KEGG   ORTHOLOGY: K15086Help
Entry
K15086                      KO                                     

Name
TPS14
Definition
(3S)-linalool synthase [EC:4.2.3.25]
Pathway
Monoterpenoid biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K15086  TPS14; (3S)-linalool synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.25  S-linalool synthase
     K15086  TPS14; (3S)-linalool synthase
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
ATH: 
AT1G61680(TPS14)
ALY: 
CRB: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
EGR: 
GMX: 
100782471 100783015 100789381(NES)
PVU: 
PHAVU_002G219100g PHAVU_002G219300g PHAVU_006G195600g PHAVU_006G195700g
VRA: 
106765590 106766355 106766356 106766373 106766374 106768047 106774503 106774972
VAR: 
108326386 108338184 108338349 108342452
CCAJ: 
109814060 109814089 109817871 109817878
MTR: 
MTR_0927s0010 MTR_2g010960 MTR_3g052120 MTR_3g063120 MTR_3g063140 MTR_3g063160 MTR_3g063170 MTR_3g465090 MTR_4g092010 MTR_4g092020 MTR_6g064980 MTR_6g065040
CAM: 
101494917 101495572 101503644 101505365 101515140
ADU: 
107468546 107468547 107468751 107480611
AIP: 
107622334 107622335 107622336 107622340 107623232
LJA: 
Lj0g3v0198989.1(Lj0g3v0198989.1) Lj0g3v0198989.2(Lj0g3v0198989.2) Lj0g3v0198989.3(Lj0g3v0198989.3) Lj0g3v0306569.1(Lj0g3v0306569.1) Lj6g3v2135290.1(Lj6g3v2135290.1)
LANG: 
109334775
FVE: 
101298852 101299453
PPER: 
18780456
PMUM: 
103324595 103343969 103343970 103344406 107882105
MDM: 
103427814(NES) 103434640 103446596 103446597 103456160 108170734
PXB: 
103958115 103958297 108866779
ZJU: 
107421470 107421878
CSV: 
101204552 101204794
CMO: 
103485748 103485753 103489227
RCU: 
8259987(RcSeTPS4) 8267425(RcSeTPS13)
JCU: 
105629808 105629819 105629820 105649410 105649411
POP: 
POPTR_0004s02970g(POPTRDRAFT_855580) POPTR_0004s02990g(POPTRDRAFT_856834) POPTR_0011s03490g
VVI: 
100244313 100248531 100267150 100852527 100852561 100852776 100853562 100853639 100853679 100854717 100854729 100854809 104878270 104878369
SLY: 
101244812(TPS37) 101245403(TPS39)
SPEN: 
107019618 107032586
SOT: 
102580873 102592813
INI: 
109163834 109167275 109167276 109167277 109167278 109167279
SIND: 
105156792 105175396 105175469 105175470
BVG: 
104883052 104901069 104901071
NNU: 
104591086 104591099
OSA: 
4328124(LIS)
DOSA: 
Os02t0121700-01(Os02g0121700) Os10t0489500-00(Os10g0489500)
OBR: 
102705662 102711045
BDI: 
100823591
ATS: 
F775_10369 F775_13412 F775_16851 F775_19146 F775_19147 F775_20658 F775_27744 F775_31422
SBI: 
8085232 8085234
ZMA: 
103654934 103654935 732758(TPS2) 732759(TPS3)
SITA: 
101779235 101783156 105914065
MUS: 
103973658 103998578
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Chen F, Tholl D, D'Auria JC, Farooq A, Pichersky E, Gershenzon J
  Title
Biosynthesis and emission of terpenoid volatiles from Arabidopsis flowers.
  Journal
Plant Cell 15:481-94 (2003)
DOI:10.1105/tpc.007989
Reference
  Authors
Cseke L, Dudareva N, Pichersky E
  Title
Structure and evolution of linalool synthase.
  Journal
Mol Biol Evol 15:1491-8 (1998)
DOI:10.1093/oxfordjournals.molbev.a025876
Reference
  Authors
Aubourg S, Lecharny A, Bohlmann J
  Title
Genomic analysis of the terpenoid synthase ( AtTPS) gene family of Arabidopsis thaliana.
  Journal
Mol Genet Genomics 267:730-45 (2002)
DOI:10.1007/s00438-002-0709-y
KEGG   ENZYME: 4.2.3.25Help
Entry
EC 4.2.3.25                 Enzyme                                 

