KEGG   ORTHOLOGY: K08093Help
Entry
K08093                      KO                                     

Name
hxlA
Definition
3-hexulose-6-phosphate synthase [EC:4.1.2.43]
Pathway
Pentose phosphate pathway
Methane metabolism
Carbon metabolism
Biosynthesis of amino acids
Module
M00345  
Formaldehyde assimilation, ribulose monophosphate pathway
M00580  
Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K08093  hxlA; 3-hexulose-6-phosphate synthase
   01230 Biosynthesis of amino acids
    K08093  hxlA; 3-hexulose-6-phosphate synthase
  Carbohydrate metabolism
   00030 Pentose phosphate pathway
    K08093  hxlA; 3-hexulose-6-phosphate synthase
  Energy metabolism
   00680 Methane metabolism
    K08093  hxlA; 3-hexulose-6-phosphate synthase
KEGG modules [BR:ko00002]
 Pathway module
  Energy metabolism
   Methane metabolism
    M00345  Formaldehyde assimilation, ribulose monophosphate pathway
     K08093  hxlA; 3-hexulose-6-phosphate synthase
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00580  Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
     K08093  hxlA; 3-hexulose-6-phosphate synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.43  3-hexulose-6-phosphate synthase
     K08093  hxlA; 3-hexulose-6-phosphate synthase
BRITE hierarchy
Other DBs
RN: 
COG: 
GO: 
Genes
EUM: 
STM: 
SEO: 
SEV: 
SEY: 
SEM: 
SEJ: 
SEB: 
SEF: 
SETU: 
SETC: 
CFSAN001921_03340
SENR: 
STMDT2_26611
SEND: 
DT104_27571
SENI: 
CY43_14395
SEH: 
SeHA_C2929(hxlA)
SHB: 
SU5_03243
SENH: 
CFSAN002069_18505
SEEH: 
SEEH1578_22575
ECLZ: 
LI64_16165
KPN: 
KPN_02957
KPY: 
KPNIH31_18210
KMI: 
VW41_11030
KOC: 
AB185_13840
PGE: 
LG71_08965
SOD: 
Sant_0061
MCA: 
MCA3043 MCA3049
MMT: 
Metme_0742 Metme_4080
MDN: 
JT25_012675 JT25_012930
MDH: 
AYM39_02470 AYM39_02740
MAH: 
MEALZ_3953(hps1)
MEJ: 
Q7A_2498 Q7A_2501
MEC: 
Q7C_1679 Q7C_1682
MFA: 
Mfla_0250 Mfla_1654
MMB: 
Mmol_0313 Mmol_1338
MEH: 
M301_0304 M301_1547
MEI: 
Msip34_0268
MEP: 
MPQ_0281(sgbH) MPQ_1561
MBAC: 
BN1209_0202(rmpA) BN1209_0771(rmpA)
MBAT: 
BN1208_0845(hps)
MEU: 
ACJ67_02420 ACJ67_07420
NSA: 
Nitsa_1660
SLH: 
YH65_04865
GAL: 
A0U94_14275
KBA: 
A0U89_15345
BSU: 
BSU03460(hxlA)
BSR: 
I33_0397(hxlA)
BSL: 
A7A1_1851
BSH: 
BSU6051_03460(hxlA)
BSY: 
I653_01730
BSUT: 
BSUB_00396(hxlA)
BSUL: 
BSUA_00396(hxlA)
BSUS: 
Q433_02070
BSS: 
BSUW23_01790(hxlA)
BST: 
GYO_0559(hxlA)
BSO: 
BSNT_06681(hxlA)
BSN: 
BSn5_13315
BSQ: 
B657_03460(hxlA)
BSX: 
C663_0338(hxlA)
BSP: 
U712_01790
BLI: 
BL02045(hxlA)
BLD: 
BLi02805(hxlA)
BLH: 
BaLi_c29000(hxlA)
BAY: 
RBAM_003630(hxlA)
BAQ: 
BACAU_0303(hxlA)
BYA: 
BANAU_0305(hxlA)
BAMP: 
B938_01575
BAML: 
BAM5036_0322(hxlA)
BAMA: 
RBAU_0337(hxlA)
BAMN: 
BASU_0321(hxlA)
BAMB: 
BAPNAU_0307(hxlA)
BAMT: 
AJ82_01980
BAMY: 
V529_03250(hxlA)
BMP: 
NG74_00345(hxlA)
BAO: 
BAMF_0310(hxlA)
BAZ: 
BAMTA208_01555(hxlA)
BQL: 
LL3_00318(hxlA)
BXH: 
BAXH7_00321(hxlA)
BQY: 
MUS_0325(hxlA)
BAMI: 
KSO_017855
BAMC: 
U471_03230
BAMF: 
U722_01860
BAE: 
BATR1942_20410
BATR: 
TD68_19410
BCL: 
ABC3351(hxlA)
BPU: 
BPUM_2333
BPUM: 
BW16_12650
BPUS: 
UP12_11780
BMQ: 
BMQ_0891(hxlA) BMQ_1538(hxlA) BMQ_2942(hxlA)
BMD: 
BMD_0891(hxlA) BMD_1519(hxlA) BMD_2971(hxlA)
BMH: 
BMWSH_3691 BMWSH_4350(hxlA)
BMEG: 
BG04_3186(hxlA) BG04_3830(hxlA) BG04_4896(hxlA) BG04_5472 BG04_5588(hxlA) BG04_5930(hxlA)
BAG: 
Bcoa_0968
BJS: 
MY9_0361
BIF: 
N288_21395 N288_22430
BMET: 
BMMGA3_06845(hxlA)
GST: 
HW35_08370
BACW: 
QR42_11740
BACP: 
SB24_07990
BACB: 
OY17_04480
BACY: 
QF06_00690
BACL: 
