KEGG   ORTHOLOGY: K11337Help
Entry
K11337                      KO                                     

Name
bchC
Definition
bacteriochlorophyllide a dehydrogenase [EC:1.1.1.396]
Pathway
Porphyrin and chlorophyll metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of cofactors and vitamins
   00860 Porphyrin and chlorophyll metabolism
    K11337  bchC; bacteriochlorophyllide a dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.396  bacteriochlorophyllide a dehydrogenase
     K11337  bchC; bacteriochlorophyllide a dehydrogenase
BRITE hierarchy
Other DBs
RN: 
Genes
ALV: 
TVI: 
TMB: 
MPUR: 
HHA: 
HHC: 
EBS: 
PDQ: 
RAC: 
LIM: 
LIH: 
L63ED372_00627(yjjN)
HYR: 
BSY239_1382(bchC)
RGE: 
RGE_33710(bchC)
RBN: 
RBXJA2T_09437
RDP: 
RD2015_1036
METR: 
BSY238_2447(bchC)
BEB: 
AEM42_07470
AGC: 
BSY240_3669(bchC)
BRA: 
BRADO1617(bchC)
BBT: 
BBta_6438(bchC)
BRS: 
S23_19170(bchC)
AOL: 
S58_59190
RPA: 
RPA1521(bchC)
RPB: 
RPB_4002
RPC: 
RPC_1292
RPD: 
RPD_3757
RPE: 
RPE_1326
RPT: 
Rpal_1709
RPX: 
Rpdx1_3999
BOS: 
BSY19_4056(bchC)
MEX: 
Mext_2729
MEA: 
Mex_1p2926(bchC)
MDI: 
METDI3495(bchC)
MCH: 
Mchl_2956
MRD: 
Mrad2831_2819
MET: 
M446_3696
MPO: 
Mpop_2851
MOR: 
MOC_3184(bchC)
META: 
Y590_13135
MAQU: 
Maq22A_1p32540
MSL: 
Msil_2051
RVA: 
Rvan_0209
BVR: 
BVIR_598
BSB: 
Bresu_3046
BRL: 
BZG35_15460
RSP: 
RSP_0263(bchC)
RSH: 
Rsph17029_1907
RSQ: 
Rsph17025_2037
RSK: 
RSKD131_1590
RCP: 
RCAP_rcc00686(bchC)
JAN: 
Jann_0180(bchC)
RDE: 
RD1_0112(bchC)
RLI: 
RLO149_p940150(bchC)
DSH: 
Dshi_3516(bchC)
RED: 
roselon_01077
PTP: 
RCA23_c29610(bchC)
RSU: 
NHU_04286(bchC)
RHM: 
B5V46_17490
RHC: 
RGUI_1962
SUAM: 
BOO69_19415
TOM: 
BWR18_20235
RMM: 
ROSMUCSMR3_00906
LVS: 
LOKVESSMR4R_03678(lgoD)
HBC: 
AEM38_14590
SPHI: 
TS85_22900
SSAN: 
NX02_18455
CIJ: 
WG74_05040
BLAS: 
BSY18_3554(bchC)
ELQ: 
Ga0102493_111839
PNS: 
A9D12_01285
PORL: 
BG023_112669
AMV: 
ACMV_18800(bchC)
RRU: 
Rru_A2981
RRF: 
F11_15270
RCE: 
RC1_2093(bchC)
RPM: 
RSPPHO_01501(bchC)
RRS: 
RoseRS_3261
RCA: 
Rcas_3747
CAU: 
Caur_0416
CAG: 
Cagg_3128
CHL: 
Chy400_0443
OBT: 
OPIT5_20325
CTM: 
Cabther_A1526
GPH: 
GEMMAAP_06525
CTE: 
CT1422(bchC)
CPC: 
Cpar_0742
CLZ: 
BIU88_03605
CCH: 
Cag_0401
CPH: 
Cpha266_1791
CPB: 
Cphamn1_0938
CLI: 
Clim_0898
PVI: 
Cvib_1240
PLT: 
Plut_1422
PPH: 
Ppha_0980
PAA: 
Paes_1534
PROC: 
Ptc2401_00668(yjjN)
PRS: 
B9H02_04015
CTS: 
Ctha_2719
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kim EJ, Kim JS, Lee IH, Rhee HJ, Lee JK
  Title
Superoxide generation by chlorophyllide a reductase of Rhodobacter sphaeroides.
  Journal
J Biol Chem 283:3718-30 (2008)
DOI:10.1074/jbc.M707774200
Reference
PMID:8437569
  Authors
McGlynn P, Hunter CN
  Title
Genetic analysis of the bchC and bchA genes of Rhodobacter sphaeroides.
  Journal
Mol Gen Genet 236:227-34 (1993)
DOI:10.1007/BF00277117
  Sequence

