KEGG ORTHOLOGY: K10703

ORTHOLOGY: K10703

Entry

K10703 KO

Name

PHS1, PAS2

Definition

very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [EC:4.2.1.134]

Pathway

ko00062	Fatty acid elongation
ko01040	Biosynthesis of unsaturated fatty acids
ko01212	Fatty acid metabolism

Module

M00415

Fatty acid biosynthesis, elongation, endoplasmic reticulum

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01212 Fatty acid metabolism
    K10703  PHS1, PAS2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
  Lipid metabolism
   00062 Fatty acid elongation
    K10703  PHS1, PAS2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
   01040 Biosynthesis of unsaturated fatty acids
    K10703  PHS1, PAS2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
KEGG modules [BR:ko00002]
Pathway module
  Carbohydrate and lipid metabolism
   Fatty acid metabolism
    M00415  Fatty acid biosynthesis, elongation, endoplasmic reticulum
     K10703  PHS1, PAS2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
Enzymes [BR:ko01000]
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.134  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
     K10703  PHS1, PAS2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
Lipid biosynthesis proteins [BR:ko01004]
Fatty acid synthase
  Component type
   K10703  PHS1, PAS2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

Other DBs

RN:

R07760 R10827

Genes

HSA:	201562(HACD2) 401494(HACD4) 51495(HACD3) 9200(HACD1)
PTR:	450331(HACD1) 744160(HACD4) 746499(HACD2) 747950(HACD3)
PPS:	100970660(HACD1) 100979084(HACD2) 100986064(HACD3) 100995506(HACD4)
GGO:	101127709(HACD3) 101136535(HACD4) 101151156(HACD2) 109028458(HACD1)
PON:	100172398(HACD2) 100174644(HACD3) 100442069(HACD4) 100446614(HACD1)
NLE:	100590465(HACD2) 100599328(HACD4) 100604226(HACD3) 100606599(HACD1)
MCC:	700635(HACD1) 709590(HACD3) 711051(HACD4) 715374(HACD2)
MCF:	101865117(HACD3) 102117284(HACD4) 102127341(HACD1) 102134779(HACD2)
CSAB:	103219384(HACD4) 103228165(HACD2) 103237958(HACD1) 103245466(HACD3)
RRO:	104655329(HACD1) 104655408(HACD2) 104655951(HACD3) 104670296(HACD4)
CJC:	100387676(HACD4) 100408770(HACD1) 100412428(HACD2) 100413343(HACD3)
SBQ:	101033969(PTPLAD1) 101036309(PTPLAD2) 101046641 101050076(PTPLB)
MMU:	30963(Hacd1) 57874(Hacd3) 66775(Hacd4) 70757(Hacd2)
RNO:	288058(Hacd2) 300783(Hacd3) 362540(Hacd4) 680115(Hacd1)
CGE:	100752449(Hacd3) 100765668(Hacd2) 100772448(Hacd1) 100774830(Hacd4)
NGI:	103734827(Hacd1) 103736789(Hacd3) 103741991(Hacd2) 103743953(Hacd4)
HGL:	101698416(Hacd4) 101703393(Hacd2) 101718268(Hacd1) 101719524(Hacd3)
CCAN:	109692334(Hacd3) 109697197(Hacd4) 109697405(Hacd1) 109701080(Hacd2)
OCU:	100339262(HACD3) 100343182(HACD4) 100346386(HACD1) 100352022(HACD2)
TUP:	102477817(HACD1) 102479872(HACD3) 102490208(HACD2) 102497590(HACD4)
CFA:	478345(HACD3) 574011(HACD1) 608764(HACD2) 611337(HACD4)
AML:	100464409(HACD1) 100476116(HACD3) 100476304(HACD4) 100482012(HACD2)
UMR:	103662151(HACD4) 103664207(HACD1) 103678825(HACD2) 103679073(HACD3)
FCA:	101084111(HACD3) 101088195(HACD4) 101092752(HACD1) 101100993(HACD2)
PTG:	102949189(HACD2) 102960714(HACD4) 102962823(HACD3) 102968266(HACD1)
AJU:	106971054(HACD4) 106979880(HACD1) 106980190(HACD3) 106984070(HACD2)
BTA:	100125237(HACD3) 613886(HACD2) 615191(HACD1) 618814(HACD4)
BOM:	102266008(HACD3) 102269541(HACD2) 102280214(HACD4) 102283288(HACD1)
BIU:	109555850(HACD2) 109562856(HACD4) 109564690(HACD3) 109567983(HACD1)
PHD:	102322405(HACD1) 102330664(HACD4) 102342791(HACD2) 102345023(HACD3)
CHX:	102170231(HACD4) 102183078(HACD1) 102186599(HACD3) 102190073(HACD2)
OAS:	101102210(HACD4) 101120135(HACD2) 101120835(HACD3) 443484(HACD1)
SSC:	100154613(HACD3) 100523084(HACD1) 100523711(HACD4)
CFR:	102503531(HACD2) 102513006(HACD3) 102517774(HACD4) 102522520(HACD1)
BACU:	103007060(HACD4) 103007654(HACD2) 103010311(HACD3) 103016241(HACD1)
LVE:	103070282(HACD4) 103080072(HACD3) 103080415(HACD1) 103090885(HACD2)
ECB:	100053192(HACD3) 100064435(HACD4) 100068422(HACD1) 100070489(HACD2)
MYB:	102239522(HACD2) 102243865(HACD1) 102250072(HACD4) 102260168(HACD3)
MYD:	102761248(HACD2) 102765145(HACD3) 102765511(HACD4) 102767778(HACD1)
HAI:	109385238(HACD3) 109388107(HACD2) 109393552(HACD1) 109396414(HACD4)
RSS:	109444300(HACD3) 109451053(HACD2) 109457442(HACD4) 109458435(HACD1)
PALE:	102878765(HACD3) 102881141(HACD4) 102890540(HACD2) 102896669(HACD1)
LAV:	100663966(HACD4) 100666774(HACD3) 100673955(HACD1) 100677465(HACD2)
MDO:	100019614(HACD2) 100021176(HACD4) 100024526(HACD3)
SHR:	100917310(HACD4) 100919102(HACD3) 100929810(HACD2) 100932461(HACD1)
OAA:	100082970(HACD4) 100090771 100681153(HACD1)
GGA:	415539(HACD3) 420518(HACD1) 424251(HACD2) 427232(PTPLAD2)
MGP:	100542802(HACD3) 100547269(HACD1) 100548753(HACD2) 104915048(HACD4)
CJO:	107306178(HACD4) 107309029(HACD1) 107316814(HACD2) 107318903(HACD3)
APLA:	101790464(HACD3) 101799288(HACD4) 101800675(HACD1) 101801258(HACD2)
TGU:	100222541(HACD3) 100223714(HACD2) 100225517(HACD4) 100226789(HACD1)
GFR:	102038446(HACD1) 102042345(HACD4) 102045004(HACD2) 102045414(HACD3)
