KEGG   ORTHOLOGY: K14582Help
Entry
K14582                      KO                                     

Name
nahB, doxE
Definition
cis-1,2-dihydro-1,2-dihydroxynaphthalene/dibenzothiophene dihydrodiol dehydrogenase [EC:1.3.1.29 1.3.1.60]
Pathway
Polycyclic aromatic hydrocarbon degradation
Naphthalene degradation
Degradation of aromatic compounds
Module
M00534  
Naphthalene degradation, naphthalene => salicylate
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K14582  nahB, doxE; cis-1,2-dihydro-1,2-dihydroxynaphthalene/dibenzothiophene dihydrodiol dehydrogenase
  Xenobiotics biodegradation and metabolism
   00626 Naphthalene degradation
    K14582  nahB, doxE; cis-1,2-dihydro-1,2-dihydroxynaphthalene/dibenzothiophene dihydrodiol dehydrogenase
   00624 Polycyclic aromatic hydrocarbon degradation
    K14582  nahB, doxE; cis-1,2-dihydro-1,2-dihydroxynaphthalene/dibenzothiophene dihydrodiol dehydrogenase
KEGG modules [BR:ko00002]
 Pathway module
  Secondary metabolism
   Aromatics degradation
    M00534  Naphthalene degradation, naphthalene => salicylate
     K14582  nahB, doxE; cis-1,2-dihydro-1,2-dihydroxynaphthalene/dibenzothiophene dihydrodiol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.29  cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
     K14582  nahB, doxE; cis-1,2-dihydro-1,2-dihydroxynaphthalene/dibenzothiophene dihydrodiol dehydrogenase
    1.3.1.60  dibenzothiophene dihydrodiol dehydrogenase
     K14582  nahB, doxE; cis-1,2-dihydro-1,2-dihydroxynaphthalene/dibenzothiophene dihydrodiol dehydrogenase
BRITE hierarchy
Other DBs
Genes
PSC: 
PSTU: 
PBM: 
ALT: 
RMN: 
BMK: 
DM80_1445(bphB)
PNA: 
AG: 
AAA16128(doxE)
TaxonomyKoalaUniProt
Reference
PMID:8226631
  Authors
Denome SA, Stanley DC, Olson ES, Young KD
  Title
Metabolism of dibenzothiophene and naphthalene in Pseudomonas strains: complete DNA sequence of an upper naphthalene catabolic pathway.
  Journal
J Bacteriol 175:6890-901 (1993)
DOI:10.1128/JB.175.21.6890-6901.1993
  Sequence

KEGG   ENZYME: 1.3.1.29Help
Entry
EC 1.3.1.29                 Enzyme                                 

Name
cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase;
(+)-cis-naphthalene dihydrodiol dehydrogenase;
naphthalene dihydrodiol dehydrogenase;
cis-dihydrodiol naphthalene dehydrogenase;
cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(1R,2S)-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase
Reaction(IUBMB)
(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+ [RN:R04115]
Reaction(KEGG)
Substrate
(1R,2S)-1,2-dihydronaphthalene-1,2-diol [CPD:C04314];
NAD+ [CPD:C00003]
Product
naphthalene-1,2-diol [CPD:C03012];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts, at half the rate, on cis-anthracene dihydrodiol and cis-phenanthrene dihydrodiol.
History
EC 1.3.1.29 created 1976
Pathway
Polycyclic aromatic hydrocarbon degradation
Naphthalene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K14582  
cis-1,2-dihydro-1,2-dihydroxynaphthalene/dibenzothiophene dihydrodiol dehydrogenase
Genes
PSC: 
PSTU: 
PBM: 
ALT: 
RMN: 
BMK: 
DM80_1445(bphB)
PNA: 
Taxonomy
Reference
1  [PMID:4369091]
  Authors
Patel TR, Gibson DT.
  Title
Purification and propeties of (plus)-cis-naphthalene dihydrodiol dehydrogenase of Pseudomonas putida.
  Journal
J. Bacteriol. 119 (1974) 879-88.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
53986-49-5
KEGG   REACTION: R09183Help
Entry
R09183                      Reaction                               

Definition
Benzo[a]pyrene-cis-9,10-dihydrodiol + NAD+ <=> 9,10-Dihydroxybenzo[a]pyrene + NADH + H+
Equation
Comment
benzo[a]pyrene-cis-9,10-dihydrodiol:NAD+ 9,10-oxidoreductase
Reaction class
C00003_C00004
C18276_C18278
Enzyme
Pathway
Polycyclic aromatic hydrocarbon degradation
Microbial metabolism in diverse environments
Orthology
K14582  
cis-1,2-dihydro-1,2-dihydroxynaphthalene/dibenzothiophene dihydrodiol dehydrogenase [EC:1.3.1.29 1.3.1.60]
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