KEGG   ORTHOLOGY: K11336Help
Entry
K11336                      KO                                     

Name
bchF
Definition
3-vinyl bacteriochlorophyllide hydratase [EC:4.2.1.165]
Pathway
Porphyrin and chlorophyll metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of cofactors and vitamins
   00860 Porphyrin and chlorophyll metabolism
    K11336  bchF; 3-vinyl bacteriochlorophyllide hydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.165  chlorophyllide a 31-hydratase
     K11336  bchF; 3-vinyl bacteriochlorophyllide hydratase
BRITE hierarchy
Other DBs
Genes
ALV: 
TVI: 
TMB: 
MPUR: 
HHA: 
HHC: 
EBS: 
PDQ: 
RAC: 
LIM: 
LIH: 
L63ED372_00659
HYR: 
BSY239_1283(bchF)
RGE: 
RGE_33450(bchF)
RBN: 
RBXJA2T_09567
RDP: 
RD2015_1015
METR: 
BSY238_2468(bchF)
BEB: 
AEM42_07585
AGC: 
BSY240_3645(bchF)
BRA: 
BRADO1638(bchF)
BBT: 
BBta_6418(bchF)
BRS: 
S23_19370(bchF)
AOL: 
S58_59000
RPA: 
RPA1541(bchF)
RPB: 
RPB_3982
RPC: 
RPC_1312
RPD: 
RPD_3737
RPE: 
RPE_1346
RPT: 
Rpal_1729
RPX: 
Rpdx1_3979
BOS: 
BSY19_4034(bchF)
MEX: 
Mext_4817
MEA: 
Mex_1p5274(bchF)
MDI: 
METDI5874(bchF)
MCH: 
Mchl_5284
MRD: 
Mrad2831_1849
MET: 
M446_3717
MPO: 
Mpop_5362
MOR: 
MOC_2253(bchF)
META: 
Y590_24615
MAQU: 
Maq22A_c01675
MSL: 
Msil_2043
RVA: 
Rvan_0999
BVR: 
BVIR_569
BSB: 
Bresu_3063
BRL: 
BZG35_15535
RSP: 
RSP_0284(bchF)
RSH: 
Rsph17029_1927
RSQ: 
Rsph17025_1011
RSK: 
RSKD131_1610
RCP: 
RCAP_rcc00666(bchF)
JAN: 
Jann_0162(bchF)
RDE: 
RD1_0140(bchF)
RLI: 
RLO149_p940700(bchF)
DSH: 
Dshi_3533(bchF)
RED: 
roselon_01095
PTP: 
RCA23_c29930(bchF)
RSU: 
NHU_00210(bchF)
RHM: 
B5V46_02450
RHC: 
RGUI_1987
SUAM: 
BOO69_19195
TOM: 
BWR18_20070
RMM: 
ROSMUCSMR3_00880
LVS: 
LOKVESSMR4R_03603
HBC: 
AEM38_14370
SPHI: 
TS85_23010
SSAN: 
NX02_18330
CIJ: 
WG74_05110
BLAS: 
BSY18_2709(bchF)
ELQ: 
Ga0102493_111824
PNS: 
A9D12_01355
PORL: 
BG023_112684
AMV: 
ACMV_18950(bchF)
RRU: 
Rru_A0624
RRF: 
F11_03200
RCE: 
RC1_2116(bchF)
RPM: 
RSPPHO_00022(bchF)
RRS: 
RoseRS_3262
RCA: 
Rcas_3748
CAU: 
Caur_0415
CAG: 
Cagg_3129
CHL: 
Chy400_0442
CTM: 
Cabther_B0080
GPH: 
GEMMAAP_06390
CTE: 
CT1421(bchF)
CPC: 
Cpar_0743
CLZ: 
BIU88_03610
CCH: 
Cag_0402
CPH: 
Cpha266_1790
CPB: 
Cphamn1_0939
CLI: 
Clim_0899
PVI: 
Cvib_1239
PLT: 
Plut_1421
PPH: 
Ppha_0981
PAA: 
Paes_1533
PROC: 
Ptc2401_00669
PRS: 
B9H02_04020
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kim EJ, Kim JS, Lee IH, Rhee HJ, Lee JK
  Title
Superoxide generation by chlorophyllide a reductase of Rhodobacter sphaeroides.
  Journal
J Biol Chem 283:3718-30 (2008)
DOI:10.1074/jbc.M707774200
Reference
PMID:8385667
  Authors
Burke DH, Alberti M, Hearst JE
  Title
bchFNBH bacteriochlorophyll synthesis genes of Rhodobacter capsulatus and identification of the third subunit of light-independent protochlorophyllide reductase in bacteria and plants.
  Journal
J Bacteriol 175:2414-22 (1993)
DOI:10.1128/JB.175.8.2414-2422.1993
  Sequence

KEGG   ENZYME: 4.2.1.165Help
Entry
EC 4.2.1.165                Enzyme                                 

Name
chlorophyllide a 31-hydratase;
bchF (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
chlorophyllide-a 31-hydro-lyase
Reaction(IUBMB)
(1) 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a = chlorophyllide a + H2O [RN:R09059];
(2) 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a = 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O [RN:R09054]
Reaction(KEGG)
Substrate
3-devinyl-3-(1-hydroxyethyl)chlorophyllide a [CPD:C18154];
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a [CPD:C18153]
Product
chlorophyllide a [CPD:C02139];
H2O [CPD:C00001];
3-deacetyl-3-vinylbacteriochlorophyllide a [CPD:C18152]
Comment
The enzyme, together with EC 1.3.7.15, chlorophyllide-a reductase, and EC 1.1.1.396, bacteriochlorophyllide-a dehydrogenase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. The enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. The enzyme catalyses the hydration of a vinyl group on ring A, converting it to a hydroxyethyl group.
History
EC 4.2.1.165 created 2016
Pathway
Porphyrin and chlorophyll metabolism
Biosynthesis of secondary metabolites
Orthology
K11336  
3-vinyl bacteriochlorophyllide hydratase
Genes
ALV: 
TVI: 
TMB: 
MPUR: 
HHA: 
HHC: 
EBS: 
PDQ: 
RAC: 
LIM: 
LIH: 
L63ED372_00659
HYR: 
BSY239_1283(bchF)
RGE: 
RGE_33450(bchF)
RBN: 
RBXJA2T_09567
RDP: 
RD2015_1015
METR: 
BSY238_2468(bchF)
BEB: 
AEM42_07585
AGC: 
BSY240_3645(bchF)
BRA: 
BRADO1638(bchF)
BBT: 
BBta_6418(bchF)
BRS: 
S23_19370(bchF)
AOL: 
S58_59000
RPA: 
RPA1541(bchF)
RPB: 
RPB_3982
RPC: 
RPC_1312
RPD: 
RPD_3737
RPE: 
RPE_1346
RPT: 
Rpal_1729
RPX: 
Rpdx1_3979
BOS: 
BSY19_4034(bchF)
MEX: 
Mext_4817
MEA: 
Mex_1p5274(bchF)
MDI: 
METDI5874(bchF)
MCH: 
Mchl_5284
MRD: 
Mrad2831_1849
MET: 
M446_3717
MPO: 
Mpop_5362
MOR: 
MOC_2253(bchF)
META: 
Y590_24615
MAQU: 
Maq22A_c01675
MSL: 
Msil_2043
RVA: 
Rvan_0999
BVR: 
BVIR_569
BSB: 
Bresu_3063
BRL: 
BZG35_15535
RSP: 
RSP_0284(bchF)
RSH: 
Rsph17029_1927
RSQ: 
Rsph17025_1011
RSK: 
RSKD131_1610
RCP: 
RCAP_rcc00666(bchF)
JAN: 
Jann_0162(bchF)
RDE: 
RD1_0140(bchF)
RLI: 
RLO149_p940700(bchF)
DSH: 
Dshi_3533(bchF)