FAB:	101806852(HACD4) 101810478(HACD2) 101817288(HACD3) 101817785(HACD1)
PHI:	102104879(HACD4) 102107099(HACD2) 102107704(HACD1) 102108630(HACD3)
CCW:	104683887(HACD3) 104685211(HACD4) 104689351(HACD1) 109145688(HACD2)
FPG:	101913688(HACD4) 101913832(HACD3) 101917611(HACD1) 101924533(HACD2)
FCH:	102051229(HACD1) 102052347(HACD2) 102057117(HACD3) 102058226(HACD4)
CLV:	102086789(HACD1) 102087259(HACD3) 102089080(HACD2) 102092183(HACD4)
AAM:	106484416(HACD4) 106487656(HACD3) 106489953(HACD1) 106499043(HACD2)
ASN:	102372217(HACD3) 102376647(HACD4) 102381766(PTPLA) 102383472(HACD2)
AMJ:	102561980(HACD2) 102563025(HACD4) 102564740(HACD1) 102568329(HACD3)
PSS:	102444601(HACD1) 102445253(HACD3) 102445343(HACD4) 102452110(HACD2)
CMY:	102932870(HACD1) 102935203(HACD2) 102940963(HACD4) 102942131
CPIC:	101944120(HACD4) 101948528(HACD1) 101950627(HACD2) 101952448(HACD3)
ACS:	100554600(hacd2) 100555369(hacd3) 100559315(hacd4) 100562288(hacd1)
PBI:	103049929(HACD3) 103057408(HACD4) 103061643(HACD2) 103067518(HACD1)
GJA:	107108159(HACD4) 107113909(HACD2) 107120973(HACD1) 107123789(HACD3)
XLA:	108711496(hacd3.L) 108712807(hacd3.S) 108713839 108719872(hacd1.S) 446806(hacd2.S) 447050 494792(hacd1.L)
XTR:	100145048(hacd1) 100216187(hacd2) 100379797(hacd3) 100490902(hacd4)
DRE:	334121(hacd2) 393441(hacd3) 553326(hacd1) 561303(si:ch73-41h24.1)
IPU:	108264727(hacd3) 108266254(hacd2) 108267784(hacd4) 108268178(hacd1) 108270680
TRU:	101065304 101067691(hacd4) 101070268(hacd2) 101071733(hacd3) 101071736(hacd1)
TNG:	GSTEN00016014G001 GSTEN00031772G001
LCO:	104918229(hacd2) 104922314(hacd3) 104927197(hacd4) 104929560(hacd1) 104929620
MZE:	101467683 101468089(hacd3) 101472136(hacd4) 101479872(hacd1) 101481030(hacd2)
OLA:	101155409 101162008(hacd1) 101163569(hacd3) 101172608(hacd4) 101174470(hacd2)
XMA:	102221140 102222666 102227054(hacd2) 102229999(hacd1) 102234597(hacd3)
CSEM:	103377442(hacd1) 103385367(hacd4) 103391652(hacd2) 103398371(hacd3)
SASA:	100196500(phs1) 100286513(hacd3) 106562668 106577593(hacd4) 106578705 106582347(hacd2) 106587944 106587959 106587973 106590135
LCM:	102350254 102357175(HACD1) 102361655(HACD3) 102362801(HACD4)
CMK:	103171834(hacd2) 103181578(hacd1) 103182850(hacd4) 103186443(hacd3)
BFO:	BRAFLDRAFT_111868 BRAFLDRAFT_168702 BRAFLDRAFT_225388 BRAFLDRAFT_77431
CIN:	100175762 100184399
SPU:	592170 592581
SKO:	100370601 100376136
DME:	Dmel_CG6746 Dmel_CG9267
DPO:	Dpse_GA19829 Dpse_GA21658
DAN:	Dana_GF15500 Dana_GF21639
DER:	Dere_GG10197 Dere_GG10286
DPE:	Dper_GL14177 Dper_GL25700
DSE:	Dsec_GM25510 Dsec_GM26451
DSI:	Dsimw501_GD22057(Dsim_GD22057) Dsimw501_GD22144(Dsim_GD22144)
DWI:	Dwil_GK15278 Dwil_GK23928
DYA:	Dyak_GE11580 Dyak_GE12555
DGR:	Dgri_GH11094 Dgri_GH13780
DMO:	Dmoj_GI17184 Dmoj_GI18216
DVI:	Dvir_GJ18122 Dvir_GJ22182
MDE:	101900017 101900652
AGA:	AgaP_AGAP003814 AgaP_AGAP003815
AAG:	AaeL_AAEL005059 AaeL_AAEL005065 AaeL_AAEL005223 AaeL_AAEL005229
CQU:	CpipJ_CPIJ011113 CpipJ_CPIJ011114
AME:	100577192 413078
BIM:	100744206 100744962
BTER:	100642777 100645881
SOC:	105197427 105200204
AEC:	105148293 105153349
PBAR:	105425289 105429232
HST:	105183312 105188575
CFO:	105251955 105255797
NVI:	100115280 100119292
TCA:	656186 657574
BMOR:	101746115 732939
PXY:	105382787 105388332 105394763
API:	100144797
PHU:	Phum_PHUM075720 Phum_PHUM307650
DPX:	DAPPUDRAFT_219048 DAPPUDRAFT_305850
ISC:	IscW_ISCW018099 IscW_ISCW021603
CEL:	CELE_T15B7.2(hpo-8)
CBR:	CBG19031
NAI:	NECAME_00058
BMY:	Bm1_32340
LOA:	LOAG_01917 LOAG_03759
HRO:	HELRODRAFT_103959 HELRODRAFT_67129
LGI:	LOTGIDRAFT_120462 LOTGIDRAFT_222938
CRG:	105317723 105344957 105346790
OBI:	106881918 106882568
SMM:	Smp_022700.2 Smp_022700.5 Smp_121880
OVI:	T265_07008 T265_14247
NVE:	NEMVE_v1g140243 NEMVE_v1g174728
ADF:	107346286 107348530
HMG:	100205849 101237619
TAD:	TRIADDRAFT_54534 TRIADDRAFT_64088
AQU:	100631401 100641930 105313298
ATH:	AT5G10480(PAS2) AT5G59770
ALY:	ARALYDRAFT_358193 ARALYDRAFT_909004
CRB:	CARUB_v10003916mg CARUB_v10027086mg
EUS:	EUTSA_v10014612mg EUTSA_v10014620mg EUTSA_v10027965mg
BRP:	103846802 103851552 103855870
BNA:	106372468 106384895 106385553 106386856 106405914 106430302 106441127
THJ:	104798725 104810801 104819292
CIT:	102610324 102621321
CIC:	CICLE_v10029246mg
TCC:	18590754 18611467
GRA:	105788887 105804148
GHI:	107913394 107950284 107963934
EGR:	104426317 104432769
GMX:	100527150 100527607 100818356
PVU:	PHAVU_002G147400g PHAVU_003G289100g PHAVU_011G067100g
VRA:	106755143 106755607 106776467 106779219
VAR:	108319827 108323452 108332862
CCAJ:	109798479 109801425 109818376
MTR:	MTR_4g060990 MTR_8g471160
CAM:	101495386 101495713 101507943
ADU:	107476878 107487258
AIP:	107629135 107633062 107642273
LJA:	Lj0g3v0016519.1(Lj0g3v0016519.1) Lj0g3v0339429.1(Lj0g3v0339429.1) Lj0g3v0339429.2(Lj0g3v0339429.2) Lj3g3v3155120.1(Lj3g3v3155120.1)
LANG:	109349147 109355362 109363351
FVE:	101300284 101304749
PPER:	18772196 18773179
PMUM:	103322718 103334912
MDM:	103413128 103421525 103422925 103427477 103429989 103448194
PXB:	103937488 103948952 103954176
