| Entry |
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| Name |
taxadien-5alpha-ol O-acetyltransferase;
acetyl coenzyme A:taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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| Sysname |
acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase
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| Reaction(IUBMB) |
acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate [RN: R06307]
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| Reaction(KEGG) |
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| Substrate |
acetyl-CoA [CPD: C00024];
taxa-4(20),11-dien-5alpha-ol [CPD: C11895]
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| Product |
CoA [CPD: C00010];
taxa-4(20),11-dien-5alpha-yl acetate
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| Comment |
This is the third enzyme in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel), which is widely used in the treatment of carcinomas, sarcomas and melanomas.
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| History |
EC 2.3.1.162 created 2002
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| Pathway |
| Diterpenoid biosynthesis | | Biosynthesis of secondary metabolites |
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| Orthology |
| taxadien-5-alpha-ol O-acetyltransferase |
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| Reference |
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| Authors |
Walker K, Ketchum RE, Hezari M, Gatfield D, Goleniowski M, Barthol A, Croteau R. |
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| Title |
Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis. |
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| Journal |
Arch. Biochem. Biophys. 364 (1999) 273-9. |
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| Reference |
|
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| Authors |
Walker K, Schoendorf A, Croteau R. |
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| Title |
Molecular cloning of a taxa-4(20),11(12)-dien-5alpha-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. |
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| Journal |
Arch. Biochem. Biophys. 374 (2000) 371-80. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 229032-29-5 |
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