| Entry |
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| Name |
prolycopene isomerase;
CRTISO;
carotene cis-trans isomerase;
ZEBRA2 (gene name);
carotene isomerase;
carotenoid isomerase
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| Class |
Isomerases;
cis-trans-Isomerases;
cis-trans Isomerases (only sub-subclass identified to date)
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| Sysname |
7,9,7',9'-tetracis-lycopene cis-trans-isomerase
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| Reaction(IUBMB) |
7,9,7',9'-tetracis-lycopene = all-trans-lycopene [RN: R07512]
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| Reaction(KEGG) |
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| Substrate |
7,9,7',9'-tetracis-lycopene [CPD: C15858]
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| Product |
all-trans-lycopene [CPD: C05432]
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| Comment |
Requires FADH2 [1]. The enzyme is involved in carotenoid biosynthesis.
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| History |
EC 5.2.1.13 created 2011
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| Pathway |
| Carotenoid biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Orthology |
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| Genes |
ATH: | | ALY: | | CRB: | | EUS: | | BRP: | | BNA: | | THJ: | | CIT: | | CIC: | | TCC: | | GRA: | | GHI: | | EGR: | | GMX: | | PVU: | | VRA: | | VAR: | | CCAJ: | | MTR: | | CAM: | | ADU: | | AIP: | | LJA: | | LANG: | | FVE: | | PPER: | | PMUM: | | MDM: | | PXB: | | ZJU: | | CSV: | | CMO: | | RCU: | | JCU: | | POP: | | VVI: | | SLY: | | SPEN: | | SOT: | | INI: | | SIND: | | BVG: | | NNU: | | OSA: | | DOSA: | | OBR: | | BDI: | | ZMA: | | SITA: | | PDA: | | EGU: | | MUS: | | ATR: | | SMO: | | PPP: | | CME: | | PMK: | | PFV: | | PCH: | | PCZ: | | PCP: | | PSEM: | | MMT: | | MDN: | | MAH: | | OAI: | | OME: | | GPB: | | DEU: | | BMX: | | DOL: | | DAL: | | AFW: | | SAMY: | | DTI: | | PGA: | | PGL: | | GTE: | | PPY: | | PPM: | | PPO: | | PPOL: | | PPQ: | | PPOY: | | PTA: | | PPEO: | | CBK: | | CBT: | | MGJ: | | MYG: | | NFA: | | SBH: | | KPL: | | KAL: | | SAQ: | | EYY: | | SYN: | | SYZ: | | SYY: | | SYT: | | SYS: | | SYQ: | | SYJ: | | SYW: | | SYC: | | SYF: | | SYD: | | SYE: | | SYG: | | SYR: | | SYX: | | SYP: | | CYA: | | CYB: | | SYNP: | | SYNK: | | SYNR: | | SYND: | | SYU: | | SYH: | | SYNW: | | CGC: | | CYI: | | DSL: | | CMP: | | LEP: | | LEN: | | LET: | | LBO: | | PSEU: | | PMA: | | PMM: | | PMT: | | PMN: | | PMI: | | PMB: | | PMC: | | PMF: | | PMG: | | PMH: | | PMJ: | | PME: | | PRC: | | PRM: | | AMR: | | MAR: | | MPK: | | CAN: | | CSN: | | HAO: | | GEN: | | GEE: | | CYT: | | CYP: | | CYC: | | CYN: | | CYH: | | CYJ: | | TER: | | MIC: | | ARP: | | GEI: | | OAC: | | ONI: | | MPRO: | | CEP: | | ANA: | | NPU: | | NOS: | | NOP: | | NON: | | AVA: | | ANB: | | ACY: | | AWA: | | CSG: | | CALO: | | CALT: | | CALH: | | RIV: | | FIS: | | NCN: | | CTHE: | | PLP: | | SCS: | | CEO: | | STQ: | | SBU: | | SCC: | | SGP: | | LBI: | | LBF: | | CTM: | | FTE: | | CTE: | | CPC: | | CCH: | | CPH: | | CPB: | | CLI: | | PVI: | | PLT: | | PPH: | | PAA: | | PROC: | | CTS: | | MPG: | |
» show all
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| Reference |
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| Authors |
Yu Q, Ghisla S, Hirschberg J, Mann V, Beyer P |
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| Title |
Plant carotene cis-trans isomerase CRTISO: a new member of the FAD(RED)-dependent flavoproteins catalyzing non-redox reactions. |
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| Journal |
J. Biol. Chem. 286 (2011) 8666-76. |
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| Reference |
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| Authors |
Li Q, Farre G, Naqvi S, Breitenbach J, Sanahuja G, Bai C, Sandmann G, Capell T, Christou P, Zhu C |
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| Title |
Cloning and functional characterization of the maize carotenoid isomerase and beta-carotene hydroxylase genes and their regulation during endosperm maturation. |
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| Journal |
Transgenic. Res. 19 (2010) 1053-68. |
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| Reference |
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| Authors |
Isaacson T, Ronen G, Zamir D, Hirschberg J |
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| Title |
Cloning of tangerine from tomato reveals a carotenoid isomerase essential for the production of beta-carotene and xanthophylls in plants. |
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| Journal |
Plant. Cell. 14 (2002) 333-42. |
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| Sequence |
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| Reference |
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| Authors |
Chai C, Fang J, Liu Y, Tong H, Gong Y, Wang Y, Liu M, Wang Y, Qian Q, Cheng Z, Chu C |
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| Title |
ZEBRA2, encoding a carotenoid isomerase, is involved in photoprotection in rice. |
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| Journal |
Plant. Mol. Biol. 75 (2011) 211-21. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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