KEGG   ORTHOLOGY: K17753Help
Entry
K17753                      KO                                     

Name
HICDH
Definition
isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
Pathway
Citrate cycle (TCA cycle)
Lysine biosynthesis
2-Oxocarboxylic acid metabolism
Biosynthesis of amino acids
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01210 2-Oxocarboxylic acid metabolism
    K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
   01230 Biosynthesis of amino acids
    K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
  Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
  Amino acid metabolism
   00300 Lysine biosynthesis
    K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.286  isocitrate---homoisocitrate dehydrogenase
     K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
BRITE hierarchy
Other DBs
Genes
PHO: 
PH1722(PH1722)
PAB: 
PAB0289(leuB-2)
PYN: 
PYS: 
TKO: 
THS: 
THV: 
TCH: 
TaxonomyKoalaUniProt
Reference
  Authors
Miyazaki K
  Title
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase.
  Journal
Biochem Biophys Res Commun 331:341-6 (2005)
DOI:10.1016/j.bbrc.2005.03.169
  Sequence
[pho:PH1722]
KEGG   ENZYME: 1.1.1.286Help
Entry
EC 1.1.1.286                Enzyme                                 

Name
isocitrate---homoisocitrate dehydrogenase;
homoisocitrate---isocitrate dehydrogenase;
PH1722
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(1) isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH [RN:R00709];
(2) (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+ [RN:R01934]
Reaction(KEGG)
Substrate
isocitrate [CPD:C00311];
NAD+ [CPD:C00003];
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate [CPD:C05662]
Product
2-oxoglutarate [CPD:C00026];
CO2 [CPD:C00011];
NADH [CPD:C00004];
2-oxoadipate [CPD:C00322];
H+ [CPD:C00080]
Comment
Requires Mn2+ and K+ or NH4+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+) and EC 1.1.1.87, homoisocitrate dehydrogenase, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrates. The enzyme may play a role in both the lysine and glutamate biosynthesis pathways.
History
EC 1.1.1.286 created 2005
Pathway
Citrate cycle (TCA cycle)
Lysine biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Biosynthesis of antibiotics
Orthology
K17753  
isocitrate--homoisocitrate dehydrogenase
Genes
PHO: 
PH1722(PH1722)
PAB: 
PAB0289(leuB-2)
PYN: 
PYS: 
TKO: 
THS: 
THV: 
TCH: 
Taxonomy
Reference
1  [PMID:15845397]
  Authors
Miyazaki K.
  Title
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase.
  Journal
Biochem. Biophys. Res. Commun. 331 (2005) 341-6.
  Sequence
[pho:PH1722]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
KEGG   REACTION: R00709Help
Entry
R00709                      Reaction                               

Name
isocitrate:NAD+ oxidoreductase (decarboxylating)
Definition
Isocitrate + NAD+ <=> 2-Oxoglutarate + CO2 + NADH + H+
Equation
Reaction class
C00003_C00004
C00026_C00311
C00011_C00311
Enzyme
1.1.1.41        1.1.1.286
Pathway
Citrate cycle (TCA cycle)
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Biosynthesis of antibiotics
Carbon metabolism
2-Oxocarboxylic acid metabolism
Biosynthesis of amino acids
Module
M00009  
Citrate cycle (TCA cycle, Krebs cycle)
M00010  
Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
Orthology
K00030  
isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]
K17753  
isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
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