KEGG   MODULE: M00053
Entry
M00053            Pathway   Module                                 
Name
Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP
Definition
(K00525+K00526,K10807+K10808) (K00940,K18533)
Diagram
M00053

Orthology
K00525,K00526,K10807,K10808  
ribonucleoside-diphosphate reductase [EC:1.17.4.1] [RN:R02017 R02019 R02024 R02018]
K00940,K18533  
nucleoside-diphosphate kinase [EC:2.7.4.6] [RN:R01137 R01857 R02326 R02331]
Class
Pathway modules; Nucleotide metabolism; Purine metabolism
Pathway
map00230  Purine metabolism
map00240  Pyrimidine metabolism
map01232  Nucleotide metabolism
map01100  Metabolic pathways
Reaction
R02017 C00008 -> C00206  
 
R01137 C00206 -> C00131  
 
R02019 C00035 -> C00361  
 
R01857 C00361 -> C00286  
 
R02024 C00112 -> C00705  
 
R02326 C00705 -> C00458  
 
R02018 C00015 -> C01346  
 
R02331 C01346 -> C00460  
 
Compound
C00008  ADP
C00206  dADP
C00131  dATP
C00035  GDP
C00361  dGDP
C00286  dGTP
C00112  CDP
C00705  dCDP
C00458  dCTP
C00015  UDP
C01346  dUDP
C00460  dUTP
Reference
PMID:28458037
  Authors
Okesli A, Khosla C, Bassik MC
  Title
Human pyrimidine nucleotide biosynthesis as a target for antiviral chemotherapy.
  Journal
Curr Opin Biotechnol 48:127-134 (2017)
DOI:10.1016/j.copbio.2017.03.010

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (12)   
   KEGG COMPOUND (12)   
Chemical reaction (11)   
   KEGG ENZYME (3)   
   KEGG REACTION (8)   
Gene (6)   
   KEGG ORTHOLOGY (6)   
Literature (1)   
   PubMed (1)   
All databases (34)   

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