| Entry |
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| Name |
zeta-carotene isomerase;
Z-ISO;
15-cis-zeta-carotene isomerase
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| Class |
Isomerases;
cis-trans-Isomerases;
cis-trans Isomerases (only sub-subclass identified to date)
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| Sysname |
9,15,9'-tricis-zeta-carotene cis-trans-isomerase
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| Reaction(IUBMB) |
9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene [RN: R09655]
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| Reaction(KEGG) |
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| Substrate |
9,15,9'-tricis-zeta-carotene [CPD: C19764]
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| Product |
9,9'-dicis-zeta-carotene [CPD: C15857]
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| Comment |
The enzyme catalyses the cis-trans isomerization of the 15-15' carbon-carbon double bond in 9,15,9'-tricis-zeta-carotene, which is required for biosynthesis of all plant carotenoids. Requires heme b.
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| History |
EC 5.2.1.12 created 2011
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| Pathway |
| Carotenoid biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Orthology |
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| Genes |
ATH: | | ALY: | | CRB: | | EUS: | | BRP: | | BNA: | | THJ: | | CIT: | | CIC: | | TCC: | | GRA: | | GHI: | | EGR: | | GMX: | | PVU: | | VRA: | | VAR: | | CCAJ: | | MTR: | | CAM: | | ADU: | | AIP: | | LJA: | | LANG: | | FVE: | | PPER: | | PMUM: | | MDM: | | PXB: | | ZJU: | | CSV: | | CMO: | | RCU: | | JCU: | | POP: | | VVI: | | SLY: | | SPEN: | | SOT: | | INI: | | SIND: | | BVG: | | NNU: | | OSA: | | DOSA: | | OBR: | | BDI: | | ATS: | | ZMA: | | SITA: | | PDA: | | EGU: | | MUS: | | ATR: | | SMO: | | PPP: | | CRE: | | CSL: | | CVR: | | APRO: | | GSL: | | FCY: | | AAF: | | EHX: | | GTT: | |
» show all
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| Reference |
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| Authors |
Chen Y, Li F, Wurtzel ET |
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| Title |
Isolation and characterization of the Z-ISO gene encoding a missing component of carotenoid biosynthesis in plants. |
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| Journal |
Plant. Physiol. 153 (2010) 66-79. |
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| Sequence |
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| Reference |
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| Authors |
Li F, Murillo C, Wurtzel ET |
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| Title |
Maize Y9 encodes a product essential for 15-cis-zeta-carotene isomerization. |
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| Journal |
Plant. Physiol. 144 (2007) 1181-9. |
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| Sequence |
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| Reference |
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| Authors |
Beltran J, Kloss B, Hosler JP, Geng J, Liu A, Modi A, Dawson JH, Sono M, Shumskaya M, Ampomah-Dwamena C, Love JD, Wurtzel ET |
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| Title |
Control of carotenoid biosynthesis through a heme-based cis-trans isomerase. |
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| Journal |
Nat. Chem. Biol. 11 (2015) 598-605. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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