KEGG   ORTHOLOGY: K16269Help
Entry
K16269            Tight     KO                                     

Name
todD, tcbB
Definition
cis-1,2-dihydrobenzene-1,2-diol dehydrogenase [EC:1.3.1.19 1.3.1.-]
Pathway
Chlorocyclohexane and chlorobenzene degradation
Benzoate degradation
Toluene degradation
Polycyclic aromatic hydrocarbon degradation
Styrene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Degradation of aromatic compounds
Module
M00547  
Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
   00623 Toluene degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
   00643 Styrene degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
   00624 Polycyclic aromatic hydrocarbon degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
KEGG modules [BR:ko00002]
 Pathway module
  Secondary metabolism
   Aromatics degradation
    M00547  Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol
     K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.19  cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
     K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
    1.3.1.-  
     K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
BRITE hierarchy
Other DBs
Genes
PPF: 
PPX: 
T1E_4270(tobD)
PMON: 
PMOT: 
BPT: 
Bpet3742(hcaB)
AG: 
AAC43636(tcbB)
TaxonomyKoalaUniProt
Reference
PMID:2670929
  Authors
Zylstra GJ, Gibson DT
  Title
Toluene degradation by Pseudomonas putida F1. Nucleotide sequence of the todC1C2BADE genes and their expression in Escherichia coli.
  Journal
J Biol Chem 264:14940-6 (1989)
Reference
PMID:8626733
  Authors
Werlen C, Kohler HP, van der Meer JR
  Title
The broad substrate chlorobenzene dioxygenase and cis-chlorobenzene dihydrodiol dehydrogenase of Pseudomonas sp. strain P51 are linked evolutionarily to the enzymes for benzene and toluene degradation.
  Journal
J Biol Chem 271:4009-16 (1996)
DOI:10.1074/jbc.271.8.4009
  Sequence

KEGG   ENZYME: 1.3.1.19Help
Entry
EC 1.3.1.19                 Enzyme                                 

Name
cis-1,2-dihydrobenzene-1,2-diol dehydrogenase;
cis-benzene glycol dehydrogenase;
cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase
Reaction(IUBMB)
cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+ [RN:R00812]
Reaction(KEGG)
Substrate
cis-1,2-dihydrobenzene-1,2-diol [CPD:C04091];
NAD+ [CPD:C00003]
Product
catechol [CPD:C00090];
NADH [CPD:C00004];
H+ [CPD:C00080]
History
EC 1.3.1.19 created 1972
Pathway
Chlorocyclohexane and chlorobenzene degradation
Benzoate degradation
Toluene degradation
Polycyclic aromatic hydrocarbon degradation
Styrene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K16269  
cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
Genes
PPF: 
PPX: 
T1E_4270(tobD)
PMON: 
PMOT: 
BPT: 
Bpet3742(hcaB)
Taxonomy
Reference
1  [PMID:4362337]
  Authors
Axcell BC, Geary PJ.
  Title
The metabolism of benzene by bacteria. Purification and some properties of the enzyme cis-1,2-dihydroxycyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase (cis-benzene glycol dehydrogenase).
  Journal
Biochem. J. 136 (1973) 927-34.
Reference
2  [PMID:4298226]
  Authors
Gibson DT, Koch JR, Kallio RE.
  Title
Oxidative degradation of aromatic hydrocarbons by microorganisms. I. Enzymatic formation of catechol from benzene.
  Journal
Biochemistry. 7 (1968) 2653-62.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
51923-03-6

KEGG   REACTION: R04088Help
Entry
R04088                      Reaction                               

Name
toluene-cis-1,2-dihydrodiol:NAD+ oxidoreductase
Definition
Toluene-cis-dihydrodiol + NAD+ <=> 2,3-Dihydroxytoluene + NADH + H+
Equation
Reaction class
C00003_C00004
C02923_C04592
Enzyme
Pathway
Toluene degradation
Microbial metabolism in diverse environments
Degradation of aromatic compounds
Module
M00547  
Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol
Orthology
K16269  
cis-1,2-dihydrobenzene-1,2-diol dehydrogenase [EC:1.3.1.19 1.3.1.-]
Other DBs
RHEA: 

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