KEGG ORTHOLOGY: K13035

ORTHOLOGY: K13035

Entry

K13035 KO

Name

NIT4

Definition

beta-cyano-L-alanine hydratase/nitrilase [EC:3.5.5.4 4.2.1.65]

Pathway

ko00460

Cyanoamino acid metabolism

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Metabolism of other amino acids
   00460 Cyanoamino acid metabolism
    K13035  NIT4; beta-cyano-L-alanine hydratase/nitrilase
Enzymes [BR:ko01000]
3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.5  In nitriles
    3.5.5.4  cyanoalanine nitrilase
     K13035  NIT4; beta-cyano-L-alanine hydratase/nitrilase
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.65  3-cyanoalanine hydratase
     K13035  NIT4; beta-cyano-L-alanine hydratase/nitrilase

Other DBs

RN:

R00486 R01267

GO:

0047427 0047558

Genes

RSS:	109441485
ATH:	AT5G22300(NIT4)
ALY:	ARALYDRAFT_662033
CRB:	CARUB_v10001274mg
EUS:	EUTSA_v10013949mg
BRP:	103851433(NIT-T4)
BNA:	106384710 106427339
THJ:	104810929
CIT:	102624718 102626612
CIC:	CICLE_v10020864mg CICLE_v10028755mg
TCC:	18590263 18598346
GRA:	105766626 105792876
GHI:	107948779 107953166 107954122
EGR:	104421327 104421328
GMX:	100778110 100810230
PVU:	PHAVU_011G096700g
VRA:	106775914
VAR:	108339531
CCAJ:	109799314
MTR:	MTR_4g052380 MTR_4g052390
CAM:	101500877
ADU:	107478319
AIP:	107630108
LJA:	Lj0g3v0205259.1(Lj0g3v0205259.1) Lj3g3v2981810.1(Lj3g3v2981810.1) Lj3g3v2981810.2(Lj3g3v2981810.2) Lj3g3v2981810.3(Lj3g3v2981810.3) Lj3g3v2981810.4(Lj3g3v2981810.4)
LANG:	109351736(NIT4) 109353638(NIT4B)
FVE:	101314432
PPER:	18770202 18774569
PMUM:	103329255 103341728
MDM:	103407841 103424813
PXB:	103936462 103966370
ZJU:	107409663 107415031
CSV:	101209360
CMO:	103501743
RCU:	8263319 8263320 8263321 8263322
JCU:	105635907 105647068
POP:	POPTR_0004s20980g POPTR_0006s22420g(POPTRDRAFT_417421) POPTR_0009s16260g(POPTRDRAFT_199891) POPTR_0016s07510g(POPTRDRAFT_835475)
VVI:	100240765 100241354 100241359 100243086 100248203 100250098 100253338 100263621 100265384 100853652
SLY:	101266793
SPEN:	107004945
SOT:	102595618
INI:	109160194
SIND:	105170044
BVG:	104899831
NNU:	104589516 104597484 104601345 104603451
OSA:	4330077(NIT4)
DOSA:	Os02t0635200-01(Os02g0635200)
OBR:	102702164
BDI:	100822856
ATS:	F775_32076
SBI:	8074793
ZMA:	542093(NIT2)
SITA:	101767363
PDA:	103705226
EGU:	105042779
MUS:	103994490
ATR:	18426973 18444517
SMO:	SELMODRAFT_133005(NIT4-2) SELMODRAFT_171766(NIT4-1)
PPP:	PHYPADRAFT_88254
TVS:	TRAVEDRAFT_139011
DSQ:	DICSQDRAFT_95867
PCO:	PHACADRAFT_265079 PHACADRAFT_86834
SHS:	STEHIDRAFT_117582
PSQ:	PUNSTDRAFT_56713
FME:	FOMMEDRAFT_140077
MRR:	Moror_928
SCM:	SCHCODRAFT_255433
SLA:	SERLADRAFT_455401

» show all

Reference

PMID:11060302

Authors

Piotrowski M, Schonfelder S, Weiler EW

Title

The Arabidopsis thaliana isogene NIT4 and its orthologs in tobacco encode beta-cyano-L-alanine hydratase/nitrilase.

Journal

J Biol Chem 276:2616-21 (2001)
DOI:10.1074/jbc.M007890200

Sequence

[ath:AT5G22300]

All links

Ontology (4)   
   KEGG BRITE (2)   
   GO (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (6)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (363)   
   KEGG GENES (110)   
   KEGG MGENES (7)   
   RefGene (1)   
   EGENES (241)   
   OC (4)   
Protein sequence (57)   
   UniProt (55)   
   SWISS-PROT (2)   
Literature (1)   
   PubMed (1)   
All databases (437)   

Download RDF

ENZYME: 4.2.1.65

Entry

EC 4.2.1.65 Enzyme

Name

3-cyanoalanine hydratase;
beta-cyanoalanine hydrolase;
beta-cyanoalanine hydratase;
beta-CNAla hydrolase;
beta-CNA nitrilase;
L-asparagine hydro-lyase

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

L-asparagine hydro-lyase (3-cyanoalanine-forming)

Reaction(IUBMB)

