KEGG ORTHOLOGY: K08097

ORTHOLOGY: K08097

Entry

K08097 KO

Name

comA

Definition

phosphosulfolactate synthase [EC:4.4.1.19]

Pathway

ko00680

Methane metabolism

Module

M00358

Coenzyme M biosynthesis

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Energy metabolism
   00680 Methane metabolism
    K08097  comA; phosphosulfolactate synthase
KEGG modules [BR:ko00002]
Pathway module
  Energy metabolism
   Methane metabolism
    M00358  Coenzyme M biosynthesis
     K08097  comA; phosphosulfolactate synthase
Enzymes [BR:ko01000]
4. Lyases
  4.4  Carbon-sulfur lyases
   4.4.1  Carbon-sulfur lyases (only sub-subclass identified to date)
    4.4.1.19  phosphosulfolactate synthase
     K08097  comA; phosphosulfolactate synthase

Other DBs

RN:

R07476

COG:

COG1809

GO:

0043817

Genes

LOK:	Loa_02095 Loa_02096
DPG:	DESPIGER_2203
AVI:	Avi_9196
XAU:	Xaut_4872 Xaut_5052 Xaut_5069
AMV:	ACMV_19940
BSU:	BSU10950(yitD)
BSR:	I33_1230(yitD)
BSL:	A7A1_0911
BSH:	BSU6051_10950(yitD)
BSY:	I653_05540
BSUT:	BSUB_01192(yitD)
BSUL:	BSUA_01192(yitD)
BSUS:	Q433_06185
BSS:	BSUW23_05550(yitD)
BST:	GYO_1401(yitD)
BSN:	BSn5_17370
BSQ:	B657_10950(slpS)
BSX:	C663_1118(comA)
BSP:	U712_05605
BLI:	BL02005(yitD)
BLD:	BLi02155(yitD)
BLH:	BaLi_c22300(yitD)
BAE:	BATR1942_03110
BATR:	TD68_02710
BCO:	Bcell_3136
BCK:	BCO26_1398(yitD)
BAG:	Bcoa_3122
BCOA:	BF29_414(yitD)
BJS:	MY9_1193
BACI:	B1NLA3E_03505
GST:	HW35_17420
BACY:	QF06_04410
BACL:	BS34A_12090(yitD)
BALM:	BsLM_1140
BGY:	BGLY_2293(yitD)
BGI:	BGM20_20755
BBE:	BBR47_23190(comA)
BLR:	BRLA_c016650
PJD:	Pjdr2_2292
PMS:	KNP414_02661
PMQ:	PM3016_2903
PMW:	B2K_14740
PLV:	ERIC2_c33000(comA)
PBJ:	VN24_25310
PNP:	IJ22_24320
POW:	IJ21_30190
PSWU:	SY83_19300
TCO:	Theco_1988
ANX:	ACH33_09010
AAC:	Aaci_1301 Aaci_2433
AAD:	TC41_1228 TC41_2723(comA)
BTS:	Btus_1783
TUM:	CBW65_20240
NTR:	B0W44_13255
LPD:	AYR62_02825
OOE:	OEOE_0441
STH:	STH2643
DRM:	Dred_1677
DAE:	Dtox_2359
DCA:	Desca_1257
DKU:	Desku_1279
DRU:	Desru_2345
DGI:	Desgi_3259
DFG:	B0537_07980
PTH:	PTH_1816
DAU:	Daud_1309
TJR:	TherJR_1470
HMO:	HM1_0946
TMR:	Tmar_1045
SAY:	TPY_1196(comA)
SAP:	Sulac_2457
MTA:	Moth_0118
ADG:	Adeg_1603
HOR:	Hore_21790
AAR:	Acear_1343
HHL:	Halha_1510
LPIL:	LIP_0779
MSA:	Mycsm_01875
MRH:	MycrhN_2934
MCB:	Mycch_5452 Mycch_5966
SALS:	SLNWT_0539
ARE:	AL755_00580
NCA:	Noca_4816 Noca_4839
FRI:	FraEuI1c_5954
AMQ:	AMETH_2056
PDX:	Psed_1619 Psed_6288
CWO:	Cwoe_0088
SYD:	Syncc9605_1170
SYNK:	KR100_08215
HAU:	Haur_1567
SUS:	Acid_4865
ASX:	CDL62_17125
SRU:	SRU_0020
SRM:	SRM_00021(comA)
RMR:	Rmar_0022
RMG:	Rhom172_0022
RBAR:	AWN76_012815
CPI:	Cpin_1670 Cpin_5589
NKO:	Niako_4703
NSO:	NIASO_11290
NIA:	A8C56_02190 A8C56_07490
FLA:	SY85_06285
ARB:	A9P82_00090
PHE:	Phep_4158
PEP:	AQ505_01190
PCM:	AY601_4372
PSTY:	BFS30_06080
PSN:	Pedsa_3036
SHG:	Sph21_1338
SCN:	Solca_4247
MUP:	A0256_08050
CMR:	Cycma_1455
CAMU:	CA2015_1351
BBD:	Belba_0911
EVI:	Echvi_1147
ALM:	AO498_02300
CHU:	CHU_0004
DFE:	Dfer_4445
SLI:	Slin_0707
SRD:	SD10_06655
SMON:	AWR27_12200
LBY:	Lbys_3154
RSI:	Runsl_3058
EOL:	Emtol_2406
FAE:	FAES_0308
FIB:	A6C57_14855
FLI:	Fleli_2960
HSW:	Hsw_3670
HYM:	N008_11020
HYD:	PK28_15930
HYE:	AM218_00550
HYG:	AUC43_05885
HYP:	A0257_15910
PKO:	PKOR_08170
RUF:	TH63_00780
RTI:	DC20_11260
RUD:	TH61_09245
MTT:	Ftrac_2674
FLM:	MY04_3220
FBT:	D770_13430
FTE:	Fluta_3660
BBAU:	AEM51_13675
MJA:	MJ_0255
MFE:	Mefer_0102
MVU:	Metvu_1522
MFS:	MFS40622_0491
MIF:	Metin_1007
MJH:	JH146_0170
MIG:	Metig_0856
MMP:	MMP0273(comA)
MMQ:	MmarC5_1399
MMX:	MmarC6_0679
MMZ:	MmarC7_1277
MMD:	GYY_01400
MMAK:	MMKA1_02790(comA) MMKA1_02800(comA)
MMAO:	MMOS7_03070(comA)
MAE:	Maeo_0153
MVN:	Mevan_1285
MVO:	Mvol_1330
MOK:	Metok_0167
MTH:	MTH_1674
MMG:	MTBMA_c02530(comA)
METC:	MTCT_1527
MWO:	MWSIV6_0212(comA)
MST:	Msp_1270(comA)
MSI:	Msm_0086
MEB:	Abm4_0691(comA)
MMIL:	sm9_0980(comA)
MEYE:	TL18_05470
MOL:	YLM1_0878
MEL:	Metbo_2244
MEW:	MSWAN_0399
METH:	MBMB1_0449(comA)
MFC:	BRM9_1809(comA)
MFI:	DSM1535_2450(comA)
MCUB:	MCBB_0411(comA)
MFV:	Mfer_1060
MKA:	MK0394(comA)
FAC:	FACI_IFERC01G1194
NGA:	Ngar_c10400(comA) Ngar_c26460
NVN:	NVIE_024140(comA) NVIE_028040
NEV:	NTE_01035 NTE_03133
TAA:	NMY3_01362(yitD_1) NMY3_02409(yitD_2)