ZJU:	107425132 107425142
CSV:	101212013 101214048
CMO:	103490580 103493277
RCU:	8277640 8286117
JCU:	105628210 105641681
POP:	POPTR_0001s24210g(POPTRDRAFT_706239) POPTR_0007s14290g(POPTRDRAFT_719769)
VVI:	100255240 100261741
SLY:	101245050 101246492 101262991
SPEN:	107002947 107004641 107018380
SOT:	102586361 102591777
INI:	109180148 109188898 109192762
SIND:	105169658 105170380 105176449
BVG:	104895506 104900172
NNU:	104594622 104595487 104611912
OSA:	107277374(P0009G03.7) 4324520(P0009G03.9) 4324521 4335343(HACD) 4339019
DOSA:	Os01t0150200-01(Os01g0150200) Os01t0150400-00(Os01g0150400) Os01t0150500-00(Os01g0150500) Os01t0150800-01(Os01g0150800) Os04t0271200-01(Os04g0271200) Os05t0460800-01(Os05g0460800)
OBR:	102714459 102717559 102717835
BDI:	100821089 100840117 100842646 106866263
ATS:	F775_09786 F775_22178 F775_30966 F775_33237
ZMA:	100274548 100284318(cl20712_1(629)) 100383128
SITA:	101782661 101782841 101783244
PDA:	103703452 103705939
EGU:	105044431 105045727
MUS:	103968992 103975400 103991715
ATR:	18434145 18442669
SMO:	SELMODRAFT_122503(PAS2-1) SELMODRAFT_125223(PAS2-2) SELMODRAFT_451040
PPP:	PHYPADRAFT_205799 PHYPADRAFT_218307
CRE:	CHLREDRAFT_95439
VCN:	VOLCADRAFT_61480 VOLCADRAFT_83422
OLU:	OSTLU_13214 OSTLU_29682 OSTLU_87349
OTA:	Ot05g03810
BPG:	Bathy03g04510 Bathy04g02110
MIS:	MICPUN_58684 MICPUN_59337
MPP:	MICPUCDRAFT_44656 MICPUCDRAFT_58952
CSL:	COCSUDRAFT_14404 COCSUDRAFT_83443
CVR:	CHLNCDRAFT_137564 CHLNCDRAFT_143333
APRO:	F751_6284
CME:	CYME_CMR006C
GSL:	Gasu_12280
CCP:	CHC_T00005797001 CHC_T00008580001
SCE:	YJL097W(PHS1)
AGO:	AGOS_AFR090W
ERC:	Ecym_6346
KLA:	KLLA0F14146g
LTH:	KLTH0D03410g
VPO:	Kpol_1016p17
ZRO:	ZYRO0G15334g
CGR:	CAGL0L03564g
NCS:	NCAS_0A09490(NCAS0A09490)
NDI:	NDAI_0G05450(NDAI0G05450)
TPF:	TPHA_0B01300(TPHA0B01300)
TBL:	TBLA_0C02950(TBLA0C02950)
TDL:	TDEL_0D01380(TDEL0D01380)
KAF:	KAFR_0A01400(KAFR0A01400)
PPA:	PAS_chr3_0222
DHA:	DEHA2C17424g DEHA2C17446g
PIC:	PICST_56836 PICST_57597
PGU:	PGUG_03908 PGUG_03909
SPAA:	SPAPADRAFT_63465
LEL:	LELG_05220 LELG_05221
CAL:	CAALFM_C703040WA(CaO19.5157) CAALFM_C703050WA(CaO19.5156)
CTP:	CTRG_05223 CTRG_05224
COT:	CORT_0G04450 CORT_0G04460
CDU:	CD36_72700 CD36_72710
CTEN:	CANTEDRAFT_113290 CANTEDRAFT_120092
YLI:	YALI0F11935g
CLU:	CLUG_00450
CAUR:	QG37_03808 QG37_03809
NCR:	NCU08985
NTE:	NEUTE1DRAFT82561(NEUTE1DRAFT_82561)
SMP:	SMAC_01940
PAN:	PODANSg5141
TTT:	THITE_2023698
MTM:	MYCTH_2304523
CTHR:	CTHT_0027140
MGR:	MGG_04972 MGG_07602
TMN:	UCRPA7_2257
FGR:	FGSG_07304 FGSG_12648
FPU:	FPSE_01073 FPSE_04001
FVR:	FVEG_03595 FVEG_05273
FOX:	FOXG_02109 FOXG_05748
NHE:	NECHADRAFT_38495 NECHADRAFT_82566
TRE:	TRIREDRAFT_105055
MAW:	MAC_00591
MAJ:	MAA_05922
CMT:	CCM_01449
VAL:	VDBG_02620 VDBG_04601
VDA:	VDAG_04151 VDAG_09815
CFJ:	CFIO01_04331 CFIO01_04885
ELA:	UCREL1_11623
SSL:	SS1G_03177
BFU:	BC1G_07525
MBE:	MBM_07029 MBM_07077
PSCO:	LY89DRAFT_681296
GLZ:	GLAREA_04533
ANI:	AN5000.2
AFM:	AFUA_4G10270
AOR:	AOR_1_2122154(AO090003001195) AOR_1_2168174(AO090005001257)
ANG:	ANI_1_1650144(An16g03550) ANI_1_1990184(An04g06650)
AFV:	AFLA_026280
ACT:	ACLA_049480
NFI:	NFIA_067410 NFIA_105790
PCS:	Pc22g12490
PDP:	PDIP_25110
CIM:	CIMG_09068
CPW:	CPC735_015040
PBL:	PAAG_08221
PBN:	PADG_01997
URE:	UREG_03318
AJE:	HCAG_01309
PNO:	SNOG_12970 SNOG_15979
PTE:	PTT_07276 PTT_15392
BZE:	COCCADRAFT_109010 COCCADRAFT_34753
BSC:	COCSADRAFT_159899 COCSADRAFT_91005
BOR:	COCMIDRAFT_34556 COCMIDRAFT_97448
ZTR:	MYCGRDRAFT_87635
PFJ:	MYCFIDRAFT_45204
BCOM:	BAUCODRAFT_32422
NPA:	UCRNP2_4724
TML:	GSTUM_00009842001
SPO:	SPBC19C2.15c
CNE:	CNE00730
CNB:	CNBE0670
CGI:	CGB_E0700C
TMS:	TREMEDRAFT_25191
PPL:	POSPLDRAFT_104986
TVS:	TRAVEDRAFT_56436
DSQ:	DICSQDRAFT_133109
PCO:	PHACADRAFT_258569
SHS:	STEHIDRAFT_141441
HIR:	HETIRDRAFT_476130
PSQ:	PUNSTDRAFT_42833
ADL:	AURDEDRAFT_111144
FME:	FOMMEDRAFT_107800
GTR:	GLOTRDRAFT_58018
MRR:	Moror_14683 Moror_6971
CCI:	CC1G_11544
SCM:	SCHCODRAFT_77419
ABP:	AGABI1DRAFT71504(AGABI1DRAFT_71504)
ABV:	AGABI2DRAFT192575(AGABI2DRAFT_192575)
CPUT:	CONPUDRAFT_101959
SLA:	SERLADRAFT_466079
WSE:	WALSEDRAFT_59139
UMA:	UMAG_00007
PFP:	PFL1_00095
MGL:	MGL_2260
MLR:	MELLADRAFT_38757
ECU:	ECU05_1430
EIN:	Eint_051490
EHE:	EHEL_051560
ERO:	EROM_051500
NCE:	NCER_101417
SRE:	PTSG_07138
DDI:	DDB_G0278113 DDB_G0278683
DPP:	DICPUDRAFT_151830 DICPUDRAFT_89327
DFA:	DFA_06437 DFA_07051
EHI:	EHI_110570(58.t00004)
EDI:	EDI_053980
EIV:	EIN_047440
ACAN:	ACA1_073320 ACA1_186090 ACA1_186210 ACA1_309340
PFA:	MAL13P1.168
PFD:	PFDG_02031
PFH:	PFHG_02827
PCB:	PCHAS_135110(PC301025.00.0)
PBE:	PB001246.00.0 PB301100.00.0
PKN:	PKH_122120
PVX:	PVX_082515
PCY:	PCYB_123100
BEQ:	BEWA_020340
BBO:	BBOV_III006410(17.m07571)
CPV:	cgd3_2150
CHO:	Chro.30252
TGO:	TGME49_311290
TET:	TTHERM_00538900
PTM:	GSPATT00009568001
AAF:	AURANDRAFT_29797
PIF:	PITG_14831
PSOJ:	PHYSODRAFT_433551
SPAR:	SPRG_10884
GTT:	GUITHDRAFT_105298
TBR:	Tb10.406.0290
TCR:	511635.40
LMA:	LMJF_05_0280
LIF:	LINJ_05_0280
LDO:	LDBPK_050280
LMI:	LMXM_05_0280
LBZ:	LBRM_05_0270
NGR:	NAEGRDRAFT_33547 NAEGRDRAFT_35609
GLA:	GL50803_7512
MAD:	HP15_2720
MARI:	ACP86_20830

