KEGG   ORTHOLOGY: K12467Help
Entry
K12467                      KO                                     

Name
E4.2.3.15
Definition
myrcene/ocimene synthase [EC:4.2.3.15]
Pathway
Monoterpenoid biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K12467  E4.2.3.15; myrcene/ocimene synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.15  myrcene synthase
     K12467  E4.2.3.15; myrcene/ocimene synthase
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
ATH: 
ALY: 
CRB: 
BRP: 
BNA: 
TaxonomyKoalaUniProt
Reference
  Authors
Chen F, Tholl D, D'Auria JC, Farooq A, Pichersky E, Gershenzon J
  Title
Biosynthesis and emission of terpenoid volatiles from Arabidopsis flowers.
  Journal
Plant Cell 15:481-94 (2003)
DOI:10.1105/tpc.007989
KEGG   ENZYME: 4.2.3.15Help
Entry
EC 4.2.3.15                 Enzyme                                 

Name
myrcene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphate-lyase (myrcene-forming)
Reaction(IUBMB)
geranyl diphosphate = myrcene + diphosphate [RN:R02009]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341]
Product
myrcene [CPD:C06074];
diphosphate [CPD:C00013]
Comment
A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor.
History
EC 4.2.3.15 created 2000 as EC 4.1.99.9, transferred 2000 to EC 4.2.3.15
Pathway
Monoterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K12467  
myrcene/ocimene synthase
K21925  
(-)-camphene/tricyclene/(4S)-limonene/myrcene synthase
Genes
ATH: 
ALY: 
CRB: 
BRP: 
BNA: 
SLY: 
101245212(TPS3)
SPEN: 
SOT: 
Taxonomy
Reference
1  [PMID:9268308]
  Authors
Bohlmann J, Steele CL, Croteau R.
  Title
Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase.
  Journal
J. Biol. Chem. 272 (1997) 21784-92.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
197462-59-2
KEGG   REACTION: R02009Help
Entry
R02009                      Reaction                               

Name
geranyldiphosphate diphosphate-lyase (myrcene-forming)
Definition
Geranyl diphosphate <=> Myrcene + Diphosphate
Equation
Comment
myrcene synthase
Reaction class
C00341_C06074
Enzyme
Pathway
Monoterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K12467  
myrcene/ocimene synthase [EC:4.2.3.15]
K21925  
(-)-camphene/tricyclene/(4S)-limonene/myrcene synthase [EC:4.2.3.117 4.2.3.105 4.2.3.16 4.2.3.15]
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