KEGG   ORTHOLOGY: K15982Help
Entry
K15982                      KO                                     

Name
kshA
Definition
3-ketosteroid 9alpha-monooxygenase subunit A [EC:1.14.13.142]
Pathway
Steroid degradation
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K15982  kshA; 3-ketosteroid 9alpha-monooxygenase subunit A
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.142  3-ketosteroid 9alpha-monooxygenase
     K15982  kshA; 3-ketosteroid 9alpha-monooxygenase subunit A
BRITE hierarchy
Other DBs
RN: 
COG: 
Genes
PRE: 
PPUT: 
PPUN: 
PP4_26740(kshA)
PVR: 
PBM: 
PPUU: 
PKC: 
PKB_4313(ksha1) PKB_4338(ksha3)
PFZ: 
PPSY: 
SPL: 
SHL: 
Shal_2093
COLW: 
A3Q33_18555
PHA: 
PSHAa2137
PTN: 
PTRA_a2590(kshA)
ZAL: 
AZF00_12085 AZF00_12900 AZF00_15655
HJA: 
BST95_04800
GPB: 
HDN1F_02750
RIN: 
ACS15_4367 ACS15_4387
REU: 
Reut_A1576
REH: 
H16_B0672(hcaE)
CNC: 
CNE_2c06190(kshA) CNE_BB1p00120(kshA)
CTI: 
RALTA_B0514
CBW: 
RR42_s2318
BUR: 
Bcep18194_B1448
BCJ: 
BCAM1620
BCEN: 
DM39_3466 DM39_6233(kshA)
BCEO: 
I35_5481
BCT: 
GEM_4096 GEM_4102
BCED: 
DM42_6338(kshA)
BCEP: 
APZ15_31110
BPYR: 
ABD05_27770
BCON: 
NL30_04080
BDF: 
WI26_21190 WI26_21235
BTEI: 
WS51_05735
BPSL: 
WS57_06000 WS57_06445
BMEC: 
WJ16_26825
BFN: 
OI25_4592
PVE: 
UC34_06920
CTT: 
CtCNB1_1306
CTES: 
O987_07520
AZI: 
AzCIB_1457
THU: 
AC731_008185
NAR: 
Saro_3666
NPP: 
PP1Y_Mpl3383
SPHK: 
SKP52_00800
SWI: 
Swit_3307
SPHM: 
G432_11540 G432_14050 G432_14385
SSAN: 
NX02_17130
SPHB: 
EP837_02947 EP837_03216 EP837_03246 EP837_03584
MTU: 
Rv3526(kshA)
MTV: 
RVBD_3526
MRA: 
MRA_3565
MTF: 
TBFG_13559
MTB: 
TBMG_03565
MTK: 
TBSG_03592
MTZ: 
TBXG_003541
MTG: 
MRGA327_21785
MTE: 
CCDC5079_3267
MTUR: 
CFBS_3742
MTL: 
CCDC5180_3219
MTO: 
MTCTRI2_3590
MTD: 
UDA_3526
MTN: 
ERDMAN_3866
MTJ: 
J112_18980
MTUB: 
MT7199_3587
MTUC: 
J113_24655
MTUE: 
J114_18850
MTX: 
M943_18130
MTUH: 
I917_24735
MTUL: 
TBHG_03466
MTUT: 
HKBT1_3727
MTUU: 
HKBT2_3736
MTQ: 
HKBS1_3739
MBO: 
Mb3556
MBB: 
BCG_3590
MBT: 
JTY_3591
MBM: 
BCGMEX_3588
MBK: 
K60_036610
MBX: 
BCGT_3389
MBZ: 
LH58_19095
MAF: 
MAF_35380
MCE: 
MCAN_35371
MCQ: 
BN44_110015
MCV: 
BN43_90021
MCX: 
BN42_90018
MCZ: 
BN45_100018
MMIC: 
RN08_3901
MPA: 
MAP_1434
MAO: 
MAP4_2411 MAP4_3328
MAVI: 
RC58_11985 RC58_16505
MAVU: 
RE97_11995 RE97_16540
MAV: 
MAV_0633 MAV_3037
MAVD: 
NF84_02865 NF84_13600
MAVR: 
LA63_02930 LA63_13760
MAVA: 
LA64_02940 LA64_13755
MIT: 
OCO_05430 OCO_28760
MIA: 
OCU_05470 OCU_28620
MIE: 
LG41_02730 LG41_13600
MIR: 
OCQ_05580 OCQ_27340
MID: 
MIP_00998 MIP_03683
MYO: 
OEM_05500 OEM_27250
MSM: 
MSMEG_2870 MSMEG_5925
MSG: 
MSMEI_2796 MSMEI_5766
MSB: 
LJ00_14275 LJ00_29300
MSN: 
LI99_14280 LI99_29305
MSH: 
LI98_14285 LI98_29310
MSA: 
Mycsm_04176 Mycsm_05761
MUL: 
MUL_4089
MVA: 
Mvan_2869 Mvan_5225
MGI: 
Mflv_1533 Mflv_4566
MSP: 
Mspyr1_09170 Mspyr1_39660
MAB: 
