| Entry |
|
| Name |
2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase;
OHCU decarboxylase;
hpxQ (gene name);
PRHOXNB (gene name)
|
| Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
 |
| Sysname |
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate carboxy-lyase [(S)-allantoin-forming]
|
| Reaction(IUBMB) |
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate = (S)-allantoin + CO2 [RN: R06604]
|
| Reaction(KEGG) |
|
| Substrate |
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate [CPD: C12248]
|
| Product |
|
| Comment |
This enzyme is part of the pathway from urate to (S)-allantoin, which is present in bacteria, plants and animals (but not in humans).
|
| History |
EC 4.1.1.97 created 2014
|
| Pathway |
| Purine metabolism | | Metabolic pathways | | Microbial metabolism in diverse environments |
|
| Orthology |
| 5-hydroxyisourate hydrolase / 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | | urate oxidase / 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase |
|
| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | NLE: | | MCC: | | MCF: | | CSAB: | | RRO: | | CJC: | | SBQ: | | MMU: | | RNO: | | CGE: | | NGI: | | HGL: | | OCU: | | TUP: | | CFA: | | AML: | | UMR: | | BTA: | | BOM: | | CHX: | | OAS: | | SSC: | | CFR: | | BACU: | | LVE: | | ECB: | | HAI: | | RSS: | | LAV: | | MDO: | | SHR: | | OAA: | | XLA: | | XTR: | | DRE: | | IPU: | | TRU: | | TNG: | | LCO: | | MZE: | | OLA: | | XMA: | | CSEM: | | SASA: | | LCM: | | CMK: | | BFO: | | SPU: | | SKO: | | AGA: | | AAG: | | CQU: | | NVI: | | TCA: | | BMOR: | | PXY: | | DPX: | | CRG: | | NVE: | | ATH: | | ALY: | | CRB: | | EUS: | | BRP: | | BNA: | | THJ: | | CIT: | | CIC: | | TCC: | | GRA: | | EGR: | | GMX: | | PVU: | | VRA: | | VAR: | | CCAJ: | | MTR: | | CAM: | | ADU: | | AIP: | | LJA: | | LANG: | | FVE: | | PPER: | | PMUM: | | MDM: | | ZJU: | | CSV: | | CMO: | | RCU: | | JCU: | | POP: | | VVI: | | SLY: | | SPEN: | | SOT: | | INI: | | SIND: | | BVG: | | NNU: | | OSA: | | DOSA: | | OBR: | | BDI: | | ATS: | | ZMA: | | SITA: | | PDA: | | EGU: | | MUS: | | ATR: | | SMO: | | PPP: | | CRE: | | VCN: | | BPG: | | CSL: | | CVR: | | ENC: | | ENO: | | EEC: | | ENL: | | ECLG: | | ECLN: | | EAU: | | EKB: | | ELG: | | ECLS: | | ENX: | | KPN: | | KPU: | | KPM: | | KPP: | | KPK: | | KPH: | | KPZ: | | KPV: | | KPW: | | KPY: | | KPG: | | KPC: | | KPQ: | | KPT: | | KPE: | | KPO: | | KPR: | | KPJ: | | KPI: | | KPA: | | KPS: | | KPX: | | KPB: | | KPNE: | | KPNU: | | KVA: | | KVD: | | KVQ: | | KOX: | | KOE: | | KOY: | | KOK: | | KOC: | | KOM: | | KQU: | | EAE: | | EAR: | | ROR: | | RON: | | CED: | | KOR: | | KRD: | | SPE: | | SRR: | | SRL: | | SRY: | | SPLY: | | SRS: | | SRA: | | SMAF: | | SLQ: | | SRZ: | | RAH: | | RAQ: | | RAA: | | DDD: | | DZE: | | DDC: | | DZC: | | DSO: | | ETA: | | EPY: | | EPR: | | EAM: | | EAY: | | EBI: | | ERJ: | | EGE: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | KLN: | | PANT: | | PANP: | | PAGG: | | PAGC: | | TCI: | | XCC: | | XCB: | | XCA: | | XCP: | | XCV: | | XAC: | | XCI: | | XCT: | | XCU: | | XCN: | | XCW: | | XCR: | | XCM: | | XCF: | | XCJ: | | XFU: | | XAX: | | XAO: | | XOM: | | XOP: | | XOY: | | XOR: | | XGA: | | XVE: | | XPE: | | PSD: | | FAU: | | VNA: | | VEJ: | | VFU: | | VFL: | | PRE: | | PCR: | | PSO: | | PUR: | | PSPG: | | PSYG: | | PSYC: | | ACB: | | ABM: | | ABY: | | ABC: | | ABN: | | ABB: | | ABX: | | ABZ: | | ABR: | | ABD: | | ABAD: | | ABJ: | | ABAB: | | ABAJ: | | ABAZ: | | ABK: | | ABAU: | | ABAA: | | ABW: | | ABAL: | | ACC: | | ANO: | | ACD: | | ACI: | | AEI: | | ACW: | | AHL: | | AJN: | | ASOL: | | ALA: | | ASJ: | | MOS: | | CPS: | | COM: | | COZ: | | COLW: | | PAT: | | MSR: | | AMC: | | AMAA: | | AMAL: | | AMAE: | | AMAO: | | AMAD: | | AMAI: | | AMAG: | | AMAC: | | AMB: | | AMG: | | AMK: | | ALT: | | AAL: | | AAUS: | | ASP: | | ASQ: | | AAW: | | GAG: | | GPS: | | CEB: | | CELL: | | TTU: | | HJA: | | HAZ: | | HCH: | | HAA: | | CMAI: | | KUS: | | KMA: | | TOL: | | TOR: | | OAI: | | GSN: | | OME: | | PSE: | | AQL: | | RSO: | | RSC: | | RSL: | | RSN: | | RSM: | | RSE: | | RPI: | | RPF: | | RPJ: | | RMN: | | RIN: | | REU: | | REH: | | CNC: | | RME: | | CTI: | | CBW: | | CGD: | | CCUP: | | BMA: | | BMV: | | BMAL: | | BMAE: | | BMAQ: | | BMAI: | | BMAF: | | BMAZ: | | BMAB: | | BPS: | | BPM: | | BPL: | | BPD: | | BPR: | | BPSE: | | BPSM: | | BPSU: | | BPSD: | | BPZ: | | BPQ: | | BPK: | | BPSH: | | BPSA: | | BPSO: | | BUT: | | BTE: | | BTQ: | | BTJ: | | BTZ: | | BTD: | | BTV: | | BTHE: | | BTHM: | | BTHA: | | BTHL: | | BOK: | | BOC: | | BVI: | | BVE: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BCEN: | | BCEW: | | BCEO: | | BAM: | | BAC: | | BMU: | | BMJ: | | BMK: | | BMUL: | | BCT: | | BCED: | | BCEP: | | BDL: | | BPYR: | | BCON: | | BUB: | | BDF: | | BLAT: | | BTEI: | | BSEM: | | BPSL: | | BMEC: | | BSTG: | | BGL: | | BGP: | | BGU: | | BUG: | | BGE: | | BGF: | | BGD: | | BGO: | | BYI: | | BUK: | | BUO: | | BUE: | | BUL: | | BUQ: | | BPLA: | | BUD: | | BXE: | | BXB: | | BPH: | | BPX: | | BPY: | | BFN: | | BCAI: | | PSPW: | | PPK: | | PPNO: | | PPNM: | | PRB: | | PPUL: | | PSPU: | | PAPI: | | PVE: | | POX: | | PTX: | | PFG: | | PNR: | | PUT: | | CDN: | | AFA: | | RSB: | | RHY: | | VAP: | | CTT: | | CTES: | | RGU: | | AZO: | | TMZ: | | THU: | | BEBA: | | MFU: | | MYM: | | CCX: | | SUR: | | CCRO: | | SAMY: | | BJA: | | BJU: | | BJP: | | BRS: | | BRC: | | BRAD: | | SNO: | | MRD: | | MET: | | MOR: | | RHZ: | | PSIN: | | CCR: | | CCS: | | CAK: | | CSE: | | CHQ: | | AEX: | | RLI: | | PSF: | | NPP: | | NPN: | | NRE: | | SMAZ: | | SPHI: | | SSAN: | | SPAN: | | GOX: | | GOH: | | GOY: | | GAL: | | GBE: | | GBH: | | GBC: | | GBS: | | ACR: | | AMV: | | GDI: | | GDJ: | | GXY: | | GXL: | | KNA: | | KEU: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | APK: | | ASZ: | | ASV: | | AACE: | | APER: | | ABG: | | KBA: | | NCH: | | AZL: | | ALI: | | ATI: | | PBR: | | PGV: | | APB: | | BSU: | | BSR: | | BSL: | | BSH: | | BSY: | | BSUT: | | BSUL: | | BSUS: | | BSS: | | BST: | | BSO: | | BSN: | | BSQ: | | BSX: | | BSP: | | BHA: | | BCL: | | BMQ: | | BMD: | | BMH: | | BMEG: | | BJS: | | BACI: | | BACY: | | BACL: | | BALM: | | BEO: | | BSM: | | BFX: | | BGI: | | GGH: | | GEA: | | BSE: | | PJD: | | PMS: | | PMQ: | | PMW: | | PSAB: | | PDU: | | PBD: | | PGM: | | POD: | | PAEN: | | PAEF: | | PAEQ: | | PSTE: | | PAEA: | | PAEE: | | PAEH: | | PAEJ: | | PBJ: | | PRI: | | PNP: | | PBV: | | PXL: | | PYG: | | PSWU: | | BTS: | | MSM: | | MSG: | | MSB: | | MSN: | | MSH: | | MUL: | | MVA: | | MAB: | | MABB: | | MMV: | | MAY: | | MABO: | | MABL: | | MAZ: | | MAK: | | MYS: | | MYC: | | MCHE: | | MIZ: | | MMI: | | MMAE: | | MLI: | | MNE: | | MGO: | | ASD: | | CVA: | | CTER: | | CGY: | | NFA: | | NFR: | | NBR: | | NSL: | | NSR: | | RHA: | | RER: | | REY: | | REB: | | ROP: | | ROA: | | RPY: | | RHB: | | RAV: | | RFA: | | GBR: | | GPO: | | GOR: | | GTA: | | TPR: | | SRT: | | SCO: | | SMA: | | SGR: | | SGB: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | SALS: | | STRP: | | SFI: | | SCI: | | SRC: | | SALU: | | SALL: | | SLV: | | SGU: | | SVT: | | STRE: | | SCW: | | SLD: | | SXI: | | STRM: | | STRC: | | SAMB: | | SPRI: | | SCZ: | | SCX: | | SRW: | | STRF: | | SLE: | | SPAV: | | SLC: | | STRT: | | SGS: | | STSI: | | SLS: | | SNR: | | SPLU: | | STRD: | | SNW: | | KSK: | | CMC: | | MTS: | | MIO: | | MCW: | | MPAL: | | MIH: | | RTN: | | FRP: | | AGY: | | CART: | | CRY: | | CPHY: | | ART: | | ARR: | | ARL: | | ARE: | | ARH: | | ARY: | | ARW: | | ARZ: | | AAU: | | ACH: | | APN: | | PSUL: | | AAI: | | GAR: | | KRH: | | KFV: | | SATK: | | BFA: | | LMOI: | | IDO: | | CET: | | CCEU: | | CFL: | | SERJ: | | BLY: | | BLIN: | | MPH: | | NCA: | | AER: | | NDA: | | NAL: | | SRO: | | NOA: | | GOB: | | MMAR: | | KRA: | | SEN: | | AMD: | | AMN: | | AMM: | | AMZ: | | AOI: | | AJA: | | AMQ: | | ALU: | | PDX: | | PSEA: | | PSEE: | | PSEH: | | PSEQ: | | PECQ: | | PHH: | | AMI: | | SESP: | | KAL: | | KPHY: | | LED: | | ALL: | | AMS: | | ACTN: | | AFS: | | CAI: | | SNA: | | TBI: | | RXY: | | RRD: | | SYNP: | | DSL: | | CMP: | | LEN: | | LET: | | LBO: | | GLP: | | CTHE: | | DRA: | | DGE: | | DPD: | | DSW: | | TRA: | | MRB: | | MRE: | | MSV: | | OBG: | | PHM: | | TPX: | | ACM: | | GMA: | | TSA: | | TRS: | | SUS: | | ABAC: | | GBA: | | CPI: | | NKO: | | HSW: | | HYG: | | HJE: | | NMO: | | HWC: | | HVO: | | NOU: | | » show all
 |
| Reference |
|
| Authors |
Ramazzina I, Folli C, Secchi A, Berni R, Percudani R. |
| Title |
Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes. |
| Journal |
Nat. Chem. Biol. 2 (2006) 144-8. |
| Sequence |
|
| Reference |
|
| Authors |
Cendron L, Berni R, Folli C, Ramazzina I, Percudani R, Zanotti G |
| Title |
The structure of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase provides insights into the mechanism of uric acid degradation. |
| Journal |
J. Biol. Chem. 282 (2007) 18182-9. |
| Sequence |
|
| Reference |
|
| Authors |
Kim K, Park J, Rhee S |
| Title |
Structural and functional basis for (S)-allantoin formation in the ureide pathway. |
| Journal |
J. Biol. Chem. 282 (2007) 23457-64. |
| Sequence |
|
| Reference |
|
| Authors |
French JB, Ealick SE |
| Title |
Structural and mechanistic studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase. |
| Journal |
J. Biol. Chem. 285 (2010) 35446-54. |
| Sequence |
|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |