KEGG ORTHOLOGY: K21607

ORTHOLOGY: K21607

Entry

K21607 KO

Name

pcpD

Definition

tetrachlorobenzoquinone reductase [EC:1.1.1.404]

Pathway

ko00361

Chlorocyclohexane and chlorobenzene degradation

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Xenobiotics biodegradation and metabolism
   00361 Chlorocyclohexane and chlorobenzene degradation
    K21607  pcpD; tetrachlorobenzoquinone reductase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.404  tetrachlorobenzoquinone reductase
     K21607  pcpD; tetrachlorobenzoquinone reductase

Other DBs

RN:

R11585

COG:

COG1018 COG0633

Genes

SOD:	Sant_1981
PAO:	Pat9b_4735
TCI:	A7K98_17460
PAE:	PA3498
PAEV:	N297_3621
PAEI:	N296_3621
PNC:	NCGM2_5295
PAEB:	NCGM1900_0866
PAEM:	U769_04370
PAEL:	T223_04310
PAEU:	BN889_04544
PAEC:	M802_3620
PAEO:	M801_3486
PRE:	PCA10_15680
PCQ:	PcP3B5_07920(pobB_1) PcP3B5_28850(pobB_3)
PFC:	PflA506_5354(vanB)
PSV:	PVLB_18300
PALK:	PSAKL28_39360
AAL:	EP13_18330
AAUS:	EP12_19110
AXE:	P40_21510
RPI:	Rpic_4500
RPF:	Rpic12D_4632
RPJ:	N234_24525 N234_29130
RMN:	TK49_17075
RIN:	ACS15_4618
REU:	Reut_B3579 Reut_B4797
REH:	H16_B0739(h16_B0739)
CNC:	CNE_2c06820(pobB) CNE_2c17660
RME:	Rmet_5549(pobB)
CTI:	RALTA_B0575
CBW:	RR42_m2771 RR42_s1575
CCUP:	BKK81_20595 BKK81_25625 BKK81_29830
BCEN:	DM39_1986
BGP:	BGL_2c01180
BGE:	BC1002_4697
BYI:	BYI23_C004950 BYI23_D008340
BUO:	BRPE64_DCDS03390
BUE:	BRPE67_CCDS06780 BRPE67_DCDS10270
BPLA:	bpln_1p1360 bpln_2g01180
BXE:	Bxe_B2369
BXB:	DR64_4701
BPY:	Bphyt_4243
BCAI:	K788_00002315
PSPW:	BJG93_04570
PPK:	U875_18000
PPNO:	DA70_10510
PPNM:	LV28_20550
PRB:	X636_16120
PSPU:	NA29_21435 NA29_22295
PAPI:	SG18_14725
PVE:	UC34_06025
POX:	MB84_08065 MB84_10465
PTX:	ABW99_12525
PFG:	AB870_17050 AB870_18760
PNR:	AT302_01050 AT302_05955
BAV:	BAV0615
BHZ:	ACR54_03867(pobB)
BBRO:	BAU06_03630
BFZ:	BAU07_13835
AIS:	BUW96_05035
CDN:	BN940_17076
AFA:	UZ73_13830
POL:	Bpro_3680
VEI:	Veis_2771
DAC:	Daci_0965
DEL:	DelCs14_5558
DTS:	BI380_19870
DHK:	BO996_04910
VAP:	Vapar_3159
VPE:	Varpa_3582
VPD:	VAPA_1c32460 VAPA_2c09730
CTT:	CtCNB1_4601
CTES:	O987_27295 O987_28190
HYR:	BSY239_2702 BSY239_3348
HYB:	Q5W_01280 Q5W_24670
MMS:	mma_2506
HHT:	F506_19590
HRB:	Hrubri_1309
CARE:	LT85_0544
MESO:	BSQ44_11255
AAK:	AA2016_5653
BJU:	BJ6T_42230
BJP:	RN69_20525
AOL:	S58_21520
HMC:	HYPMC_3536(pobB)
DEQ:	XM25_18610
RHZ:	RHPLAN_44340
AEX:	Astex_2477
CBOT:	ATE48_17525
CID:	P73_2874
CON:	TQ29_05730
SMAZ:	LH19_26280
SPHI:	TS85_13180
SSAN:	NX02_22630
SCH:	Sphch_3460
SBD:	ATN00_07600
SPHR:	BSY17_2022
AAY:	WYH_01862(pobB_1) WYH_03339(pobB_2)
CMAN:	A9D14_14475
AACE:	A0U92_13920
AFI:	Acife_2356
RAV:	AAT18_24310
GOR:	KTR9_4397
GTA:	BCM27_23245
SBH:	SBI_09770

