| Entry |
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| Name |
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With oxygen as acceptor
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| Sysname |
loganin:oxygen oxidoreductase (ring-cleaving)
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| Reaction(IUBMB) |
loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O [RN: R03555]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A heme-thiolate protein (P-450). Secologanin is the precursor of the monoterpenoid indole alkaloids and ipecac alkaloids.
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| History |
EC 1.3.3.9 created 2002
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| Pathway |
| Monoterpenoid biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Orthology |
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| Reference |
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| Authors |
Yamamoto H, Katano N, Ooi A, Inoue K. |
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| Title |
Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P450. |
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| Journal |
Phytochemistry. 53 (2000) 7-12. |
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| Reference |
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| Authors |
Irmler S, Schroder G, St-Pierre B, Crouch NP, Hotze M, Schmidt J, Strack D, Matern U, Schroder J. |
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| Title |
Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase. |
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| Journal |
Plant. J. 24 (2000) 797-804. |
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| Sequence |
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| Reference |
3 |
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| Authors |
Yamamoto, H., Katano, N., Ooi, Y. and Inoue, K. |
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| Title |
Transformation of loganin and 7-deoxyloganin into secologanin by Lonicera japonica cell suspension cultures. |
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| Journal |
Phytochemistry 50 (1999) 417-422. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 258339-71-8 |
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