BS34A_04030(hxlA)
BALM: 
BsLM_0362
BEO: 
BEH_06020 BEH_12940
BSM: 
BSM4216_0641
BON: 
A361_15685 A361_15780 A361_26060
BGY: 
BGLY_3090(hxlA)
BFX: 
BC359_14510 BC359_19735
BGI: 
BGM20_16795
BXI: 
BK049_15320
BHK: 
B4U37_02010
OIH: 
OB2806
GTK: 
GT3570_09830
GTN: 
GTNG_1490
GMC: 
GY4MC1_3093
GGH: 
GHH_c21400(hxlA)
GJF: 
M493_16830
GEA: 
GARCT_00704(hxlA_1) GARCT_02004(hxlA_2)
GEL: 
IB49_02240
GSR: 
GS3922_12380
GEJ: 
A0V43_08225
GTH: 
Geoth_3109
PTL: 
AOT13_07080
ANM: 
GFC28_662
ANL: 
GFC29_964
HMN: 
HM131_14425
VIG: 
BKP57_09220
FAR: 
ABE41_010275
SJE: 
AAV35_011130
SAU: 
SA0528
SAV: 
SAV0570
SAW: 
SAHV_0568
SAH: 
SaurJH1_0607 SaurJH1_2812
SAJ: 
SaurJH9_0593 SaurJH9_2736
SAM: 
MW0525
SAS: 
SAS0528
SAR: 
SAR0574
SAC: 
SACOL0617
SAX: 
USA300HOU_0564
SAA: 
SAUSA300_0555
SAO: 
SAOUHSC_00553
SAE: 
NWMN_0533
SAD: 
SAAV_0533(hxlA)
SUU: 
M013TW_0558
SUV: 
SAVC_02440
SUE: 
SAOV_0605
SUJ: 
SAA6159_00524(hxlA)
SUK: 
SAA6008_00578(hxlA)
SUC: 
ECTR2_524(hxlA)
SUT: 
SAT0131_00631
SUQ: 
HMPREF0772_12618(hxlA)
SUZ: 
MS7_0560(hxlA)
SUD: 
ST398NM01_0645
SUX: 
SAEMRSA15_04970
SUW: 
SATW20_06400
SUG: 
SAPIG0645(hxlA)
SUF: 
SARLGA251_05060
SAUA: 
SAAG_00991
SAUE: 
RSAU_000524(hps)
SAUN: 
SAKOR_00559
SAUS: 
SA40_0511
SAUU: 
SA957_0526
SAUG: 
SA268_0524
SAUZ: 
SAZ172_0572
SAUT: 
SAI1T1_2004400
SAUJ: 
SAI2T2_1004420
SAUK: 
SAI3T3_1004410
SAUQ: 
SAI4T8_1004400
SAUV: 
SAI7S6_1004410
SAUW: 
SAI5S5_1004370
SAUX: 
SAI6T6_1004380
SAUY: 
SAI8T7_1004410
SAB: 
SAB0520
SUY: 
SA2981_0547
SAUB: 
C248_0645
SAUM: 
BN843_5640
SAUC: 
CA347_586(hxlA)
SAUR: 
SABB_00621
SAUI: 
AZ30_02885
SAUD: 
CH52_02905
SAUF: 
X998_0612(hxlA)
SAMS: 
NI36_02840
SUH: 
SAMSHR1132_05140
SEP: 
SE0341
SER: 
SERP0216
SEPP: 
SEB_00262
SEPS: 
DP17_1647(hxlA)
SHA: 
SH2420
SHH: 
ShL2_02215(hxlA)
SSP: 
SSP1619 SSP1626 SSP2148
SCA: 
SCA_0226 SCA_0711
SLG: 
SLGD_02315
SLN: 
SLUG_22330
SSD: 
SPSINT_0249
SDT: 
SPSE_2213(hxlA)
SWA: 
A284_00525 A284_10445 A284_12317
SPAS: 
STP1_1658
SXY: 
BE24_00590
SXL: 
SXYLSMQ121_2137
SXO: 
SXYL_02291
SHU: 
SHYC_10795(hxlA)
SCAP: 
AYP1020_2319
SSCH: 
LH95_10395
SSCZ: 
RN70_11130
SAGQ: 
EP23_11365
SEQO: 
SE1039_03970
SSIF: 
AL483_08720
SCV: 
A4G25_06550
MCL: 
MCCL_0037
MCAK: 
MCCS_00640
SHV: 
AAT16_06530 AAT16_11280
ESI: 
Exig_2372
EAN: 
Eab7_2216
EXM: 
U719_13055
EXU: 
ESP131_15165
PJD: 
Pjdr2_1185
GYM: 
GYMC10_3885
PPY: 
PPE_04673
PPM: 
PPSC2_24305(hxlA)
PPO: 
PPM_4826(hxlA)
PPOL: 
X809_40845
PPQ: 
PPSQR21_049250(sgbH)
PPOY: 
RE92_12975
PMS: 
KNP414_07885(hxlA)
PMQ: 
PM3016_7402
PMW: 
B2K_37330
PTA: 
HPL003_05880
PSAB: 
PSAB_01345 PSAB_23295
PDU: 
PDUR_01610 PDUR_26635
PBD: 
PBOR_34755
PGM: 
PGRAT_31065
POD: 
PODO_29415
PAEN: 
P40081_36070
PAEF: 
R50345_29525
PAEQ: 
R50912_32680
PSTE: 
PSTEL_02005 PSTEL_26045
PAEA: 
R70723_31470
PAEE: 
R70331_30230
PAEH: 
H70357_33735
PAEJ: 
H70737_29170
PBJ: 
VN24_01055 VN24_04705
PRI: 
PRIO_3567 PRIO_6499(hxlA)
PPEO: 
ABE82_24515
PNP: 
IJ22_01440 IJ22_02540 IJ22_02590 IJ22_07980
POW: 
IJ21_08240
PBV: 
AR543_06015 AR543_17150
PXL: 
BS614_16300
PYG: 
AWM70_20320
PSWU: 
SY83_08105
PRT: 
AUC31_15190
PANA: 
BBH88_04830 BBH88_17520
PMAR: 
B0X71_02090
JEO: 
JMA_08740 JMA_29170
SPSY: 
AZE41_09415
LBR: 
LVIS_0442
LBK: 
LVISKB_0449
LPQ: 
AF91_01140
LPI: 
LBPG_03035
LPAP: 
LBPC_0348
LCB: 
LCABL_04190 LCABL_04490(hps)
LCZ: 
LCAZH_0412
LCS: 
LCBD_0422 LCBD_0453
LCE: 
LC2W_0417 LC2W_0448
LCW: 
BN194_04270 BN194_04560
LCL: 
LOCK919_0475
LCX: 
LCA12A_2395
LBN: 
LBUCD034_0077(hxlA)
LSN: 
LSA_03490
LMU: 
LBLM1_00435
LLE: 