» show all

Reference

PMID:11830598

Authors

Graham DE, Xu H, White RH

Title

Identification of coenzyme M biosynthetic phosphosulfolactate synthase: a new family of sulfonate-biosynthesizing enzymes.

Journal

J Biol Chem 277:13421-9 (2002)
DOI:10.1074/jbc.M201011200

Sequence

[mja:MJ_0255]

All links

Ontology (5)   
   KEGG BRITE (3)   
   GO (1)   
   COG (1)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3334)   
   KEGG GENES (198)   
   KEGG MGENES (2415)   
   RefGene (703)   
   OC (18)   
Protein sequence (173)   
   UniProt (169)   
   SWISS-PROT (4)   
Literature (1)   
   PubMed (1)   
All databases (3521)   

Download RDF

ENZYME: 4.4.1.19

Entry

EC 4.4.1.19 Enzyme

Name

phosphosulfolactate synthase;
(2R)-phospho-3-sulfolactate synthase;
(2R)-O-phospho-3-sulfolactate sulfo-lyase

Class

Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)

Sysname

(2R)-2-O-phospho-3-sulfolactate hydrogen-sulfite-lyase (phosphoenolpyruvate-forming)

Reaction(IUBMB)

(2R)-2-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite [RN:R07476]

Reaction(KEGG)

R07476

Substrate

(2R)-2-O-phospho-3-sulfolactate

Product

phosphoenolpyruvate [CPD:C00074];
sulfite [CPD:C00094]

Comment

Requires Mg2+. The enzyme from the archaeon Methanococcus jannaschii catalyses the Michael addition of sulfite to phosphoenolpyruvate. It specifically requires phosphoenolpyruvate and its broad alkaline pH optimum suggests that it uses sulfite rather than hydrogensulfite.

