KEGG   ORTHOLOGY: K16043Help
Entry
K16043                      KO                                     

Name
iolX
Definition
scyllo-inositol 2-dehydrogenase (NAD+) [EC:1.1.1.370]
Pathway
Inositol phosphate metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K16043  iolX; scyllo-inositol 2-dehydrogenase (NAD+)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.370  scyllo-inositol 2-dehydrogenase (NAD+)
     K16043  iolX; scyllo-inositol 2-dehydrogenase (NAD+)
BRITE hierarchy
Other DBs
RN: 
COG: 
Genes
BSU: 
BSU10850(yisS)
BSR: 
BSL: 
BSH: 
BSY: 
BSUT: 
BSUL: 
BSUS: 
BSS: 
BST: 
BSO: 
BSNT_07532(yisS)
BSN: 
BSn5_17320
BSQ: 
B657_10850(yisS)
BSX: 
C663_1108(yisS)
BSP: 
U712_05555
BLI: 
BL01338(yisS)
BLD: 
BLi01181(yisS)
BLH: 
BaLi_c13090(yisS)
BAQ: 
BACAU_1058(yisS)
BYA: 
BANAU_1002(yisS)
BAMB: 
BAPNAU_2698(yisS)
BMP: 
NG74_01107(idhA)
BAO: 
BAMF_1169(yisS)
BAZ: 
BAMTA208_05090(yisS)
BQL: 
LL3_01173(yisS)
BXH: 
BAXH7_01068(yisS)
BQY: 
MUS_1133(yisS)
BAMI: 
KSO_014360
BAMF: 
U722_05590
BAE: 
BATR1942_03040
BATR: 
TD68_02655
BCL: 
ABC0429
BJS: 
MY9_1184
BLE: 
BleG1_0261
GST: 
HW35_12510
BACB: 
OY17_08180
BACY: 
QF06_04360
BACL: 
BS34A_11990(yisS)
BALM: 
BsLM_1130
BGY: 
BGLY_1207
BGI: 
BGM20_20705
GKA: 
GK1897
GTK: 
GT3570_09015
GMC: 
GY4MC1_2179
GSE: 
GT50_18790
GSR: 
GS3922_07080
GEJ: 
A0V43_07035
NTR: 
B0W44_10810
DKU: 
Desku_1639
CAP: 
CLDAP_32890
MRE: 
K649_14090
SSM: 
Spirs_1664
SCC: 
Spico_0080
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Morinaga T, Ashida H, Yoshida K
  Title
Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis.
  Journal
Microbiology 156:1538-46 (2010)
DOI:10.1099/mic.0.037499-0
  Sequence
[bsu:BSU10850]
KEGG   ENZYME: 1.1.1.370Help
Entry
EC 1.1.1.370                Enzyme                                 

Name
scyllo-inositol 2-dehydrogenase (NAD+);
iolX (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
scyllo-inositol:NAD+ 2-oxidoreductase
Reaction(IUBMB)
scyllo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ [RN:R09953]
Reaction(KEGG)
Substrate
scyllo-inositol [CPD:C06153];
NAD+ [CPD:C00003]
Product
2,4,6/3,5-pentahydroxycyclohexanone [CPD:C00691];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, found in the bacterium Bacillus subtilis, has no activity with NADP+ [cf. EC 1.1.1.371, scyllo-inositol 2-dehydrogenase (NADP+)]. It is part of a scyllo-inositol degradation pathway leading to acetyl-CoA.
History
EC 1.1.1.370 created 2014
Pathway
Inositol phosphate metabolism
Microbial metabolism in diverse environments
Orthology
K16043  
scyllo-inositol 2-dehydrogenase (NAD+)
Genes
BSU: 
BSU10850(yisS)
BSR: 
BSL: 
BSH: 
BSY: 
BSUT: 
BSUL: 
BSUS: 
BSS: 
BST: 
BSO: 
BSNT_07532(yisS)
BSN: 
BSn5_17320
BSQ: 
B657_10850(yisS)
BSX: 
C663_1108(yisS)
BSP: 
U712_05555
BLI: 
BL01338(yisS)
BLD: 
BLi01181(yisS)
BLH: 
BaLi_c13090(yisS)
BAQ: 
BACAU_1058(yisS)
BYA: 
BANAU_1002(yisS)
BAMB: 
BAPNAU_2698(yisS)
BMP: 
NG74_01107(idhA)
BAO: 
BAMF_1169(yisS)
BAZ: 
BAMTA208_05090(yisS)
BQL: 
LL3_01173(yisS)
BXH: 
BAXH7_01068(yisS)
BQY: 
MUS_1133(yisS)
BAMI: 
KSO_014360
BAMF: 
U722_05590
BAE: 
BATR1942_03040
BATR: 
TD68_02655
BCL: 
ABC0429
BJS: 
MY9_1184
BLE: 
BleG1_0261
GST: 
HW35_12510
BACB: 
OY17_08180
BACY: 
QF06_04360
BACL: 
BS34A_11990(yisS)
BALM: 
BsLM_1130
BGY: 
BGLY_1207
BGI: 
BGM20_20705
GKA: 
GK1897
GTK: 
GT3570_09015
GMC: 
GY4MC1_2179
GSE: 
GT50_18790
GSR: 
GS3922_07080
GEJ: 
A0V43_07035
NTR: 
B0W44_10810
DKU: 
Desku_1639
CAP: 
CLDAP_32890
MRE: 
K649_14090
SSM: 
Spirs_1664
SCC: 
Spico_0080
 » show all
Taxonomy
Reference
1  [PMID:20133360]
  Authors
Morinaga T, Ashida H, Yoshida K.
  Title
Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis.
  Journal
Microbiology. 156 (2010) 1538-46.
  Sequence
[bsu:BSU10850]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
KEGG   REACTION: R09953Help
Entry
R09953                      Reaction                               

Name
scyllo-inositol:NAD+ oxidoreductase
Definition
scyllo-Inositol + NAD+ <=> 2,4,6/3,5-Pentahydroxycyclohexanone + NADH + H+
Equation
Reaction class
C00003_C00004
C00691_C06153
Enzyme
Pathway
Inositol phosphate metabolism
Microbial metabolism in diverse environments
Orthology
K16043  
scyllo-inositol 2-dehydrogenase (NAD+) [EC:1.1.1.370]
Other DBs
RHEA: 
DBGET integrated database retrieval system