» show all

Reference

PMID:23676275

Authors

Yadid I, Rudolph J, Hlouchova K, Copley SD

Title

Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol.

Journal

Proc Natl Acad Sci U S A 110:E2182-90 (2013)
DOI:10.1073/pnas.1214052110

Sequence

[sch:Sphch_3460]

All links

Ontology (4)   
   KEGG BRITE (2)   
   COG (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Gene (132)   
   KEGG GENES (125)   
   OC (7)   
Literature (1)   
   PubMed (1)   
All databases (145)   

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ENZYME: 1.1.1.404

Entry

EC 1.1.1.404 Enzyme

Name

tetrachlorobenzoquinone reductase;
pcpD (gene name);
TCBQ reductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

2,3,5,6-tetrachlorohydroquinone:NAD+ oxidoreductase

Reaction(IUBMB)

2,3,5,6-tetrachlorohydroquinone + NAD+ = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH + H+ [RN:R11585]

Reaction(KEGG)

R11585

Substrate

2,3,5,6-tetrachlorohydroquinone [CPD:C03434];
NAD+ [CPD:C00003]

Product

2,3,5,6-tetrachloro-1,4-benzoquinone [CPD:C18933];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Contains FMN. The enzyme, characterized from the bacterium Sphingobium chlorophenolicum, participates in the degradation of pentachlorophenol.

History

EC 1.1.1.404 created 2017

Pathway

ec00361	Chlorocyclohexane and chlorobenzene degradation
ec01100	Metabolic pathways
ec01120	Microbial metabolism in diverse environments

