KEGG ORTHOLOGY: K08024

ORTHOLOGY: K08024

Entry

K08024                      KO

Symbol

HHEX, HEX, PRH

Name

homeobox protein HEX

Pathway

map04950

Maturity onset diabetes of the young

map05202

Transcriptional misregulation in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K08024  HHEX, HEX, PRH; homeobox protein HEX
  09167 Endocrine and metabolic disease
   04950 Maturity onset diabetes of the young
    K08024  HHEX, HEX, PRH; homeobox protein HEX
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08024  HHEX, HEX, PRH; homeobox protein HEX
Transcription factors [BR:ko03000]
Eukaryotic type
  Helix-turn-helix
   Homeo domain ANTP: NKL
    K08024  HHEX, HEX, PRH; homeobox protein HEX

Genes

HSA:	3087(HHEX)

PTR:	450612(HHEX)

PPS:	100989300(HHEX)

GGO:	101153044(HHEX)

PON:	100438299(HHEX)

NLE:	100588773(HHEX)

HMH:	116478679(HHEX)

MCC:	699012(HHEX)

MCF:	102130174(HHEX)

MTHB:

126962047

MNI:	105480238(HHEX)

CSAB:

103216269(HHEX)

CATY:

105587120(HHEX)

PANU:

101010992(HHEX)

TGE:	112631611(HHEX)

MLEU:

105545539(HHEX)

RRO:	104676504(HHEX)

RBB:	108532594(HHEX)

TFN:	117091774(HHEX)

PTEH:

111552204(HHEX)

CANG:

105515930(HHEX)

CJC:	100385860(HHEX)

SBQ:	101049534(HHEX)

CIMI:

108282304(HHEX)

MMUR:

105872148(HHEX)

LCAT:

123649645(HHEX)

PCOQ:

105822670(HHEX)

OGA:	100962633(HHEX)

MMU:	15242(Hhex)

MCAL:

110285560(Hhex)

MPAH:

110336869(Hhex)

RNO:	79237(Hhex)

MCOC:

116103793(Hhex)

ANU:	117720844(Hhex)

MUN:	110545269(Hhex)

CGE:	100751343(Hhex)

MAUA:

101837374(Hhex)

PROB:

127233225(Hhex)

PLEU:

114702449(Hhex)

MORG:

121454327(Hhex)

MFOT:

126511862

AAMP:

119817821(Hhex)

NGI:	103747271(Hhex)

HGL:	101697305(Hhex)

CPOC:

100724337(Hhex)

CCAN:

109690720(Hhex)

DORD:

105999336(Hhex)

DSP:	122115757(Hhex)

PLOP:

125346272(Hhex)

NCAR:

124984936

MMMA:

107154410(Hhex)

OCU:

100008709

OPI:	101519116(HHEX)

TUP:	102493100(HHEX)

GVR:	103587526(HHEX)

CFA:	608175(HHEX)

CLUD:

112672062(HHEX)

VLG:	121485782(HHEX)

NPO:	129515506(HHEX)

AML:	100463548(HHEX)

UMR:	103668080(HHEX)

UAH:	113243171(HHEX)

UAR:	123800360(HHEX)

ELK:

111145351

LLV:

125085009

MPUF:

101675580(HHEX)

MNP:	132016626(HHEX)

MLK:	131828651(HHEX)

NVS:	122900930(HHEX)

ORO:	101380334(HHEX)

EJU:	114205156(HHEX)

ZCA:	113923903(HHEX)

MLX:	118023757(HHEX)

NSU:	110589347(HHEX)

LWW:	102734360(HHEX)

FCA:	101085923(HHEX)

PYU:	121036999(HHEX)

PCOO:

112854465(HHEX)

PBG:	122493031(HHEX)

PVIV:

125148373(HHEX)

LRUF:

124506996

PTG:	102972069(HHEX)

PPAD:

109264661(HHEX)

PUC:

125933385

AJU:

106965820

HHV:	120230634(HHEX)

