KEGG   ORTHOLOGY: K14594Help
Entry
K14594                      KO                                     

Name
NSY
Definition
neoxanthin synthase [EC:5.3.99.9]
Pathway
Carotenoid biosynthesis
Module
M00372  
Abscisic acid biosynthesis, beta-carotene => abscisic acid
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of terpenoids and polyketides
   00906 Carotenoid biosynthesis
    K14594  NSY; neoxanthin synthase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Other terpenoid biosynthesis
    M00372  Abscisic acid biosynthesis, beta-carotene => abscisic acid
     K14594  NSY; neoxanthin synthase
Enzymes [BR:ko01000]
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.99  Other intramolecular oxidoreductases
    5.3.99.9  neoxanthin synthase
     K14594  NSY; neoxanthin synthase
BRITE hierarchy
Other DBs
Genes
SLY: 
543649(NSY)
SPEN: 
SOT: 
TaxonomyKoalaUniProt
Reference
  Authors
Bouvier F, D'harlingue A, Backhaus RA, Kumagai MH, Camara B
  Title
Identification of neoxanthin synthase as a carotenoid cyclase paralog.
  Journal
Eur J Biochem 267:6346-52 (2000)
DOI:10.1046/j.1432-1327.2000.01722.x
  Sequence
[sly:543649]
Reference
  Authors
Al-Babili S, Hugueney P, Schledz M, Welsch R, Frohnmeyer H, Laule O, Beyer P
  Title
Identification of a novel gene coding for neoxanthin synthase from Solanum tuberosum.
  Journal
FEBS Lett 485:168-72 (2000)
DOI:10.1016/S0014-5793(00)02193-1
  Sequence
[sot:102601215]
KEGG   ENZYME: 5.3.99.9Help
Entry
EC 5.3.99.9                 Enzyme                                 

Name
neoxanthin synthase;
NSY
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
BRITE hierarchy
Sysname
violaxanthin---neoxanthin isomerase (epoxide-opening)
Reaction(IUBMB)
violaxanthin = neoxanthin [RN:R06948]
Reaction(KEGG)
R06948;
(other) R06951
Show
Substrate
violaxanthin [CPD:C08614]
Product
neoxanthin [CPD:C08606]
Comment
The opening of the epoxide ring of violaxanthin generates a chiral allene. Neoxanthin is a precursor of the plant hormone abscisic acid and the last product of carotenoid synthesis in green plants [2].
History
EC 5.3.99.9 created 2005
Pathway
Carotenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K14594  
neoxanthin synthase
Genes
SLY: 
543649(NSY)
SPEN: 
SOT: 
Taxonomy
Reference
1  [PMID:11094161]
  Authors
Al-Babili S, Hugueney P, Schledz M, Welsch R, Frohnmeyer H, Laule O, Beyer P.
  Title
Identification of a novel gene coding for neoxanthin synthase from Solanum tuberosum.
  Journal
FEBS. Lett. 485 (2000) 168-72.
  Sequence
[sot:102601215]
Reference
2  [PMID:11029576]
  Authors
Bouvier F, D'harlingue A, Backhaus RA, Kumagai MH, Camara B.
  Title
Identification of neoxanthin synthase as a carotenoid cyclase paralog.
  Journal
Eur. J. Biochem. 267 (2000) 6346-52.
  Sequence
[sly:543649]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
318960-21-3
KEGG   REACTION: R06948Help
Entry
R06948                      Reaction                               

Name
violaxanthin-neoxanthin isomerase (epoxide-opening)
Definition
Violaxanthin <=> Neoxanthin
Equation
Reaction class
C08606_C08614
Enzyme
Pathway
Carotenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Module
M00372  
Abscisic acid biosynthesis, beta-carotene => abscisic acid
Orthology
K14594  
neoxanthin synthase [EC:5.3.99.9]
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