L-asparagine = 3-cyanoalanine + H2O [RN:R01267]

Reaction(KEGG)

R01267

Substrate

L-asparagine [CPD:C00152]

Product

3-cyanoalanine;
H2O [CPD:C00001]

History

EC 4.2.1.65 created 1976

Pathway

ec00460	Cyanoamino acid metabolism
ec01100	Metabolic pathways
ec01110	Biosynthesis of secondary metabolites

Orthology

K13035

beta-cyano-L-alanine hydratase/nitrilase

Genes

RSS:	109441485
ATH:	AT5G22300(NIT4)
ALY:	ARALYDRAFT_662033
CRB:	CARUB_v10001274mg
EUS:	EUTSA_v10013949mg
BRP:	103851433(NIT-T4)
BNA:	106384710 106427339
THJ:	104810929
CIT:	102624718 102626612
CIC:	CICLE_v10020864mg CICLE_v10028755mg
TCC:	18590263 18598346
GRA:	105766626 105792876
GHI:	107948779 107953166 107954122
EGR:	104421327 104421328
GMX:	100778110 100810230
PVU:	PHAVU_011G096700g
VRA:	106775914
VAR:	108339531
CCAJ:	109799314
MTR:	MTR_4g052380 MTR_4g052390
CAM:	101500877
ADU:	107478319
AIP:	107630108
LJA:	Lj0g3v0205259.1(Lj0g3v0205259.1) Lj3g3v2981810.1(Lj3g3v2981810.1) Lj3g3v2981810.2(Lj3g3v2981810.2) Lj3g3v2981810.3(Lj3g3v2981810.3) Lj3g3v2981810.4(Lj3g3v2981810.4)
LANG:	109351736(NIT4) 109353638(NIT4B)
FVE:	101314432
PPER:	18770202 18774569
PMUM:	103329255 103341728
MDM:	103407841 103424813
PXB:	103936462 103966370
ZJU:	107409663 107415031
CSV:	101209360
CMO:	103501743
RCU:	8263319 8263320 8263321 8263322
JCU:	105635907 105647068
POP:	POPTR_0004s20980g POPTR_0006s22420g(POPTRDRAFT_417421) POPTR_0009s16260g(POPTRDRAFT_199891) POPTR_0016s07510g(POPTRDRAFT_835475)
VVI:	100240765 100241354 100241359 100243086 100248203 100250098 100253338 100263621 100265384 100853652
SLY:	101266793
SPEN:	107004945
SOT:	102595618
INI:	109160194
SIND:	105170044
BVG:	104899831
NNU:	104589516 104597484 104601345 104603451
OSA:	4330077(NIT4)
DOSA:	Os02t0635200-01(Os02g0635200)
OBR:	102702164
BDI:	100822856
ATS:	F775_32076
SBI:	8074793
ZMA:	542093(NIT2)
SITA:	101767363
PDA:	103705226
EGU:	105042779
MUS:	103994490
ATR:	18426973 18444517
SMO:	SELMODRAFT_133005(NIT4-2) SELMODRAFT_171766(NIT4-1)
PPP:	PHYPADRAFT_88254
TVS:	TRAVEDRAFT_139011
DSQ:	DICSQDRAFT_95867
PCO:	PHACADRAFT_265079 PHACADRAFT_86834
SHS:	STEHIDRAFT_117582
PSQ:	PUNSTDRAFT_56713
FME:	FOMMEDRAFT_140077
MRR:	Moror_928
SCM:	SCHCODRAFT_255433
SLA:	SERLADRAFT_455401

» show all

Reference

1 [PMID:4627358]

Authors

Castric PA, Farnden KJ, Conn EE.

Title

Cyanide metabolism in higher plants. V. The formation of asparagine from -cyanoalanine.

Journal

Arch. Biochem. Biophys. 152 (1972) 62-9.

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.65

IUBMB Enzyme Nomenclature:

4.2.1.65

ExPASy - ENZYME nomenclature database:

4.2.1.65

BRENDA, the Enzyme Database:

4.2.1.65

CAS:

37259-64-6

All links

Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (361)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (110)   
   KEGG MGENES (7)   
   RefGene (1)   
   EGENES (241)   
Protein sequence (10)   
   UniProt (5)   
   SWISS-PROT (4)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (3)   
   EMBL (1)   
All databases (387)   

Download RDF

REACTION: R01267

Entry

R01267 Reaction

Name

L-asparagine hydro-lyase (3-cyanoalanine-forming)

Definition

L-Asparagine <=> 3-Cyano-L-alanine + H2O

Equation

C00152 <=> C02512 + C00001

Reaction class

RC00483

C00152_C02512

Enzyme

3.5.5.4 4.2.1.65

Pathway

rn00460	Cyanoamino acid metabolism
rn01100	Metabolic pathways
rn01110	Biosynthesis of secondary metabolites

Orthology

K13035

beta-cyano-L-alanine hydratase/nitrilase [EC:3.5.5.4 4.2.1.65]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (3)   
   KEGG ENZYME (2)   
   KEGG RCLASS (1)   
Gene (111)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (110)   
All databases (124)   

Download RDF

DBGET integrated database retrieval system