AYR59_00780
LPD: 
AYR62_06120
LCU: 
PL11_004190
PCE: 
PECL_1750
PACI: 
A4V11_00360
OOE: 
OEOE_0131
LMM: 
MI1_09731
LGC: 
A9176_08390
WCB: 
AO080_07995 AO080_11070
WJO: 
FOL01_0737
AUR: 
HMPREF9243_0240(hxlA)
CAC: 
CA_C0396
CAE: 
SMB_G0404(sgbH)
CAY: 
CEA_G0406
CBE: 
Cbei_4647
CBZ: 
Cbs_4647
CBEI: 
LF65_06885
CSR: 
Cspa_c49610
ROB: 
CK5_18950
PFT: 
JBW_00828
EUC: 
EC1_08720
FRO: 
AALO17_19710
ERB: 
A4V01_02795 A4V01_05815 A4V01_19475
CDX: 
CDES_00570(rmpA)
RHA: 
RHA1_ro11329
ROA: 
Pd630_LPD04589
CMI: 
CMM_1123(sgaH)
CMS: 
CMS1443(hps)
CMC: 
CMN_01092(sgaH)
CMH: 
VO01_04530
MIM: 
AKG07_11695
MIH: 
BJP65_05205
MICR: 
BMW26_14455 BMW26_16485
CUM: 
NI26_12475
CUB: 
BJK06_08985
AGY: 
ATC03_10775
CART: 
PA27867_0095
ART: 
Arth_3708
ARR: 
ARUE_c04640(rmpA)
ARE: 
AL755_02190 AL755_14010
ARH: 
AHiyo8_33930
ARZ: 
AUT26_19920
AAU: 
AAur_0494(hps)
APN: 
Asphe3_02200
PSUL: 
AU252_12865
AAI: 
AARI_06580(rmpA)
GAR: 
AOZ07_14970
KPL: 
KPaMU14_03840
SATK: 
SA2016_1326 SA2016_3449 SA2016_3840 SA2016_3841
BRX: 
BH708_07835
AMQ: 
AMETH_4519(hps) AMETH_4538(hps)
PSEE: 
FRP1_13235 FRP1_13275
PSEQ: 
AD006_20915 AD006_20955
PECQ: 
AD017_00495 AD017_00535
BDE: 
BDP_0013
BDN: 
BBDE_0013
BANG: 
BBAG_0932
OLO: 
ADJ70_05660
ABAO: 
BEQ56_09840
TTR: 
Tter_2273
RBA: 
RB5319
PIR: 
VN12_13465(hxlA)
TRS: 
Terro_1472
ABAC: 
LuPra_03104(hxlA)
STR: 
Sterm_1849 Sterm_3212
RBAR: 
AWN76_010760
CPI: 
Cpin_5671
PEP: 
AQ505_07150
PCM: 
AY601_4886
PSTY: 
BFS30_16375
MUP: 
A0256_03165
CMR: 
Cycma_4041
CAMU: 
CA2015_3993
EVI: 
Echvi_3532
ALM: 
AO498_04580
PKO: 
PKOR_19965
ZPR: 
ZPR_1061
MARM: 
YQ22_17840
CAO: 
Celal_3937
CBAL: 
M667_16185
CBAT: 
M666_16170
ZGA: 
ZOBELLIA_3942(hxlA)
MPG: 
Theba_2591
MJA: 
MJ_0644
MFE: 
Mefer_0259
MVU: 
Metvu_0541
MFS: 
MFS40622_1056
MIF: 
Metin_1445
MJH: 
JH146_0865
MIG: 
Metig_0604
MAE: 
Maeo_1123
MOK: 
Metok_0605
MTH: 
MTH_888
MMG: 
MTBMA_c12830
METC: 
MTCT_0805
MWO: 
MWSIV6_1262(hpsA)
MST: 
Msp_1358
MSI: 
Msm_0426
MRU: 
mru_0712
MEB: 
Abm4_0441
MMIL: 
sm9_0586
MEYE: 
TL18_02745
MOL: 
YLM1_0353
MEL: 
Metbo_2333
MEW: 
MSWAN_0326
METH: 
MBMB1_0388
MFC: 
BRM9_1874
MFI: 
DSM1535_0057
MCUB: 
MCBB_0344(hpsA)
MFV: 
Mfer_0465
MKA: 
MK0153(sgbH) MK1449(menG)
APE: 
APE_0952.1(hxlA)
ACJ: 
ACAM_0624(hxlA)
SMR: 
Smar_0492
SHC: 
Shell_0310
IHO: 
Igni_0269
IIS: 
EYM_01130
DKA: 
DKAM_1456
DFD: 
Desfe_0079
DMU: 
Desmu_0149
TAG: 
Tagg_1068
IAG: 
Igag_1921
THG: 
TCELL_0740
HBU: 
Hbut_0129
PFM: 
Pyrfu_0648
PDL: 
Pyrde_0680
SSO: 
SSO0202(hpS-2)
SOL: 
Ssol_1184
SSOA: 
SULA_1220
SSOL: 
SULB_1221
SSOF: 
SULC_1219
STO: 
STK_02380(hxlA)
SAI: 
Saci_0802
SACN: 
SacN8_03890
SACR: 
SacRon12I_03880
SACS: 
SUSAZ_03625
SIS: 
LS215_2094
SIA: 
M1425_1931
SIM: 
M1627_2009
SID: 
M164_1939
SIY: 
YG5714_2053
SIN: 
YN1551_0865
SII: 
LD85_2191
SIH: 
SiH_1876
SIR: 
SiRe_1804
SIC: 
SiL_1785
SULA: 
BFU36_04900
MSE: 
Msed_0227
MCN: 
Mcup_1845
AHO: 
Ahos_0599
AMAN: 
B6F84_07975
PAI: 
PAE1679
PIS: 
Pisl_1686
PCL: 
Pcal_0568
PAS: 
Pars_1830
PYR: 
P186_0040
POG: 
Pogu_0300
TNE: 
Tneu_0708
PYW: 
PYWP30_00751
CMA: 
Cmaq_1871
TUZ: 
TUZN_2015
TTN: 
TTX_1521(hps)
VDI: 
Vdis_1817
VMO: 
VMUT_0258
TPE: 
Tpen_0372
THB: 
N186_02880
TCB: 
TCARB_1644
ASC: 
ASAC_0959
CLG: 
Calag_0067
FFO: 
FFONT_0403
KCR: 
Kcr_1307
AG: 
BAA19967(rmpA)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Yasueda H, Kawahara Y, Sugimoto S.
  Title
Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose monophosphate pathway used by methylotrophs, and yckH is required for their expression.
