KEGG   ORTHOLOGY: K07543Help
Entry
K07543                      KO                                     

Name
bbsE
Definition
benzylsuccinate CoA-transferase BbsE subunit [EC:2.8.3.15]
Pathway
ko00623  Toluene degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00418  Toluene degradation, anaerobic, toluene => benzoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K07543  bbsE; benzylsuccinate CoA-transferase BbsE subunit
KEGG modules [BR:ko00002]
 Pathway module
  Secondary metabolism
   Aromatics degradation
    M00418  Toluene degradation, anaerobic, toluene => benzoyl-CoA
     K07543  bbsE; benzylsuccinate CoA-transferase BbsE subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.8  Transferring sulfur-containing groups
   2.8.3  CoA-transferases
    2.8.3.15  succinyl-CoA:(R)-benzylsuccinate CoA-transferase
     K07543  bbsE; benzylsuccinate CoA-transferase BbsE subunit
BRITE hierarchy
Other DBs
RN: R05588
GO: 0018728
Genes
BYI: BYI23_C006090(bbsE)
BUE: BRPE67_CCDS05370(bbsE)
BBR: BB4333(bbsE)
BBX: BBS798_4110(bbsE)
AXY: AXYL_00933
VEI: Veis_4270
EBA: c2A312(bbsE)
AZI: AzCIB_4522
GME: Gmet_1521(bbsE)
GEO: Geob_2420(bbsE)
DTO: TOL2_C01510(bbsE) TOL2_C04940(bhsE)
AG: AAF89840(bbsE)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Leuthner B, Heider J
  Title
Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of beta oxidation of the intermediate benzylsuccinate.
  Journal
J Bacteriol 182:272-7 (2000)
DOI:10.1128/JB.182.2.272-277.2000
  Sequence

KEGG   ORTHOLOGY: K07544Help
Entry
K07544                      KO                                     

Name
bbsF
Definition
benzylsuccinate CoA-transferase BbsF subunit [EC:2.8.3.15]
Pathway
ko00623  Toluene degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00418  Toluene degradation, anaerobic, toluene => benzoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K07544  bbsF; benzylsuccinate CoA-transferase BbsF subunit
KEGG modules [BR:ko00002]
 Pathway module
  Secondary metabolism
   Aromatics degradation
    M00418  Toluene degradation, anaerobic, toluene => benzoyl-CoA
     K07544  bbsF; benzylsuccinate CoA-transferase BbsF subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.8  Transferring sulfur-containing groups
   2.8.3  CoA-transferases
    2.8.3.15  succinyl-CoA:(R)-benzylsuccinate CoA-transferase
     K07544  bbsF; benzylsuccinate CoA-transferase BbsF subunit
BRITE hierarchy
Other DBs
RN: R05588
GO: 0018728
Genes
BYI: BYI23_C006080
BBR: BB4334(bbsF)
BBX: BBS798_4111(bbsF)
AXY: AXYL_00934
VEI: Veis_4269
EBA: c2A311(bbsF)
AZI: AzCIB_4521
GME: Gmet_1522(bbsF)
GEO: Geob_2421(bbsF)
DTO: TOL2_C01520(bbsF) TOL2_C04950(bhsF)
AG: AAF89841(bbsF)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Leuthner B, Heider J
  Title
Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of beta oxidation of the intermediate benzylsuccinate.
  Journal
J Bacteriol 182:272-7 (2000)
DOI:10.1128/JB.182.2.272-277.2000
  Sequence