» show all

Reference

PMID:17719544 (S.cerevisiae)

Authors

Denic V, Weissman JS

Title

A molecular caliper mechanism for determining very long-chain fatty acid length.

Journal

Cell 130:663-77 (2007)
DOI:10.1016/j.cell.2007.06.031

Reference

PMID:18554506

Authors

Ikeda M, Kanao Y, Yamanaka M, Sakuraba H, Mizutani Y, Igarashi Y, Kihara A

Title

Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis.

Journal

FEBS Lett 582:2435-40 (2008)
DOI:10.1016/j.febslet.2008.06.007

Sequence

[hsa:9200 201562 51495 401494]

All links

Ontology (4)   
   KEGG BRITE (4)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (1558)   
   KEGG GENES (808)   
   KEGG MGENES (404)   
   RefGene (76)   
   EGENES (251)   
   OC (19)   
Protein sequence (436)   
   UniProt (414)   
   SWISS-PROT (22)   
Literature (2)   
   PubMed (2)   
All databases (2014)   

Download RDF

ORTHOLOGY: K18880

Entry

K18880 KO

Name

HCD1

Definition

very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [EC:4.2.1.134]

Pathway

ko00062	Fatty acid elongation
ko04626	Plant-pathogen interaction

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Lipid metabolism
   00062 Fatty acid elongation
    K18880  HCD1; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
Organismal Systems
  Environmental adaptation
   04626 Plant-pathogen interaction
    K18880  HCD1; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
Enzymes [BR:ko01000]
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.134  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
     K18880  HCD1; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

Genes

ATH:	AT4G14440(HCD1)
ALY:	ARALYDRAFT_915421
CRB:	CARUB_v10005626mg
EUS:	EUTSA_v10026117mg
BRP:	103863519
BNA:	106365726 106390743

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (8)   
   KEGG GENES (7)   
   OC (1)   
Protein sequence (7)   
   UniProt (6)   
   SWISS-PROT (1)   
All databases (24)   

Download RDF

ENZYME: 4.2.1.134

Entry

EC 4.2.1.134 Enzyme

Name

very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase;
PHS1 (gene name);
PAS2 (gene name)

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

very-long-chain (3R)-3-hydroxyacyl-CoA hydro-lyase

Reaction(IUBMB)

a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H2O [RN:R10827]

Reaction(KEGG)

R10827;
(other) R07760

Substrate

very-long-chain (3R)-3-hydroxyacyl-CoA [CPD:C20878]

Product

very-long-chain trans-2,3-dehydroacyl-CoA [CPD:C20879];
H2O [CPD:C00001]

Comment

This is the third component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long chain acyl CoAs. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase.