  Journal
J Bacteriol 181:7154-60 (1999)
KEGG   ORTHOLOGY: K13812Help
Entry
K13812                      KO                                     

Name
fae-hps
Definition
bifunctional enzyme Fae/Hps [EC:4.2.1.147 4.1.2.43]
Pathway
Pentose phosphate pathway
Methane metabolism
Carbon metabolism
Biosynthesis of amino acids
Module
M00345  
Formaldehyde assimilation, ribulose monophosphate pathway
M00580  
Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K13812  fae-hps; bifunctional enzyme Fae/Hps
   01230 Biosynthesis of amino acids
    K13812  fae-hps; bifunctional enzyme Fae/Hps
  Carbohydrate metabolism
   00030 Pentose phosphate pathway
    K13812  fae-hps; bifunctional enzyme Fae/Hps
  Energy metabolism
   00680 Methane metabolism
    K13812  fae-hps; bifunctional enzyme Fae/Hps
KEGG modules [BR:ko00002]
 Pathway module
  Energy metabolism
   Methane metabolism
    M00345  Formaldehyde assimilation, ribulose monophosphate pathway
     K13812  fae-hps; bifunctional enzyme Fae/Hps
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00580  Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
     K13812  fae-hps; bifunctional enzyme Fae/Hps
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.43  3-hexulose-6-phosphate synthase
     K13812  fae-hps; bifunctional enzyme Fae/Hps
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.147  5,6,7,8-tetrahydromethanopterin hydro-lyase
     K13812  fae-hps; bifunctional enzyme Fae/Hps
BRITE hierarchy
Other DBs
Genes
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MAE: 
MOK: 
MAC: 
MBA: 
Mbar_A0935
MBY: 
MSBRM_0067
MBW: 
MSBRW_0061
MBAR: 
MSBR2_2313
MBAK: 
MSBR3_2375
MMA: 
MM_1279
MMAZ: 
MmTuc01_1325
MMJ: 
MSMAS_0037
MMAC: 
MSMAC_0037
MVC: 
MSVAZ_0074
MEK: 
MSKOL_0070
MLS: 
MSLAZ_0035
METM: 
MSMTP_0040
MEF: 
MSWH1_0036
MEQ: 
MSWHS_0037
MSJ: 
MSSAC_0046
MSZ: 
MSSIH_0039
MSW: 
MSSIT_0039
MTHE: 
MSTHC_1499
MTHR: 
MSTHT_1787
MHOR: 
MSHOH_0037
MBU: 
Mbur_1994(fae-hps)
MMET: 
MCMEM_0222
MMH: 
Mmah_0234
MHAZ: 
BHR79_02340
MEV: 
Metev_1698
MZH: 
Mzhil_0262
MPY: 
Mpsy_1425
MHZ: 
Metho_0261
MTP: 
Mthe_0988
MCJ: 
MCON_1383
MHI: 
Mhar_0019
MHU: 
Mhun_1628
MLA: 
Mlab_0996
MEM: 
Memar_1085
MBG: 
BN140_1075
MEMA: 
MMAB1_1386(fae-hps)
MPI: 
Mpet_0801
MBN: 
Mboo_0772
MFO: 
Metfor_2057
MPL: 
Mpal_1036
MPD: 
MCP_2904(fae_hps)
MEZ: 
Mtc_0381(fae)
RCI: 
RCIX775(fae-hps)
MMG: 
MTBMA_c00570(fae_hps)
METC: 
MTCT_1339
MWO: 
MWSIV6_0011(fae-hps)
MST: 
Msp_1498
MSI: 
Msm_1213
MRU: 
mru_2131
MEB: 
Abm4_0046
MMIL: 
sm9_0074
MEYE: 
TL18_10355
MOL: 
YLM1_1686
MEL: 
Metbo_0071
MEW: 
MSWAN_0017
METH: 
MBMB1_0009(fae-hps)
MFC: 
BRM9_0060
MFI: 
DSM1535_1378(fae-hps)
MCUB: 
MCBB_0021(fae-hps_1)
MFV: 
Mfer_0572
AFU: 
AF_1305
AFG: 
AFULGI_00014160
APO: 
Arcpr_1052
AVE: 
Arcve_1411
AST: 
Asulf_01087
FPL: 
Ferp_2129
GAC: 
GACE_2158
GAH: 
GAH_00575
BARC: 
AOA65_1083(faeB-hpsB)
BARB: 
AOA66_1278
LOKI: 
Lokiarch_06870 Lokiarch_17920 Lokiarch_47420
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Grochowski LL, Xu H, White RH
  Title
Ribose-5-phosphate biosynthesis in Methanocaldococcus jannaschii occurs in the absence of a pentose-phosphate pathway.
  Journal
J Bacteriol 187:7382-9 (2005)
DOI:10.1128/JB.187.21.7382-7389.2005
  Sequence
[mja:MJ_1447]
KEGG   ORTHOLOGY: K13831Help
Entry
K13831                      KO                                     

Name
hps-phi
Definition
3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase [EC:4.1.2.43 5.3.1.27]
Pathway
Pentose phosphate pathway
Methane metabolism
Carbon metabolism
Biosynthesis of amino acids
Module
M00345  
Formaldehyde assimilation, ribulose monophosphate pathway
M00580  
Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
   01230 Biosynthesis of amino acids
    K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
  Carbohydrate metabolism
   00030 Pentose phosphate pathway
    K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
  Energy metabolism
   00680 Methane metabolism
    K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
KEGG modules [BR:ko00002]
 Pathway module
  Energy metabolism
   Methane metabolism
    M00345  Formaldehyde assimilation, ribulose monophosphate pathway
     K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00580  Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
     K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.43  3-hexulose-6-phosphate synthase
     K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.1  Interconverting aldoses and ketoses, and related compounds
    5.3.1.27  6-phospho-3-hexuloisomerase
     K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
BRITE hierarchy
Other DBs
Genes
MCA: 
MAH: 
MEALZ_1912(hpsi2)
DAO: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MVN: 
Mevan_0582
MAC: 
MA_4504
MBA: 
Mbar_A1170
MBY: 
MSBRM_3392
MBW: 
MSBRW_3553
MBAR: 
MSBR2_3345
MBAK: 
MSBR3_3372
MMA: 
MM_1215
MMAZ: 
MmTuc01_1255
MMJ: 
MSMAS_0097
MMAC: 
MSMAC_0105
MVC: 
MSVAZ_0103
MEK: 
MSKOL_0099
MLS: 
MSLAZ_3053
METM: 
MSMTP_0201
MEF: 
MSWH1_3047
MEQ: 
MSWHS_1919
MSJ: 
MSSAC_4300
MSZ: 
MSSIH_3802
MSW: 
MSSIT_3879
MTHE: 
MSTHC_1625
MTHR: 
MSTHT_1664
MHOR: 
MSHOH_0117
MMET: 
MCMEM_0644
MMH: 
Mmah_1222
MHAZ: 
BHR79_07435
MEV: 
Metev_0697
MZH: 
Mzhil_0311
MPY: 
Mpsy_1396
MHZ: 
Metho_0283
MTP: 
Mthe_0455
MCJ: 
MCON_0429
MHI: 
Mhar_1869
MHU: 
Mhun_0647
MLA: 
Mlab_1453
MEM: 
Memar_0744
MBG: 
BN140_1140
MEMA: 
MMAB1_1456(hpsA)
MPI: 
Mpet_0679
MBN: 
Mboo_0707
MFO: 
Metfor_2503
MPL: 
Mpal_2121
MPD: 
MCP_0861
MEZ: 
Mtc_1411
RCI: 
RCIX1492
AFU: 
AF_0861
AFG: 
AFULGI_00009430
APO: 
Arcpr_1797
AVE: 
Arcve_1683
AST: 
Asulf_00326
FPL: 
Ferp_2198
GAC: 
GACE_0250
GAH: 
GAH_00051
TAR: 
TALC_01565
MAX: 
MMALV_16840
MER: 
MMINT_19420
MEAR: 
Mpt1_c14440(faeB)
MARC: 
AR505_0014
PHO: 
PH1938(PH1938)
PAB: 
PAB1222
PFU: 
PF0220
PFI: 
PFC_00160
PYN: 
PNA2_0868
PYA: 
PYCH_13020
PYS: 
Py04_0376
PYC: 
TQ32_01240
TKO: 
TK0475
TON: 
TON_0336
TGA: 
TGAM_1891(hps)
TSI: 
TSIB_0428
TBA: 
TERMP_00758
THE: 
GQS_03555
THA: 
TAM4_82
THM: 
CL1_0365
TLT: 
OCC_09933
THS: 
TES1_0756
TNU: 
BD01_0222
TEU: 
TEU_06790
TGY: 
X802_02210
THV: 
ADU37_CDS03570
TPEP: 
A0127_02350
PPAC: 
PAP_05755
ABI: 
Aboo_0457
ACF: 
AciM339_0590
BARB: 
AOA66_0495
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Orita I, Yurimoto H, Hirai R, Kawarabayasi Y, Sakai Y, Kato N
  Title
The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway.