MAB_0080c MAB_4173
MABB: 
MASS_0082 MASS_3633 MASS_4172
MMV: 
MYCMA_0050 MYCMA_1991 MYCMA_2322
MAY: 
LA62_00405 LA62_18430 LA62_21215
MABO: 
NF82_00400 NF82_18165 NF82_20905
MABL: 
MMASJCM_0083 MMASJCM_3622 MMASJCM_4259
MAZ: 
LA61_00410 LA61_18330 LA61_21110
MAK: 
LH56_03320 LH56_06085
MYS: 
NF92_03375 NF92_06120 NF92_22610
MYC: 
NF90_03375 NF90_06120 NF90_22620
MCHE: 
BB28_00390 BB28_18525 BB28_21490
MIZ: 
BAB75_00690 BAB75_20635 BAB75_23955
MMC: 
Mmcs_0296 Mmcs_4640
MKM: 
Mkms_0306 Mkms_4728
MJL: 
Mjls_0287 Mjls_5022
MJD: 
JDM601_3668 JDM601_4270
MMI: 
MMAR_5015
MMAE: 
MMARE11_48250
MRH: 
MycrhN_2306 MycrhN_3476 MycrhN_4240
MMM: 
W7S_02660 W7S_13945
MCB: 
Mycch_1569 Mycch_4570 Mycch_4587
MLI: 
MULP_05266
MKN: 
MKAN_11805
MKS: 
LG40_11650
MKI: 
LH54_11795
MNE: 
D174_08275 D174_24200
MYV: 
G155_04100 G155_04755 G155_07820 G155_09255 G155_24375
MYE: 
AB431_00270 AB431_15090 AB431_26315
MGO: 
AFA91_11130
MFT: 
XA26_07730 XA26_09130 XA26_15580 XA26_18510 XA26_49330
MHAD: 
B586_04665
MPHL: 
MPHLCCUG_00577(kshA_1) MPHLCCUG_00595(kshA_2) MPHLCCUG_02604(kshA_6)
MVQ: 
MYVA_1646 MYVA_5096(kshA) MYVA_5113
ASD: 
AS9A_0922(kshA)
NFA: 
NFA_22480 NFA_33560 NFA_33740 NFA_4750
NFR: 
ERS450000_00679(kshA_1) ERS450000_00697(kshA_2) ERS450000_01849(kshA_3) ERS450000_03761(kshA_5)
NCY: 
NOCYR_0504 NOCYR_2420(ksh) NOCYR_2512
NBR: 
O3I_002680
NNO: 
NONO_c05000 NONO_c44660 NONO_c58790(kshA)
NSL: 
BOX37_02190 BOX37_11865
NSR: 
NS506_01263(kshA) NS506_04325 NS506_06286 NS506_06781
RHA: 
RHA1_ro02490 RHA1_ro04538(kshA) RHA1_ro05811 RHA1_ro09003(kshA)
RER: 
RER_07540(kshA) RER_13800(kshA) RER_51130(kshA)
REY: 
O5Y_03665 O5Y_04070 O5Y_06500 O5Y_18435 O5Y_24235
REB: 
XU06_03905 XU06_04315 XU06_06760 XU06_24655
ROP: 
ROP_44530(kshA) ROP_58730(kshA2)
ROA: 
Pd630_LPD00990 Pd630_LPD02435 Pd630_LPD06716
REQ: 
REQ_06790 REQ_08980(kshA) REQ_10570 REQ_15470 REQ_40110 REQ_42740 REQ_43730 REQ_45190
RPY: 
Y013_19020 Y013_19240
RAV: 
AAT18_03960 AAT18_21250 AAT18_21975
RHW: 
BFN03_15205
GBR: 
Gbro_0919
GPO: 
GPOL_c41100(kshA1) GPOL_c41200(kshA2)
GOR: 
KTR9_0819(kshA)
GOQ: 
ACH46_03115 ACH46_03235
GTA: 
BCM27_04760 BCM27_05105
TPR: 
Tpau_3849
DTM: 
BJL86_0697
SALU: 
DC74_7441
SALL: 
SAZ_38410
SVT: 
SVTN_35870
ARL: 
AFL94_17000 AFL94_17140
ARY: 
ATC04_01245 ATC04_01315
NCA: 
Noca_2518
NDK: 
I601_0574(kshA_1) I601_3444(kshA_2)
PSIM: 
KR76_14170 KR76_18045 KR76_27070
TCU: 
Tcur_3509
AMD: 
AMED_2519
AMN: 
RAM_12805
AMM: 
AMES_2491
AMZ: 
B737_2492
AOI: 
AORI_2481
AJA: 
AJAP_26420(kshA)
AMQ: 
AMETH_4841
ALU: 
BB31_28905
KAL: 
KALB_5125
KPHY: 
AOZ06_42845
LED: 
BBK82_38955
ALL: 
CRK57807 CRK59604
STP: 
Strop_2672
SAQ: 
Sare_2880
AMS: 
AMIS_19170
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Capyk JK, D'Angelo I, Strynadka NC, Eltis LD
  Title
Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis.
