678501(EHHADH)

APRI:

131200954(EHHADH)

PTEX:

113436767(EHHADH)

NSS:	113426038(EHHADH)

VKO:	123025753(EHHADH)

PMUA:

114597690(EHHADH)

PRAF:

128414455(EHHADH)

ZVI:	118093712(EHHADH)

HCG:	128351913(EHHADH)

GJA:	107123582(EHHADH)

STOW:

125438180(EHHADH)

EMC:	129331804(EHHADH)

XLA:	108703045(ehhadh.S)

XTR:	100216115(ehhadh)

NPR:	108795601(EHHADH)

RTEM:

120943840(EHHADH)

BBUF:

121007524(EHHADH)

BGAR:

122945387(EHHADH)

MUO:	115473831(EHHADH)

GSH:	117360921(EHHADH)

DRE:	100000859(ehhadh)

SRX:	107749878(ehhadh)

SANH:

107663901(ehhadh)

SGH:

107596516

CAUA:

113108839(ehhadh)

CGIB:

127965244

PTET:

122351568(ehhadh)

LROH:

127171390(ehhadh)

OMC:	131546932(ehhadh)

PPRM:

120487255(ehhadh)

RKG:	130085777(ehhadh)

MAMB:

125270062(ehhadh)

CIDE:

127518238

MASI:

127447182

TROS:

130556176(ehhadh)

TDW:	130427882(ehhadh)

MANU:

129452342(ehhadh)

IPU:

108266325

IFU:	128608419(ehhadh)

PHYP:

113525435(ehhadh)

SMEO:

124382620(ehhadh)

TFD:	113636615(ehhadh)

TVC:	132850513(ehhadh)

AMEX:

103032907(ehhadh)

CMAO:

118811897(ehhadh)

EEE:	113574639(ehhadh)

CHAR:

105908680(ehhadh)

TRU:	101073728(ehhadh)

TFS:	130522172(ehhadh)

TNG:	GSTEN00030532G001

LCO:	104919050(ehhadh)

NCC:	104957955(ehhadh)

TBEN:

117485854(ehhadh)

CGOB:

115025945(ehhadh)

PGEO:

117466946(ehhadh)

GACU:

117556838(ehhadh)

EMAC:

134866818(ehhadh)

ELY:	117251679(ehhadh)

EFO:	125899991(ehhadh)

PLEP:

121948720(ehhadh)

SLUC:

116049496(ehhadh)

ECRA:

117953467(ehhadh)

ESP:	116698260(ehhadh)

PFLV:

114563758(ehhadh)

GAT:	120833480(ehhadh)

PPUG:

119228649(ehhadh)

AFB:	129104453(ehhadh)

CLUM:

117750890(ehhadh)

PSWI:

130203448(ehhadh)

MSAM:

119904012(ehhadh)

SCHU:

122885695(ehhadh)

CUD:	121522181(ehhadh)

ALAT:

119026408(ehhadh)

MZE:	101484421(ehhadh)

ONL:	100709434(ehhadh)

OAU:	116323006(ehhadh)

OLA:	101170799(ehhadh)

OML:	112155124(ehhadh)

CSAI:

133446002(ehhadh)

XMA:	102219640(ehhadh)

XCO:	114148066(ehhadh)

XHE:	116722977(ehhadh)

PRET:

103461662(ehhadh)

PFOR:

103150606(ehhadh)

PLAI:

106963921(ehhadh)

PMEI:

106933048(ehhadh)

GAF:	122839879(ehhadh)

PPRL:

129361486(ehhadh)

CVG:	107087127(ehhadh)

CTUL:

119771920(ehhadh)

GMU:	124871138(ehhadh)

NFU:	107390106(ehhadh)

KMR:	108240797(ehhadh)

ALIM:

106523328(ehhadh)

NWH:	119419099(ehhadh)

AOCE:

111588505(ehhadh)

MCEP:

125018015(ehhadh)

CSEM:

103392204(ehhadh)

POV:	109631473(ehhadh)

SSEN:

122765508(ehhadh)

HHIP:

117755359(ehhadh)

HSP:	118120384(ehhadh)

SMAU:

118282583(ehhadh)

LCF:

108901033

SDU:	111218377(ehhadh)

SLAL:

111651262(ehhadh)

XGL:	120802001(ehhadh)

HCQ:	109523309(ehhadh)

SSCV:

125973324

SBIA:

133511792(ehhadh)

PEE:	133410933(ehhadh)

PTAO:

133486644(ehhadh)

BPEC:

110166609(ehhadh)

MALB:

109957167(ehhadh)

BSPL:

114847834(ehhadh)

SJO:	128367872(ehhadh)

SASA:

100195275(ehhadh)

STRU:

115155396(ehhadh)

OTW:	112218409(ehhadh)

OMY:	110501984(ehhadh)

OGO:	124035923(ehhadh)

ONE:	115121742(ehhadh)

OKI:	109882746(ehhadh)

OKE:	118386454(ehhadh)

SALP:

112072998(ehhadh)

CCLU:

121554858(ehhadh)

ELS:	105029884(ehhadh)

SFM:	108928073(ehhadh)

PKI:	111841633(ehhadh)

AANG:

118223161(ehhadh)

LOC:	102697242(ehhadh)

PSPA:

121323163(ehhadh)

ARUT:

117406299(ehhadh)

PSEX:

120531176(ehhadh)

LCM:	102356308(EHHADH)

BFO:	118407380 118430607

BBEL:

109465671 109480267

CIN:	100180564 100182913

SCLV:

120345665 120345918

SPU:	588204 753669

LPIC:

129274156

APLC:

110973407

AJC:

117109929

LGI:	LOTGIDRAFT_202473

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105343896 117683556

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

RPHI:

DPOL:

LAK:

TAD:	TRIADDRAFT_63801

» show all

Reference

PMID:8188243

Authors

Hoefler G, Forstner M, McGuinness MC, Hulla W, Hiden M, Krisper P, Kenner L, Ried T, Lengauer C, Zechner R, et al.

Title

cDNA cloning of the human peroxisomal enoyl-CoA hydratase: 3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme and localization to chromosome 3q26.3-3q28: a free left Alu Arm is inserted in the 3' noncoding region.

Journal

Genomics 19:60-7 (1994)
DOI:10.1006/geno.1994.1013

Sequence

[hsa:1962]

Reference

PMID:20167786

Authors

Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL

Title

Regulation of cellular metabolism by protein lysine acetylation.

Journal

Science 327:1000-4 (2010)
DOI:10.1126/science.1179689

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