KEGG   ORTHOLOGY: K15097Help
Entry
K15097                      KO                                     

Name
E4.2.3.10
Definition
(-)-endo-fenchol synthase [EC:4.2.3.10]
Pathway
Monoterpenoid biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K15097  E4.2.3.10; (-)-endo-fenchol synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.10  (-)-endo-fenchol synthase
     K15097  E4.2.3.10; (-)-endo-fenchol synthase
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
AG: 
TaxonomyKoalaUniProt
Reference
  Authors
Iijima Y, Davidovich-Rikanati R, Fridman E, Gang DR, Bar E, Lewinsohn E, Pichersky E
  Title
The biochemical and molecular basis for the divergent patterns in the biosynthesis of terpenes and phenylpropenes in the peltate glands of three cultivars of basil.
  Journal
Plant Physiol 136:3724-36 (2004)
DOI:10.1104/pp.104.051318
  Sequence

KEGG   ENZYME: 4.2.3.10Help
Entry
EC 4.2.3.10                 Enzyme                                 

Name
(-)-endo-fenchol synthase;
(-)-endo-fenchol cyclase;
geranyl pyrophosphate:(-)-endo-fenchol cyclase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]
Reaction(IUBMB)
geranyl diphosphate + H2O = (-)-endo-fenchol + diphosphate [RN:R02004]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
(-)-endo-fenchol [CPD:C02344];
diphosphate [CPD:C00013]
Comment
(3R)-Linalyl diphosphate is an intermediate in the reaction
History
EC 4.2.3.10 created 1992 as EC 4.6.1.8, transferred 2000 to EC 4.2.3.10
Pathway
Monoterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K15097  
(-)-endo-fenchol synthase
Reference
1  [PMID:2919880]
  Authors
Croteau R, Miyazaki JH, Wheeler CJ.
  Title
Monoterpene biosynthesis: mechanistic evaluation of the geranyl pyrophosphate:(-)-endo-fenchol cyclase from fennel (Foeniculum vulgare).
  Journal
Arch. Biochem. Biophys. 269 (1989) 507-16.
Reference
2  [PMID:3170591]
  Authors
Croteau R, Satterwhite DM, Wheeler CJ, Felton NM.
  Title
Biosynthesis of monoterpenes. Stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (-)-endo-fenchol.
  Journal
J. Biol. Chem. 263 (1988) 15449-53.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
117758-41-5
KEGG   REACTION: R02004Help
Entry
R02004                      Reaction                               

Name
geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]
Definition
Geranyl diphosphate + H2O <=> (-)-endo-Fenchol + Diphosphate
Equation
Reaction class
C00341_C02344
Enzyme
Pathway
Monoterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K15097  
(-)-endo-fenchol synthase [EC:4.2.3.10]
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