KEGG   ENZYME: 1.1.1.396Help
Entry
EC 1.1.1.396                Enzyme                                 

Name
bacteriochlorophyllide a dehydrogenase;
bchC (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide-a:NAD+ oxidoreductase (bacteriochlorophyllide a-forming)
Reaction(IUBMB)
(1) 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD+ = bacteriochlorophyllide a + NADH + H+ [RN:R09055];
(2) 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD+ = 3-acetyl-3-devinylchlorophyllide a + NADH + H+
Reaction(KEGG)
Substrate
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a [CPD:C18153];
NAD+ [CPD:C00003];
3-devinyl-3-(1-hydroxyethyl)chlorophyllide a [CPD:C18154]
Product
bacteriochlorophyllide a [CPD:C18155];
NADH [CPD:C00004];
H+ [CPD:C00080];
3-acetyl-3-devinylchlorophyllide a
Comment
The enzyme, together with EC 1.3.7.15, chlorophyllide-a reductase, and EC 4.2.1.165, chlorophyllide-a 31-hydratase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. The enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. The enzyme oxidizes a hydroxyl group on ring A, converting it to an oxo group.
History
EC 1.1.1.396 created 2016
Pathway
Porphyrin and chlorophyll metabolism
Biosynthesis of secondary metabolites
Orthology
K11337  
bacteriochlorophyllide a dehydrogenase
Genes
ALV: 
TVI: 
TMB: 
MPUR: 
HHA: 
HHC: 
EBS: 
PDQ: 
RAC: 
LIM: 
LIH: 
L63ED372_00627(yjjN)
HYR: 
BSY239_1382(bchC)
RGE: 
RGE_33710(bchC)
RBN: 
RBXJA2T_09437
RDP: 
RD2015_1036
METR: 
BSY238_2447(bchC)
BEB: 
AEM42_07470
AGC: 
BSY240_3669(bchC)
BRA: 
BRADO1617(bchC)
BBT: 
BBta_6438(bchC)
BRS: 
S23_19170(bchC)
AOL: 
S58_59190
RPA: 
RPA1521(bchC)
RPB: 
RPB_4002
RPC: 
RPC_1292
RPD: 
RPD_3757
RPE: 
RPE_1326
RPT: 
Rpal_1709
RPX: 
Rpdx1_3999
BOS: 
BSY19_4056(bchC)
MEX: 
Mext_2729
MEA: 
Mex_1p2926(bchC)
MDI: 
METDI3495(bchC)
MCH: 
Mchl_2956
MRD: 
Mrad2831_2819
MET: 
M446_3696
MPO: 
Mpop_2851
MOR: 
MOC_3184(bchC)
META: 
Y590_13135
MAQU: 
Maq22A_1p32540
MSL: 
Msil_2051
RVA: 
Rvan_0209
BVR: 
BVIR_598
BSB: 
Bresu_3046
BRL: 
BZG35_15460
RSP: 
RSP_0263(bchC)
RSH: 
Rsph17029_1907
RSQ: 
Rsph17025_2037
RSK: 
RSKD131_1590
RCP: 
RCAP_rcc00686(bchC)
JAN: 
Jann_0180(bchC)
RDE: 
RD1_0112(bchC)
RLI: 
RLO149_p940150(bchC)
DSH: 
Dshi_3516(bchC)
RED: 
roselon_01077
PTP: 
RCA23_c29610(bchC)
RSU: 
NHU_04286(bchC)
RHM: 
B5V46_17490
RHC: 
RGUI_1962
SUAM: 
BOO69_19415
TOM: 
BWR18_20235
RMM: 
ROSMUCSMR3_00906
LVS: 
LOKVESSMR4R_03678(lgoD)
HBC: 
AEM38_14590
SPHI: 
TS85_22900
SSAN: 
NX02_18455
CIJ: 
WG74_05040
BLAS: 
BSY18_3554(bchC)
ELQ: 
Ga0102493_111839
PNS: 
A9D12_01285
PORL: 
BG023_112669
AMV: 
ACMV_18800(bchC)
RRU: 
Rru_A2981
RRF: 
F11_15270
RCE: 
RC1_2093(bchC)
RPM: 
RSPPHO_01501(bchC)
RRS: 
RoseRS_3261
RCA: 
Rcas_3747
CAU: 
Caur_0416
CAG: 
Cagg_3128
CHL: 
Chy400_0443
OBT: 
OPIT5_20325
CTM: 
Cabther_A1526
GPH: 
GEMMAAP_06525
CTE: 
CT1422(bchC)
CPC: 
Cpar_0742
CLZ: 
BIU88_03605
CCH: 
Cag_0401
CPH: 
Cpha266_1791
CPB: 
Cphamn1_0938
CLI: 
Clim_0898
PVI: 
Cvib_1240
PLT: 
Plut_1422
PPH: 
Ppha_0980
PAA: 
Paes_1534
PROC: 
Ptc2401_00668(yjjN)
PRS: 
B9H02_04015
CTS: 
Ctha_2719
 » show all
Taxonomy
Reference
1  [PMID:2555268]
  Authors
Wellington CL, Beatty JT
  Title
Promoter mapping and nucleotide sequence of the bchC bacteriochlorophyll biosynthesis gene from Rhodobacter capsulatus.
  Journal
Gene. 83 (1989) 251-61.
  Sequence
Reference
2  [PMID:8437569]
  Authors
McGlynn P, Hunter CN
  Title
Genetic analysis of the bchC and bchA genes of Rhodobacter sphaeroides.
  Journal
Mol. Gen. Genet. 236 (1993) 227-34.
  Sequence
[rsp:RSP_0263]
Reference
3  [PMID:26088139]
  Authors
Lange C, Kiesel S, Peters S, Virus S, Scheer H, Jahn D, Moser J
  Title
Broadened Substrate Specificity of 3-Hydroxyethyl Bacteriochlorophyllide a Dehydrogenase (BchC) Indicates a New Route for the Biosynthesis of Bacteriochlorophyll a.
  Journal
J. Biol. Chem. 290 (2015) 19697-709.
  Sequence
[cte:CT1422]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
KEGG   REACTION: R09055Help
Entry
R09055                      Reaction                               

Name
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide-a:NAD+ oxidoreductase (bacteriochlorophyllide a-forming)
Definition
3-Hydroxyethylbacteriochlorophyllide a + NAD+ <=> Bacteriochlorophyllide a + NADH + H+
Equation
Reaction class
C18153_C18155
Enzyme
Pathway
Porphyrin and chlorophyll metabolism
Biosynthesis of secondary metabolites
Orthology
K11337  
bacteriochlorophyllide a dehydrogenase [EC:1.1.1.396]
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