KEGG   ORTHOLOGY: K13545Help
Entry
K13545                      KO                                     

Name
RCCR, ACD2
Definition
red chlorophyll catabolite reductase [EC:1.3.7.12]
Pathway
Porphyrin and chlorophyll metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of cofactors and vitamins
   00860 Porphyrin and chlorophyll metabolism
    K13545  RCCR, ACD2; red chlorophyll catabolite reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.7  With an iron-sulfur protein as acceptor
    1.3.7.12  red chlorophyll catabolite reductase
     K13545  RCCR, ACD2; red chlorophyll catabolite reductase
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
RSS: 
ATH: 
AT4G37000(ACD2)
ALY: 
CRB: 
EUS: 
BRP: 
103862886(RCCR)
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
18611120
GRA: 
105803912
GHI: 
107897716 107913254
EGR: 
104418575
GMX: 
100777640 100780934
PVU: 
PHAVU_008G280200g PHAVU_008G280300g
VRA: 
106763057
VAR: 
108337053
CCAJ: 
109806983
MTR: 
MTR_5g096150
CAM: 
101488374
ADU: 
107496225
AIP: 
107608673
LJA: 
Lj2g3v3246900.1(Lj2g3v3246900.1) Lj2g3v3315570.1(Lj2g3v3315570.1)
LANG: 
109356885
FVE: 
101301239
PPER: 
18769442
PMUM: 
103339882
MDM: 
103401375
PXB: 
103964494
ZJU: 
107424775
CSV: 
101202861 101223133(CsRCCR)
CMO: 
103497431 103497432
RCU: 
8262890
JCU: 
105639704
POP: 
POPTR_0007s11040g(POPTRDRAFT_819935) POPTR_0007s11060g(POPTRDRAFT_764544) POPTR_0007s11070g(POPTRDRAFT_764546)
VVI: 
100252439
SLY: 
778267(rccr)
SPEN: 
107014711
SOT: 
102591737
INI: 
109177802
SIND: 
105177623 105177624
BVG: 
104883759
NNU: 
104608870
OSA: 
4348519(RCCR1)
DOSA: 
Os10t0389100-00(Os10g0389100) Os10t0389200-01(Os10g0389200) Os10t0389300-01(Os10g0389300)
OBR: 
102703616
BDI: 
100843855
ATS: 
F775_01432 F775_01961
ZMA: 
100272914
SITA: 
101780665
PDA: 
103701815
EGU: 
105041580 105048691
MUS: 
103999342
ATR: 
18421357
SMO: 
SELMODRAFT_186296 SELMODRAFT_269565
PPP: 
PHYPADRAFT_130472
AG: 
CAB77705(RCCR)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wuthrich KL, Bovet L, Hunziker PE, Donnison IS, Hortensteiner S
  Title
Molecular cloning, functional expression and characterisation of RCC reductase involved in chlorophyll catabolism.
  Journal
Plant J 21:189-98 (2000)
DOI:10.1046/j.1365-313x.2000.00667.x
  Sequence
Reference
  Authors
Mach JM, Castillo AR, Hoogstraten R, Greenberg JT
  Title
The Arabidopsis-accelerated cell death gene ACD2 encodes red chlorophyll catabolite reductase and suppresses the spread of disease symptoms.
  Journal
Proc Natl Acad Sci U S A 98:771-6 (2001)
DOI:10.1073/pnas.021465298
  Sequence
[ath:AT4G37000]
KEGG   ENZYME: 1.3.7.12Help
Entry
EC 1.3.7.12                 Enzyme                                 

