KEGG ORTHOLOGY: K10216

ORTHOLOGY: K10216

Entry

K10216 KO

Name

dmpD, xylF

Definition

2-hydroxymuconate-semialdehyde hydrolase [EC:3.7.1.9]

Pathway

ko00362	Benzoate degradation
ko00622	Xylene degradation
ko00643	Styrene degradation
ko01220	Degradation of aromatic compounds

Module

M00569

Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K10216  dmpD, xylF; 2-hydroxymuconate-semialdehyde hydrolase
  Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K10216  dmpD, xylF; 2-hydroxymuconate-semialdehyde hydrolase
   00622 Xylene degradation
    K10216  dmpD, xylF; 2-hydroxymuconate-semialdehyde hydrolase
   00643 Styrene degradation
    K10216  dmpD, xylF; 2-hydroxymuconate-semialdehyde hydrolase
KEGG modules [BR:ko00002]
Pathway module
  Secondary metabolism
   Aromatics degradation
    M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
     K10216  dmpD, xylF; 2-hydroxymuconate-semialdehyde hydrolase
Enzymes [BR:ko01000]
3. Hydrolases
  3.7  Acting on carbon-carbon bonds
   3.7.1  In ketonic substances
    3.7.1.9  2-hydroxymuconate-6-semialdehyde hydrolase
     K10216  dmpD, xylF; 2-hydroxymuconate-semialdehyde hydrolase

Other DBs

RN:

R02604 R05362 R05865

GO:

0018775

Genes

PSD:	DSC_09175
PPSE:	BN5_3615(nahN)
PPJ:	RK21_04238
PSC:	A458_06525
PSTU:	UIB01_22735
PBM:	CL52_14705
PFK:	PFAS1_28780
AEI:	AOY20_01960
AJO:	RZ95_18625
ASJ:	AsACE_CH00356
MAD:	HP15_1112(dmpD) HP15_4033(xylF)
MSR:	AU15_09325 AU15_21085
MLQ:	ASQ50_09220
MSQ:	BKP64_13855
SPOI:	IMCC21906_00397 IMCC21906_02716
ZAL:	AZF00_03860 AZF00_17825
CYQ:	Q91_0515 Q91_1790(bphD1) Q91_2195
CZA:	CYCME_0226 CYCME_0664 CYCME_2092
APAC:	S7S_13285
GBI:	PG2T_07330 PG2T_09695
TBN:	TBH_C0921
AQL:	BXU06_16870
RPI:	Rpic_4621
RPF:	Rpic12D_3545
REU:	Reut_B5690
RME:	Rmet_1306
BVI:	Bcep1808_7611
BUR:	Bcep18194_B1183 Bcep18194_B2956
BCEN:	DM39_4829(xylF)
BCT:	GEM_5398
BCED:	DM42_4988(xylF)
BCON:	NL30_24575
BDF:	WI26_16010
BTEI:	WS51_00585
BPSL:	WS57_12140
BUQ:	AC233_11165
PPK:	U875_01820
PRB:	X636_07650
BBH:	BN112_4274
BBX:	BBS798_3919
BFZ:	BAU07_03835
AJS:	Ajs_0221
ACID:	CBP33_01100 CBP33_05470
VEI:	Veis_2786
CTT:	CtCNB1_3150
ADN:	Alide_0336
ADK:	Alide2_0281
HYL:	LPB072_18175
MPT:	Mpe_A2274
MASW:	AM586_18645
LCH:	Lcho_3344
RBU:	PG1C_08185 PG1C_11270
DAR:	Daro_1331 Daro_3786
AZO:	azo1968(xylF)
AZI:	AzCIB_4406
TMZ:	Tmz1t_3110
ARC:	ABLL_2439
MESO:	BSQ44_10055
SAME:	SAMCFNEI73_pB0463
NAR:	Saro_3858
NPP:	PP1Y_AT15665 PP1Y_AT31623
NPN:	JI59_24610
NRE:	BES08_18550 BES08_20400
SMAZ:	LH19_27440
ERY:	CP97_03160 CP97_14200
CNA:	AB433_18150
BACI:	B1NLA3E_01490 B1NLA3E_14010
BSM:	BSM4216_1785
GMC:	GY4MC1_1593
GJF:	M493_17935
GTH:	Geoth_1676
PTL:	AOT13_14455
PNP:	IJ22_48610
BTS:	Btus_0963
SIV:	SSIL_0071
SSIL:	SOLI23_18480
SAY:	TPY_0645(mhpC)
SAP:	Sulac_2994
RHA:	RHA1_ro08081
ROA:	Pd630_LPD12026
RAV:	AAT18_00600
GOQ:	ACH46_18245
ARZ:	AUT26_01405
NAE:	BHE16_09080
ICA:	Intca_1090
JTE:	ASJ30_00170
NOA:	BKM31_20825
FSY:	FsymDg_2032
AMQ:	AMETH_2411(mhpC)
PDX:	Psed_6034
AFS:	AFR_28670
CAP:	CLDAP_40940
TTJ:	TTHB237
TTL:	TtJL18_2419
TPI:	TREPR_1321