BTA:	539542(HHEX)

BOM:	102269887(HHEX)

BIU:	109553190(HHEX)

BBUB:

102390282(HHEX)

BBIS:

104990201(HHEX)

CHX:	102174536(HHEX)

OAS:	101104445(HHEX)

BTAX:

128068074(HHEX)

ODA:	120873698(HHEX)

CCAD:

122446532(HHEX)

MBEZ:

129555539(HHEX)

SSC:	397232(HHEX)

CFR:	102509094(HHEX)

CBAI:

105081828(HHEX)

CDK:	105084235(HHEX)

VPC:	102532298(HHEX)

BACU:

103017026(HHEX)

BMUS:

118882256(HHEX)

LVE:	103075626(HHEX)

OOR:	101276461(HHEX)

DLE:	111172490(HHEX)

PCAD:

102977010(HHEX)

PSIU:

116742003(HHEX)

NASI:

112396060(HHEX)

ECB:	100071280(HHEX)

EPZ:	103563511(HHEX)

EAI:	106845088(HHEX)

MYB:	102244809(HHEX)

MYD:	102758222(HHEX)

MMYO:

118669956(HHEX)

MLF:

102438006

PKL:	118719296(HHEX)

EFUS:

103300048(HHEX)

MNA:	107543252(HHEX)

DRO:	112307372(HHEX)

SHON:

118987985(HHEX)

AJM:	119057769(HHEX)

PDIC:

114498073(HHEX)

PHAS:

123829147(HHEX)

MMF:	118632262(HHEX)

PPAM:

129069824(HHEX)

HAI:	109380909(HHEX)

RFQ:	117036418(HHEX)

PALE:

102878210(HHEX)

PGIG:

120609308(HHEX)

PVP:	105293077(HHEX)

RAY:	107514009(HHEX)

MJV:	108396633(HHEX)

TOD:	119233523(HHEX)

SARA:

101546009(HHEX)

LAV:	100676315(HHEX)

TMU:

101341447

DNM:	101432630(HHEX)

MDO:	100018287(HHEX)

GAS:	123236327(HHEX)

SHR:	100919359(HHEX)

AFZ:

127551696

PCW:	110192780(HHEX)

OAA:	114810021(HHEX)

GGA:	396182(HHEX)

PCOC:

116231762(HHEX)

MGP:	100542434(HHEX)

CJO:	107316110(HHEX)

TPAI:

128077871(HHEX)

LMUT:

125693390(HHEX)

NMEL:

110400278(HHEX)

APLA:

101801436(HHEX)

ACYG:

106047583(HHEX)

CATA:

118246693(HHEX)

AFUL:

116491489(HHEX)

TGU:	100227282(HHEX)

LSR:	110473712(HHEX)

SCAN:

115485531(HHEX)

PMOA:

120501954(HHEX)

OTC:	121341659(HHEX)

PRUF:

121350074(HHEX)

FAB:	101819564(HHEX)

OMA:	130255033(HHEX)

PMAJ:

107206706(HHEX)

CCAE:

111944995(HHEX)

CCW:	104696251(HHEX)

CBRC:

103624622(HHEX)

ETL:	114071450(HHEX)

ZAB:	102067943(HHEX)

ACHL:

103798244(HHEX)

SVG:	106852658(HHEX)

MMEA:

130582485(HHEX)

HRT:	120755560(HHEX)

FPG:	101914528(HHEX)

CLV:	102087283(HHEX)

EGZ:	104129062(HHEX)

NNI:	104013857(HHEX)

ACUN:

113481665(HHEX)

TALA:

104355900(HHEX)

AFOR:

103897847(HHEX)

ACHC:

115348046(HHEX)

HLE:	104830241(HHEX)

AGEN:

126042774

GCL:

127017800

CSTI:

104557183(HHEX)

MUI:

104548873

LDI:	104345823(HHEX)

OHA:	104330482(HHEX)

SHAB:

115608909(HHEX)

DPUB:

104297795(HHEX)

CPEA:

104390910(HHEX)

RTD:	128911758(HHEX)

CUCA:

104067945(HHEX)

TEO:	104377885(HHEX)

AAM:	106491515(HHEX)

NPD:	112957736(HHEX)

DNE:	112979738(HHEX)

ASN:	102376388(HHEX)

AMJ:	102565970(HHEX)

CPOO:

109323849(HHEX)

GGN:	109287155(HHEX)

PSS:	102452956(HHEX)

CMY:	102945086(HHEX)

CCAY:

125640420(HHEX)

DCC:	119859507(HHEX)

CPIC:

101952688(HHEX)

TST:	117880706(HHEX)

CABI:

116832418(HHEX)

MRV:	120369480(HHEX)

ACS:	100565248(hhex)

ASAO:

132771086(HHEX)

PVT:	110073575(HHEX)

SUND:

121926353(HHEX)

PBI:	103065806(HHEX)

PMUR:

107283400(HHEX)

CTIG:

120304924(HHEX)

PGUT:

117673196(HHEX)

APRI:

131201199(HHEX)

PTEX:

113442791(HHEX)

NSS:	113414047(HHEX)

VKO:	123018497(HHEX)

PMUA:

114597336(HHEX)

PRAF:

128414063(HHEX)

ZVI:	118096490(HHEX)

HCG:	128351987(HHEX)

GJA:	107106486(HHEX)

STOW:

125438077(HHEX)

EMC:	129331681(HHEX)

XLA:	108697398(hhex.S) 373590(hhex.L)

XTR:	395060(hhex)

NPR:	108788827(HHEX)

RTEM:

120946943(HHEX)

BBUF:

121004351(HHEX)

BGAR:

122940607(HHEX)

MUO:	115470106(HHEX)

GSH:	117359888(HHEX)

DRE:	30098(hhex)

SRX:	107715335 107746752

SANH:

107659700 107688034

SGH:	107595156 107597790

CCAR:

109084975 109091321

CAUA:

113055890 113111360

CGIB:

127968740 128025580

PTET:

122333531(hhex)

LROH:

127174467(hhex)

OMC:	131551063(hhex)

PPRM:

120462705(hhex)

MAMB:

125255007(hhex)

CIDE:

127523216

MASI:

127423551 127426681

TROS:

130566257(hhex)

TDW:	130439036(hhex)

MANU:

129421308(hhex)

IPU:

108274140

IFU:	128616576(hhex)

PHYP:

113527536(hhex)

SMEO:

124388966(hhex)

TFD:	113634069(hhex)

TVC:	132862768(hhex)

CMAO:

118809060(hhex)

EEE:	113586120(hhex)

CHAR:

105888824(hhex)

TRU:	101065627(hhex)

TFS:	130539196(hhex)

TNG:	GSTEN00010830G001

LCO:	104928865(hhex)

NCC:

104952083

TBEN:

117473381(hhex)

CGOB:

115024671(hhex)

PGEO:

117465238(hhex)

GACU:

117537661(hhex)

EMAC:

134871414(hhex)

ELY:	117246888(hhex)

EFO:	125881017(hhex)

PLEP:

121958776(hhex)

SLUC:

116067494(hhex)

ECRA:

117936766(hhex)

ESP:	116671540(hhex)

PFLV:

114548247(hhex)

GAT:	120818869(hhex)

PPUG:

119213367(hhex)

AFB:	129093360(hhex)

PSWI:

130203444(hhex)

MSAM:

119916134(hhex)

SCHU:

122867499(hhex)

CUD:	121528426(hhex)

ALAT:

119009649(hhex)

MZE:	101468063(hhex)

ONL:	100696209(hhex)

OAU:	116320116(hhex)

OLA:	105356611(hhex)

OML:	112162358(hhex)

CSAI:

133419286(hhex)

XMA:	102225577(hhex)

XCO:	114151247(hhex)

XHE:	116727370(hhex)

PRET:

103482191(hhex)

