KEGG   ORTHOLOGY: K10814Help
Entry
K10814                      KO                                     

Name
hcnA
Definition
hydrogen cyanide synthase HcnA [EC:1.4.99.5]
Pathway
Cyanoamino acid metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of other amino acids
   00460 Cyanoamino acid metabolism
    K10814  hcnA; hydrogen cyanide synthase HcnA
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.99  With unknown physiological acceptors
    1.4.99.5  glycine dehydrogenase (cyanide-forming)
     K10814  hcnA; hydrogen cyanide synthase HcnA
Bacterial toxins [BR:ko02042]
 Not specified
  Hydrogen cyanide production
   K10814  hcnA; hydrogen cyanide synthase HcnA
BRITE hierarchy
Other DBs
Genes
VCY: 
VCT: 
PAE: 
PA2193(hcnA)
PAEV: 
PAEI: 
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PDK: 
PADK2_14690
PSG: 
G655_14185
PRP: 
M062_11375
PAEP: 
PA1S_14765
PAER: 
PA1R_gp5664
PAEM: 
U769_14365
PAEL: 
T223_15995
PAES: 
SCV20265_3181
PAEU: 
BN889_02406(hcnA)
PAEG: 
AI22_19020
PAEC: 
M802_2263
PAEO: 
M801_2265
PMOS: 
O165_023010
PFL: 
PFL_2577(hcnA)
PPRC: 
PFLCHA0_c26420(hcnA)
PPRO: 
PPC_2622(hcnA)
PFO: 
Pfl01_3516(hcnA)
PFE: 
PSF113_2367(hcnA)
PMAN: 
OU5_6068
PCG: 
AXG94_04390
PEN: 
PSEEN5522(hcnA)
PBA: 
PSEBR_a3361
PBC: 
CD58_12305
PCH: 
EY04_11740
PCZ: 
PCL1606_36280
PCP: 
JM49_18115
PFZ: 
AV641_13595
PALK: 
PSAKL28_52500
PSW: 
LK03_05930
PPV: 
NJ69_19230
PSEM: 
TO66_12560
PSEC: 
CCOS191_5265(hcnA)
PPSY: 
AOC04_10135
PSOS: 
POS17_2580(hcnA)
PKR: 
AYO71_19315
PRR: 
AT705_00060
PLZ: 
S4054249_17870
PALN: 
B0W48_15825
CVI: 
CV_1684(hcnA)
CVC: 
BKX93_21650
 » show all
TaxonomyKoalaUniProt
Reference
PMID:233722
  Authors
Castric PA
  Title
Glycine metabolism by Pseudomonas aeruginosa: hydrogen cyanide biosynthesis.
  Journal
J Bacteriol 130:826-31 (1977)
  Sequence
[pae:PA2193]
Reference
PMID:9620970
  Authors
Laville J, Blumer C, Von Schroetter C, Gaia V, Defago G, Keel C, Haas D
  Title
Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0.
  Journal
J Bacteriol 180:3187-96 (1998)
  Sequence