Name
red chlorophyll catabolite reductase;
RCCR;
RCC reductase;
red Chl catabolite reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
primary fluorescent chlorophyll catabolite:ferredoxin oxidoreductase
Reaction(IUBMB)
primary fluorescent chlorophyll catabolite + 2 oxidized ferredoxin [iron-sulfur] cluster = red chlorophyll catabolite + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ [RN:R09032]
Reaction(KEGG)
Substrate
primary fluorescent chlorophyll catabolite [CPD:C18098];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]
Product
red chlorophyll catabolite [CPD:C18022];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080]
Comment
The enzyme participates in chlorophyll degradation, which occurs during leaf senescence and fruit ripening in higher plants. The reaction requires reduced ferredoxin, which is generated from NADPH produced either through the pentose-phosphate pathway or by the action of photosystem I [1,2]. This reaction takes place while red chlorophyll catabolite is still bound to EC 1.14.15.17, pheophorbide a oxygenase [3]. Depending on the plant species used as the source of enzyme, one of two possible C-1 epimers of primary fluorescent chlorophyll catabolite (pFCC), pFCC-1 or pFCC-2, is normally formed, with all genera or species within a family producing the same isomer [3,4]. After modification and export, pFCCs are eventually imported into the vacuole, where the acidic environment causes their non-enzymic conversion into colourless breakdown products called non-fluorescent chlorophyll catabolites (NCCs) [2].
History
EC 1.3.7.12 created 2007 as EC 1.3.1.80, transferred 2016 to EC 1.3.7.12
Pathway
Porphyrin and chlorophyll metabolism
Biosynthesis of secondary metabolites
Orthology
K13545  
red chlorophyll catabolite reductase
Genes
RSS: 
ATH: 
AT4G37000(ACD2)
ALY: 
CRB: 
EUS: 
BRP: 
103862886(RCCR)
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
18611120
GRA: 
105803912
GHI: 
107897716 107913254
EGR: 
104418575
GMX: 
100777640 100780934
PVU: 
PHAVU_008G280200g PHAVU_008G280300g
VRA: 
106763057
VAR: 
108337053
CCAJ: 
109806983
MTR: 
MTR_5g096150
CAM: 
101488374
ADU: 
107496225
AIP: 
107608673
LJA: 
Lj2g3v3246900.1(Lj2g3v3246900.1) Lj2g3v3315570.1(Lj2g3v3315570.1)
LANG: 
109356885
FVE: 
101301239
PPER: 
18769442
PMUM: 
103339882
MDM: 
103401375
PXB: 
103964494
ZJU: 
107424775
CSV: 
101202861 101223133(CsRCCR)
CMO: 
103497431 103497432
RCU: 
8262890
JCU: 
105639704
POP: 
POPTR_0007s11040g(POPTRDRAFT_819935) POPTR_0007s11060g(POPTRDRAFT_764544) POPTR_0007s11070g(POPTRDRAFT_764546)
VVI: 
100252439
SLY: 
778267(rccr)
SPEN: 
107014711
SOT: 
102591737
INI: 
109177802
SIND: 
105177623 105177624
BVG: 
104883759
NNU: 
104608870
OSA: 
4348519(RCCR1)
DOSA: 
Os10t0389100-00(Os10g0389100) Os10t0389200-01(Os10g0389200) Os10t0389300-01(Os10g0389300)
OBR: 
102703616
BDI: 
100843855
ATS: 
F775_01432 F775_01961
ZMA: 
100272914
SITA: 
101780665
PDA: 
103701815
EGU: 
105041580 105048691
MUS: 
103999342
ATR: 
18421357
SMO: 
SELMODRAFT_186296 SELMODRAFT_269565
PPP: 
PHYPADRAFT_130472
 » show all
Taxonomy
Reference
1  [PMID:12223835]
  Authors
Rodoni S, Muhlecker W, Anderl M, Krautler B, Moser D, Thomas H, Matile P, Hortensteiner S.
  Title
Chlorophyll Breakdown in Senescent Chloroplasts (Cleavage of Pheophorbide a in Two Enzymic Steps).
  Journal
Plant. Physiol. 115 (1997) 669-676.
Reference
2  [PMID:10743659]
  Authors
Wuthrich KL, Bovet L, Hunziker PE, Donnison IS, Hortensteiner S.
  Title
Molecular cloning, functional expression and characterisation of RCC reductase involved in chlorophyll catabolism.
  Journal
Plant. J. 21 (2000) 189-98.
  Sequence
Reference
3  [PMID:17237353]
  Authors
Pruzinska A, Anders I, Aubry S, Schenk N, Tapernoux-Luthi E, Muller T, Krautler B, Hortensteiner S.
  Title
In vivo participation of red chlorophyll catabolite reductase in chlorophyll breakdown.
  Journal
Plant. Cell. 19 (2007) 369-87.
  Sequence
[ath:AT4G37000]
Reference
4  [PMID:16669755]
  Authors
Hortensteiner S.
  Title
Chlorophyll degradation during senescence.
  Journal
Annu. Rev. Plant. Biol. 57 (2006) 55-77.
Reference
5  [PMID:12223836]
  Authors
Rodoni S, Vicentini F, Schellenberg M, Matile P, Hortensteiner S.
  Title
Partial Purification and Characterization of Red Chlorophyll Catabolite Reductase, a Stroma Protein Involved in Chlorophyll Breakdown.
  Journal
Plant. Physiol. 115 (1997) 677-682.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
KEGG   REACTION: R09032Help
Entry
R09032                      Reaction                               

Name
primary fluorescent chlorophyll catabolite:ferredoxin oxidoreductase
Definition
Primary fluorescent chlorophyll catabolite + 2 Oxidized ferredoxin <=> Red chlorophyll catabolite + 2 Reduced ferredoxin + 2 H+
Equation
C18098 + 2 C00139 <=> C18022 + 2 C00138 + 2 C00080
Reaction class
C18022_C18098
Enzyme
Pathway
Porphyrin and chlorophyll metabolism
Biosynthesis of secondary metabolites
Orthology
K13545  
red chlorophyll catabolite reductase [EC:1.3.7.12]
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