KEGG ORTHOLOGY: K18978

ORTHOLOGY: K18978

Entry

K18978 KO

Name

gapN

Definition

glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] [EC:1.2.1.90]

Pathway

ko00010	Glycolysis / Gluconeogenesis
ko00030	Pentose phosphate pathway
ko01200	Carbon metabolism

Module

M00308	Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P
M00633	Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01200 Carbon metabolism
    K18978  gapN; glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]
  Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K18978  gapN; glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]
   00030 Pentose phosphate pathway
    K18978  gapN; glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]
KEGG modules [BR:ko00002]
Pathway module
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00308  Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P
     K18978  gapN; glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]
    M00633  Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P
     K18978  gapN; glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.90  glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]
     K18978  gapN; glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]

Other DBs

RN:

R01058 R10860

COG:

COG1012

Genes

HAL:	VNG_0937G(gap)
HSL:	OE_2367F(aldH3)
HHB:	Hhub_2122
NMO:	Nmlp_1397(aldH2)
HALI:	BV210_12380
HTU:	Htur_1629
HDA:	BB347_04210
NMG:	Nmag_3488
NAT:	NJ7G_3347
NPE:	Natpe_2432
HLR:	HALLA_11300
PFU:	PF0755
PFI:	PFC_02935
TKO:	TK0705
TSI:	TSIB_1868
TLT:	OCC_12546
TNU:	BD01_0877
THV:	ADU37_CDS19860
PPAC:	PAP_03390
APE:	APE_1786.1(gapN)
ACJ:	ACAM_1119(gapN)
SMR:	Smar_0084
SHC:	Shell_0726
DKA:	DKAM_1444
DFD:	Desfe_0067
DMU:	Desmu_1044
TAG:	Tagg_1262
IAG:	Igag_1780
THG:	TCELL_0871
SSO:	SSO3194(gapN-3)
SOL:	Ssol_0932
SSOA:	SULA_0965
SSOL:	SULB_0967
SSOF:	SULC_0966
STO:	STK_24770(gapN)
SAI:	Saci_0227
SACN:	SacN8_01100
SACR:	SacRon12I_01100
SACS:	SUSAZ_01140
SIS:	LS215_2328
SIA:	M1425_2165
SIM:	M1627_2245
SID:	M164_2168
SIY:	YG5714_2291
SIN:	YN1551_0624
SII:	LD85_2431
SIH:	SiH_2110
SIR:	SiRe_2042
SIC:	SiL_2017
SULA:	BFU36_06100
MSE:	Msed_1298
MCN:	Mcup_0943
PAS:	Pars_0554
POG:	Pogu_1837
CMA:	Cmaq_0979
TUZ:	TUZN_1133
TTN:	TTX_1169(gapN)
VDI:	Vdis_2334
VMO:	VMUT_0605
THF:	MA03_02735
ASC:	ASAC_1423
CLG:	Calag_1262
FFO:	FFONT_0138
CSU:	CSUB_C0048
NAA:	Nps_02395
AG:	CAA71651(gapN)

» show all

Reference

PMID:9497334

Authors

Brunner NA, Brinkmann H, Siebers B, Hensel R

Title

NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase from Thermoproteus tenax. The first identified archaeal member of the aldehyde dehydrogenase superfamily is a glycolytic enzyme with unusual regulatory properties.

Journal

J Biol Chem 273:6149-56 (1998)
DOI:10.1074/jbc.273.11.6149

Sequence

[ag:CAA71651]

All links

Ontology (4)   
   KEGG BRITE (3)   
   COG (1)   
Pathway (12)   
   KEGG PATHWAY (10)   
   KEGG MODULE (2)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (70)   
   KEGG GENES (66)   
   KEGG MGENES (1)   
   RefGene (1)   
   OC (2)   
Protein sequence (64)   
   UniProt (62)   
   SWISS-PROT (2)   
Literature (1)   
   PubMed (1)   
All databases (155)   

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ENZYME: 1.2.1.90

Entry

EC 1.2.1.90 Enzyme

Name

glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+];
non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase;
GAPN

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

D-glyceraldehyde-3-phosphate:NAD(P)+ oxidoreductase

Reaction(IUBMB)

D-glyceraldehyde 3-phosphate + NAD(P)+ + H2O = 3-phospho-D-glycerate + NAD(P)H + 2 H+ [RN:R01058 R10860]

Reaction(KEGG)

R01058 R10860

Substrate

D-glyceraldehyde 3-phosphate [CPD:C00118];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Product

3-phospho-D-glycerate [CPD:C00197];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme is part of the modified Embden-Meyerhof-Parnas pathway of the archaeon Thermoproteus tenax. cf. EC 1.2.1.9 [glyceraldehyde-3-phosphate dehydrogenase (NADP+)].