History

EC 4.4.1.19 created 2003

Pathway

ec00680	Methane metabolism
ec01120	Microbial metabolism in diverse environments

Orthology

K08097

phosphosulfolactate synthase

Genes

LOK:	Loa_02095 Loa_02096
DPG:	DESPIGER_2203
AVI:	Avi_9196
XAU:	Xaut_4872 Xaut_5052 Xaut_5069
AMV:	ACMV_19940
BSU:	BSU10950(yitD)
BSR:	I33_1230(yitD)
BSL:	A7A1_0911
BSH:	BSU6051_10950(yitD)
BSY:	I653_05540
BSUT:	BSUB_01192(yitD)
BSUL:	BSUA_01192(yitD)
BSUS:	Q433_06185
BSS:	BSUW23_05550(yitD)
BST:	GYO_1401(yitD)
BSN:	BSn5_17370
BSQ:	B657_10950(slpS)
BSX:	C663_1118(comA)
BSP:	U712_05605
BLI:	BL02005(yitD)
BLD:	BLi02155(yitD)
BLH:	BaLi_c22300(yitD)
BAE:	BATR1942_03110
BATR:	TD68_02710
BCO:	Bcell_3136
BCK:	BCO26_1398(yitD)
BAG:	Bcoa_3122
BCOA:	BF29_414(yitD)
BJS:	MY9_1193
BACI:	B1NLA3E_03505
GST:	HW35_17420
BACY:	QF06_04410
BACL:	BS34A_12090(yitD)
BALM:	BsLM_1140
BGY:	BGLY_2293(yitD)
BGI:	BGM20_20755
BBE:	BBR47_23190(comA)
BLR:	BRLA_c016650
PJD:	Pjdr2_2292
PMS:	KNP414_02661
PMQ:	PM3016_2903
PMW:	B2K_14740
PLV:	ERIC2_c33000(comA)
PBJ:	VN24_25310
PNP:	IJ22_24320
POW:	IJ21_30190
PSWU:	SY83_19300
TCO:	Theco_1988
ANX:	ACH33_09010
AAC:	Aaci_1301 Aaci_2433
AAD:	TC41_1228 TC41_2723(comA)
BTS:	Btus_1783
TUM:	CBW65_20240
NTR:	B0W44_13255
LPD:	AYR62_02825
OOE:	OEOE_0441
STH:	STH2643
DRM:	Dred_1677
DAE:	Dtox_2359
DCA:	Desca_1257
DKU:	Desku_1279
DRU:	Desru_2345
DGI:	Desgi_3259
DFG:	B0537_07980
PTH:	PTH_1816
DAU:	Daud_1309
TJR:	TherJR_1470
HMO:	HM1_0946
TMR:	Tmar_1045
SAY:	TPY_1196(comA)
SAP:	Sulac_2457
MTA:	Moth_0118
ADG:	Adeg_1603
HOR:	Hore_21790
AAR:	Acear_1343
HHL:	Halha_1510
LPIL:	LIP_0779
MSA:	Mycsm_01875
MRH:	MycrhN_2934
MCB:	Mycch_5452 Mycch_5966
SALS:	SLNWT_0539
ARE:	AL755_00580
NCA:	Noca_4816 Noca_4839
FRI:	FraEuI1c_5954
AMQ:	AMETH_2056
PDX:	Psed_1619 Psed_6288
CWO:	Cwoe_0088
SYD:	Syncc9605_1170
SYNK:	KR100_08215
HAU:	Haur_1567
SUS:	Acid_4865
ASX:	CDL62_17125
SRU:	SRU_0020
SRM:	SRM_00021(comA)
RMR:	Rmar_0022
RMG:	Rhom172_0022
RBAR:	AWN76_012815
CPI:	Cpin_1670 Cpin_5589
NKO:	Niako_4703
NSO:	NIASO_11290
NIA:	A8C56_02190 A8C56_07490
FLA:	SY85_06285
ARB:	A9P82_00090
PHE:	Phep_4158
PEP:	AQ505_01190
PCM:	AY601_4372
PSTY:	BFS30_06080
PSN:	Pedsa_3036
SHG:	Sph21_1338
SCN:	Solca_4247
MUP:	A0256_08050
CMR:	Cycma_1455
CAMU:	CA2015_1351
BBD:	Belba_0911
EVI:	Echvi_1147
ALM:	AO498_02300
CHU:	CHU_0004
DFE:	Dfer_4445
SLI:	Slin_0707
SRD:	SD10_06655
SMON:	AWR27_12200
LBY:	Lbys_3154
RSI:	Runsl_3058
EOL:	Emtol_2406
FAE:	FAES_0308
FIB:	A6C57_14855
FLI:	Fleli_2960
HSW:	Hsw_3670
HYM:	N008_11020
HYD:	PK28_15930
HYE:	AM218_00550
HYG:	AUC43_05885
HYP:	A0257_15910
PKO:	PKOR_08170
RUF:	TH63_00780
RTI:	DC20_11260
RUD:	TH61_09245
MTT:	Ftrac_2674
FLM:	MY04_3220
FBT:	D770_13430
FTE:	Fluta_3660
BBAU:	AEM51_13675
MJA:	MJ_0255
MFE:	Mefer_0102
MVU:	Metvu_1522
MFS:	MFS40622_0491
MIF:	Metin_1007
MJH:	JH146_0170
MIG:	Metig_0856
MMP:	MMP0273(comA)
MMQ:	MmarC5_1399
MMX:	MmarC6_0679
MMZ:	MmarC7_1277
MMD:	GYY_01400
MMAK:	MMKA1_02790(comA) MMKA1_02800(comA)
MMAO:	MMOS7_03070(comA)
MAE:	Maeo_0153
MVN:	Mevan_1285
MVO:	Mvol_1330
MOK:	Metok_0167
MTH:	MTH_1674
MMG:	MTBMA_c02530(comA)
METC:	MTCT_1527
MWO:	MWSIV6_0212(comA)
MST:	Msp_1270(comA)
MSI:	Msm_0086
MEB:	Abm4_0691(comA)
MMIL:	sm9_0980(comA)
MEYE:	TL18_05470
MOL:	YLM1_0878
MEL:	Metbo_2244
MEW:	MSWAN_0399
METH:	MBMB1_0449(comA)
MFC:	BRM9_1809(comA)
MFI:	DSM1535_2450(comA)
MCUB:	MCBB_0411(comA)
MFV:	Mfer_1060
MKA:	MK0394(comA)
FAC:	FACI_IFERC01G1194
NGA:	Ngar_c10400(comA) Ngar_c26460
NVN:	NVIE_024140(comA) NVIE_028040
NEV:	NTE_01035 NTE_03133
TAA:	NMY3_01362(yitD_1) NMY3_02409(yitD_2)