  Journal
J Biol Chem 284:9937-46 (2009)
DOI:10.1074/jbc.M900719200
  Sequence
[mtu:Rv3526]
KEGG   ORTHOLOGY: K15983Help
Entry
K15983                      KO                                     

Name
kshB
Definition
3-ketosteroid 9alpha-monooxygenase subunit B [EC:1.14.13.142]
Pathway
Steroid degradation
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K15983  kshB; 3-ketosteroid 9alpha-monooxygenase subunit B
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.142  3-ketosteroid 9alpha-monooxygenase
     K15983  kshB; 3-ketosteroid 9alpha-monooxygenase subunit B
BRITE hierarchy
Other DBs
RN: 
COG: 
Genes
PSG: 
PRE: 
PPUT: 
PPUN: 
PP4_27180(kshB)
PVR: 
PSC: 
PSH: 
PSTU: 
PBM: 
PPUU: 
PKC: 
PKB_4319(kshB)
PPSY: 
AOC04_07880
SPL: 
Spea_2130
SHL: 
Shal_2102
COLW: 
A3Q33_18810
PHA: 
PSHAa0878
PTN: 
PTRA_a1005(kshB)
AQL: 
BXU06_10045
RIN: 
ACS15_4390
REU: 
Reut_A1546
REH: 
H16_B0643(h16_B0643)
CNC: 
CNE_2c05890
CTI: 
RALTA_B0492
CBW: 
RR42_m2029 RR42_s2340
CCUP: 
BKK81_32785
BUR: 
Bcep18194_B1416
BCJ: 
BCAM1644
BCEN: 
DM39_6206(hmp)
BCEO: 
I35_5504
BCT: 
GEM_4012
BCED: 
DM42_6314(hmp)
BCEP: 
APZ15_30835
BPYR: 
ABD05_27655
BCON: 
NL30_03965
BDF: 
WI26_21355
BTEI: 
WS51_05845
BPSL: 
WS57_05865
BMEC: 
WJ16_26955
BFN: 
OI25_4611
PVE: 
UC34_06905
CTT: 
CtCNB1_1359
CTES: 
O987_07770
AZI: 
AzCIB_1462
THU: 
AC731_008070
SYB: 
TZ53_23495
MTU: 
Rv3571(kshB)
MTV: 
RVBD_3571
MTC: 
MT3676
MRA: 
MRA_3610(hmp)
MTF: 
TBFG_13604
MTB: 
TBMG_03610
MTK: 
TBSG_03637
MTZ: 
TBXG_003585
MTG: 
MRGA327_22045
MTE: 
CCDC5079_3312
MTUR: 
CFBS_3788(hmp)
MTL: 
CCDC5180_3264
MTO: 
MTCTRI2_3636(hmp)
MTD: 
UDA_3571(hmp)
MTN: 
ERDMAN_3918(hmp)
MTJ: 
J112_19230
MTUB: 
MT7199_3634
MTUE: 
J114_19100
MTX: 
M943_18365
MTUH: 
I917_25090
MTUL: 
TBHG_03512
MTUT: 
HKBT1_3773(hmp)
MTUU: 
HKBT2_3782(hmp)
MTQ: 
HKBS1_3785(hmp)
MBO: 
Mb3602(hmp)
MBB: 
BCG_3636(hmp)
MBT: 
JTY_3637(hmp)
MBM: 
BCGMEX_3634(hmp)
MBK: 
K60_037090
MBX: 
BCGT_3438
MBZ: 
LH58_19340
MAF: 
MAF_35840(hmp)
MCE: 
MCAN_35841(hmp)
MCQ: 
BN44_110066(hmp)
MCV: 
BN43_90072(hmp)
MCX: 
BN42_90069(hmp)
MCZ: 
BN45_100085(hmp)
MMIC: 
RN08_3948
MPA: 
MAP_0496c
MAO: 
MAP4_3371
MAVI: 
RC58_16720
MAVU: 
RE97_16755
MAV: 
MAV_0590
MAVD: 
NF84_02650
MAVR: 
LA63_02715
MAVA: 
LA64_02725
MIT: 
OCO_04980 OCO_28550
MIA: 
OCU_05020 OCU_28420
MIE: 
LG41_02510 LG41_13500
MIR: 
OCQ_05140 OCQ_27130
MID: 
MIP_00939 MIP_03722
MYO: 
OEM_05040 OEM_27010
MSM: 
MSMEG_2893 MSMEG_6039
MSG: 
MSMEI_2819(hmp) MSMEI_5878(hmp)
MSB: 
LJ00_14390 LJ00_29855
MSN: 
LI99_14395 LI99_29860
MSH: 
LI98_14400 LI98_29865
MSA: 
Mycsm_04157 Mycsm_05841
MUL: 
MUL_4142(hmp)
MVA: 
