KEGG   ORTHOLOGY: K16050Help
Entry
K16050                      KO                                     

Name
hsaD
Definition
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase [EC:3.7.1.17]
Pathway
Steroid degradation
Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K16050  hsaD; 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
  Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K16050  hsaD; 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.7  Acting on carbon-carbon bonds
   3.7.1  In ketonic substances
    3.7.1.17  4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
     K16050  hsaD; 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
BRITE hierarchy
Other DBs
RN: 
COG: 
Genes
PRE: 
PPUT: 
PPUN: 
PP4_27040(mhpC)
PVR: 
PPUU: 
PKC: 
PFZ: 
PPSY: 
SPL: 
SHL: 
COLW: 
A3Q33_18715
PHA: 
PSHAa0893(tesD)
PTN: 
PTRA_a1026(hsaD)
ZAL: 
AZF00_11435
HJA: 
BST95_09500
GBI: 
PG2T_02180
RIN: 
ACS15_4349
REU: 
Reut_A1513
REH: 
H16_B0600(bphD)
CNC: 
CNE_2c05450(fabG2)
CTI: 
RALTA_B0404(mhpC)
CBW: 
RR42_s2308
BUR: 
Bcep18194_B1463
BCJ: 
BCAM1609
BCEN: 
DM39_3387
BCEO: 
I35_5469
BCT: 
GEM_4115
BCED: 
DM42_6349
BCEP: 
APZ15_31175
BPYR: 
ABD05_27840
BCON: 
NL30_04160
BDF: 
WI26_21125
BTEI: 
WS51_05675
BPSL: 
WS57_06065
BMEC: 
WJ16_26770
BUL: 
BW21_2676(hsaD)
BPLA: 
bpln_1g12680
BUD: 
AQ610_12660
BFN: 
OI25_4585
PVE: 
UC34_07060
CTT: 
CtCNB1_1354
CTES: 
O987_07745
THU: 
AC731_008590
CHQ: 
AQ619_10455
SSAN: 
NX02_12715
MTU: 
Rv3569c(hsaD)
MTV: 
RVBD_3569c
MTC: 
MT3674(bphD)
MRA: 
MRA_3608(bphD)
MTF: 
TBFG_13602
MTB: 
TBMG_03608
MTK: 
TBSG_03635
MTZ: 
TBXG_003583
MTG: 
MRGA327_22035
MTI: 
MRGA423_22555
MTE: 
CCDC5079_3310
MTUR: 
CFBS_3786(bphD)
MTL: 
CCDC5180_3262
MTO: 
MTCTRI2_3634(bphD)
MTD: 
UDA_3569c(bphD)
MTN: 
ERDMAN_3916(bphD)
MTJ: 
J112_19220
MTUB: 
MT7199_3632
MTUC: 
J113_24995
MTUE: 
J114_19090
MTX: 
M943_18355
MTUH: 
I917_25075
MTUL: 
TBHG_03510
MTUT: 
HKBT1_3771(bphD)
MTUU: 
HKBT2_3780(bphD)
MTQ: 
HKBS1_3783(bphD)
MBO: 
Mb3600c(bphD)
MBB: 
BCG_3634c(bphD)
MBT: 
JTY_3635(bphD)
MBM: 
BCGMEX_3632c(bphD)
MBK: 
K60_037070
MBX: 
BCGT_3436
MBZ: 
LH58_19330
MAF: 
MAF_35820(bphD)
MCE: 
MCAN_35821(bphD)
MCQ: 
BN44_110064(bphD)
MCV: 
BN43_90070(bphD)
MCX: 
BN42_90067(bphD)
MCZ: 
BN45_100083(bphD)
MMIC: 
RN08_3946
MPA: 
MAP_0498
MAO: 
MAP4_3369
MAVI: 
RC58_16710
MAVU: 
RE97_16745
MAV: 
MAV_0592
MAVD: 
NF84_02660
MAVR: 
LA63_02725 LA63_11615
MAVA: 
LA64_02735
MIT: 
OCO_05010
MIA: 
OCU_05050
MIE: 
LG41_02520
MIR: 
OCQ_05160
MID: 
MIP_00941
MYO: 
OEM_05070
MSM: 
MSMEG_6037
MSG: 
MSMEI_5876(bphD)
MSB: 
LJ00_29845
MSN: 
LI99_29850
MSH: 
LI98_29855
MSA: 
