KEGG ORTHOLOGY: K18251

ORTHOLOGY: K18251

Entry

K18251 KO

Name

phtAa

Definition

phthalate 3,4-dioxygenase subunit alpha [EC:1.14.12.-]

Pathway

ko00624	Polycyclic aromatic hydrocarbon degradation
ko01220	Degradation of aromatic compounds

Module

M00636

Phthalate degradation, phthalate => protocatechuate

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K18251  phtAa; phthalate 3,4-dioxygenase subunit alpha
  Xenobiotics biodegradation and metabolism
   00624 Polycyclic aromatic hydrocarbon degradation
    K18251  phtAa; phthalate 3,4-dioxygenase subunit alpha
KEGG modules [BR:ko00002]
Pathway module
  Secondary metabolism
   Aromatics degradation
    M00636  Phthalate degradation, phthalate => protocatechuate
     K18251  phtAa; phthalate 3,4-dioxygenase subunit alpha
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.12  With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
    1.14.12.-
     K18251  phtAa; phthalate 3,4-dioxygenase subunit alpha

Other DBs

RN:

R09227

Genes

MVA:	Mvan_0463
MGI:	Mflv_0595 Mflv_0685
MSP:	Mspyr1_01400
MMC:	Mmcs_1622
MKM:	Mkms_1647
MJL:	Mjls_1595
MRH:	MycrhN_3142

Reference

PMID:15313184

Authors

Stingley RL, Khan AA, Cerniglia CE.

Title

Molecular characterization of a phenanthrene degradation pathway in Mycobacterium vanbaalenii PYR-1.

Journal

Biochem Biophys Res Commun 322:133-46 (2004)
DOI:10.1016/j.bbrc.2004.07.089

Sequence

[mva:Mvan_0463]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (9)   
   KEGG GENES (8)   
   OC (1)   
Protein sequence (6)   
   UniProt (6)   
Literature (1)   
   PubMed (1)   
All databases (28)   

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ORTHOLOGY: K18252

Entry

K18252 KO

Name

phtAb

Definition

phthalate 3,4-dioxygenase subunit beta [EC:1.14.12.-]

Pathway

ko00624	Polycyclic aromatic hydrocarbon degradation
ko01220	Degradation of aromatic compounds

Module

M00636

Phthalate degradation, phthalate => protocatechuate

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K18252  phtAb; phthalate 3,4-dioxygenase subunit beta
  Xenobiotics biodegradation and metabolism
   00624 Polycyclic aromatic hydrocarbon degradation
    K18252  phtAb; phthalate 3,4-dioxygenase subunit beta
KEGG modules [BR:ko00002]
Pathway module
  Secondary metabolism
   Aromatics degradation
    M00636  Phthalate degradation, phthalate => protocatechuate
     K18252  phtAb; phthalate 3,4-dioxygenase subunit beta
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.12  With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
    1.14.12.-
     K18252  phtAb; phthalate 3,4-dioxygenase subunit beta

Other DBs

RN:

R09227

Genes

MVA:	Mvan_0464
MGI:	Mflv_0594 Mflv_0684
MSP:	Mspyr1_01410
MMC:	Mmcs_1623
MKM:	Mkms_1648
MJL:	Mjls_1596
MRH:	MycrhN_3143

Reference

PMID:15313184

Authors

Stingley RL, Khan AA, Cerniglia CE.

Title

Molecular characterization of a phenanthrene degradation pathway in Mycobacterium vanbaalenii PYR-1.

Journal

Biochem Biophys Res Commun 322:133-46 (2004)
DOI:10.1016/j.bbrc.2004.07.089

Sequence

[mva:Mvan_0464]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (9)   
   KEGG GENES (8)   
   OC (1)   
Protein sequence (6)   
   UniProt (6)   
Literature (1)   
   PubMed (1)   
All databases (28)   

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ORTHOLOGY: K18253

Entry

K18253 KO

Name

phtAc

Definition

phthalate 3,4-dioxygenase ferredoxin component

Pathway

ko00624	Polycyclic aromatic hydrocarbon degradation
ko01220	Degradation of aromatic compounds

Module

M00636

Phthalate degradation, phthalate => protocatechuate

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K18253  phtAc; phthalate 3,4-dioxygenase ferredoxin component
  Xenobiotics biodegradation and metabolism
   00624 Polycyclic aromatic hydrocarbon degradation
    K18253  phtAc; phthalate 3,4-dioxygenase ferredoxin component
KEGG modules [BR:ko00002]
Pathway module
  Secondary metabolism
   Aromatics degradation
    M00636  Phthalate degradation, phthalate => protocatechuate
     K18253  phtAc; phthalate 3,4-dioxygenase ferredoxin component

Other DBs

RN:

R09227

Genes

MGI:	Mflv_0591 Mflv_0681
MSP:	Mspyr1_01440
MRH:	MycrhN_3146

Reference

PMID:15313184

Authors

Stingley RL, Khan AA, Cerniglia CE.

