| Entry |
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| Name |
(S)-beta-macrocarpene synthase;
TPS6;
TPS11;
(S)-beta-macrocarpene lyase (decyclizing)
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| Class |
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
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| Sysname |
(S)-beta-macrocarpene lyase (ring-opening)
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| Reaction(IUBMB) |
(S)-beta-bisabolene = (S)-beta-macrocarpene [RN: R09625]
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| Reaction(KEGG) |
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| Substrate |
(S)-beta-bisabolene [CPD: C19751]
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| Product |
(S)-beta-macrocarpene [CPD: C19752]
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| Comment |
The synthesis of (S)-beta-macrocarpene from (2E,6E)-farnesyl diphosphate proceeds in two steps. The first step is the cyclization to (S)-beta-bisabolene (cf. EC 4.2.3.55, (S)-beta-bisabolene synthase). The second step is the isomerization to (S)-beta-macrocarpene.
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| History |
EC 5.5.1.17 created 2011
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| Pathway |
| Sesquiterpenoid and triterpenoid biosynthesis | | Biosynthesis of secondary metabolites |
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| Orthology |
| (S)-beta-macrocarpene synthase |
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| Genes |
 |
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| Reference |
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| Authors |
Kollner TG, Schnee C, Li S, Svatos A, Schneider B, Gershenzon J, Degenhardt J |
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| Title |
Protonation of a neutral (S)-beta-bisabolene intermediate is involved in (S)-beta-macrocarpene formation by the maize sesquiterpene synthases TPS6 and TPS11. |
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| Journal |
J. Biol. Chem. 283 (2008) 20779-88. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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