» show all

Reference

PMID:2194577

Authors

Nordlund I, Shingler V

Title

Nucleotide sequences of the meta-cleavage pathway enzymes 2-hydroxymuconic semialdehyde dehydrogenase and 2-hydroxymuconic semialdehyde hydrolase from Pseudomonas CF600.

Journal

Biochim Biophys Acta 1049:227-30 (1990)
DOI:10.1016/0167-4781(90)90046-5

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Ontology (4)   
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Pathway (13)   
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Chemical reaction (10)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (6)   
Gene (854)   
   KEGG GENES (112)   
   KEGG MGENES (617)   
   RefGene (121)   
   EGENES (1)   
   OC (3)   
Protein sequence (91)   
   UniProt (91)   
Literature (1)   
   PubMed (1)   
All databases (973)   

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ENZYME: 3.7.1.9

Entry

EC 3.7.1.9 Enzyme

Name

2-hydroxymuconate-6-semialdehyde hydrolase;
2-hydroxy-6-oxohepta-2,4-dienoate hydrolase;
2-hydroxymuconic semialdehyde hydrolase;
HMSH;
HOD hydrolase;
xylF (gene name);
2-hydroxymuconate-semialdehyde formylhydrolase;
2-hydroxymuconate-semialdehyde hydrolase

Class

Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances

Sysname

2-hydroxymuconate-6-semialdehyde formylhydrolase

Reaction(IUBMB)

2-hydroxymuconate-6-semialdehyde + H2O = formate + 2-oxopent-4-enoate [RN:R02604]

Reaction(KEGG)

R02604;
(other) R05296 R05362 R05865

Substrate

2-hydroxymuconate-6-semialdehyde [CPD:C00682];
H2O [CPD:C00001]

Product

formate [CPD:C00058];
2-oxopent-4-enoate [CPD:C00596]

Comment

The enzyme is involved in the degradation of catechols.

History

EC 3.7.1.9 created 1990, modified 2013

Pathway

ec00362	Benzoate degradation
ec00622	Xylene degradation
ec00643	Styrene degradation
ec01100	Metabolic pathways
ec01120	Microbial metabolism in diverse environments