KEGG   ORTHOLOGY: K10815Help
Entry
K10815                      KO                                     

Name
hcnB
Definition
hydrogen cyanide synthase HcnB [EC:1.4.99.5]
Pathway
Cyanoamino acid metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of other amino acids
   00460 Cyanoamino acid metabolism
    K10815  hcnB; hydrogen cyanide synthase HcnB
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.99  With unknown physiological acceptors
    1.4.99.5  glycine dehydrogenase (cyanide-forming)
     K10815  hcnB; hydrogen cyanide synthase HcnB
Bacterial toxins [BR:ko02042]
 Not specified
  Hydrogen cyanide production
   K10815  hcnB; hydrogen cyanide synthase HcnB
BRITE hierarchy
Other DBs
Genes
VCY: 
VCT: 
PAE: 
PA2194(hcnB)
PAEV: 
PAEI: 
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PDK: 
PADK2_14685
PSG: 
G655_14180
PRP: 
M062_11380
PAEP: 
PA1S_14760
PAER: 
PA1R_gp5665
PAEM: 
U769_14360
PAEL: 
T223_15990
PAES: 
SCV20265_3180
PAEU: 
BN889_02407(hcnB)
PAEG: 
AI22_19025
PAEC: 
M802_2264
PAEO: 
M801_2266
PMOS: 
O165_023005
PFL: 
PFL_2578(hcnB)
PPRC: 
PFLCHA0_c26430(ooxA)
PPRO: 
PPC_2623(hcnB)
PFO: 
Pfl01_3515(hcnB)
PFE: 
PSF113_2368(hcnB)
PMAN: 
OU5_6069
PCG: 
AXG94_04385
PEN: 
PSEEN5521(hcnB)
PBA: 
PSEBR_a3360
PBC: 
CD58_12310
PCH: 
EY04_11745
PCZ: 
PCL1606_36270
PCP: 
JM49_18110
PFZ: 
AV641_13590
PALK: 
PSAKL28_52490
PSW: 
LK03_05925
PPV: 
NJ69_19235
PSEM: 
TO66_12565
PSEC: 
CCOS191_5264(hcnB)
PPSY: 
AOC04_10130
PSOS: 
POS17_2581(hcnB)
PKR: 
AYO71_19310
PRR: 
AT705_00065
PLZ: 
S4054249_17865
PALN: 
B0W48_15830
CVI: 
CV_1683(hcnB)
CVC: 
BKX93_21645
 » show all
TaxonomyKoalaUniProt
Reference
PMID:233722
  Authors
Castric PA
  Title
Glycine metabolism by Pseudomonas aeruginosa: hydrogen cyanide biosynthesis.
  Journal
J Bacteriol 130:826-31 (1977)
  Sequence
[pae:PA2194]
Reference
PMID:9620970
  Authors
Laville J, Blumer C, Von Schroetter C, Gaia V, Defago G, Keel C, Haas D
  Title
Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0.
  Journal
J Bacteriol 180:3187-96 (1998)
  Sequence

KEGG   ORTHOLOGY: K10816Help
Entry
K10816                      KO                                     

Name
hcnC
Definition
hydrogen cyanide synthase HcnC [EC:1.4.99.5]
Pathway
Cyanoamino acid metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of other amino acids
   00460 Cyanoamino acid metabolism
    K10816  hcnC; hydrogen cyanide synthase HcnC
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.99  With unknown physiological acceptors
    1.4.99.5  glycine dehydrogenase (cyanide-forming)
     K10816  hcnC; hydrogen cyanide synthase HcnC
Bacterial toxins [BR:ko02042]
 Not specified
  Hydrogen cyanide production
   K10816  hcnC; hydrogen cyanide synthase HcnC
BRITE hierarchy
Other DBs
Genes
VCY: 
VCT: 
PAE: 
PA2195(hcnC)
PAEV: 
PAEI: 
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PDK: 
PADK2_14680
PSG: 
G655_14175
PRP: 
M062_11385
PAEP: 
PA1S_14755
PAER: 
PA1R_gp5666
PAEM: 
U769_14355
PAEL: 
T223_15985
PAES: 
SCV20265_3179
PAEU: 
BN889_02408(hcnC)
PAEG: 
AI22_19030
PAEC: 
M802_2265
PAEO: 
M801_2267
PMOS: 
O165_023000
PFL: 
PFL_2579(hcnC)
PPRC: 
PFLCHA0_c26440
PPRO: 
PPC_2624(hcnC)
PFO: 
Pfl01_3514(hcnC)
PFE: 
PSF113_2369(hcnC)
PMAN: 
OU5_6070
PCG: 
AXG94_04380
PEN: 
PSEEN5520(hcnC)
PBA: 
PSEBR_a3359
PBC: 
CD58_12315
PCH: 
EY04_11750
PCZ: 
PCL1606_36260
PCP: 
JM49_18105
PFZ: 
AV641_13585
PALK: 
PSAKL28_52480
PPV: 
NJ69_19240
PSEM: 
TO66_12570
PSEC: 
CCOS191_5263(hcnC)
PPSY: 
AOC04_10125
PSOS: 
POS17_2582(hcnC)
PKR: 
AYO71_19305
PRR: 
AT705_00070
PLZ: 
S4054249_17860
PALN: 
B0W48_15835
CVI: 
CV_1682(hcnC)
CVC: 
BKX93_21640
 » show all
TaxonomyKoalaUniProt
Reference
PMID:233722
  Authors
Castric PA
  Title
Glycine metabolism by Pseudomonas aeruginosa: hydrogen cyanide biosynthesis.
  Journal
J Bacteriol 130:826-31 (1977)
  Sequence
[pae:PA2195]
Reference
PMID:9620970
  Authors
Laville J, Blumer C, Von Schroetter C, Gaia V, Defago G, Keel C, Haas D
  Title
Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0.
  Journal
J Bacteriol 180:3187-96 (1998)
  Sequence