History

EC 4.2.1.134 created 2012, modified 2014

Pathway

ec00062	Fatty acid elongation
ec01040	Biosynthesis of unsaturated fatty acids
ec01110	Biosynthesis of secondary metabolites

Orthology

K10703	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
K18880	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

Genes

HSA:	201562(HACD2) 401494(HACD4) 51495(HACD3) 9200(HACD1)
PTR:	450331(HACD1) 744160(HACD4) 746499(HACD2) 747950(HACD3)
PPS:	100970660(HACD1) 100979084(HACD2) 100986064(HACD3) 100995506(HACD4)
GGO:	101127709(HACD3) 101136535(HACD4) 101151156(HACD2) 109028458(HACD1)
PON:	100172398(HACD2) 100174644(HACD3) 100442069(HACD4) 100446614(HACD1)
NLE:	100590465(HACD2) 100599328(HACD4) 100604226(HACD3) 100606599(HACD1)
MCC:	700635(HACD1) 709590(HACD3) 711051(HACD4) 715374(HACD2)
MCF:	101865117(HACD3) 102117284(HACD4) 102127341(HACD1) 102134779(HACD2)
CSAB:	103219384(HACD4) 103228165(HACD2) 103237958(HACD1) 103245466(HACD3)
RRO:	104655329(HACD1) 104655408(HACD2) 104655951(HACD3) 104670296(HACD4)
CJC:	100387676(HACD4) 100408770(HACD1) 100412428(HACD2) 100413343(HACD3)
SBQ:	101033969(PTPLAD1) 101036309(PTPLAD2) 101046641 101050076(PTPLB)
MMU:	30963(Hacd1) 57874(Hacd3) 66775(Hacd4) 70757(Hacd2)
RNO:	288058(Hacd2) 300783(Hacd3) 362540(Hacd4) 680115(Hacd1)
CGE:	100752449(Hacd3) 100765668(Hacd2) 100772448(Hacd1) 100774830(Hacd4)
NGI:	103734827(Hacd1) 103736789(Hacd3) 103741991(Hacd2) 103743953(Hacd4)
HGL:	101698416(Hacd4) 101703393(Hacd2) 101718268(Hacd1) 101719524(Hacd3)
CCAN:	109692334(Hacd3) 109697197(Hacd4) 109697405(Hacd1) 109701080(Hacd2)
OCU:	100339262(HACD3) 100343182(HACD4) 100346386(HACD1) 100352022(HACD2)
TUP:	102477817(HACD1) 102479872(HACD3) 102490208(HACD2) 102497590(HACD4)
CFA:	478345(HACD3) 574011(HACD1) 608764(HACD2) 611337(HACD4)
AML:	100464409(HACD1) 100476116(HACD3) 100476304(HACD4) 100482012(HACD2)
UMR:	103662151(HACD4) 103664207(HACD1) 103678825(HACD2) 103679073(HACD3)
FCA:	101084111(HACD3) 101088195(HACD4) 101092752(HACD1) 101100993(HACD2)
PTG:	102949189(HACD2) 102960714(HACD4) 102962823(HACD3) 102968266(HACD1)
AJU:	106971054(HACD4) 106979880(HACD1) 106980190(HACD3) 106984070(HACD2)
BTA:	100125237(HACD3) 613886(HACD2) 615191(HACD1) 618814(HACD4)
BOM:	102266008(HACD3) 102269541(HACD2) 102280214(HACD4) 102283288(HACD1)
BIU:	109555850(HACD2) 109562856(HACD4) 109564690(HACD3) 109567983(HACD1)
PHD:	102322405(HACD1) 102330664(HACD4) 102342791(HACD2) 102345023(HACD3)
CHX:	102170231(HACD4) 102183078(HACD1) 102186599(HACD3) 102190073(HACD2)
OAS:	101102210(HACD4) 101120135(HACD2) 101120835(HACD3) 443484(HACD1)
SSC:	100154613(HACD3) 100523084(HACD1) 100523711(HACD4)
CFR:	102503531(HACD2) 102513006(HACD3) 102517774(HACD4) 102522520(HACD1)
BACU:	103007060(HACD4) 103007654(HACD2) 103010311(HACD3) 103016241(HACD1)
LVE:	103070282(HACD4) 103080072(HACD3) 103080415(HACD1) 103090885(HACD2)
ECB:	100053192(HACD3) 100064435(HACD4) 100068422(HACD1) 100070489(HACD2)
MYB:	102239522(HACD2) 102243865(HACD1) 102250072(HACD4) 102260168(HACD3)
MYD:	102761248(HACD2) 102765145(HACD3) 102765511(HACD4) 102767778(HACD1)
HAI:	109385238(HACD3) 109388107(HACD2) 109393552(HACD1) 109396414(HACD4)
RSS:	109444300(HACD3) 109451053(HACD2) 109457442(HACD4) 109458435(HACD1)
PALE:	102878765(HACD3) 102881141(HACD4) 102890540(HACD2) 102896669(HACD1)
LAV:	100663966(HACD4) 100666774(HACD3) 100673955(HACD1) 100677465(HACD2)
MDO:	100019614(HACD2) 100021176(HACD4) 100024526(HACD3)
SHR:	100917310(HACD4) 100919102(HACD3) 100929810(HACD2) 100932461(HACD1)
OAA:	100082970(HACD4) 100090771 100681153(HACD1)
GGA:	415539(HACD3) 420518(HACD1) 424251(HACD2) 427232(PTPLAD2)
MGP:	100542802(HACD3) 100547269(HACD1) 100548753(HACD2) 104915048(HACD4)
CJO:	107306178(HACD4) 107309029(HACD1) 107316814(HACD2) 107318903(HACD3)
APLA:	101790464(HACD3) 101799288(HACD4) 101800675(HACD1) 101801258(HACD2)
TGU:	100222541(HACD3) 100223714(HACD2) 100225517(HACD4) 100226789(HACD1)
GFR:	102038446(HACD1) 102042345(HACD4) 102045004(HACD2) 102045414(HACD3)
FAB:	101806852(HACD4) 101810478(HACD2) 101817288(HACD3) 101817785(HACD1)
PHI:	102104879(HACD4) 102107099(HACD2) 102107704(HACD1) 102108630(HACD3)
CCW:	104683887(HACD3) 104685211(HACD4) 104689351(HACD1) 109145688(HACD2)
FPG:	101913688(HACD4) 101913832(HACD3) 101917611(HACD1) 101924533(HACD2)
FCH:	102051229(HACD1) 102052347(HACD2) 102057117(HACD3) 102058226(HACD4)
CLV:	102086789(HACD1) 102087259(HACD3) 102089080(HACD2) 102092183(HACD4)
AAM:	106484416(HACD4) 106487656(HACD3) 106489953(HACD1) 106499043(HACD2)
ASN:	102372217(HACD3) 102376647(HACD4) 102381766(PTPLA) 102383472(HACD2)
AMJ:	102561980(HACD2) 102563025(HACD4) 102564740(HACD1) 102568329(HACD3)
PSS:	102444601(HACD1) 102445253(HACD3) 102445343(HACD4) 102452110(HACD2)
