KEGG   MODULE: M00374Help
Entry
M00374            Pathway   Module                                 

Name
Dicarboxylate-hydroxybutyrate cycle
Definition
(K00169+K00170+K00171+K00172,K03737) K01007 K01595 K00024 (K01676,K01679,K01677+K01678) (K00239+K00240-K00241-K00242,K00244+K00245+K00246+K00247) (K01902+K01903) (K15038,K15017) K14465 (K14466,K14467) K14534 (K15016,K01715 (K01782,K01825,K07516)) K00626
Module map
M00374

Orthology
pyruvate ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196]
K03737  
putative pyruvate-flavodoxin oxidoreductase [EC:1.2.7.-] [RN:R01196]
K01007  
pyruvate, water dikinase [EC:2.7.9.2] [RN:R00199]
K01595  
phosphoenolpyruvate carboxylase [EC:4.1.1.31] [RN:R00345]
K00024  
malate dehydrogenase [EC:1.1.1.37] [RN:R00342]
fumarate hydratase [EC:4.2.1.2] [RN:R01082]
succinate dehydrogenase [EC:1.3.99.1] [RN:R00408]
succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405]
succinyl-coA reductase [EC:1.2.1.76] [RN:R09280]
K14465  
succinate semialdehyde reductase (NADPH) [EC:1.1.1.-] [RN:R09281]
4-hydroxybutyryl-CoA synthetase (4-hydroxybutyrate-CoA ligase, AMP-forming) [EC:6.2.1.-] [RN:R09279]
K14534  
4-hydroxybutyryl-CoA dehydratase / vinylacetyl-CoA-Delta-isomerase [EC:4.2.1.120 5.3.3.3] [RN:R05337 R03031]
K01715  
3-hydroxybutyryl-CoA dehydratase [EC:4.2.1.17] [RN:R03026]
K15016  
3-hydroxybutyryl-CoA dehydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35] [RN:R03026 R01975]
3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] [RN:R01975]
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238]
Ortholog tableTaxonomy
Class
Pathway module; Energy metabolism; Carbon fixation
BRITE hierarchy
Pathway
Carbon metabolism
Carbon fixation pathways in prokaryotes
Reaction
Compound
C00024  
Acetyl-CoA
C00022  
Pyruvate
C00074  
Phosphoenolpyruvate
C00036  
Oxaloacetate
C00149  
(S)-Malate
C00122  
Fumarate
C00042  
Succinate
C00091  
Succinyl-CoA
C00232  
Succinate semialdehyde
C00989  
4-Hydroxybutanoic acid
C11062  
4-Hydroxybutyryl-CoA
C02331  
Vinylacetyl-CoA
C00877  
Crotonoyl-CoA
C01144  
(S)-3-Hydroxybutanoyl-CoA
C00332  
Acetoacetyl-CoA
Other DBs
BSID: 
Reference
  Authors
Huber H, Gallenberger M, Jahn U, Eylert E, Berg IA, Kockelkorn D, Eisenreich W, Fuchs G
  Title
A dicarboxylate/4-hydroxybutyrate autotrophic carbon assimilation cycle in the hyperthermophilic Archaeum Ignicoccus hospitalis.
  Journal
Proc Natl Acad Sci U S A 105:7851-6 (2008)

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