KEGG   ENZYME: 1.4.99.5Help
Entry
EC 1.4.99.5                 Enzyme                                 

Name
glycine dehydrogenase (cyanide-forming);
hydrogen cyanide synthase;
HCN synthase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)
Reaction(IUBMB)
glycine + 2 acceptor = hydrogen cyanide + CO2 + 2 reduced acceptor [RN:R05704]
Reaction(KEGG)
Substrate
glycine [CPD:C00037];
acceptor [CPD:C00028]
Product
hydrogen cyanide [CPD:C01326];
CO2 [CPD:C00011];
reduced acceptor [CPD:C00030]
Comment
The enzyme from Pseudomonas sp. contains FAD. The enzyme is membrane-bound, and the 2-electron acceptor is a component of the respiratory chain. The enzyme can act with various artificial electron acceptors, including phenazine methosulfate.
History
EC 1.4.99.5 created 2002
Pathway
Cyanoamino acid metabolism
Biosynthesis of secondary metabolites
Orthology
K10814  
hydrogen cyanide synthase HcnA
K10815  
hydrogen cyanide synthase HcnB
K10816  
hydrogen cyanide synthase HcnC
Genes
VCY: 
VCT: 
PAE: 
PA2193(hcnA) PA2194(hcnB) PA2195(hcnC)
PAEV: 
PAEI: 
PAU: 
PA14_36310(hcnC) PA14_36320(hcnB) PA14_36330(hcnA)
PAP: 
PSPA7_3101(hcnC) PSPA7_3102(hcnB) PSPA7_3103(hcnA)
PAG: 
PLES_31301(hcnC) PLES_31311(hcnB) PLES_31321(hcnA)
PAF: 
PAM18_2840(hcnC) PAM18_2841(hcnB) PAM18_2842(hcnA)
PNC: 
NCGM2_3175(hcnA) NCGM2_3176(hcnB) NCGM2_3177(hcnC)
PDK: 
PADK2_14680 PADK2_14685 PADK2_14690
PSG: 
G655_14175 G655_14180 G655_14185
PRP: 
M062_11375 M062_11380 M062_11385
PAEP: 
PA1S_14755 PA1S_14760 PA1S_14765
PAER: 
PA1R_gp5664 PA1R_gp5665 PA1R_gp5666
PAEM: 
U769_14355 U769_14360 U769_14365
PAEL: 
T223_15985 T223_15990 T223_15995
PAES: 
SCV20265_3179 SCV20265_3180 SCV20265_3181
PAEU: 
BN889_02406(hcnA) BN889_02407(hcnB) BN889_02408(hcnC)
PAEG: 
AI22_19020 AI22_19025 AI22_19030
PAEC: 
M802_2263 M802_2264 M802_2265
PAEO: 
M801_2265 M801_2266 M801_2267
PMOS: 
O165_023000 O165_023005 O165_023010
PFL: 
PFL_2577(hcnA) PFL_2578(hcnB) PFL_2579(hcnC)
PPRC: 
PFLCHA0_c26420(hcnA) PFLCHA0_c26430(ooxA) PFLCHA0_c26440
PPRO: 
PPC_2622(hcnA) PPC_2623(hcnB) PPC_2624(hcnC)
PFO: 
Pfl01_3514(hcnC) Pfl01_3515(hcnB) Pfl01_3516(hcnA)
PFE: 
PSF113_2367(hcnA) PSF113_2368(hcnB) PSF113_2369(hcnC)
PMAN: 
OU5_6068 OU5_6069 OU5_6070
PCG: 
AXG94_04380 AXG94_04385 AXG94_04390
PEN: 
PSEEN5520(hcnC) PSEEN5521(hcnB) PSEEN5522(hcnA)