CMY:	102932870(HACD1) 102935203(HACD2) 102940963(HACD4) 102942131
CPIC:	101944120(HACD4) 101948528(HACD1) 101950627(HACD2) 101952448(HACD3)
ACS:	100554600(hacd2) 100555369(hacd3) 100559315(hacd4) 100562288(hacd1)
PBI:	103049929(HACD3) 103057408(HACD4) 103061643(HACD2) 103067518(HACD1)
GJA:	107108159(HACD4) 107113909(HACD2) 107120973(HACD1) 107123789(HACD3)
XLA:	108711496(hacd3.L) 108712807(hacd3.S) 108713839 108719872(hacd1.S) 446806(hacd2.S) 447050 494792(hacd1.L)
XTR:	100145048(hacd1) 100216187(hacd2) 100379797(hacd3) 100490902(hacd4)
DRE:	334121(hacd2) 393441(hacd3) 553326(hacd1) 561303(si:ch73-41h24.1)
IPU:	108264727(hacd3) 108266254(hacd2) 108267784(hacd4) 108268178(hacd1) 108270680
TRU:	101065304 101067691(hacd4) 101070268(hacd2) 101071733(hacd3) 101071736(hacd1)
TNG:	GSTEN00016014G001 GSTEN00031772G001
LCO:	104918229(hacd2) 104922314(hacd3) 104927197(hacd4) 104929560(hacd1) 104929620
MZE:	101467683 101468089(hacd3) 101472136(hacd4) 101479872(hacd1) 101481030(hacd2)
OLA:	101155409 101162008(hacd1) 101163569(hacd3) 101172608(hacd4) 101174470(hacd2)
XMA:	102221140 102222666 102227054(hacd2) 102229999(hacd1) 102234597(hacd3)
CSEM:	103377442(hacd1) 103385367(hacd4) 103391652(hacd2) 103398371(hacd3)
SASA:	100196500(phs1) 100286513(hacd3) 106562668 106577593(hacd4) 106578705 106582347(hacd2) 106587944 106587959 106587973 106590135
LCM:	102350254 102357175(HACD1) 102361655(HACD3) 102362801(HACD4)
CMK:	103171834(hacd2) 103181578(hacd1) 103182850(hacd4) 103186443(hacd3)
BFO:	BRAFLDRAFT_111868 BRAFLDRAFT_168702 BRAFLDRAFT_225388 BRAFLDRAFT_77431
CIN:	100175762 100184399
SPU:	592170 592581
SKO:	100370601 100376136
DME:	Dmel_CG6746 Dmel_CG9267
DPO:	Dpse_GA19829 Dpse_GA21658
DAN:	Dana_GF15500 Dana_GF21639
DER:	Dere_GG10197 Dere_GG10286
DPE:	Dper_GL14177 Dper_GL25700
DSE:	Dsec_GM25510 Dsec_GM26451
DSI:	Dsimw501_GD22057(Dsim_GD22057) Dsimw501_GD22144(Dsim_GD22144)
DWI:	Dwil_GK15278 Dwil_GK23928
DYA:	Dyak_GE11580 Dyak_GE12555
DGR:	Dgri_GH11094 Dgri_GH13780
DMO:	Dmoj_GI17184 Dmoj_GI18216
DVI:	Dvir_GJ18122 Dvir_GJ22182
MDE:	101900017 101900652
AGA:	AgaP_AGAP003814 AgaP_AGAP003815
AAG:	AaeL_AAEL005059 AaeL_AAEL005065 AaeL_AAEL005223 AaeL_AAEL005229
CQU:	CpipJ_CPIJ011113 CpipJ_CPIJ011114
AME:	100577192 413078
BIM:	100744206 100744962
BTER:	100642777 100645881
SOC:	105197427 105200204
AEC:	105148293 105153349
PBAR:	105425289 105429232
HST:	105183312 105188575
CFO:	105251955 105255797
NVI:	100115280 100119292
TCA:	656186 657574
BMOR:	101746115 732939
PXY:	105382787 105388332 105394763
API:	100144797
PHU:	Phum_PHUM075720 Phum_PHUM307650
DPX:	DAPPUDRAFT_219048 DAPPUDRAFT_305850
ISC:	IscW_ISCW018099 IscW_ISCW021603
CEL:	CELE_T15B7.2(hpo-8)
CBR:	CBG19031
NAI:	NECAME_00058
BMY:	Bm1_32340
LOA:	LOAG_01917 LOAG_03759
HRO:	HELRODRAFT_103959 HELRODRAFT_67129
LGI:	LOTGIDRAFT_120462 LOTGIDRAFT_222938
CRG:	105317723 105344957 105346790
OBI:	106881918 106882568
SMM:	Smp_022700.2 Smp_022700.5 Smp_121880
OVI:	T265_07008 T265_14247
NVE:	NEMVE_v1g140243 NEMVE_v1g174728
ADF:	107346286 107348530
HMG:	100205849 101237619
TAD:	TRIADDRAFT_54534 TRIADDRAFT_64088
AQU:	100631401 100641930 105313298
ATH:	AT4G14440(HCD1) AT5G10480(PAS2) AT5G59770
ALY:	ARALYDRAFT_358193 ARALYDRAFT_909004 ARALYDRAFT_915421
CRB:	CARUB_v10003916mg CARUB_v10005626mg CARUB_v10027086mg
EUS:	EUTSA_v10014612mg EUTSA_v10014620mg EUTSA_v10026117mg EUTSA_v10027965mg
BRP:	103846802 103851552 103855870 103863519
BNA:	106365726 106372468 106384895 106385553 106386856 106390743 106405914 106430302 106441127
THJ:	104798725 104810801 104819292
CIT:	102610324 102621321
CIC:	CICLE_v10029246mg
TCC:	18590754 18611467
GRA:	105788887 105804148
GHI:	107913394 107950284 107963934
EGR:	104426317 104432769
GMX:	100527150 100527607 100818356
PVU:	PHAVU_002G147400g PHAVU_003G289100g PHAVU_011G067100g
VRA:	106755143 106755607 106776467 106779219
VAR:	108319827 108323452 108332862
CCAJ:	109798479 109801425 109818376
MTR:	MTR_4g060990 MTR_8g471160
CAM:	101495386 101495713 101507943
ADU:	107476878 107487258
AIP:	107629135 107633062 107642273
LJA:	Lj0g3v0016519.1(Lj0g3v0016519.1) Lj0g3v0339429.1(Lj0g3v0339429.1) Lj0g3v0339429.2(Lj0g3v0339429.2) Lj3g3v3155120.1(Lj3g3v3155120.1)
LANG:	109349147 109355362 109363351
FVE:	101300284 101304749
PPER:	18772196 18773179
PMUM:	103322718 103334912
MDM:	103413128 103421525 103422925 103427477 103429989 103448194
PXB:	103937488 103948952 103954176
ZJU:	107425132 107425142
CSV:	101212013 101214048
CMO:	103490580 103493277
RCU:	8277640 8286117
JCU:	105628210 105641681
POP:	POPTR_0001s24210g(POPTRDRAFT_706239) POPTR_0007s14290g(POPTRDRAFT_719769)
VVI:	100255240 100261741
SLY:	101245050 101246492 101262991
SPEN:	107002947 107004641 107018380
SOT:	102586361 102591777
INI:	109180148 109188898 109192762