RED: 
roselon_01095
PTP: 
RCA23_c29930(bchF)
RSU: 
NHU_00210(bchF)
RHM: 
B5V46_02450
RHC: 
RGUI_1987
SUAM: 
BOO69_19195
TOM: 
BWR18_20070
RMM: 
ROSMUCSMR3_00880
LVS: 
LOKVESSMR4R_03603
HBC: 
AEM38_14370
SPHI: 
TS85_23010
SSAN: 
NX02_18330
CIJ: 
WG74_05110
BLAS: 
BSY18_2709(bchF)
ELQ: 
Ga0102493_111824
PNS: 
A9D12_01355
PORL: 
BG023_112684
AMV: 
ACMV_18950(bchF)
RRU: 
Rru_A0624
RRF: 
F11_03200
RCE: 
RC1_2116(bchF)
RPM: 
RSPPHO_00022(bchF)
RRS: 
RoseRS_3262
RCA: 
Rcas_3748
CAU: 
Caur_0415
CAG: 
Cagg_3129
CHL: 
Chy400_0442
CTM: 
Cabther_B0080
GPH: 
GEMMAAP_06390
CTE: 
CT1421(bchF)
CPC: 
Cpar_0743
CLZ: 
BIU88_03610
CCH: 
Cag_0402
CPH: 
Cpha266_1790
CPB: 
Cphamn1_0939
CLI: 
Clim_0899
PVI: 
Cvib_1239
PLT: 
Plut_1421
PPH: 
Ppha_0981
PAA: 
Paes_1533
PROC: 
Ptc2401_00669
PRS: 
B9H02_04020
 » show all
Taxonomy
Reference
1  [PMID:1080053]
  Authors
Pudek MR, Richards WR
  Title
A possible alternate pathway of bacteriochlorophyll biosynthesis in a mutant of Rhodopseudomonas sphaeroides.
  Journal
Biochemistry. 14 (1975) 3132-7.
Reference
2  [PMID:8385667]
  Authors
Burke DH, Alberti M, Hearst JE
  Title
bchFNBH bacteriochlorophyll synthesis genes of Rhodobacter capsulatus and identification of the third subunit of light-independent protochlorophyllide reductase in bacteria and plants.
  Journal
J. Bacteriol. 175 (1993) 2414-22.
  Sequence
Reference
3  [PMID:26088139]
  Authors
Lange C, Kiesel S, Peters S, Virus S, Scheer H, Jahn D, Moser J
  Title
Broadened Substrate Specificity of 3-Hydroxyethyl Bacteriochlorophyllide a Dehydrogenase (BchC) Indicates a New Route for the Biosynthesis of Bacteriochlorophyll a.
  Journal
J. Biol. Chem. 290 (2015) 19697-709.
  Sequence
[cte:CT1421]
Reference
4  [PMID:26331578]
  Authors
Harada J, Teramura M, Mizoguchi T, Tsukatani Y, Yamamoto K, Tamiaki H
  Title
Stereochemical conversion of C3-vinyl group to 1-hydroxyethyl group in bacteriochlorophyll c by the hydratases BchF and BchV: adaptation of green sulfur bacteria to limited-light environments.
  Journal
Mol. Microbiol. 98 (2015) 1184-98.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
KEGG   REACTION: R09059Help
Entry
R09059                      Reaction                               

Name
3-hydroxyethylchlorophyllide-a hydro-lyase (chlorophyllide-a-forming)
Definition
Chlorophyllide + H2O <=> 3-Hydroxyethylchlorophyllide a
Equation
Reaction class
C02139_C18154
Enzyme
Pathway
Porphyrin and chlorophyll metabolism
Biosynthesis of secondary metabolites
Orthology
K11336  
3-vinyl bacteriochlorophyllide hydratase [EC:4.2.1.165]
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