PBA: 
PSEBR_a3359 PSEBR_a3360 PSEBR_a3361
PBC: 
CD58_12305 CD58_12310 CD58_12315
PCH: 
EY04_11740 EY04_11745 EY04_11750
PCZ: 
PCL1606_36260 PCL1606_36270 PCL1606_36280
PCP: 
JM49_18105 JM49_18110 JM49_18115
PFZ: 
AV641_13585 AV641_13590 AV641_13595
PALK: 
PSAKL28_52480 PSAKL28_52490 PSAKL28_52500
PSW: 
LK03_05925 LK03_05930
PPV: 
NJ69_19230 NJ69_19235 NJ69_19240
PSEM: 
TO66_12560 TO66_12565 TO66_12570
PSEC: 
CCOS191_5263(hcnC) CCOS191_5264(hcnB) CCOS191_5265(hcnA)
PPSY: 
AOC04_10125 AOC04_10130 AOC04_10135
PSOS: 
POS17_2580(hcnA) POS17_2581(hcnB) POS17_2582(hcnC)
PKR: 
AYO71_19305 AYO71_19310 AYO71_19315
PRR: 
AT705_00060 AT705_00065 AT705_00070
PLZ: 
S4054249_17860 S4054249_17865 S4054249_17870
PALN: 
B0W48_15825 B0W48_15830 B0W48_15835
CVI: 
CV_1682(hcnC) CV_1683(hcnB) CV_1684(hcnA)
CVC: 
BKX93_21640 BKX93_21645 BKX93_21650
 » show all
Taxonomy
Reference
1  [PMID:234422]
  Authors
Wissing F.
  Title
Cyanide production from glycine by a homogenate from a Pseudomonas species.
  Journal
J. Bacteriol. 121 (1975) 695-9.
Reference
2  [PMID:233722]
  Authors
Castric PA.
  Title
Glycine metabolism by Pseudomonas aeruginosa: hydrogen cyanide biosynthesis.
  Journal
J. Bacteriol. 130 (1977) 826-31.
  Sequence
Reference
3  [PMID:9620970]
  Authors
Laville J, Blumer C, Von Schroetter C, Gaia V, Defago G, Keel C, Haas D.
  Title
Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0.
  Journal
J. Bacteriol. 180 (1998) 3187-96.
  Sequence
Reference
4  [PMID:10763748]
  Authors
Blumer C, Haas D.
  Title
Mechanism, regulation, and ecological role of bacterial cyanide biosynthesis.
  Journal
Arch. Microbiol. 173 (2000) 170-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
KEGG   REACTION: R05704Help
Entry
R05704                      Reaction                               

Name
glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)
Definition
Glycine + 2 Acceptor <=> Hydrogen cyanide + CO2 + 2 Reduced acceptor
Equation
Reaction class
C00037_C01326
Enzyme
Pathway
Cyanoamino acid metabolism
Biosynthesis of secondary metabolites
Orthology
K10814  
hydrogen cyanide synthase HcnA [EC:1.4.99.5]
K10815  
hydrogen cyanide synthase HcnB [EC:1.4.99.5]
K10816  
hydrogen cyanide synthase HcnC [EC:1.4.99.5]
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