KEGG   REACTION: R04558Help
Entry
R04558                      Reaction                               

Definition
N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide + L-Glutamine <=> D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + L-Glutamate
Equation
Comment
Imidazole glycerol phosphate synthase, hisH/hisF
two-step reaction: (1a) Glutamine + H2O = Glutamate + NH3, (1b) NH3 + PRFAR = IGP + AICAR + H2O
RPair
C00025_C00064 main
C04677_C04916 main
C00064_C04666 trans
C00025_C04916 trans
C04666_C04916 main
Enzyme
2.4.2.-         4.1.3.-
Pathway
Histidine metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Biosynthesis of amino acids
Orthology
K01663  
glutamine amidotransferase / cyclase [EC:2.4.2.- 4.1.3.-]
K02500  
cyclase [EC:4.1.3.-]
K02501  
glutamine amidotransferase [EC:2.4.2.-]
Reference
1  [PMID:11264293]
Beismann-Driemeyer S, Sterner R.
Imidazole glycerol phosphate synthase from Thermotoga maritima. Quaternary structure, steady-state kinetics, and reaction mechanism of the bienzyme complex.
J. Biol. Chem. 276 (2001) 20387-96.

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