  Journal
J Bacteriol 187:3636-42 (2005)
DOI:10.1128/JB.187.11.3636-3642.2005
  Sequence
[pho:PH1938]
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate  pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
DOI:10.1128/JB.00492-06
KEGG   ENZYME: 4.1.2.43Help
Entry
EC 4.1.2.43                 Enzyme                                 

Name
3-hexulose-6-phosphate synthase;
D-arabino-3-hexulose 6-phosphate formaldehyde-lyase;
3-hexulosephosphate synthase;
3-hexulose phosphate synthase;
HPS
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
D-arabino-hex-3-ulose-6-phosphate formaldehyde-lyase (D-ribulose-5-phosphate-forming)
Reaction(IUBMB)
D-arabino-hex-3-ulose 6-phosphate = D-ribulose 5-phosphate + formaldehyde [RN:R05338]
Reaction(KEGG)
Substrate
D-arabino-hex-3-ulose 6-phosphate [CPD:C06019]
Product
D-ribulose 5-phosphate [CPD:C00199];
formaldehyde [CPD:C00067]
Comment
Requires Mg2+ or Mn2+ for maximal activity [1]. The enzyme is specific for D-ribulose 5-phosphate as substrate as ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and fructose 6-phosphate cannot act as substrate. In addition to formaldehyde, the enzyme can also use glycolaldehyde and methylglyoxal [7]. This enzyme, along with EC 5.3.1.27, 6-phospho-3-hexuloisomerase, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds [1]. The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyses the reactions of this enzyme and EC 5.3.1.27, 6-phospho-3-hexuloisomerase [6]. This enzyme is a member of the orotidine 5'-monophosphate decarboxylase (OMPDC) suprafamily [5].
History
EC 4.1.2.43 created 2008
Pathway
Pentose phosphate pathway
Methane metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K08093  
3-hexulose-6-phosphate synthase
K13812  
bifunctional enzyme Fae/Hps
K13831  
3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
Genes
EUM: 
STM: 
SEO: 
SEV: 
SEY: 
SEM: 
SEJ: 
SEB: 
SEF: 
SETU: 
SETC: 
CFSAN001921_03340
SENR: 
STMDT2_26611
SEND: 
DT104_27571
SENI: 
CY43_14395
SEH: 
SeHA_C2929(hxlA)
SHB: 
SU5_03243
SENH: 
CFSAN002069_18505
SEEH: 
SEEH1578_22575
ECLZ: 
LI64_16165
KPN: 
KPN_02957
KPY: 
KPNIH31_18210
KMI: 
VW41_11030
KOC: 
AB185_13840
PGE: 
LG71_08965
SOD: 
Sant_0061
MCA: 
MCA2738 MCA3043 MCA3049
MMT: 
Metme_0742 Metme_4080
MDN: 
JT25_012675 JT25_012930
MDH: 
AYM39_02470 AYM39_02740
MAH: 
MEALZ_1912(hpsi2) MEALZ_3953(hps1)
MEJ: 
Q7A_2498 Q7A_2501
MEC: 
Q7C_1679 Q7C_1682
MFA: 
Mfla_0250 Mfla_1654
MMB: 
Mmol_0313 Mmol_1338
MEH: 
M301_0304 M301_1547
MEI: 
Msip34_0268
MEP: 
MPQ_0281(sgbH) MPQ_1561
MBAC: 
BN1209_0202(rmpA) BN1209_0771(rmpA)
MBAT: 
BN1208_0845(hps)
MEU: 
ACJ67_02420 ACJ67_07420
NSA: 
Nitsa_1660
SLH: 
YH65_04865
DAO: 
Desac_1176
GAL: 
A0U94_14275
KBA: 
A0U89_15345
BSU: 
BSU03460(hxlA)
BSR: 
I33_0397(hxlA)
BSL: 
A7A1_1851
BSH: 
BSU6051_03460(hxlA)
BSY: 
I653_01730
BSUT: 
BSUB_00396(hxlA)
BSUL: 
BSUA_00396(hxlA)
BSUS: 
Q433_02070
BSS: 
BSUW23_01790(hxlA)
BST: 
GYO_0559(hxlA)
BSO: 
BSNT_06681(hxlA)
BSN: 
BSn5_13315
BSQ: 
B657_03460(hxlA)
BSX: 
C663_0338(hxlA)
BSP: 
U712_01790
BLI: 
BL02045(hxlA)
BLD: 
BLi02805(hxlA)
BLH: 
BaLi_c29000(hxlA)
BAY: 
RBAM_003630(hxlA)
BAQ: 
BACAU_0303(hxlA)
BYA: 
BANAU_0305(hxlA)
BAMP: 
B938_01575
BAML: 
BAM5036_0322(hxlA)
BAMA: 
RBAU_0337(hxlA)
BAMN: 
BASU_0321(hxlA)
BAMB: 
BAPNAU_0307(hxlA)
BAMT: 
AJ82_01980
BAMY: 
V529_03250(hxlA)
BMP: 
NG74_00345(hxlA)
BAO: 
BAMF_0310(hxlA)
BAZ: 
BAMTA208_01555(hxlA)
BQL: 
LL3_00318(hxlA)
BXH: 
BAXH7_00321(hxlA)
BQY: 
MUS_0325(hxlA)
BAMI: 
KSO_017855
BAMC: 
U471_03230
BAMF: 
U722_01860
BAE: 
BATR1942_20410
BATR: 
TD68_19410
BCL: 
ABC3351(hxlA)
BPU: 
BPUM_2333
BPUM: 
BW16_12650
BPUS: 
UP12_11780
BMQ: 
BMQ_0891(hxlA) BMQ_1538(hxlA) BMQ_2942(hxlA)
BMD: 
BMD_0891(hxlA) BMD_1519(hxlA) BMD_2971(hxlA)
BMH: 
BMWSH_3691 BMWSH_4350(hxlA)
BMEG: 
BG04_3186(hxlA) BG04_3830(hxlA) BG04_4896(hxlA) BG04_5472 BG04_5588(hxlA) BG04_5930(hxlA)
BAG: 
Bcoa_0968
BJS: 
MY9_0361
BIF: 
N288_21395 N288_22430
BMET: 
BMMGA3_06845(hxlA)
GST: 
HW35_08370
BACW: 
QR42_11740
BACP: 
SB24_07990
BACB: 
OY17_04480
BACY: 
QF06_00690
BACL: 
BS34A_04030(hxlA)
BALM: 
BsLM_0362
BEO: 
BEH_06020 BEH_12940
BSM: 
BSM4216_0641
BON: 
A361_15685 A361_15780 A361_26060
BGY: 
BGLY_3090(hxlA)
BFX: 
BC359_14510 BC359_19735
BGI: 
BGM20_16795
BXI: 
BK049_15320
BHK: 
B4U37_02010
OIH: 
OB2806
GTK: 
GT3570_09830
GTN: 
GTNG_1490
GMC: 
GY4MC1_3093
GGH: 
GHH_c21400(hxlA)
GJF: 
M493_16830
GEA: 
GARCT_00704(hxlA_1) GARCT_02004(hxlA_2)
GEL: 
IB49_02240
GSR: 
GS3922_12380
GEJ: 
A0V43_08225
GTH: 
Geoth_3109
PTL: 
AOT13_07080
ANM: 
GFC28_662
ANL: 
GFC29_964
HMN: 
HM131_14425
VIG: 
BKP57_09220
FAR: 
ABE41_010275
SJE: 
AAV35_011130
SAU: 
SA0528
SAV: 
SAV0570
SAW: 
SAHV_0568
SAH: 
SaurJH1_0607 SaurJH1_2812
SAJ: 
SaurJH9_0593 SaurJH9_2736
SAM: 
MW0525
SAS: 
SAS0528
SAR: 
SAR0574
SAC: 
SACOL0617
SAX: 
USA300HOU_0564
SAA: 
SAUSA300_0555
SAO: 
SAOUHSC_00553
SAE: 
NWMN_0533
SAD: 
SAAV_0533(hxlA)
SUU: 
M013TW_0558
SUV: 
SAVC_02440
SUE: 
SAOV_0605
SUJ: 
SAA6159_00524(hxlA)
SUK: 
SAA6008_00578(hxlA)
SUC: 
ECTR2_524(hxlA)
SUT: 
SAT0131_00631
SUQ: 
HMPREF0772_12618(hxlA)
SUZ: 
MS7_0560(hxlA)
SUD: 
ST398NM01_0645
SUX: 
SAEMRSA15_04970
SUW: 
SATW20_06400
SUG: 
SAPIG0645(hxlA)
SUF: 
SARLGA251_05060
SAUA: 
SAAG_00991
SAUE: 
RSAU_000524(hps)
SAUN: 
SAKOR_00559
SAUS: 
SA40_0511
SAUU: 
SA957_0526
SAUG: 
SA268_0524
SAUZ: 
SAZ172_0572
SAUT: 
SAI1T1_2004400
SAUJ: 
SAI2T2_1004420
SAUK: 
SAI3T3_1004410
SAUQ: 
SAI4T8_1004400
SAUV: 
SAI7S6_1004410
SAUW: 
SAI5S5_1004370
SAUX: 
SAI6T6_1004380
SAUY: 
SAI8T7_1004410
SAB: 
SAB0520
SUY: 
SA2981_0547
SAUB: 
C248_0645
SAUM: 
BN843_5640
SAUC: 
CA347_586(hxlA)
SAUR: 
SABB_00621
SAUI: 
AZ30_02885
SAUD: 
CH52_02905
SAUF: 
X998_0612(hxlA)
SAMS: 
NI36_02840
SUH: 
SAMSHR1132_05140
SEP: 
SE0341
SER: 
SERP0216
SEPP: 
SEB_00262
SEPS: 
DP17_1647(hxlA)
SHA: 
SH2420
SHH: 
ShL2_02215(hxlA)
SSP: 
SSP1619 SSP1626 SSP2148
SCA: 
SCA_0226 SCA_0711
SLG: 
SLGD_02315
SLN: 
SLUG_22330
SSD: 
SPSINT_0249
SDT: 
SPSE_2213(hxlA)
SWA: 
A284_00525 A284_10445 A284_12317
SPAS: 
STP1_1658
SXY: 
BE24_00590
SXL: 
SXYLSMQ121_2137
SXO: 
SXYL_02291
SHU: 
SHYC_10795(hxlA)
SCAP: 
AYP1020_2319
SSCH: 
LH95_10395
SSCZ: 
RN70_11130
SAGQ: 
EP23_11365
SEQO: 
SE1039_03970
SSIF: 
AL483_08720
SCV: 
A4G25_06550
MCL: 
MCCL_0037
MCAK: 
MCCS_00640
SHV: 
AAT16_06530 AAT16_11280
ESI: 
Exig_2372
EAN: 
Eab7_2216
EXM: 
U719_13055
EXU: 
ESP131_15165
PJD: 
Pjdr2_1185
GYM: 
GYMC10_3885
PPY: 
PPE_04673
PPM: 
PPSC2_24305(hxlA)
PPO: 
PPM_4826(hxlA)
PPOL: 
X809_40845
PPQ: 
PPSQR21_049250(sgbH)
PPOY: 
RE92_12975
PMS: 
KNP414_07885(hxlA)
PMQ: 
PM3016_7402
PMW: 
B2K_37330
PTA: 
HPL003_05880
PSAB: 
PSAB_01345 PSAB_23295
PDU: 
PDUR_01610 PDUR_26635
PBD: 
PBOR_34755
PGM: 
PGRAT_31065
POD: 
PODO_29415
PAEN: 
P40081_36070
PAEF: 
R50345_29525
PAEQ: 
R50912_32680
PSTE: 
PSTEL_02005 PSTEL_26045
PAEA: 
R70723_31470
PAEE: 
R70331_30230
PAEH: 
H70357_33735
PAEJ: 
H70737_29170
PBJ: 
VN24_01055 VN24_04705
PRI: 
PRIO_3567 PRIO_6499(hxlA)
PPEO: 
ABE82_24515
PNP: 
IJ22_01440 IJ22_02540 IJ22_02590 IJ22_07980
POW: 
IJ21_08240
PBV: 
AR543_06015 AR543_17150
PXL: 
BS614_16300
PYG: 
AWM70_20320
PSWU: 
SY83_08105
PRT: 
AUC31_15190
PANA: 
BBH88_04830 BBH88_17520
PMAR: 
B0X71_02090
JEO: 
JMA_08740 JMA_29170
SPSY: 
AZE41_09415
LBR: 
LVIS_0442
LBK: 
LVISKB_0449
LPQ: 
AF91_01140
LPI: 
LBPG_03035
LPAP: 
LBPC_0348
LCB: 
LCABL_04190 LCABL_04490(hps)
LCZ: 
LCAZH_0412
LCS: 
LCBD_0422 LCBD_0453
LCE: 
LC2W_0417 LC2W_0448
LCW: 
BN194_04270 BN194_04560
LCL: 
LOCK919_0475
LCX: 
LCA12A_2395
LBN: 
LBUCD034_0077(hxlA)
LSN: 
LSA_03490
LMU: 
LBLM1_00435
LLE: 
AYR59_00780
LPD: 
AYR62_06120
LCU: 
PL11_004190
PCE: 
PECL_1750
PACI: 
A4V11_00360
OOE: 
OEOE_0131
LMM: 
MI1_09731
LGC: 
A9176_08390
WCB: 
AO080_07995 AO080_11070
WJO: 
FOL01_0737
AUR: 
HMPREF9243_0240(hxlA)
CAC: 
CA_C0396
CAE: 
SMB_G0404(sgbH)
CAY: 
CEA_G0406
CBE: 
Cbei_4647
CBZ: 
Cbs_4647
CBEI: 
LF65_06885
CSR: 
Cspa_c49610
ROB: 
CK5_18950
PFT: 
JBW_00828
EUC: 
EC1_08720
FRO: 
AALO17_19710
ERB: 
A4V01_02795 A4V01_05815 A4V01_19475
CDX: 
CDES_00570(rmpA)
