KEGG   ORTHOLOGY: K07545Help
Entry
K07545                      KO                                     

Name
bbsG
Definition
(R)-benzylsuccinyl-CoA dehydrogenase [EC:1.3.8.3]
Pathway
Toluene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Degradation of aromatic compounds
Module
M00418  
Toluene degradation, anaerobic, toluene => benzoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K07545  bbsG; (R)-benzylsuccinyl-CoA dehydrogenase
KEGG modules [BR:ko00002]
 Pathway module
  Secondary metabolism
   Aromatics degradation
    M00418  Toluene degradation, anaerobic, toluene => benzoyl-CoA
     K07545  bbsG; (R)-benzylsuccinyl-CoA dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.8  With a flavin as acceptor
    1.3.8.3  (R)-benzylsuccinyl-CoA dehydrogenase
     K07545  bbsG; (R)-benzylsuccinyl-CoA dehydrogenase
BRITE hierarchy
Other DBs
RN: 
Genes
VEI: 
EBA: 
c2A310(bbsG)
AZI: 
GME: 
Gmet_1523(bbsG)
GEO: 
Geob_2422(bbsG)
DTO: 
AG: 
AAF89842(bbsG)
TaxonomyKoalaUniProt
Reference
  Authors
Leuthner B, Heider J
  Title
Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of beta oxidation of the intermediate benzylsuccinate.
  Journal
J Bacteriol 182:272-7 (2000)
DOI:10.1128/JB.182.2.272-277.2000
  Sequence
Reference
  Authors
Leutwein C, Heider J
  Title
(R)-Benzylsuccinyl-CoA dehydrogenase of Thauera aromatica, an enzyme of the anaerobic toluene catabolic pathway.
  Journal
Arch Microbiol 178:517-24 (2002)
DOI:10.1007/s00203-002-0484-5
  Sequence

KEGG   ENZYME: 1.3.8.3Help
Entry
EC 1.3.8.3                  Enzyme                                 

Name
(R)-benzylsuccinyl-CoA dehydrogenase;
BbsG;
(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
BRITE hierarchy
Sysname
(R)-benzylsuccinyl-CoA:electron transfer flavoprotein oxidoreductase
Reaction(IUBMB)
(R)-2-benzylsuccinyl-CoA + electron-transfer flavoprotein = (E)-2-benzylidenesuccinyl-CoA + reduced electron-transfer flavoprotein
Reaction(KEGG)
(other) R05584
Show
Substrate
(R)-2-benzylsuccinyl-CoA [CPD:C09817];
electron-transfer flavoprotein [CPD:C04253]
Product
(E)-2-benzylidenesuccinyl-CoA [CPD:C09818];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Requires FAD as prosthetic group. Unlike other acyl-CoA dehydrogenases, this enzyme exhibits high substrate- and enantiomer specificity; it is highly specific for (R)-benzylsuccinyl-CoA and is inhibited by (S)-benzylsuccinyl-CoA. Forms the third step in the anaerobic toluene metabolic pathway in Thauera aromatica. Ferricenium ion is an effective artificial electron acceptor.
History
EC 1.3.8.3 created 2003 as EC 1.3.99.21, transferred 2012 to EC 1.3.8.3
Pathway
Toluene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K07545  
(R)-benzylsuccinyl-CoA dehydrogenase
Genes
VEI: 
EBA: 
c2A310(bbsG)
AZI: 
GME: 
Gmet_1523(bbsG)
GEO: 
Geob_2422(bbsG)
DTO: 
Taxonomy
Reference
1  [PMID:10589736]
  Authors
Leutwein C, Heider J.
  Title
Anaerobic toluene-catabolic pathway in denitrifying Thauera aromatica: activation and beta-oxidation of the first intermediate, (R)-(+)-benzylsuccinate.
  Journal
Microbiology. 145 ( Pt 11) (1999) 3265-71.
Reference
2  [PMID:12420174]
  Authors
Leutwein C, Heider J.
  Title
(R)-Benzylsuccinyl-CoA dehydrogenase of Thauera aromatica, an enzyme of the anaerobic toluene catabolic pathway.
  Journal
Arch. Microbiol. 178 (2002) 517-24.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 

KEGG   REACTION: R05584Help
Entry
R05584                      Reaction                               

Name
(R)-benzylsuccinyl-CoA:electron transfer flavoprotein oxidoreductase
Definition
Benzylsuccinyl-CoA + 2 Electron-transferring flavoprotein <=> E-Phenylitaconyl-CoA + 2 Reduced electron-transferring flavoprotein
Equation
C09817 + 2 C04253 <=> C09818 + 2 C04570
Comment
BbsG
Reaction class
C09817_C09818
Enzyme
Pathway
Toluene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Degradation of aromatic compounds
Module
M00418  
Toluene degradation, anaerobic, toluene => benzoyl-CoA
Orthology
K07545  
(R)-benzylsuccinyl-CoA dehydrogenase [EC:1.3.8.3]

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