KEGG   ORTHOLOGY: K17070Help
Entry
K17070                      KO                                     

Name
dcmA
Definition
dichloromethane dehalogenase [EC:4.5.1.3]
Pathway
Chloroalkane and chloroalkene degradation
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Xenobiotics biodegradation and metabolism
   00625 Chloroalkane and chloroalkene degradation
    K17070  dcmA; dichloromethane dehalogenase
Enzymes [BR:ko01000]
 4. Lyases
  4.5  Carbon-halide lyases
   4.5.1  Carbon-halide lyases (only sub-subclass identified to date)
    4.5.1.3  dichloromethane dehalogenase
     K17070  dcmA; dichloromethane dehalogenase
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
MDI: 
METDI2656(dcmA)
HDN: 
TaxonomyKoalaUniProt
Reference
  Authors
Vuilleumier S, Chistoserdova L, Lee MC, Bringel F, Lajus A, Zhou Y, Gourion B, Barbe V, Chang J, Cruveiller S, Dossat C, Gillett W, Gruffaz C, Haugen E, Hourcade E, Levy R, Mangenot S, Muller E, Nadalig T, Pagni M, Penny C, Peyraud R, Robinson DG, Roche D, Rouy Z, Saenampechek C, Salvignol G, Vallenet D, Wu Z, Marx CJ, Vorholt JA, Olson MV, Kaul R, Weissenbach J, Medigue C, Lidstrom ME
  Title
Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources.
  Journal
PLoS One 4:e5584 (2009)
DOI:10.1371/journal.pone.0005584
  Sequence
[mdi:METDI2656]
KEGG   ENZYME: 4.5.1.3Help
Entry
EC 4.5.1.3                  Enzyme                                 

Name
dichloromethane dehalogenase;
dichloromethane chloride-lyase (chloride-hydrolysing)
Class
Lyases;
Carbon-halide lyases;
Carbon-halide lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)
Reaction(IUBMB)
dichloromethane + H2O = formaldehyde + 2 chloride [RN:R00603]
Reaction(KEGG)
Substrate
dichloromethane [CPD:C02271];
H2O [CPD:C00001]
Product
formaldehyde [CPD:C00067];
chloride [CPD:C00698]
Comment
Requires glutathione.
History
EC 4.5.1.3 created 1989
Pathway
Chloroalkane and chloroalkene degradation
Microbial metabolism in diverse environments
Orthology
K17070  
dichloromethane dehalogenase
Genes
MDI: 
METDI2656(dcmA)
HDN: 
Taxonomy
Reference
1  [PMID:3988708]
  Authors
Kohler-Staub D, Leisinger T.
  Title
Dichloromethane dehalogenase of Hyphomicrobium sp. strain DM2.
  Journal
J. Bacteriol. 162 (1985) 676-81.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
97002-70-5
KEGG   REACTION: R00603Help
Entry
R00603                      Reaction                               

Name
dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)
Definition
Dichloromethane + H2O <=> Formaldehyde + 2 Hydrochloric acid
Equation
Reaction class
C00067_C02271
Enzyme
Pathway
Chloroalkane and chloroalkene degradation
Microbial metabolism in diverse environments
Orthology
K17070  
dichloromethane dehalogenase [EC:4.5.1.3]
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