RHA: 
RHA1_ro11329
ROA: 
Pd630_LPD04589
CMI: 
CMM_1123(sgaH)
CMS: 
CMS1443(hps)
CMC: 
CMN_01092(sgaH)
CMH: 
VO01_04530
MIM: 
AKG07_11695
MIH: 
BJP65_05205
MICR: 
BMW26_14455 BMW26_16485
CUM: 
NI26_12475
CUB: 
BJK06_08985
AGY: 
ATC03_10775
CART: 
PA27867_0095
ART: 
Arth_3708
ARR: 
ARUE_c04640(rmpA)
ARE: 
AL755_02190 AL755_14010
ARH: 
AHiyo8_33930
ARZ: 
AUT26_19920
AAU: 
AAur_0494(hps)
APN: 
Asphe3_02200
PSUL: 
AU252_12865
AAI: 
AARI_06580(rmpA)
GAR: 
AOZ07_14970
KPL: 
KPaMU14_03840
SATK: 
SA2016_1326 SA2016_3449 SA2016_3840 SA2016_3841
BRX: 
BH708_07835
AMQ: 
AMETH_4519(hps) AMETH_4538(hps)
PSEE: 
FRP1_13235 FRP1_13275
PSEQ: 
AD006_20915 AD006_20955
PECQ: 
AD017_00495 AD017_00535
BDE: 
BDP_0013
BDN: 
BBDE_0013
BANG: 
BBAG_0932
OLO: 
ADJ70_05660
ABAO: 
BEQ56_09840
TTR: 
Tter_2273
RBA: 
RB5319
PIR: 
VN12_13465(hxlA)
TRS: 
Terro_1472
ABAC: 
LuPra_03104(hxlA)
STR: 
Sterm_1849 Sterm_3212
RBAR: 
AWN76_010760
CPI: 
Cpin_5671
PEP: 
AQ505_07150
PCM: 
AY601_4886
PSTY: 
BFS30_16375
MUP: 
A0256_03165
CMR: 
Cycma_4041
CAMU: 
CA2015_3993
EVI: 
Echvi_3532
ALM: 
AO498_04580
PKO: 
PKOR_19965
ZPR: 
ZPR_1061
MARM: 
YQ22_17840
CAO: 
Celal_3937
CBAL: 
M667_16185
CBAT: 
M666_16170
ZGA: 
ZOBELLIA_3942(hxlA)
MPG: 
Theba_2591
MJA: 
MJ_0644 MJ_1447
MFE: 
Mefer_0259 Mefer_1012
MVU: 
Metvu_0541 Metvu_1176
MFS: 
MFS40622_0906 MFS40622_1056
MIF: 
Metin_1286 Metin_1445
MJH: 
JH146_0570 JH146_0865
MIG: 
Metig_0604 Metig_0664
MMP: 
MMP1270
MMQ: 
MmarC5_0321
MMX: 
MmarC6_1403
MMZ: 
MmarC7_0516
MMD: 
GYY_07185
MMAK: 
MMKA1_14950
MMAO: 
MMOS7_13770
MAE: 
Maeo_0614 Maeo_1123
MVN: 
Mevan_0582
MOK: 
Metok_0605 Metok_1249
MAC: 
MA_4504 MA_4608
MBA: 
Mbar_A0935 Mbar_A1170
MBY: 
MSBRM_0067 MSBRM_3392
MBW: 
MSBRW_0061 MSBRW_3553
MBAR: 
MSBR2_2313 MSBR2_3345
MBAK: 
MSBR3_2375 MSBR3_3372
MMA: 
MM_1215 MM_1279
MMAZ: 
MmTuc01_1255 MmTuc01_1325
MMJ: 
MSMAS_0037 MSMAS_0097
MMAC: 
MSMAC_0037 MSMAC_0105
MVC: 
MSVAZ_0074 MSVAZ_0103
MEK: 
MSKOL_0070 MSKOL_0099
MLS: 
MSLAZ_0035 MSLAZ_3053
METM: 
MSMTP_0040 MSMTP_0201
MEF: 
MSWH1_0036 MSWH1_3047
MEQ: 
MSWHS_0037 MSWHS_1919
MSJ: 
MSSAC_0046 MSSAC_4300
MSZ: 
MSSIH_0039 MSSIH_3802
MSW: 
MSSIT_0039 MSSIT_3879
MTHE: 
MSTHC_1499 MSTHC_1625
MTHR: 
MSTHT_1664 MSTHT_1787
MHOR: 
MSHOH_0037 MSHOH_0117
MBU: 
Mbur_1994(fae-hps)
MMET: 
MCMEM_0222 MCMEM_0644
MMH: 
Mmah_0234 Mmah_1222
MHAZ: 
BHR79_02340 BHR79_07435
MEV: 
Metev_0697 Metev_1698
MZH: 
Mzhil_0262 Mzhil_0311
MPY: 
Mpsy_1396 Mpsy_1425
MHZ: 
Metho_0261 Metho_0283
MTP: 
Mthe_0455 Mthe_0988
MCJ: 
MCON_0429 MCON_1383
MHI: 
Mhar_0019 Mhar_1869
MHU: 
Mhun_0647 Mhun_1628
MLA: 
Mlab_0996 Mlab_1453
MEM: 
Memar_0744 Memar_1085
MBG: 
BN140_1075 BN140_1140
MEMA: 
MMAB1_1386(fae-hps) MMAB1_1456(hpsA)
MPI: 
Mpet_0679 Mpet_0801
MBN: 
Mboo_0707 Mboo_0772
MFO: 
Metfor_2057 Metfor_2503
MPL: 
Mpal_1036 Mpal_2121
MPD: 
MCP_0861 MCP_2904(fae_hps)
MEZ: 
Mtc_0381(fae) Mtc_1411
RCI: 
RCIX1492 RCIX775(fae-hps)
MTH: 
MTH_888
MMG: 
MTBMA_c00570(fae_hps) MTBMA_c12830
METC: 
MTCT_0805 MTCT_1339
MWO: 
MWSIV6_0011(fae-hps) MWSIV6_1262(hpsA)
MST: 
Msp_1358 Msp_1498
MSI: 
Msm_0426 Msm_1213
MRU: 
mru_0712 mru_2131
MEB: 
Abm4_0046 Abm4_0441
MMIL: 
sm9_0074 sm9_0586
MEYE: 
TL18_02745 TL18_10355
MOL: 
YLM1_0353 YLM1_1686
MEL: 
Metbo_0071 Metbo_2333
MEW: 
MSWAN_0017 MSWAN_0326
METH: 
MBMB1_0009(fae-hps) MBMB1_0388
MFC: 
BRM9_0060 BRM9_1874
MFI: 
DSM1535_0057 DSM1535_1378(fae-hps)
MCUB: 
MCBB_0021(fae-hps_1) MCBB_0344(hpsA)
MFV: 
Mfer_0465 Mfer_0572
MKA: 
MK0153(sgbH) MK1449(menG)
AFU: 
AF_0861 AF_1305
AFG: 
AFULGI_00009430 AFULGI_00014160
APO: 
Arcpr_1052 Arcpr_1797
AVE: 
Arcve_1411 Arcve_1683
AST: 
Asulf_00326 Asulf_01087
FPL: 
Ferp_2129 Ferp_2198
GAC: 
GACE_0250 GACE_2158
GAH: 
GAH_00051 GAH_00575
TAR: 
TALC_01565
MAX: 
MMALV_16840
MER: 
MMINT_19420
MEAR: 
Mpt1_c14440(faeB)
MARC: 
AR505_0014
PHO: 
PH1938(PH1938)
PAB: 
PAB1222
PFU: 
PF0220
PFI: 
PFC_00160
PYN: 
PNA2_0868
PYA: 
PYCH_13020
PYS: 
Py04_0376
PYC: 
TQ32_01240
TKO: 
TK0475
TON: 
TON_0336
TGA: 
TGAM_1891(hps)
TSI: 
TSIB_0428
TBA: 