PFOR:

103142406(hhex)

PLAI:

106962759(hhex)

PMEI:

106934372(hhex)

GAF:	122823341(hhex)

PPRL:

129352271(hhex)

CVG:

107087634

CTUL:

119796107(hhex)

GMU:	124874833(hhex)

NFU:

107373864

KMR:	108245160(hhex)

ALIM:

106511129

NWH:

119424082

AOCE:

111565180(hhex)

MCEP:

125022082(hheX)

CSEM:

103381667(hhex)

POV:

109626804

SSEN:

122758904(hhex)

HHIP:

117753239(hhex)

HSP:	118100129(hhex)

SMAU:

118287890(hhex)

LCF:

108876773

SDU:	111237079(hhex)

SLAL:

111664327(hhex)

XGL:	120794583(hhex)

HCQ:	109529322(hhex)

SSCV:

125991234

SBIA:

133495621(hhex)

PEE:	133418012(hhex)

PTAO:

133469567(hhex)

BPEC:

110154272

MALB:

109966665(hhex)

BSPL:

114845975(hhex)

SJO:	128381024(hhex)

SASA:

100194834(hhex) 106569727 106613997(HHEX)

STRU:

115183297 115183298

OTW:	112243034(hhex)

OMY:	100305190(hhex) 118936241

OGO:	124021750 124022354

ONE:	115128153(hhex)

OKI:	109885922 116364472

OKE:	118382821 127929296

SALP:

112078626

SNH:	120017768 120043044

CCLU:

121578721 123483963

ELS:	105025286(hhex)

SFM:	108939487(hhex)

PKI:	111853673(hhex)

AANG:

118220116(hhex)

LOC:	102686128(hhex)

PSPA:

121321448 121325213

ARUT:

117415216 117418075

PSEX:

120540323(hhex)

LCM:	102355934 102364437(HHEX)

CMK:	103180609(hhex)

RTP:	109910558 109912163(hhex)

CPLA:

122555170 122561095(hhex)

HOC:	132817614 132826450(hhex)

LERI:

129703910(hhex)

PMRN:

116941261(HHEX)

LRJ:	133345592(HHEX)

BFO:

118414820

BBEL:

109471510

CIN:	778638(hex)

SCLV:

120328551

SPU:	115918645 575826

APLC:

110982500

AJC:

117123274

SKO:	100303530(hhex)

DSR:

110191222

DMN:

108154332

DMO:	Dmoj_GI23524

DAZ:

DNV:

DHE:

GFS:

AGA:

ACOZ:

AAG:

AALB:

CQU:	CpipJ_CPIJ003318

CPII:

120428787

AROA:

105685045

TCA:	103315017(Hex)

DPA:

SOY:

CSET:

NVL:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209061

BANY:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

HAW:

HZE:

TNL:

SLIU:

OFU:

PGW:

CCRN:

ZNE:

BROR:

FCD:

DPX:	DAPPUDRAFT_229438

DMK:

DPZ:

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

TUT:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

CEL:	CELE_M6.3(pha-2)

CBR:	CBG_08137(Cbr-pha-2)

CRQ:	GCK72_022182

LOA:	LOAG_11830

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

MYI:

PMAX:

MCAF:

RPHI:

DPOL:

OSN:

LAK:	106163113 106173800

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

Reference

PMID:18498250

Authors

Soufi A, Jayaraman PS

Title

PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate.

Journal

Biochem J 412:399-413 (2008)
DOI:10.1042/BJ20080035

Reference

PMID:8096636

Authors

Bedford FK, Ashworth A, Enver T, Wiedemann LM

Title

HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human.

Journal

Nucleic Acids Res 21:1245-9 (1993)
DOI:10.1093/nar/21.5.1245

Sequence

[hsa:3087]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Gene (715)   
   KEGG GENES (482)   
   KEGG MGENES (137)   
   RefGene (92)   
   OC (4)   
Literature (2)   
   PubMed (2)   
All databases (723)   

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