Mvan_2893 Mvan_5309
MGI: 
Mflv_1462
MSP: 
Mspyr1_47050
MAB: 
MAB_0583c
MABB: 
MASS_0552 MASS_2901 MASS_3931
MMV: 
MYCMA_12635 MYCMA_1638 MYCMA_2177
MAY: 
LA62_02950 LA62_15065 LA62_19910
MABO: 
NF82_02945 NF82_14835 NF82_19640
MABL: 
MMASJCM_0572 MMASJCM_2965 MMASJCM_3937
MAZ: 
LA61_02865 LA61_14965 LA61_19810
MAK: 
LH56_04580 LH56_09285 LH56_19700
MYS: 
NF92_04640 NF92_09430 NF92_20210
MYC: 
NF90_04640 NF90_09430 NF90_20215
MCHE: 
BB28_02780 BB28_14925 BB28_20180 BB28_22430
MIZ: 
BAB75_03530 BAB75_15975 BAB75_22365
MMC: 
Mmcs_0319 Mmcs_4710
MKM: 
Mkms_0329 Mkms_4796
MJL: 
Mjls_0310 Mjls_4115 Mjls_5095
MJD: 
JDM601_3855(hmp) JDM601_4248(hmp)
MMI: 
MMAR_5066(hmp)
MMAE: 
MMARE11_48810(hmp)
MRH: 
MycrhN_2242
MMM: 
W7S_02435 W7S_13835
MCB: 
Mycch_1592 Mycch_4676
MLI: 
MULP_05324(hmp)
MKN: 
MKAN_12135
MKS: 
LG40_11980
MKI: 
LH54_12125
MNE: 
D174_24715
MYV: 
G155_04260 G155_26490
MYE: 
AB431_15185 AB431_26560
MGO: 
AFA91_10575
MFT: 
XA26_08090 XA26_53640
MHAD: 
B586_04440
MPHL: 
MPHLCCUG_00490(hmp_1) MPHLCCUG_02629(hmp_3)
MVQ: 
MYVA_1666(kshB) MYVA_5219
ASD: 
AS9A_0920
NFA: 
NFA_50680
NFR: 
ERS450000_04823(hmp_4) ERS450000_05814(hmp_5)
NCY: 
NOCYR_1557 NOCYR_2402 NOCYR_4851
NBR: 
O3I_006885 O3I_038125
NNO: 
NONO_c36770 NONO_c51650(kshB1) NONO_c58770(kshB2) NONO_c68680
NSL: 
BOX37_11740 BOX37_15565 BOX37_27470 BOX37_29000
NSR: 
NS506_06779 NS506_07836
RHA: 
RHA1_ro05833(kshB) RHA1_ro06056 RHA1_ro09002(kshB)
RER: 
RER_17750(kshB)
REY: 
O5Y_08515
REB: 
XU06_08755
ROP: 
ROP_58950(kshB) ROP_61150(kshB)
ROA: 
Pd630_LPD02458 Pd630_LPD02696
REQ: 
REQ_36320
RPY: 
Y013_08850 Y013_19255
RHB: 
NY08_2915
RAV: 
AAT18_18675
RFA: 
A3L23_01127(hmp_2)
RHW: 
BFN03_03160
GBR: 
Gbro_3782
GPO: 
GPOL_c00590 GPOL_c36520 GPOL_c41340
GOR: 
KTR9_3740(kshB) KTR9_5394
GOQ: 
ACH46_15935
GTA: 
BCM27_00520 BCM27_04885 BCM27_19590 BCM27_22040
TPR: 
Tpau_3851
SRT: 
Srot_0411
DTM: 
BJL86_0694
SALU: 
DC74_7443
SALL: 
SAZ_38420
SVT: 
SVTN_35880
SLD: 
T261_3457
SRW: 
TUE45_04033(hmp_3)
SPLU: 
LK06_026215
LXY: 
O159_24870
ARL: 
AFL94_16990
ARY: 
ATC04_01230
JTE: 
ASJ30_13640
NCA: 
Noca_2520
NDK: 
I601_3442(hmp_2)
PSIM: 
KR76_14160 KR76_27080
TCU: 
Tcur_3520
SVI: 
Svir_18640
AMD: 
AMED_2517
AMN: 
RAM_12795
AMM: 
AMES_2489
AMZ: 
B737_2490
AOI: 
AORI_2479
AJA: 
AJAP_26430(kshB)
AMQ: 
AMETH_4843
ALU: 
BB31_28915
KAL: 
KALB_5127
KPHY: 
AOZ06_42855
LED: 
BBK82_38965
ALL: 
CRK57817 CRK59606
STP: 
Strop_2674
SAQ: 
Sare_2882
AMS: 
AMIS_19150
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Capyk JK, D'Angelo I, Strynadka NC, Eltis LD
  Title
Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis.
  Journal
J Biol Chem 284:9937-46 (2009)
DOI:10.1074/jbc.M900719200
  Sequence
[mtu:Rv3571]
KEGG   ENZYME: 1.14.13.142Help
Entry
EC 1.14.13.142              Enzyme                                 

Name
3-ketosteroid 9alpha-monooxygenase;
KshAB;
3-ketosteroid 9alpha-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
androsta-1,4-diene-3,17-dione,NADH:oxygen oxidoreductase (9alpha-hydroxylating)
Reaction(IUBMB)
androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O [RN:R09860]
Reaction(KEGG)
Substrate
androsta-1,4-diene-3,17-dione [CPD:C20144];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
9alpha-hydroxyandrosta-1,4-diene-3,17-dione [CPD:C14909];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis. It is a two-component system consisting of a terminal oxygenase (KshA) and a ferredoxin reductase (KshB). The oxygenase contains a Rieske-type iron-sulfur center and non-heme iron. The reductase component is a flavoprotein containing an NAD-binding domain and a plant-type iron-sulfur cluster. The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione.
History
EC 1.14.13.142 created 2012
Pathway
Steroid degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K15982  
3-ketosteroid 9alpha-monooxygenase subunit A
K15983  
3-ketosteroid 9alpha-monooxygenase subunit B
Genes
PSG: 
PRE: 
PPUT: 
PPUN: 
PP4_26740(kshA) PP4_27180(kshB)
PVR: 
PSC: 
PSH: 
PSTU: 
PBM: 
PPUU: 
PKC: 
PKB_4313(ksha1) PKB_4319(kshB) PKB_4338(ksha3)
PFZ: 
AV641_09605
PPSY: 
AOC04_06430 AOC04_07880
SPL: 
Spea_2121 Spea_2130
SHL: 
Shal_2093 Shal_2102
COLW: 
A3Q33_18555 A3Q33_18810
PHA: 
PSHAa0878 PSHAa2137
PTN: 
PTRA_a1005(kshB) PTRA_a2590(kshA)
ZAL: 
AZF00_12085 AZF00_12900 AZF00_15655
HJA: 
BST95_04800
GPB: 
HDN1F_02750
AQL: 
BXU06_10045
RIN: 
ACS15_4367 ACS15_4387 ACS15_4390
REU: 
Reut_A1546 Reut_A1576
REH: 
H16_B0643(h16_B0643) H16_B0672(hcaE)
CNC: 
CNE_2c05890 CNE_2c06190(kshA) CNE_BB1p00120(kshA)
CTI: 
RALTA_B0492 RALTA_B0514
CBW: 
RR42_m2029 RR42_s2318 RR42_s2340
CCUP: 
BKK81_32785
BUR: 
Bcep18194_B1416 Bcep18194_B1448
BCJ: 
BCAM1620 BCAM1644
BCEN: 
DM39_3466 DM39_6206(hmp) DM39_6233(kshA)
BCEO: 
I35_5481 I35_5504
BCT: 
GEM_4012 GEM_4096 GEM_4102
BCED: 
DM42_6314(hmp) DM42_6338(kshA)
BCEP: 
APZ15_30835 APZ15_31110
BPYR: 
ABD05_27655 ABD05_27770
BCON: 
NL30_03965 NL30_04080
BDF: 
WI26_21190 WI26_21235 WI26_21355
BTEI: 
WS51_05735 WS51_05845
BPSL: 
WS57_05865 WS57_06000 WS57_06445
BMEC: 
WJ16_26825 WJ16_26955
BFN: 
OI25_4592 OI25_4611
PVE: 
UC34_06905 UC34_06920
CTT: 
CtCNB1_1306 CtCNB1_1359
CTES: 
O987_07520 O987_07770
AZI: 
AzCIB_1457 AzCIB_1462
THU: 
AC731_008070 AC731_008185
NAR: 
Saro_3666
NPP: 
PP1Y_Mpl3383
SPHK: 
SKP52_00800
SWI: 
Swit_3307
SPHM: 
G432_11540 G432_14050 G432_14385
SSAN: 
NX02_17130
SYB: 
TZ53_23495
SPHB: 
EP837_02947 EP837_03216 EP837_03246 EP837_03584
MTU: 
Rv3526(kshA) Rv3571(kshB)
MTV: 
RVBD_3526 RVBD_3571
MTC: 
MT3676
MRA: 
MRA_3565 MRA_3610(hmp)
MTF: 
TBFG_13559 TBFG_13604
MTB: 
TBMG_03565 TBMG_03610
MTK: 
TBSG_03592 TBSG_03637
MTZ: 
TBXG_003541 TBXG_003585
MTG: 
MRGA327_21785 MRGA327_22045
MTE: 
CCDC5079_3267 CCDC5079_3312
MTUR: 
CFBS_3742 CFBS_3788(hmp)
MTL: 
CCDC5180_3219 CCDC5180_3264
MTO: 
MTCTRI2_3590 MTCTRI2_3636(hmp)
MTD: 
UDA_3526 UDA_3571(hmp)
MTN: 
ERDMAN_3866 ERDMAN_3918(hmp)
MTJ: 
J112_18980 J112_19230
MTUB: 
MT7199_3587 MT7199_3634
MTUC: 
J113_24655
MTUE: 
J114_18850 J114_19100
MTX: 
M943_18130 M943_18365
MTUH: 
I917_24735 I917_25090
MTUL: 
TBHG_03466 TBHG_03512
MTUT: 
HKBT1_3727 HKBT1_3773(hmp)
MTUU: 
HKBT2_3736 HKBT2_3782(hmp)
MTQ: 
HKBS1_3739 HKBS1_3785(hmp)
MBO: 
Mb3556 Mb3602(hmp)
MBB: 
BCG_3590 BCG_3636(hmp)
MBT: 
JTY_3591 JTY_3637(hmp)
MBM: 
BCGMEX_3588 BCGMEX_3634(hmp)
MBK: 
K60_036610 K60_037090
MBX: 
BCGT_3389 BCGT_3438
MBZ: 
LH58_19095 LH58_19340
MAF: 
MAF_35380 MAF_35840(hmp)
MCE: 
MCAN_35371 MCAN_35841(hmp)
MCQ: 
BN44_110015 BN44_110066(hmp)
MCV: 
BN43_90021 BN43_90072(hmp)
MCX: 
BN42_90018 BN42_90069(hmp)
MCZ: 
BN45_100018 BN45_100085(hmp)
MMIC: 
RN08_3901 RN08_3948
MPA: 
MAP_0496c MAP_1434
MAO: 
MAP4_2411 MAP4_3328 MAP4_3371
MAVI: 
RC58_11985 RC58_16505 RC58_16720
MAVU: 
RE97_11995 RE97_16540 RE97_16755
MAV: 
MAV_0590 MAV_0633 MAV_3037
MAVD: 
NF84_02650 NF84_02865 NF84_13600
MAVR: 
LA63_02715 LA63_02930 LA63_13760
MAVA: 
LA64_02725 LA64_02940 LA64_13755
MIT: 
OCO_04980 OCO_05430 OCO_28550 OCO_28760
MIA: 
OCU_05020 OCU_05470 OCU_28420 OCU_28620
MIE: 
LG41_02510 LG41_02730 LG41_13500 LG41_13600
MIR: 
OCQ_05140 OCQ_05580 OCQ_27130 OCQ_27340
MID: 
MIP_00939 MIP_00998 MIP_03683 MIP_03722
MYO: 
OEM_05040 OEM_05500 OEM_27010 OEM_27250
MSM: 
MSMEG_2870 MSMEG_2893 MSMEG_5925 MSMEG_6039
MSG: 
MSMEI_2796 MSMEI_2819(hmp) MSMEI_5766 MSMEI_5878(hmp)
MSB: 
LJ00_14275 LJ00_14390 LJ00_29300 LJ00_29855
MSN: 
LI99_14280 LI99_14395 LI99_29305 LI99_29860
MSH: 
LI98_14285 LI98_14400 LI98_29310 LI98_29865
MSA: 
Mycsm_04157 Mycsm_04176 Mycsm_05761 Mycsm_05841
MUL: 
MUL_4089 MUL_4142(hmp)
MVA: 
Mvan_2869 Mvan_2893 Mvan_5225 Mvan_5309
MGI: 
Mflv_1462 Mflv_1533 Mflv_4566
MSP: 
Mspyr1_09170 Mspyr1_39660 Mspyr1_47050
MAB: 
MAB_0080c MAB_0583c MAB_4173
MABB: 
MASS_0082 MASS_0552 MASS_2901 MASS_3633 MASS_3931 MASS_4172
MMV: 
MYCMA_0050 MYCMA_12635 MYCMA_1638 MYCMA_1991 MYCMA_2177 MYCMA_2322
MAY: 
LA62_00405 LA62_02950 LA62_15065 LA62_18430 LA62_19910 LA62_21215
MABO: 
NF82_00400 NF82_02945 NF82_14835 NF82_18165 NF82_19640 NF82_20905
MABL: 
MMASJCM_0083 MMASJCM_0572 MMASJCM_2965 MMASJCM_3622 MMASJCM_3937 MMASJCM_4259
MAZ: 
LA61_00410 LA61_02865 LA61_14965 LA61_18330 LA61_19810 LA61_21110
MAK: 