Name
S-linalool synthase;
LIS;
Lis;
3S-linalool synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming]
Reaction(IUBMB)
geranyl diphosphate + H2O = (3S)-linalool + diphosphate [RN:R07631]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
(3S)-linalool [CPD:C11389];
diphosphate [CPD:C00013]
Comment
Requires Mn2+ or Mg2+ for activity. Neither (S)- nor (R)-linalyl diphosphate can act as substrate for the enzyme from the flower Clarkia breweri [1]. Unlike many other monoterpene synthases, only a single product, (3S)-linalool, is formed.
History
EC 4.2.3.25 created 2006
Pathway
Monoterpenoid biosynthesis
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K15086  
(3S)-linalool synthase
Genes
ATH: 
AT1G61680(TPS14)
ALY: 
CRB: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
EGR: 
GMX: 
100782471 100783015 100789381(NES)
PVU: 
PHAVU_002G219100g PHAVU_002G219300g PHAVU_006G195600g PHAVU_006G195700g
VRA: 
106765590 106766355 106766356 106766373 106766374 106768047 106774503 106774972
VAR: 
108326386 108338184 108338349 108342452
CCAJ: 
109814060 109814089 109817871 109817878
MTR: 
MTR_0927s0010 MTR_2g010960 MTR_3g052120 MTR_3g063120 MTR_3g063140 MTR_3g063160 MTR_3g063170 MTR_3g465090 MTR_4g092010 MTR_4g092020 MTR_6g064980 MTR_6g065040
CAM: 
101494917 101495572 101503644 101505365 101515140
ADU: 
107468546 107468547 107468751 107480611
AIP: 
107622334 107622335 107622336 107622340 107623232
LJA: 
Lj0g3v0198989.1(Lj0g3v0198989.1) Lj0g3v0198989.2(Lj0g3v0198989.2) Lj0g3v0198989.3(Lj0g3v0198989.3) Lj0g3v0306569.1(Lj0g3v0306569.1) Lj6g3v2135290.1(Lj6g3v2135290.1)
LANG: 
109334775
FVE: 
101298852 101299453
PPER: 
18780456
PMUM: 
103324595 103343969 103343970 103344406 107882105
MDM: 
103427814(NES) 103434640 103446596 103446597 103456160 108170734
PXB: 
103958115 103958297 108866779
ZJU: 
107421470 107421878
CSV: 
101204552 101204794
CMO: 
103485748 103485753 103489227
RCU: 
8259987(RcSeTPS4) 8267425(RcSeTPS13)
JCU: 
105629808 105629819 105629820 105649410 105649411
POP: 
POPTR_0004s02970g(POPTRDRAFT_855580) POPTR_0004s02990g(POPTRDRAFT_856834) POPTR_0011s03490g
VVI: 
100244313 100248531 100267150 100852527 100852561 100852776 100853562 100853639 100853679 100854717 100854729 100854809 104878270 104878369
SLY: 
101244812(TPS37) 101245403(TPS39)
SPEN: 
107019618 107032586
SOT: 
102580873 102592813
INI: 
109163834 109167275 109167276 109167277 109167278 109167279
SIND: 
105156792 105175396 105175469 105175470
BVG: 
104883052 104901069 104901071
NNU: 
104591086 104591099
OSA: 
4328124(LIS)
DOSA: 
Os02t0121700-01(Os02g0121700) Os10t0489500-00(Os10g0489500)
OBR: 
102705662 102711045
BDI: 
100823591
ATS: 
F775_10369 F775_13412 F775_16851 F775_19146 F775_19147 F775_20658 F775_27744 F775_31422
SBI: 
8085232 8085234
ZMA: 
103654934 103654935 732758(TPS2) 732759(TPS3)
SITA: 
101779235 101783156 105914065
MUS: 
103973658 103998578
 » show all
Taxonomy
Reference
1  [PMID:7864636]
  Authors
Pichersky E, Lewinsohn E, Croteau R.
  Title
Purification and characterization of S-linalool synthase, an enzyme involved in the production of floral scent in Clarkia breweri.
  Journal
Arch. Biochem. Biophys. 316 (1995) 803-7.
Reference
2  [PMID:11532177]
  Authors
Lucker J, Bouwmeester HJ, Schwab W, Blaas J, van der Plas LH, Verhoeven HA.
  Title
Expression of Clarkia S-linalool synthase in transgenic petunia plants results in the accumulation of S-linalyl-beta-D-glucopyranoside.
  Journal
Plant. J. 27 (2001) 315-24.
Reference
3  [PMID:8768373]
  Authors
Dudareva N, Cseke L, Blanc VM, Pichersky E.
  Title
Evolution of floral scent in Clarkia: novel patterns of S-linalool synthase gene expression in the C. breweri flower.
  Journal
Plant. Cell. 8 (1996) 1137-48.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
160477-81-6
KEGG   REACTION: R07631Help
Entry
R07631                      Reaction                               

Name
geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming]
Definition
Geranyl diphosphate + H2O <=> (+)-Linalool + Diphosphate
Equation
Reaction class
C00341_C11389
Enzyme
Pathway
Monoterpenoid biosynthesis
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K15086  
(3S)-linalool synthase [EC:4.2.3.25]
DBGET integrated database retrieval system