KEGG   ORTHOLOGY: K10156Help
Entry
K10156                      KO                                     

Name
eizS
Definition
epi-isozizaene synthase [EC:4.2.3.37]
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of terpenoids and polyketides
   00909 Sesquiterpenoid and triterpenoid biosynthesis
    K10156  eizS; epi-isozizaene synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.37  epi-isozizaene synthase
     K10156  eizS; epi-isozizaene synthase
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
SCO: 
SCO5222(SC7E4.19)
SMA: 
SAV_3032(tpc2)
SHY: 
SHO: 
SDV: 
SALB: 
SALS: 
SCI: 
SLV: 
SGU: 
SCW: 
TU94_21765
SAMB: 
SAM23877_5010(cyc)
SCX: 
AS200_17635
SRW: 
TUE45_05742(cyc1)
STRF: 
ASR50_23820
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lin X, Hopson R, Cane DE
  Title
Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase.
  Journal
J Am Chem Soc 128:6022-3 (2006)
DOI:10.1021/ja061292s
KEGG   ENZYME: 4.2.3.37Help
Entry
EC 4.2.3.37                 Enzyme                                 

Name
epi-isozizaene synthase;
SCO5222 protein
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate [RN:R07830]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-epi-isozizaene [CPD:C16269];
diphosphate [CPD:C00013]
Comment
Requires Mg2+ for activity. The displacement of the diphosphate group of farnesyl diphosphate occurs with retention of configuration [1]. In the soil-dwelling bacterium Streptomyces coelicolor A3(2), the product of this reaction is used by EC 1.14.13.106, epi-isozizaene 5-monooxygenase, to produce the sesquiterpene antibiotic albaflavenone [2].
History
EC 4.2.3.37 created 2008
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K10156  
epi-isozizaene synthase
Genes
SCO: 
SCO5222(SC7E4.19)
SMA: 
SAV_3032(tpc2)
SHY: 
SHO: 
SDV: 
SALB: 
SALS: 
SCI: 
SLV: 
SGU: 
SCW: 
TU94_21765
SAMB: 
SAM23877_5010(cyc)
SCX: 
AS200_17635
SRW: 
TUE45_05742(cyc1)
STRF: 
ASR50_23820
 » show all
Taxonomy
Reference
1  [PMID:16669656]
  Authors
Lin X, Hopson R, Cane DE.
  Title
Genome mining in streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase.
  Journal
J. Am. Chem. Soc. 128 (2006) 6022-3.
  Sequence
[sco:SCO5222]
Reference
2  [PMID:18234666]
  Authors
Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE
  Title
Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2).
  Journal
J. Biol. Chem. 283 (2008) 8183-9.
  Sequence
[sco:SCO5222]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
KEGG   REACTION: R07830Help
Entry
R07830                      Reaction                               

Name
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming]
Definition
trans,trans-Farnesyl diphosphate <=> (+)-epi-Isozizaene + Diphosphate
Equation
Reaction class
C00448_C16269
Enzyme
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K10156  
epi-isozizaene synthase [EC:4.2.3.37]
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