LH56_03320 LH56_04580 LH56_06085 LH56_09285 LH56_19700
MYS: 
NF92_03375 NF92_04640 NF92_06120 NF92_09430 NF92_20210 NF92_22610
MYC: 
NF90_03375 NF90_04640 NF90_06120 NF90_09430 NF90_20215 NF90_22620
MCHE: 
BB28_00390 BB28_02780 BB28_14925 BB28_18525 BB28_20180 BB28_21490 BB28_22430
MIZ: 
BAB75_00690 BAB75_03530 BAB75_15975 BAB75_20635 BAB75_22365 BAB75_23955
MMC: 
Mmcs_0296 Mmcs_0319 Mmcs_4640 Mmcs_4710
MKM: 
Mkms_0306 Mkms_0329 Mkms_4728 Mkms_4796
MJL: 
Mjls_0287 Mjls_0310 Mjls_4115 Mjls_5022 Mjls_5095
MJD: 
JDM601_3668 JDM601_3855(hmp) JDM601_4248(hmp) JDM601_4270
MMI: 
MMAR_5015 MMAR_5066(hmp)
MMAE: 
MMARE11_48250 MMARE11_48810(hmp)
MRH: 
MycrhN_2242 MycrhN_2306 MycrhN_3476 MycrhN_4240
MMM: 
W7S_02435 W7S_02660 W7S_13835 W7S_13945
MCB: 
Mycch_1569 Mycch_1592 Mycch_4570 Mycch_4587 Mycch_4676
MLI: 
MULP_05266 MULP_05324(hmp)
MKN: 
MKAN_11805 MKAN_12135
MKS: 
LG40_11650 LG40_11980
MKI: 
LH54_11795 LH54_12125
MNE: 
D174_08275 D174_24200 D174_24715
MYV: 
G155_04100 G155_04260 G155_04755 G155_07820 G155_09255 G155_24375 G155_26490
MYE: 
AB431_00270 AB431_15090 AB431_15185 AB431_26315 AB431_26560
MGO: 
AFA91_10575 AFA91_11130
MFT: 
XA26_07730 XA26_08090 XA26_09130 XA26_15580 XA26_18510 XA26_49330 XA26_53640
MHAD: 
B586_04440 B586_04665
MPHL: 
MPHLCCUG_00490(hmp_1) MPHLCCUG_00577(kshA_1) MPHLCCUG_00595(kshA_2) MPHLCCUG_02604(kshA_6) MPHLCCUG_02629(hmp_3)
MVQ: 
MYVA_1646 MYVA_1666(kshB) MYVA_5096(kshA) MYVA_5113 MYVA_5219
ASD: 
AS9A_0920 AS9A_0922(kshA)
NFA: 
NFA_22480 NFA_33560 NFA_33740 NFA_4750 NFA_50680
NFR: 
ERS450000_00679(kshA_1) ERS450000_00697(kshA_2) ERS450000_01849(kshA_3) ERS450000_03761(kshA_5) ERS450000_04823(hmp_4) ERS450000_05814(hmp_5)
NCY: 
NOCYR_0504 NOCYR_1557 NOCYR_2402 NOCYR_2420(ksh) NOCYR_2512 NOCYR_4851
NBR: 
O3I_002680 O3I_006885 O3I_038125
NNO: 
NONO_c05000 NONO_c36770 NONO_c44660 NONO_c51650(kshB1) NONO_c58770(kshB2) NONO_c58790(kshA) NONO_c68680
NSL: 
BOX37_02190 BOX37_11740 BOX37_11865 BOX37_15565 BOX37_27470 BOX37_29000
NSR: 
NS506_01263(kshA) NS506_04325 NS506_06286 NS506_06779 NS506_06781 NS506_07836
RHA: 
RHA1_ro02490 RHA1_ro04538(kshA) RHA1_ro05811 RHA1_ro05833(kshB) RHA1_ro06056 RHA1_ro09002(kshB) RHA1_ro09003(kshA)
RER: 
RER_07540(kshA) RER_13800(kshA) RER_17750(kshB) RER_51130(kshA)
REY: 
O5Y_03665 O5Y_04070 O5Y_06500 O5Y_08515 O5Y_18435 O5Y_24235
REB: 
XU06_03905 XU06_04315 XU06_06760 XU06_08755 XU06_24655
ROP: 
ROP_44530(kshA) ROP_58730(kshA2) ROP_58950(kshB) ROP_61150(kshB)
ROA: 
Pd630_LPD00990 Pd630_LPD02435 Pd630_LPD02458 Pd630_LPD02696 Pd630_LPD06716
REQ: 
REQ_06790 REQ_08980(kshA) REQ_10570 REQ_15470 REQ_36320 REQ_40110 REQ_42740 REQ_43730 REQ_45190
RPY: 
Y013_08850 Y013_19020 Y013_19240 Y013_19255
RHB: 
NY08_2915
RAV: 
AAT18_03960 AAT18_18675 AAT18_21250 AAT18_21975
RFA: 
A3L23_01127(hmp_2)
RHW: 
BFN03_03160 BFN03_15205
GBR: 
Gbro_0919 Gbro_3782
GPO: 
GPOL_c00590 GPOL_c36520 GPOL_c41100(kshA1) GPOL_c41200(kshA2) GPOL_c41340
GOR: 
KTR9_0819(kshA) KTR9_3740(kshB) KTR9_5394
GOQ: 
ACH46_03115 ACH46_03235 ACH46_15935
GTA: 
BCM27_00520 BCM27_04760 BCM27_04885 BCM27_05105 BCM27_19590 BCM27_22040
TPR: 
Tpau_3849 Tpau_3851
SRT: 
Srot_0411
DTM: 
BJL86_0694 BJL86_0697
SALU: 
DC74_7441 DC74_7443
SALL: 
SAZ_38410 SAZ_38420
SVT: 
SVTN_35870 SVTN_35880
SLD: 
T261_3457
SRW: 
TUE45_04033(hmp_3)
SPLU: 
LK06_026215
LXY: 
O159_24870
ARL: 
AFL94_16990 AFL94_17000 AFL94_17140
ARY: 
ATC04_01230 ATC04_01245 ATC04_01315
JTE: 
ASJ30_13640
NCA: 
Noca_2518 Noca_2520
NDK: 
I601_0574(kshA_1) I601_3442(hmp_2) I601_3444(kshA_2)
PSIM: 
KR76_14160 KR76_14170 KR76_18045 KR76_27070 KR76_27080
TCU: 
Tcur_3509 Tcur_3520
SVI: 
Svir_18640
AMD: 
AMED_2517 AMED_2519
AMN: 
RAM_12795 RAM_12805
AMM: 
AMES_2489 AMES_2491
AMZ: 
B737_2490 B737_2492
AOI: 
AORI_2479 AORI_2481
AJA: 
AJAP_26420(kshA) AJAP_26430(kshB)
AMQ: 
AMETH_4841 AMETH_4843
ALU: 
BB31_28905 BB31_28915
KAL: 
KALB_5125 KALB_5127
KPHY: 
AOZ06_42845 AOZ06_42855
LED: 
BBK82_38955 BBK82_38965
ALL: 
CRK57807 CRK57817 CRK59604 CRK59606
STP: 
Strop_2672 Strop_2674
SAQ: 
Sare_2880 Sare_2882
AMS: 
AMIS_19150 AMIS_19170
 » show all
Taxonomy
Reference
1  [PMID:19561185]
  Authors
Petrusma M, Dijkhuizen L, van der Geize R
  Title
Rhodococcus rhodochrous DSM 43269 3-ketosteroid 9alpha-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate  specificity.
  Journal
Appl. Environ. Microbiol. 75 (2009) 5300-7.
Reference
2  [PMID:19234303]
  Authors
Capyk JK, D'Angelo I, Strynadka NC, Eltis LD
  Title
Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis.
  Journal
J. Biol. Chem. 284 (2009) 9937-46.
  Sequence
Reference
3  [PMID:21987574]
  Authors
Capyk JK, Casabon I, Gruninger R, Strynadka NC, Eltis LD
  Title
Activity of 3-ketosteroid 9alpha-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosis.
  Journal
J. Biol. Chem. 286 (2011) 40717-24.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
KEGG   REACTION: R09860Help
Entry
R09860                      Reaction                               

Name
androsta-1,4-diene-3,17-dione,NADH:oxygen oxidoreductase (9alpha-hydroxylating)
Definition
Androsta-1,4-diene-3,17-dione + NADH + H+ + Oxygen <=> 9alpha-Hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O
Equation
Comment
subsequently R09885
Reaction class
C00003_C00004
C14909_C20144
Enzyme
Pathway
Steroid degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K15982  
3-ketosteroid 9alpha-monooxygenase subunit A [EC:1.14.13.142]
K15983  
3-ketosteroid 9alpha-monooxygenase subunit B [EC:1.14.13.142]
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