Title

Molecular characterization of a phenanthrene degradation pathway in Mycobacterium vanbaalenii PYR-1.

Journal

Biochem Biophys Res Commun 322:133-46 (2004)
DOI:10.1016/j.bbrc.2004.07.089

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (5)   
   KEGG GENES (4)   
   OC (1)   
Protein sequence (3)   
   UniProt (3)   
Literature (1)   
   PubMed (1)   
All databases (20)   

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ORTHOLOGY: K18254

Entry

K18254 KO

Name

phtAd

Definition

phthalate 3,4-dioxygenase ferredoxin reductase component [EC:1.18.1.3]

Pathway

ko00624	Polycyclic aromatic hydrocarbon degradation
ko01220	Degradation of aromatic compounds

Module

M00636

Phthalate degradation, phthalate => protocatechuate

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K18254  phtAd; phthalate 3,4-dioxygenase ferredoxin reductase component
  Xenobiotics biodegradation and metabolism
   00624 Polycyclic aromatic hydrocarbon degradation
    K18254  phtAd; phthalate 3,4-dioxygenase ferredoxin reductase component
KEGG modules [BR:ko00002]
Pathway module
  Secondary metabolism
   Aromatics degradation
    M00636  Phthalate degradation, phthalate => protocatechuate
     K18254  phtAd; phthalate 3,4-dioxygenase ferredoxin reductase component
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.18  Acting on iron-sulfur proteins as donors
   1.18.1  With NAD+ or NADP+ as acceptor
    1.18.1.3  ferredoxin---NAD+ reductase
     K18254  phtAd; phthalate 3,4-dioxygenase ferredoxin reductase component

Other DBs

RN:

R09227

COG:

COG0446

GO:

0008860

Genes

MVA:	Mvan_0467
MGI:	Mflv_0590 Mflv_0680
MSP:	Mspyr1_01450
MMC:	Mmcs_1625
MKM:	Mkms_1651
MJL:	Mjls_1599
MRH:	MycrhN_3147

Reference

PMID:15313184

Authors

Stingley RL, Khan AA, Cerniglia CE.

Title

Molecular characterization of a phenanthrene degradation pathway in Mycobacterium vanbaalenii PYR-1.

Journal

Biochem Biophys Res Commun 322:133-46 (2004)
DOI:10.1016/j.bbrc.2004.07.089

Sequence

[mva:Mvan_0467]

All links

Ontology (5)   
   KEGG BRITE (3)   
   GO (1)   
   COG (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (9)   
   KEGG GENES (8)   
   OC (1)   
Protein sequence (5)   
   UniProt (5)   
Literature (1)   
   PubMed (1)   
All databases (30)   

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REACTION: R09227

Entry

R09227 Reaction

Definition

Phthalate + Oxygen + NADH + H+ <=> Phthalate 3,4-cis-dihydrodiol + NAD+

Equation

C01606 + C00007 + C00004 + C00080 <=> C18314 + C00003

Comment

phthalate 3,4-dioxygenase

Reaction class

RC00001	C00003_C00004
RC00098	C01606_C18314

Enzyme

1.14.12.-

Pathway

rn00624	Polycyclic aromatic hydrocarbon degradation
rn01120	Microbial metabolism in diverse environments
rn01220	Degradation of aromatic compounds

Module

M00636

Phthalate degradation, phthalate => protocatechuate

Orthology

K18251	phthalate 3,4-dioxygenase subunit alpha [EC:1.14.12.-]
K18252	phthalate 3,4-dioxygenase subunit beta [EC:1.14.12.-]
K18253	phthalate 3,4-dioxygenase ferredoxin component
K18254	phthalate 3,4-dioxygenase ferredoxin reductase component [EC:1.18.1.3]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG RCLASS (2)   
   UMBBD-RN (1)   
Gene (32)   
   KEGG ORTHOLOGY (4)   
   KEGG GENES (28)   
All databases (49)   

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