TERMP_00758
THE: 
GQS_03555
THA: 
TAM4_82
THM: 
CL1_0365
TLT: 
OCC_09933
THS: 
TES1_0756
TNU: 
BD01_0222
TEU: 
TEU_06790
TGY: 
X802_02210
THV: 
ADU37_CDS03570
TPEP: 
A0127_02350
PPAC: 
PAP_05755
ABI: 
Aboo_0457
ACF: 
AciM339_0590
APE: 
APE_0952.1(hxlA)
ACJ: 
ACAM_0624(hxlA)
SMR: 
Smar_0492
SHC: 
Shell_0310
IHO: 
Igni_0269
IIS: 
EYM_01130
DKA: 
DKAM_1456
DFD: 
Desfe_0079
DMU: 
Desmu_0149
TAG: 
Tagg_1068
IAG: 
Igag_1921
THG: 
TCELL_0740
HBU: 
Hbut_0129
PFM: 
Pyrfu_0648
PDL: 
Pyrde_0680
SSO: 
SSO0202(hpS-2)
SOL: 
Ssol_1184
SSOA: 
SULA_1220
SSOL: 
SULB_1221
SSOF: 
SULC_1219
STO: 
STK_02380(hxlA)
SAI: 
Saci_0802
SACN: 
SacN8_03890
SACR: 
SacRon12I_03880
SACS: 
SUSAZ_03625
SIS: 
LS215_2094
SIA: 
M1425_1931
SIM: 
M1627_2009
SID: 
M164_1939
SIY: 
YG5714_2053
SIN: 
YN1551_0865
SII: 
LD85_2191
SIH: 
SiH_1876
SIR: 
SiRe_1804
SIC: 
SiL_1785
SULA: 
BFU36_04900
MSE: 
Msed_0227
MCN: 
Mcup_1845
AHO: 
Ahos_0599
AMAN: 
B6F84_07975
PAI: 
PAE1679
PIS: 
Pisl_1686
PCL: 
Pcal_0568
PAS: 
Pars_1830
PYR: 
P186_0040
POG: 
Pogu_0300
TNE: 
Tneu_0708
PYW: 
PYWP30_00751
CMA: 
Cmaq_1871
TUZ: 
TUZN_2015
TTN: 
TTX_1521(hps)
VDI: 
Vdis_1817
VMO: 
VMUT_0258
TPE: 
Tpen_0372
THB: 
N186_02880
TCB: 
TCARB_1644
ASC: 
ASAC_0959
CLG: 
Calag_0067
FFO: 
FFONT_0403
KCR: 
Kcr_1307
BARC: 
AOA65_1083(faeB-hpsB)
BARB: 
AOA66_0495 AOA66_1278
LOKI: 
Lokiarch_06870 Lokiarch_17920 Lokiarch_47420
 » show all
Taxonomy
Reference
1  [PMID:4219834]
  Authors
Ferenci T, Strom T, Quayle JR
  Title
Purification and properties of 3-hexulose phosphate synthase and phospho-3-hexuloisomerase from Methylococcus capsulatus.
  Journal
Biochem. J. 144 (1974) 477-86.
Reference
2  [PMID:564713]
  Authors
Kato N, Ohashi H, Tani Y, Ogata K
  Title
3-Hexulosephosphate synthase from Methylomonas aminofaciens 77a. Purification, properties and kinetics.
  Journal
Biochim. Biophys. Acta. 523 (1978) 236-44.
Reference
3  [PMID:8595859]
  Authors
Yanase H, Ikeyama K, Mitsui R, Ra S, Kita K, Sakai Y, Kato N
  Title
Cloning and sequence analysis of the gene encoding 3-hexulose-6-phosphate synthase from the methylotrophic bacterium, Methylomonas aminofaciens 77a, and its expression in Escherichia coli.
  Journal
FEMS. Microbiol. Lett. 135 (1996) 201-5.
  Sequence
Reference
4  [PMID:16278835]
  Authors
Yurimoto H, Kato N, Sakai Y
  Title
Assimilation, dissimilation, and detoxification of formaldehyde, a central metabolic intermediate of methylotrophic metabolism.
  Journal
Chem. Rec. 5 (2005) 367-75.
Reference
5  [PMID:16428816]
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci. Biotechnol. Biochem. 70 (2006) 10-21.
Reference
6  [PMID:15901685]
  Authors
Orita I, Yurimoto H, Hirai R, Kawarabayasi Y, Sakai Y, Kato N
  Title
The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway.
  Journal
J. Bacteriol. 187 (2005) 3636-42.
  Sequence
[pho:PH1938]
Reference
7
  Authors
Kato, N., Miyamoto, N., Shimao, M. and Sakazawa, C.
  Title
3-Hexulose phosphate pynthase from a new facultative methylotroph, Mycobacterium gastri MB19.
  Journal
Agric. Biol. Chem. 52 (1988) 2659-2661.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
KEGG   REACTION: R05338Help
Entry
R05338                      Reaction                               

Name
D-arabino-hex-3-ulose-6-phosphate formaldehyde-lyase (D-ribulose-5-phosphate-forming)
Definition
D-Ribulose 5-phosphate + Formaldehyde <=> D-arabino-Hex-3-ulose 6-phosphate
Equation
Reaction class
C00067_C06019
C00199_C06019
Enzyme
Pathway
Pentose phosphate pathway
Methane metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Carbon metabolism
Biosynthesis of amino acids
Module
M00345  
Formaldehyde assimilation, ribulose monophosphate pathway
M00580  
Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
Orthology
K08093  
3-hexulose-6-phosphate synthase [EC:4.1.2.43]
K13812  
bifunctional enzyme Fae/Hps [EC:4.2.1.147 4.1.2.43]
K13831  
3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase [EC:4.1.2.43 5.3.1.27]
DBGET integrated database retrieval system