SIND:	105169658 105170380 105176449
BVG:	104895506 104900172
NNU:	104594622 104595487 104611912
OSA:	107277374(P0009G03.7) 4324520(P0009G03.9) 4324521 4335343(HACD) 4339019
DOSA:	Os01t0150200-01(Os01g0150200) Os01t0150400-00(Os01g0150400) Os01t0150500-00(Os01g0150500) Os01t0150800-01(Os01g0150800) Os04t0271200-01(Os04g0271200) Os05t0460800-01(Os05g0460800)
OBR:	102714459 102717559 102717835
BDI:	100821089 100840117 100842646 106866263
ATS:	F775_09786 F775_22178 F775_30966 F775_33237
ZMA:	100274548 100284318(cl20712_1(629)) 100383128
SITA:	101782661 101782841 101783244
PDA:	103703452 103705939
EGU:	105044431 105045727
MUS:	103968992 103975400 103991715
ATR:	18434145 18442669
SMO:	SELMODRAFT_122503(PAS2-1) SELMODRAFT_125223(PAS2-2) SELMODRAFT_451040
PPP:	PHYPADRAFT_205799 PHYPADRAFT_218307
CRE:	CHLREDRAFT_95439
VCN:	VOLCADRAFT_61480 VOLCADRAFT_83422
OLU:	OSTLU_13214 OSTLU_29682 OSTLU_87349
OTA:	Ot05g03810
BPG:	Bathy03g04510 Bathy04g02110
MIS:	MICPUN_58684 MICPUN_59337
MPP:	MICPUCDRAFT_44656 MICPUCDRAFT_58952
CSL:	COCSUDRAFT_14404 COCSUDRAFT_83443
CVR:	CHLNCDRAFT_137564 CHLNCDRAFT_143333
APRO:	F751_6284
CME:	CYME_CMR006C
GSL:	Gasu_12280
CCP:	CHC_T00005797001 CHC_T00008580001
SCE:	YJL097W(PHS1)
AGO:	AGOS_AFR090W
ERC:	Ecym_6346
KLA:	KLLA0F14146g
LTH:	KLTH0D03410g
VPO:	Kpol_1016p17
ZRO:	ZYRO0G15334g
CGR:	CAGL0L03564g
NCS:	NCAS_0A09490(NCAS0A09490)
NDI:	NDAI_0G05450(NDAI0G05450)
TPF:	TPHA_0B01300(TPHA0B01300)
TBL:	TBLA_0C02950(TBLA0C02950)
TDL:	TDEL_0D01380(TDEL0D01380)
KAF:	KAFR_0A01400(KAFR0A01400)
PPA:	PAS_chr3_0222
DHA:	DEHA2C17424g DEHA2C17446g
PIC:	PICST_56836 PICST_57597
PGU:	PGUG_03908 PGUG_03909
SPAA:	SPAPADRAFT_63465
LEL:	LELG_05220 LELG_05221
CAL:	CAALFM_C703040WA(CaO19.5157) CAALFM_C703050WA(CaO19.5156)
CTP:	CTRG_05223 CTRG_05224
COT:	CORT_0G04450 CORT_0G04460
CDU:	CD36_72700 CD36_72710
CTEN:	CANTEDRAFT_113290 CANTEDRAFT_120092
YLI:	YALI0F11935g
CLU:	CLUG_00450
CAUR:	QG37_03808 QG37_03809
NCR:	NCU08985
NTE:	NEUTE1DRAFT82561(NEUTE1DRAFT_82561)
SMP:	SMAC_01940
PAN:	PODANSg5141
TTT:	THITE_2023698
MTM:	MYCTH_2304523
CTHR:	CTHT_0027140
MGR:	MGG_04972 MGG_07602
TMN:	UCRPA7_2257
FGR:	FGSG_07304 FGSG_12648
FPU:	FPSE_01073 FPSE_04001
FVR:	FVEG_03595 FVEG_05273
FOX:	FOXG_02109 FOXG_05748
NHE:	NECHADRAFT_38495 NECHADRAFT_82566
TRE:	TRIREDRAFT_105055
MAW:	MAC_00591
MAJ:	MAA_05922
CMT:	CCM_01449
VAL:	VDBG_02620 VDBG_04601
VDA:	VDAG_04151 VDAG_09815
CFJ:	CFIO01_04331 CFIO01_04885
ELA:	UCREL1_11623
SSL:	SS1G_03177
BFU:	BC1G_07525
MBE:	MBM_07029 MBM_07077
PSCO:	LY89DRAFT_681296
GLZ:	GLAREA_04533
ANI:	AN5000.2
AFM:	AFUA_4G10270
AOR:	AOR_1_2122154(AO090003001195) AOR_1_2168174(AO090005001257)
ANG:	ANI_1_1650144(An16g03550) ANI_1_1990184(An04g06650)
AFV:	AFLA_026280
ACT:	ACLA_049480
NFI:	NFIA_067410 NFIA_105790
PCS:	Pc22g12490
PDP:	PDIP_25110
CIM:	CIMG_09068
CPW:	CPC735_015040
PBL:	PAAG_08221
PBN:	PADG_01997
URE:	UREG_03318
AJE:	HCAG_01309
PNO:	SNOG_12970 SNOG_15979
PTE:	PTT_07276 PTT_15392
BZE:	COCCADRAFT_109010 COCCADRAFT_34753
BSC:	COCSADRAFT_159899 COCSADRAFT_91005
BOR:	COCMIDRAFT_34556 COCMIDRAFT_97448
ZTR:	MYCGRDRAFT_87635
PFJ:	MYCFIDRAFT_45204
BCOM:	BAUCODRAFT_32422
NPA:	UCRNP2_4724
TML:	GSTUM_00009842001
SPO:	SPBC19C2.15c
CNE:	CNE00730
CNB:	CNBE0670
CGI:	CGB_E0700C
TMS:	TREMEDRAFT_25191
PPL:	POSPLDRAFT_104986
TVS:	TRAVEDRAFT_56436
DSQ:	DICSQDRAFT_133109
PCO:	PHACADRAFT_258569
SHS:	STEHIDRAFT_141441
HIR:	HETIRDRAFT_476130
PSQ:	PUNSTDRAFT_42833
ADL:	AURDEDRAFT_111144
FME:	FOMMEDRAFT_107800
GTR:	GLOTRDRAFT_58018
MRR:	Moror_14683 Moror_6971
CCI:	CC1G_11544
SCM:	SCHCODRAFT_77419
ABP:	AGABI1DRAFT71504(AGABI1DRAFT_71504)
ABV:	AGABI2DRAFT192575(AGABI2DRAFT_192575)
CPUT:	CONPUDRAFT_101959
SLA:	SERLADRAFT_466079
WSE:	WALSEDRAFT_59139
UMA:	UMAG_00007
PFP:	PFL1_00095
MGL:	MGL_2260
MLR:	MELLADRAFT_38757
ECU:	ECU05_1430
EIN:	Eint_051490
EHE:	EHEL_051560
ERO:	EROM_051500
NCE:	NCER_101417
SRE:	PTSG_07138
DDI:	DDB_G0278113 DDB_G0278683
DPP:	DICPUDRAFT_151830 DICPUDRAFT_89327
DFA:	DFA_06437 DFA_07051
EHI:	EHI_110570(58.t00004)
EDI:	EDI_053980
EIV:	EIN_047440
ACAN:	ACA1_073320 ACA1_186090 ACA1_186210 ACA1_309340
PFA:	MAL13P1.168
PFD:	PFDG_02031
PFH:	PFHG_02827
PCB:	PCHAS_135110(PC301025.00.0)
PBE:	PB001246.00.0 PB301100.00.0
PKN:	PKH_122120
PVX:	PVX_082515
PCY:	PCYB_123100
BEQ:	BEWA_020340
BBO:	BBOV_III006410(17.m07571)
CPV:	cgd3_2150
CHO:	Chro.30252
TGO:	TGME49_311290
TET:	TTHERM_00538900
PTM:	GSPATT00009568001
AAF:	AURANDRAFT_29797
PIF:	PITG_14831
PSOJ:	PHYSODRAFT_433551
SPAR:	SPRG_10884
GTT:	GUITHDRAFT_105298
TBR:	Tb10.406.0290
TCR:	511635.40
LMA:	LMJF_05_0280
LIF:	LINJ_05_0280
LDO:	LDBPK_050280
LMI:	LMXM_05_0280
LBZ:	LBRM_05_0270
NGR:	NAEGRDRAFT_33547 NAEGRDRAFT_35609
GLA:	GL50803_7512
MAD:	HP15_2720
MARI:	ACP86_20830