KEGG   ENZYME: 2.8.3.15Help
Entry
EC 2.8.3.15                 Enzyme                                 

Name
succinyl-CoA:(R)-benzylsuccinate CoA-transferase;
benzylsuccinate CoA-transferase
Class
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
BRITE hierarchy
Sysname
succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase
Reaction(IUBMB)
succinyl-CoA + (R)-2-benzylsuccinate = succinate + (R)-2-benzylsuccinyl-CoA [RN:R05588]
Reaction(KEGG)
Substrate
succinyl-CoA [CPD:C00091];
(R)-2-benzylsuccinate [CPD:C09816]
Product
succinate [CPD:C00042];
(R)-2-benzylsuccinyl-CoA [CPD:C09817]
Comment
Involved in anaerobic catabolism of toluene and is a strictly toluene-induced enzyme that catalyses the reversible regio- and enantio-selective synthesis of (R)-2-benzylsuccinyl-CoA. The enzyme from Thauera aromatica is inactive when (R)-benzylsuccinate is replaced by (S)-benzylsuccinate.
History
EC 2.8.3.15 created 2003
Pathway
ec00623  Toluene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K07543  benzylsuccinate CoA-transferase BbsE subunit
K07544  benzylsuccinate CoA-transferase BbsF subunit
Genes
BYI: BYI23_C006080 BYI23_C006090(bbsE)
BUE: BRPE67_CCDS05370(bbsE)
BBR: BB4333(bbsE) BB4334(bbsF)
BBX: BBS798_4110(bbsE) BBS798_4111(bbsF)
AXY: AXYL_00933 AXYL_00934
VEI: Veis_4269 Veis_4270
EBA: c2A311(bbsF) c2A312(bbsE)
AZI: AzCIB_4521 AzCIB_4522
GME: Gmet_1521(bbsE) Gmet_1522(bbsF)
GEO: Geob_2420(bbsE) Geob_2421(bbsF)
DTO: TOL2_C01510(bbsE) TOL2_C01520(bbsF) TOL2_C04940(bhsE) TOL2_C04950(bhsF)
 » show all
Taxonomy
Reference
1  [PMID:11418570]
  Authors
Leutwein C, Heider J.
  Title
Succinyl-CoA:(R)-benzylsuccinate CoA-transferase: an enzyme of the anaerobic toluene catabolic pathway in denitrifying bacteria.
  Journal
J. Bacteriol. 183 (2001) 4288-95.
  Sequence
Reference
2  [PMID:10589736]
  Authors
Leutwein C, Heider J.
  Title
Anaerobic toluene-catabolic pathway in denitrifying Thauera aromatica: activation and beta-oxidation of the first intermediate, (R)-(+)-benzylsuccinate.
  Journal
Microbiology. 145 ( Pt 11) (1999) 3265-71.
Reference
3  [PMID:10629170]
  Authors
Leuthner B, Heider J.
  Title
Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of beta oxidation of the intermediate benzylsuccinate.
  Journal
J. Bacteriol. 182 (2000) 272-7.
  Sequence
Reference
4  [PMID:11749953]
  Authors
Heider J.
  Title
A new family of CoA-transferases.
  Journal
FEBS. Lett. 509 (2001) 345-9.
Other DBs
ExplorEnz - The Enzyme Database: 2.8.3.15
IUBMB Enzyme Nomenclature: 2.8.3.15
ExPASy - ENZYME nomenclature database: 2.8.3.15
UM-BBD (Biocatalysis/Biodegradation Database): 2.8.3.15
BRENDA, the Enzyme Database: 2.8.3.15
CAS: 260966-56-1

KEGG   REACTION: R05588Help
Entry
R05588                      Reaction                               

Definition
Benzylsuccinate + Succinyl-CoA <=> Benzylsuccinyl-CoA + Succinate
Equation
Comment
BbsE,BbsF
Reaction class
RC00014  C00042_C00091
RC00137  C09816_C09817
Enzyme
Pathway
rn00623  Toluene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00418  Toluene degradation, anaerobic, toluene => benzoyl-CoA
Orthology
K07543  benzylsuccinate CoA-transferase BbsE subunit [EC:2.8.3.15]
K07544  benzylsuccinate CoA-transferase BbsF subunit [EC:2.8.3.15]
Other DBs
RHEA: 16472

DBGET integrated database retrieval system