KEGG   ORTHOLOGY: K14176Help
Entry
K14176                      KO                                     

Name
ECS1
Definition
epi-cedrol synthase [EC:4.2.3.39]
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of terpenoids and polyketides
   00909 Sesquiterpenoid and triterpenoid biosynthesis
    K14176  ECS1; epi-cedrol synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.39  epi-cedrol synthase
     K14176  ECS1; epi-cedrol synthase
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
AG: 
AAF80333(ECS1)
TaxonomyKoalaUniProt
Reference
  Authors
Mercke P, Crock J, Croteau R, Brodelius PE
  Title
Cloning, expression, and characterization of epi-cedrol synthase, a sesquiterpene cyclase from Artemisia annua L.
  Journal
Arch Biochem Biophys 369:213-22 (1999)
DOI:10.1006/abbi.1999.1358
  Sequence

KEGG   ENZYME: 4.2.3.39Help
Entry
EC 4.2.3.39                 Enzyme                                 

Name
epi-cedrol synthase;
8-epicedrol synthase;
epicedrol synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = 8-epi-cedrol + diphosphate [RN:R09140]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
8-epi-cedrol [CPD:C18245];
diphosphate [CPD:C00013]
Comment
The enzyme is activated by Mg2+ [2]. Similar to many other plant terpenoid synthases, this enzyme produces many products from a single substrate. The predominant product is the cyclic sesquiterpenoid alcohol, 8-epi-cedrol, with minor products including cedrol and the olefins alpha-cedrene, beta-cedrene, (E)-beta-farnesene and (E)-alpha-bisabolene [1].
History
EC 4.2.3.39 created 2009
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K14176  
epi-cedrol synthase
Reference
1  [PMID:10486140]
  Authors
Mercke P, Crock J, Croteau R, Brodelius PE
  Title
Cloning, expression, and characterization of epi-cedrol synthase, a sesquiterpene cyclase from Artemisia annua L.
  Journal
Arch. Biochem. Biophys. 369 (1999) 213-22.
Reference
2  [PMID:10486139]
  Authors
Hua L, Matsuda SP
  Title
The molecular cloning of 8-epicedrol synthase from Artemisia annua.
  Journal
Arch. Biochem. Biophys. 369 (1999) 208-12.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
KEGG   REACTION: R09140Help
Entry
R09140                      Reaction                               

Name
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming)
Definition
trans,trans-Farnesyl diphosphate + H2O <=> 8-epi-Cedrol + Diphosphate
Equation
Reaction class
C00448_C18245
Enzyme
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K14176  
epi-cedrol synthase [EC:4.2.3.39]
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