KEGG   ORTHOLOGY: K14940Help
Entry
K14940                      KO                                     

Name
cofF
Definition
gamma-F420-2:alpha-L-glutamate ligase [EC:6.3.2.32]
Pathway
Methane metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Energy metabolism
   00680 Methane metabolism
    K14940  cofF; gamma-F420-2:alpha-L-glutamate ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.32  coenzyme gamma-F420-2:alpha-L-glutamate ligase
     K14940  cofF; gamma-F420-2:alpha-L-glutamate ligase
BRITE hierarchy
Other DBs
RN: 
COG: 
Genes
SON: 
SO_2200(rimK)
SAZ: 
SBL: 
SBM: 
SBN: 
SBP: 
SBT: 
SBS: 
SBB: 
SPC: 
SHP: 
Sput200_1771
SHE: 
Shewmr4_2195
SHM: 
Shewmr7_2272
SHN: 
Shewana3_2405
SHW: 
Sputw3181_2281
PSEO: 
OM33_05960
PRR: 
AT705_00405
FBL: 
Fbal_3320
LHA: 
LHA_0303
BMX: 
BMS_2472
CBOT: 
ATE48_15055
NRE: 
BES08_00495
SMAZ: 
LH19_12250
SPHM: 
G432_12675
SSAN: 
NX02_01805 NX02_02790
CMAN: 
A9D14_02485
MAI: 
MICA_511
MAN: 
A11S_494
BHK: 
B4U37_16110
TAP: 
GZ22_09970 GZ22_09975
VHL: 
BME96_08020
LAO: 
AOX59_06080 AOX59_06085
AWO: 
Awo_c26080 Awo_c26090
CLC: 
Calla_0861
SFC: 
Spiaf_0383
PSTY: 
BFS30_01295
PROC: 
Ptc2401_00937(lysX_1)
MJA: 
MJ_1001
MFE: 
Mefer_1229
MVU: 
Metvu_1301
MFS: 
MFS40622_1616
MIF: 
Metin_0765
MJH: 
JH146_0956
MIG: 
Metig_0022
MMP: 
MMP0170(cofF)
MMQ: 
MmarC5_1505
MMX: 
MmarC6_0780
MMZ: 
MmarC7_1170
MMD: 
GYY_00870
MMAK: 
MMKA1_01750(cofF)
MMAO: 
MMOS7_02010(cofF)
MAE: 
Maeo_1379
MVN: 
Mevan_1175
MVO: 
Mvol_1455
MOK: 
Metok_0654
MAC: 
MA_1361(rimK)
MMA: 
MM_2347
MMAZ: 
MmTuc01_2397
MMJ: 
MSMAS_2353
MMAC: 
MSMAC_2094
MLS: 
MSLAZ_0946
MEF: 
MSWH1_2290
MEQ: 
MSWHS_2785
MHOR: 
MSHOH_2976
MMET: 
MCMEM_1893
MZH: 
Mzhil_0669
MPY: 
Mpsy_2134(rimK)
VG: 
29122638(BJD26_gp120)
 » show all
TaxonomyVtaxonomyKoalaUniProt
Reference
  Authors
Li H, Xu H, Graham DE, White RH
  Title
Glutathione synthetase homologs encode alpha-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses.
  Journal
Proc Natl Acad Sci U S A 100:9785-90 (2003)
DOI:10.1073/pnas.1733391100
  Sequence
[mja:MJ_1001]
KEGG   ENZYME: 6.3.2.32Help
Entry
EC 6.3.2.32                 Enzyme                                 

Name
coenzyme gamma-F420-2:alpha-L-glutamate ligase;
MJ1001;
CofF protein;
gamma-F420-2:alpha-L-glutamate ligase
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
L-glutamate:coenzyme gamma-F420-2 (ADP-forming)
Reaction(IUBMB)
ATP + coenzyme gamma-F420-2 + L-glutamate = ADP + phosphate + coenzyme alpha-F420-3 [RN:R09401]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
coenzyme gamma-F420-2;
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
coenzyme alpha-F420-3
Comment
The enzyme caps the gamma-glutamyl tail of the hydride carrier coenzyme F420 [1].
History
EC 6.3.2.32 created 2010
Pathway
Methane metabolism
Microbial metabolism in diverse environments
Orthology
K14940  
gamma-F420-2:alpha-L-glutamate ligase
Genes
SON: 
SO_2200(rimK)
SAZ: 
SBL: 
SBM: 
SBN: 
SBP: 
SBT: 
SBS: 
SBB: 
SPC: 
SHP: 
Sput200_1771
SHE: 
Shewmr4_2195
SHM: 
Shewmr7_2272
SHN: 
Shewana3_2405
SHW: 
Sputw3181_2281
PSEO: 
OM33_05960
PRR: 
AT705_00405
FBL: 
Fbal_3320
LHA: 
LHA_0303
BMX: 
BMS_2472
CBOT: 
ATE48_15055
NRE: 
BES08_00495
SMAZ: 
LH19_12250
SPHM: 
G432_12675
SSAN: 
NX02_01805 NX02_02790
CMAN: 
A9D14_02485
MAI: 
MICA_511
MAN: 
A11S_494
BHK: 
B4U37_16110
TAP: 
GZ22_09970 GZ22_09975
VHL: 
BME96_08020
LAO: 
AOX59_06080 AOX59_06085
AWO: 
Awo_c26080 Awo_c26090
CLC: 
Calla_0861
SFC: 
Spiaf_0383
PSTY: 
BFS30_01295
PROC: 
Ptc2401_00937(lysX_1)
MJA: 
MJ_1001
MFE: 
Mefer_1229
MVU: 
Metvu_1301
MFS: 
MFS40622_1616
MIF: 
Metin_0765
MJH: 
JH146_0956
MIG: 
Metig_0022
MMP: 
MMP0170(cofF)
MMQ: 
MmarC5_1505
MMX: 
MmarC6_0780
MMZ: 
MmarC7_1170
MMD: 
GYY_00870
MMAK: 
MMKA1_01750(cofF)
MMAO: 
MMOS7_02010(cofF)
MAE: 
Maeo_1379
MVN: 
Mevan_1175
MVO: 
Mvol_1455
MOK: 
Metok_0654
MAC: 
MA_1361(rimK)
MMA: 
MM_2347
MMAZ: 
MmTuc01_2397
MMJ: 
MSMAS_2353
MMAC: 
MSMAC_2094
MLS: 
MSLAZ_0946
MEF: 
MSWH1_2290
MEQ: 
MSWHS_2785
MHOR: 
MSHOH_2976
MMET: 
MCMEM_1893
MZH: 
Mzhil_0669
MPY: 
Mpsy_2134(rimK)
 » show all
Taxonomy
Reference
1  [PMID:12909715]
  Authors
Li H, Xu H, Graham DE, White RH
  Title
Glutathione synthetase homologs encode alpha-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 9785-90.
  Sequence
[mja:MJ_1001]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
KEGG   REACTION: R09401Help
Entry
R09401                      Reaction                               

Name
L-glutamate:coenzyme gamma-F420-2 (ADP-forming)
Definition
ATP + Coenzyme F420 + L-Glutamate <=> ADP + Coenzyme F420-3 + Orthophosphate
Equation
Reaction class
C00002_C00008
C00025_C19151
C00876_C19151
Enzyme
Pathway
Methane metabolism
Microbial metabolism in diverse environments
Orthology
K14940  
gamma-F420-2:alpha-L-glutamate ligase [EC:6.3.2.32]
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