» show all

Reference

1 [PMID:18799749]

Authors

Bach L, Michaelson LV, Haslam R, Bellec Y, Gissot L, Marion J, Da Costa M, Boutin JP, Miquel M, Tellier F, Domergue F, Markham JE, Beaudoin F, Napier JA, Faure JD

Title

The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development.

Journal

Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 14727-31.

Sequence

[ath:AT5G10480]

Reference

2 [PMID:18272525]

Authors

Kihara A, Sakuraba H, Ikeda M, Denpoh A, Igarashi Y

Title

Membrane topology and essential amino acid residues of Phs1, a 3-hydroxyacyl-CoA dehydratase involved in very long-chain fatty acid elongation.

Journal

J. Biol. Chem. 283 (2008) 11199-209.

Sequence

[sce:YJL097W]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.134

IUBMB Enzyme Nomenclature:

4.2.1.134

ExPASy - ENZYME nomenclature database:

4.2.1.134

BRENDA, the Enzyme Database:

4.2.1.134

All links

Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (4)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (1548)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (815)   
   KEGG MGENES (404)   
   RefGene (76)   
   EGENES (251)   
Protein sequence (2411)   
   UniProt (2347)   
   SWISS-PROT (24)   
   RefSeq(pep) (40)   
DNA sequence (47)   
   RefSeq(nuc) (42)   
   GenBank (4)   
   EMBL (1)   
Protein domain (1)   
   InterPro (1)   
All databases (4023)   

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REACTION: R10827

Entry

R10827 Reaction

Name

very-long-chain (3R)-3-hydroxyacyl-CoA hydro-lyase

Definition

Very-long-chain (3R)-3-hydroxyacyl-CoA <=> Very-long-chain trans-2,3-dehydroacyl-CoA + H2O

Equation

C20878 <=> C20879 + C00001

Comment

Elongation of C16/C18 acyl-CoAs to very-long-chain acyl CoAs.

Reaction class

RC00770

C20878_C20879

Enzyme

4.2.1.134

Pathway

rn00062	Fatty acid elongation
rn01110	Biosynthesis of secondary metabolites

Module

M00415

Fatty acid biosynthesis, elongation, endoplasmic reticulum

Orthology

K10703

very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [EC:4.2.1.134]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (809)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (808)   
All databases (820)   

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