KEGG   ORTHOLOGY: K13034Help
Entry
K13034                      KO                                     

Name
ATCYSC1
Definition
L-3-cyanoalanine synthase/ cysteine synthase [EC:2.5.1.47 4.4.1.9]
Pathway
Cysteine and methionine metabolism
Cyanoamino acid metabolism
Sulfur metabolism
Carbon metabolism
Biosynthesis of amino acids
Module
M00021  
Cysteine biosynthesis, serine => cysteine
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K13034  ATCYSC1; L-3-cyanoalanine synthase/ cysteine synthase
   01230 Biosynthesis of amino acids
    K13034  ATCYSC1; L-3-cyanoalanine synthase/ cysteine synthase
  Energy metabolism
   00920 Sulfur metabolism
    K13034  ATCYSC1; L-3-cyanoalanine synthase/ cysteine synthase
  Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K13034  ATCYSC1; L-3-cyanoalanine synthase/ cysteine synthase
  Metabolism of other amino acids
   00460 Cyanoamino acid metabolism
    K13034  ATCYSC1; L-3-cyanoalanine synthase/ cysteine synthase
KEGG modules [BR:ko00002]
 Pathway module
  Nucleotide and amino acid metabolism
   Cysteine and methionine metabolism
    M00021  Cysteine biosynthesis, serine => cysteine
     K13034  ATCYSC1; L-3-cyanoalanine synthase/ cysteine synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.47  cysteine synthase
     K13034  ATCYSC1; L-3-cyanoalanine synthase/ cysteine synthase
 4. Lyases
  4.4  Carbon-sulfur lyases
   4.4.1  Carbon-sulfur lyases (only sub-subclass identified to date)
    4.4.1.9  L-3-cyanoalanine synthase
     K13034  ATCYSC1; L-3-cyanoalanine synthase/ cysteine synthase
BRITE hierarchy
Other DBs
Genes
RSS: 
ATH: 
AT3G61440(CYSC1)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
18614120
GRA: 
105802709 105802711
GHI: 
107911578 107911579 107924412 107924413
EGR: 
104443429
GMX: 
100101899(OAS-TL3) 100806420
PVU: 
PHAVU_008G061100g
VRA: 
106759445
VAR: 
108329722
CCAJ: 
109802499
MTR: 
MTR_7g078070
CAM: 
101512608
ADU: 
107472470 107485772
AIP: 
107621508 107635094
LJA: 
Lj1g3v2682510.1(Lj1g3v2682510.1)
LANG: 
109338383 109339915
FVE: 
101292050
PPER: 
18786519
PMUM: 
103342779
MDM: 
103401891(CAS1) 103405317(CAS2) 103406176
PXB: 
103940809 103957376
ZJU: 
107404050
CSV: 
101220896
CMO: 
103497706
RCU: 
8261899 8278514
JCU: 
105642966
POP: 
POPTR_0002s16220g(POPTRDRAFT_552184) POPTR_0014s08210g(POPTRDRAFT_244580)
VVI: 
100255091
SLY: 
101253940 101255033
SPEN: 
107008051 107032363
SOT: 
102601315(PCAS-2) 102604154(PCAS-1)
INI: 
109171635 109184868
SIND: 
105172766
BVG: 
104887240
NNU: 
104610634
OSA: 
4335048
DOSA: 
Os04t0165700-01(Os04g0165700)
OBR: 
102715851
BDI: 
100835065
ATS: 
F775_29238
SBI: 
8066013
ZMA: 
100216722
SITA: 
101779131
PDA: 
103715474
EGU: 
105043037
MUS: 
103985756
ATR: 
18422839
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hatzfeld Y, Maruyama A, Schmidt A, Noji M, Ishizawa K, Saito K
  Title
beta-Cyanoalanine synthase is a mitochondrial cysteine synthase-like protein in spinach and Arabidopsis.
  Journal
Plant Physiol 123:1163-71 (2000)
DOI:10.1104/pp.123.3.1163
KEGG   ENZYME: 4.4.1.9Help
Entry
EC 4.4.1.9                  Enzyme                                 