» show all

Reference

1 [PMID:11830598]

Authors

Graham DE, Xu H, White RH.

Title

Identification of coenzyme M biosynthetic phosphosulfolactate synthase: a new family of sulfonate-biosynthesizing enzymes.

Journal

J. Biol. Chem. 277 (2002) 13421-9.

Sequence

[mja:MJ_0255]

Other DBs

ExplorEnz - The Enzyme Database:

4.4.1.19

IUBMB Enzyme Nomenclature:

4.4.1.19

ExPASy - ENZYME nomenclature database:

4.4.1.19

BRENDA, the Enzyme Database:

4.4.1.19

CAS:

473575-53-0

All links

Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3317)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (198)   
   KEGG MGENES (2415)   
   RefGene (703)   
Protein sequence (254)   
   UniProt (181)   
   SWISS-PROT (4)   
   RefSeq(pep) (67)   
   PDBSTR (1)   
   PMD (1)   
DNA sequence (331)   
   RefSeq(nuc) (107)   
   GenBank (117)   
   EMBL (107)   
3D Structure (1)   
   PDB (1)   
Protein domain (1)   
   InterPro (1)   
All databases (3914)   

Download RDF

REACTION: R07476

Entry

R07476 Reaction

Name

(2R)-O-phospho-3-sulfolactate sulfo-lyase

Definition

(2R)-O-Phospho-3-sulfolactate <=> Sulfite + Phosphoenolpyruvate

Equation

C11536 <=> C00094 + C00074

Reaction class

RC01799

C00074_C11536

Enzyme

4.4.1.19

Pathway

rn00680	Methane metabolism
rn01120	Microbial metabolism in diverse environments

Module

M00358

Coenzyme M biosynthesis

Orthology

K08097

phosphosulfolactate synthase [EC:4.4.1.19]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (199)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (198)   
All databases (210)   

Download RDF

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