Orthology

K10216

2-hydroxymuconate-semialdehyde hydrolase

Genes

PSD:	DSC_09175
PPSE:	BN5_3615(nahN)
PPJ:	RK21_04238
PSC:	A458_06525
PSTU:	UIB01_22735
PBM:	CL52_14705
PFK:	PFAS1_28780
AEI:	AOY20_01960
AJO:	RZ95_18625
ASJ:	AsACE_CH00356
MAD:	HP15_1112(dmpD) HP15_4033(xylF)
MSR:	AU15_09325 AU15_21085
MLQ:	ASQ50_09220
MSQ:	BKP64_13855
SPOI:	IMCC21906_00397 IMCC21906_02716
ZAL:	AZF00_03860 AZF00_17825
CYQ:	Q91_0515 Q91_1790(bphD1) Q91_2195
CZA:	CYCME_0226 CYCME_0664 CYCME_2092
APAC:	S7S_13285
GBI:	PG2T_07330 PG2T_09695
TBN:	TBH_C0921
AQL:	BXU06_16870
RPI:	Rpic_4621
RPF:	Rpic12D_3545
REU:	Reut_B5690
RME:	Rmet_1306
BVI:	Bcep1808_7611
BUR:	Bcep18194_B1183 Bcep18194_B2956
BCEN:	DM39_4829(xylF)
BCT:	GEM_5398
BCED:	DM42_4988(xylF)
BCON:	NL30_24575
BDF:	WI26_16010
BTEI:	WS51_00585
BPSL:	WS57_12140
BUQ:	AC233_11165
PPK:	U875_01820
PRB:	X636_07650
BBH:	BN112_4274
BBX:	BBS798_3919
BFZ:	BAU07_03835
AJS:	Ajs_0221
ACID:	CBP33_01100 CBP33_05470
VEI:	Veis_2786
CTT:	CtCNB1_3150
ADN:	Alide_0336
ADK:	Alide2_0281
HYL:	LPB072_18175
MPT:	Mpe_A2274
MASW:	AM586_18645
LCH:	Lcho_3344
RBU:	PG1C_08185 PG1C_11270
DAR:	Daro_1331 Daro_3786
AZO:	azo1968(xylF)
AZI:	AzCIB_4406
TMZ:	Tmz1t_3110
ARC:	ABLL_2439
MESO:	BSQ44_10055
SAME:	SAMCFNEI73_pB0463
NAR:	Saro_3858
NPP:	PP1Y_AT15665 PP1Y_AT31623
NPN:	JI59_24610
NRE:	BES08_18550 BES08_20400
SMAZ:	LH19_27440
ERY:	CP97_03160 CP97_14200
CNA:	AB433_18150
BACI:	B1NLA3E_01490 B1NLA3E_14010
BSM:	BSM4216_1785
GMC:	GY4MC1_1593
GJF:	M493_17935
GTH:	Geoth_1676
PTL:	AOT13_14455
PNP:	IJ22_48610
BTS:	Btus_0963
SIV:	SSIL_0071
SSIL:	SOLI23_18480
SAY:	TPY_0645(mhpC)
SAP:	Sulac_2994
RHA:	RHA1_ro08081
ROA:	Pd630_LPD12026
RAV:	AAT18_00600
GOQ:	ACH46_18245
ARZ:	AUT26_01405
NAE:	BHE16_09080
ICA:	Intca_1090
JTE:	ASJ30_00170
NOA:	BKM31_20825
FSY:	FsymDg_2032
AMQ:	AMETH_2411(mhpC)
PDX:	Psed_6034
AFS:	AFR_28670
CAP:	CLDAP_40940
TTJ:	TTHB237
TTL:	TtJL18_2419
TPI:	TREPR_1321

» show all

Reference

1 [PMID:4325686]

Authors

Sala-Trepat JM, Evans WC.

Title

The meta cleavage of catechol by Azotobacter species. 4-Oxalocrotonate pathway.

Journal

Eur. J. Biochem. 20 (1971) 400-13.

Reference

2 [PMID:3481421]

Authors

Harayama S, Rekik M, Wasserfallen A, Bairoch A.

Title

Evolutionary relationships between catabolic pathways for aromatics: conservation of gene order and nucleotide sequences of catechol oxidation genes of pWW0 and NAH7 plasmids.

Journal

Mol. Gen. Genet. 210 (1987) 241-7.

Reference

3 [PMID:7890778]

Authors

Diaz E, Timmis KN

Title

Identification of functional residues in a 2-hydroxymuconic semialdehyde hydrolase. A new member of the alpha/beta hydrolase-fold family of enzymes which cleaves carbon-carbon bonds.

Journal

J. Biol. Chem. 270 (1995) 6403-411.

Other DBs

ExplorEnz - The Enzyme Database:

3.7.1.9

IUBMB Enzyme Nomenclature:

3.7.1.9

ExPASy - ENZYME nomenclature database:

3.7.1.9

UM-BBD (Biocatalysis/Biodegradation Database):

3.7.1.9

BRENDA, the Enzyme Database:

3.7.1.9

CAS:

54004-61-4

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Gene (852)   
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DNA sequence (127)   
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3D Structure (10)   
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Enzyme (1)   
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REACTION: R05362

Entry

R05362 Reaction

Name

2-hydroxy-6-oxoocta-2,4,7-trienoate formylhydrolase

Definition

2-Hydroxy-6-oxoocta-2,4,7-trienoate + H2O <=> 2-Hydroxy-2,4-pentadienoate + Acrylic acid

Equation

C07087 + C00001 <=> C00596 + C00511

Reaction class

RC00753	C00596_C07087
RC01337	C00511_C07087

Enzyme

3.7.1.9

Pathway

rn00643	Styrene degradation
rn01100	Metabolic pathways
rn01120	Microbial metabolism in diverse environments
rn01220	Degradation of aromatic compounds

Orthology

K10216

2-hydroxymuconate-semialdehyde hydrolase [EC:3.7.1.9]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
   UMBBD-RN (1)   
Gene (113)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (112)   
All databases (130)   

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