Name
L-3-cyanoalanine synthase;
beta-cyanoalanine synthase;
beta-cyanoalanine synthetase;
beta-cyano-L-alanine synthase;
L-cysteine hydrogen-sulfide-lyase (adding HCN)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)
Reaction(IUBMB)
L-cysteine + hydrogen cyanide = L-3-cyanoalanine + hydrogen sulfide [RN:R03524]
Reaction(KEGG)
R03524;
(other) R02846
Show
Substrate
L-cysteine [CPD:C00097];
hydrogen cyanide [CPD:C01326]
Product
L-3-cyanoalanine [CPD:C02512];
hydrogen sulfide [CPD:C00283]
Comment
Contains pyridoxal phospate.
History
EC 4.4.1.9 created 1972, deleted 1976, reinstated 1978
Pathway
Cyanoamino acid metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13034  
L-3-cyanoalanine synthase/ cysteine synthase
Genes
RSS: 
ATH: 
AT3G61440(CYSC1)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
18614120
GRA: 
105802709 105802711
GHI: 
107911578 107911579 107924412 107924413
EGR: 
104443429
GMX: 
100101899(OAS-TL3) 100806420
PVU: 
PHAVU_008G061100g
VRA: 
106759445
VAR: 
108329722
CCAJ: 
109802499
MTR: 
MTR_7g078070
CAM: 
101512608
ADU: 
107472470 107485772
AIP: 
107621508 107635094
LJA: 
Lj1g3v2682510.1(Lj1g3v2682510.1)
LANG: 
109338383 109339915
FVE: 
101292050
PPER: 
18786519
PMUM: 
103342779
MDM: 
103401891(CAS1) 103405317(CAS2) 103406176
PXB: 
103940809 103957376
ZJU: 
107404050
CSV: 
101220896
CMO: 
103497706
RCU: 
8261899 8278514
JCU: 
105642966
POP: 
POPTR_0002s16220g(POPTRDRAFT_552184) POPTR_0014s08210g(POPTRDRAFT_244580)
VVI: 
100255091
SLY: 
101253940 101255033
SPEN: 
107008051 107032363
SOT: 
102601315(PCAS-2) 102604154(PCAS-1)
INI: 
109171635 109184868
SIND: 
105172766
BVG: 
104887240
NNU: 
104610634
OSA: 
4335048
DOSA: 
Os04t0165700-01(Os04g0165700)
OBR: 
102715851
BDI: 
100835065
ATS: 
F775_29238
SBI: 
8066013
ZMA: 
100216722
SITA: 
101779131
PDA: 
103715474
EGU: 
105043037
MUS: 
103985756
ATR: 
18422839
 » show all
Taxonomy
Reference
1  [PMID:1055433]
  Authors
Akopyan TN, Braunstein AE, Goryachenkova EV.
  Title
Beta-cyanoalanine synthase: purification and characterization.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 72 (1975) 1617-21.
Reference
2  [PMID:5001194]
  Authors
Castric PA, Conn EE.
  Title
Formation of  -cyanoalanine by O-acetylserine sulfhydrylase.
  Journal
J. Bacteriol. 108 (1971) 132-6.
Reference
3
  Authors
Hendrickson, H.R.
  Title
The beta-cyanoalanine synthase of blue lupine.
  Journal
Fed. Proc. 27 (1968) 593.
Reference
4  [PMID:5769995]
  Authors
Hendrickson HR, Conn EE.
  Title
Cyanide metabolism in higher plants. IV. Purification and properties of the beta-cyanolanine synthase of blue lupine.
  Journal
J. Biol. Chem. 244 (1969) 2632-40.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9059-53-4
KEGG   REACTION: R03524Help
Entry
R03524                      Reaction                               

Name
L-cysteine hydrogen-sulfide-lyase (adding HCN)
Definition
L-Cysteine + Hydrogen cyanide <=> Hydrogen sulfide + 3-Cyano-L-alanine
Equation
Reaction class
C00097_C02512
C00097_C00283
Enzyme
Pathway
Cyanoamino acid metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13034  
L-3-cyanoalanine synthase/ cysteine synthase [EC:2.5.1.47 4.4.1.9]
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