History

EC 1.2.1.90 created 2014

Pathway

ec00010	Glycolysis / Gluconeogenesis
ec00030	Pentose phosphate pathway
ec01100	Metabolic pathways
ec01120	Microbial metabolism in diverse environments

Orthology

K18978

glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]

Genes

HAL:	VNG_0937G(gap)
HSL:	OE_2367F(aldH3)
HHB:	Hhub_2122
NMO:	Nmlp_1397(aldH2)
HALI:	BV210_12380
HTU:	Htur_1629
HDA:	BB347_04210
NMG:	Nmag_3488
NAT:	NJ7G_3347
NPE:	Natpe_2432
HLR:	HALLA_11300
PFU:	PF0755
PFI:	PFC_02935
TKO:	TK0705
TSI:	TSIB_1868
TLT:	OCC_12546
TNU:	BD01_0877
THV:	ADU37_CDS19860
PPAC:	PAP_03390
APE:	APE_1786.1(gapN)
ACJ:	ACAM_1119(gapN)
SMR:	Smar_0084
SHC:	Shell_0726
DKA:	DKAM_1444
DFD:	Desfe_0067
DMU:	Desmu_1044
TAG:	Tagg_1262
IAG:	Igag_1780
THG:	TCELL_0871
SSO:	SSO3194(gapN-3)
SOL:	Ssol_0932
SSOA:	SULA_0965
SSOL:	SULB_0967
SSOF:	SULC_0966
STO:	STK_24770(gapN)
SAI:	Saci_0227
SACN:	SacN8_01100
SACR:	SacRon12I_01100
SACS:	SUSAZ_01140
SIS:	LS215_2328
SIA:	M1425_2165
SIM:	M1627_2245
SID:	M164_2168
SIY:	YG5714_2291
SIN:	YN1551_0624
SII:	LD85_2431
SIH:	SiH_2110
SIR:	SiRe_2042
SIC:	SiL_2017
SULA:	BFU36_06100
MSE:	Msed_1298
MCN:	Mcup_0943
PAS:	Pars_0554
POG:	Pogu_1837
CMA:	Cmaq_0979
TUZ:	TUZN_1133
TTN:	TTX_1169(gapN)
VDI:	Vdis_2334
VMO:	VMUT_0605
THF:	MA03_02735
ASC:	ASAC_1423
CLG:	Calag_1262
FFO:	FFONT_0138
CSU:	CSUB_C0048
NAA:	Nps_02395

» show all

Reference

1 [PMID:9497334]

Authors

Brunner NA, Brinkmann H, Siebers B, Hensel R

Title

Journal

J. Biol. Chem. 273 (1998) 6149-56.

Sequence

[ag:CAA71651]

Reference

2 [PMID:11354453]

Authors

Brunner NA, Siebers B, Hensel R

Title

Role of two different glyceraldehyde-3-phosphate dehydrogenases in controlling the reversible Embden-Meyerhof-Parnas pathway in Thermoproteus tenax: regulation on protein and transcript level.

Journal

Extremophiles. 5 (2001) 101-9.

Sequence

[ag:CAA71651]

Reference

3 [PMID:11842090]

Authors

Pohl E, Brunner N, Wilmanns M, Hensel R

Title

The crystal structure of the allosteric non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeum Thermoproteus tenax.

Journal

J. Biol. Chem. 277 (2002) 19938-45.

Sequence

[ag:CAA71651]

Reference

4 [PMID:15288789]

Authors

Lorentzen E, Hensel R, Knura T, Ahmed H, Pohl E

Title

Structural Basis of allosteric regulation and substrate specificity of the non-phosphorylating glyceraldehyde 3-Phosphate dehydrogenase from Thermoproteus tenax.

Journal

J. Mol. Biol. 341 (2004) 815-28.

Sequence

[ag:CAA71651]

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.90

IUBMB Enzyme Nomenclature:

1.2.1.90

ExPASy - ENZYME nomenclature database:

1.2.1.90

BRENDA, the Enzyme Database:

1.2.1.90

All links

Pathway (10)   
   KEGG PATHWAY (8)   
   KEGG MODULE (2)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (69)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (66)   
   KEGG MGENES (1)   
   RefGene (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (2)   
All databases (94)   

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REACTION: R01058

Entry

R01058 Reaction

Name

D-glyceraldehyde 3-phosphate:NADP+ oxidoreductase

Definition

D-Glyceraldehyde 3-phosphate + NADP+ + H2O <=> 3-Phospho-D-glycerate + NADPH + H+

Equation

C00118 + C00006 + C00001 <=> C00197 + C00005 + C00080

Reaction class

RC00001	C00005_C00006
RC00242	C00118_C00197

Enzyme

1.2.1.9 1.2.1.90

Pathway

rn00010	Glycolysis / Gluconeogenesis
rn00030	Pentose phosphate pathway
rn01100	Metabolic pathways
rn01120	Microbial metabolism in diverse environments
rn01200	Carbon metabolism

Module

M00308	Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P
M00633	Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P

Orthology

K00131	glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9]
K18978	glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] [EC:1.2.1.90]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (12)   
   KEGG PATHWAY (10)   
   KEGG MODULE (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (5)   
   KEGG ENZYME (2)   
   KEGG RCLASS (2)   
   SABIO-RK (1)   
Gene (711)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (709)   
All databases (735)   

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REACTION: R10860

Entry

R10860 Reaction

Name

D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase

Definition

D-Glyceraldehyde 3-phosphate + NAD+ + H2O <=> 3-Phospho-D-glycerate + NADH + H+

Equation

C00118 + C00003 + C00001 <=> C00197 + C00004 + C00080

Reaction class

RC00001	C00003_C00004
RC00242	C00118_C00197

Enzyme

1.2.1.90

Pathway

rn00010	Glycolysis / Gluconeogenesis
rn00030	Pentose phosphate pathway
rn01100	Metabolic pathways
rn01120	Microbial metabolism in diverse environments
rn01200	Carbon metabolism

Module

M00308	Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P
M00633	Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P

Orthology

K18978

glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] [EC:1.2.1.90]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (12)   
   KEGG PATHWAY (10)   
   KEGG MODULE (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (67)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (66)   
All databases (89)   

Download RDF

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