Mycsm_01915 Mycsm_01992 Mycsm_05839
MUL: 
MUL_4140(bphD)
MVA: 
Mvan_5307
MGI: 
Mflv_1464
MSP: 
Mspyr1_47030
MAY: 
LA62_22185
MABO: 
NF82_21875
MAZ: 
LA61_22080
MMC: 
Mmcs_4708
MKM: 
Mkms_4794
MJL: 
Mjls_5093
MMI: 
MMAR_5064(bphD)
MMAE: 
MMARE11_48790(bphD)
MRH: 
MycrhN_2244
MMM: 
W7S_02445
MCB: 
Mycch_4674
MLI: 
MULP_05322(bphD)
MKN: 
MKAN_12125
MKS: 
LG40_11970
MKI: 
LH54_12115
MNE: 
D174_24705
MYV: 
G155_26480
MYE: 
AB431_09620
MGO: 
AFA91_10585
MFT: 
XA26_53620
MHAD: 
B586_04450
MPHL: 
MPHLCCUG_00492(hsaD_1)
MVQ: 
MYVA_5217
ASD: 
AS9A_0925(mhpC)
NFA: 
NFA_4730
NFR: 
ERS450000_03763(hsaD_1)
NCY: 
NOCYR_0502
NBR: 
O3I_002670
NNO: 
NONO_c05020(hsaD) NONO_c29060 NONO_c37010 NONO_c58880
NSL: 
BOX37_02180
NSR: 
NS506_01261(hsaD) NS506_06808
RHA: 
RHA1_ro04540(hsaD)
RER: 
RER_07560
REY: 
O5Y_03675
REB: 
XU06_03915
ROP: 
ROP_44550
ROA: 
Pd630_LPD00992
REQ: 
REQ_01450 REQ_06810 REQ_35100
RPY: 
Y013_19030
RAV: 
AAT18_03970 AAT18_26195
RHW: 
BFN03_15195
TPR: 
Tpau_3844
DTM: 
BJL86_3316
SALU: 
DC74_7446
SALL: 
SAZ_38435
SVT: 
SVTN_35910
SLC: 
SL103_24910
STSI: 
A4E84_36410
MIO: 
AOA12_18570
LMOI: 
VV02_04600
NCA: 
Noca_2775
NDK: 
I601_3469(hsaD_2)
PSIM: 
KR76_14475
AMD: 
AMED_2523(mhpC)
AMN: 
RAM_12825
AMM: 
AMES_2495(mhpC)
AMZ: 
B737_2496(mhpC)
AOI: 
AORI_2485(mhpC)
AJA: 
AJAP_26400(hsaD)
AMQ: 
AMETH_4837(mhpC)
ALU: 
BB31_28885
KAL: 
KALB_5123
KPHY: 
AOZ06_42785
LED: 
BBK82_38920
ALL: 
CRK59593
STP: 
Strop_2670
SAQ: 
Sare_2878
AMS: 
AMIS_19190
AFS: 
AFR_13045
SYNE: 
Syn6312_0833
AWA: 
AA650_16185
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD
  Title
Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism.
  Journal
J Biol Chem 285:434-43 (2010)
DOI:10.1074/jbc.M109.058081
  Sequence
[mtu:Rv3569c]
Reference
  Authors
Ouellet H, Johnston JB, de Montellano PR
  Title
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.
  Journal
Trends Microbiol 19:530-9 (2011)
DOI:10.1016/j.tim.2011.07.009
KEGG   REACTION: R09883Help
Entry
R09883                      Reaction                               

Name
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase ( (2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming)
Definition
3-Hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O <=> 3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-Hydroxyhexa-2,4-dienoate
Equation
Reaction class
C04844_C20199
C04844_C20240
Enzyme
Pathway
Steroid degradation
Metabolic pathways
Microbial metabolism in diverse environments
Degradation of aromatic compounds
Orthology
K16050  
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase [EC:3.7.1.17]
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