Orthology

K21607

tetrachlorobenzoquinone reductase

Genes

SOD:	Sant_1981
PAO:	Pat9b_4735
TCI:	A7K98_17460
PAE:	PA3498
PAEV:	N297_3621
PAEI:	N296_3621
PNC:	NCGM2_5295
PAEB:	NCGM1900_0866
PAEM:	U769_04370
PAEL:	T223_04310
PAEU:	BN889_04544
PAEC:	M802_3620
PAEO:	M801_3486
PRE:	PCA10_15680
PCQ:	PcP3B5_07920(pobB_1) PcP3B5_28850(pobB_3)
PFC:	PflA506_5354(vanB)
PSV:	PVLB_18300
PALK:	PSAKL28_39360
AAL:	EP13_18330
AAUS:	EP12_19110
AXE:	P40_21510
RPI:	Rpic_4500
RPF:	Rpic12D_4632
RPJ:	N234_24525 N234_29130
RMN:	TK49_17075
RIN:	ACS15_4618
REU:	Reut_B3579 Reut_B4797
REH:	H16_B0739(h16_B0739)
CNC:	CNE_2c06820(pobB) CNE_2c17660
RME:	Rmet_5549(pobB)
CTI:	RALTA_B0575
CBW:	RR42_m2771 RR42_s1575
CCUP:	BKK81_20595 BKK81_25625 BKK81_29830
BCEN:	DM39_1986
BGP:	BGL_2c01180
BGE:	BC1002_4697
BYI:	BYI23_C004950 BYI23_D008340
BUO:	BRPE64_DCDS03390
BUE:	BRPE67_CCDS06780 BRPE67_DCDS10270
BPLA:	bpln_1p1360 bpln_2g01180
BXE:	Bxe_B2369
BXB:	DR64_4701
BPY:	Bphyt_4243
BCAI:	K788_00002315
PSPW:	BJG93_04570
PPK:	U875_18000
PPNO:	DA70_10510
PPNM:	LV28_20550
PRB:	X636_16120
PSPU:	NA29_21435 NA29_22295
PAPI:	SG18_14725
PVE:	UC34_06025
POX:	MB84_08065 MB84_10465
PTX:	ABW99_12525
PFG:	AB870_17050 AB870_18760
PNR:	AT302_01050 AT302_05955
BAV:	BAV0615
BHZ:	ACR54_03867(pobB)
BBRO:	BAU06_03630
BFZ:	BAU07_13835
AIS:	BUW96_05035
CDN:	BN940_17076
AFA:	UZ73_13830
POL:	Bpro_3680
VEI:	Veis_2771
DAC:	Daci_0965
DEL:	DelCs14_5558
DTS:	BI380_19870
DHK:	BO996_04910
VAP:	Vapar_3159
VPE:	Varpa_3582
VPD:	VAPA_1c32460 VAPA_2c09730
CTT:	CtCNB1_4601
CTES:	O987_27295 O987_28190
HYR:	BSY239_2702 BSY239_3348
HYB:	Q5W_01280 Q5W_24670
MMS:	mma_2506
HHT:	F506_19590
HRB:	Hrubri_1309
CARE:	LT85_0544
MESO:	BSQ44_11255
AAK:	AA2016_5653
BJU:	BJ6T_42230
BJP:	RN69_20525
AOL:	S58_21520
HMC:	HYPMC_3536(pobB)
DEQ:	XM25_18610
RHZ:	RHPLAN_44340
AEX:	Astex_2477
CBOT:	ATE48_17525
CID:	P73_2874
CON:	TQ29_05730
SMAZ:	LH19_26280
SPHI:	TS85_13180
SSAN:	NX02_22630
SCH:	Sphch_3460
SBD:	ATN00_07600
SPHR:	BSY17_2022
AAY:	WYH_01862(pobB_1) WYH_03339(pobB_2)
CMAN:	A9D14_14475
AACE:	A0U92_13920
AFI:	Acife_2356
RAV:	AAT18_24310
GOR:	KTR9_4397
GTA:	BCM27_23245
SBH:	SBI_09770

» show all

Reference

1 [PMID:19325743]

Authors

Chen L, Yang J

Title

Biochemical characterization of the tetrachlorobenzoquinone reductase involved in the biodegradation of pentachlorophenol.

Journal

Int. J. Mol. Sci. 9 (2008) 198-212.

Reference

2 [PMID:23676275]

Authors

Yadid I, Rudolph J, Hlouchova K, Copley SD

Title

Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol.

Journal

Proc. Natl. Acad. Sci. U. S. A. 110 (2013) E2182-90.

Sequence

[sch:Sphch_3460]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.404

IUBMB Enzyme Nomenclature:

1.1.1.404

ExPASy - ENZYME nomenclature database:

1.1.1.404

BRENDA, the Enzyme Database:

1.1.1.404

All links

Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (126)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (125)   
All databases (138)   

Download RDF

REACTION: R11585

Entry

R11585 Reaction

Name

2,3,5,6-tetrachlorohydroquinone:NAD+ oxidoreductase

Definition

Tetrachlorohydroquinone + NAD+ <=> Chloranil + NADH + H+

Equation

C03434 + C00003 <=> C18933 + C00004 + C00080

Enzyme

1.1.1.404

Pathway

rn00361	Chlorocyclohexane and chlorobenzene degradation
rn01100	Metabolic pathways
rn01120	Microbial metabolism in diverse environments

Orthology

K21607

tetrachlorobenzoquinone reductase [EC:1.1.1.404]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (126)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (125)   
All databases (139)   

Download RDF

DBGET integrated database retrieval system