KEGG   PATHWAY: aag03008Help
Entry
aag03008                    Pathway                                

Name
Ribosome biogenesis in eukaryotes - Aedes aegypti (yellow fever mosquito)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is  assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Ribosome biogenesis in eukaryotes
aag03008

All organismsOrtholog table
Module
H/ACA ribonucleoprotein complex [PATH:aag03008]
Organism
Aedes aegypti (yellow fever mosquito) [GN:aag]
Gene
casein kinase II subunit beta isoform X1 [KO:K03115]
casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
nucleolar protein 6 [KO:K14544]
ribosomal RNA-processing protein 7 homolog A [KO:K14545]
WD repeat-containing protein 43 [KO:K14546]
U3 small nucleolar RNA-associated protein 4 homolog [KO:K14548]
U3 small nucleolar RNA-associated protein 15 homolog [KO:K14549]
HEAT repeat-containing protein 1 homolog [KO:K14550]
WD repeat-containing protein 75 [KO:K14552]
U3 small nucleolar RNA-associated protein 18 homolog [KO:K14553]
WD repeat-containing protein 36 [KO:K14554]
transducin beta-like protein 3 [KO:K14555]
WD repeat-containing protein 3 [KO:K14556]
U3 small nucleolar RNA-associated protein 6 homolog [KO:K14557]
periodic tryptophan protein 2 homolog [KO:K14558]
U3 small nucleolar ribonucleoprotein protein MPP10 [KO:K14559]
U3 small nucleolar ribonucleoprotein protein IMP3 [KO:K14560]
U3 small nucleolar ribonucleoprotein protein IMP4 [KO:K14561]
rRNA 2'-O-methyltransferase fibrillarin [KO:K14563] [EC:2.1.1.-]
nucleolar protein 56 [KO:K14564]
nucleolar protein 58 isoform X1 [KO:K14565]
NHP2-like protein 1 homolog [KO:K12845]
H/ACA ribonucleoprotein complex subunit 4 [KO:K11131] [EC:5.4.99.-]
H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129]
H/ACA ribonucleoprotein complex subunit 1 [KO:K11128]
H/ACA ribonucleoprotein complex subunit 3 [KO:K11130]
rRNA-processing protein FCF1 homolog [KO:K14566]
U3 small nucleolar RNA-associated protein 14 homolog A [KO:K14567]
ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
ribosomal RNA small subunit methyltransferase NEP1 [KO:K14568] [EC:2.1.1.260]
ribosome biogenesis protein BMS1 homolog [KO:K14569]
RNA cytidine acetyltransferase [KO:K14521] [EC:2.3.1.-]
probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108]
ribonucleases P/MRP protein subunit POP1 [KO:K01164] [EC:3.1.26.5]
ribonuclease P protein subunit p29 [KO:K03538] [EC:3.1.26.5]
uncharacterized protein LOC5574003 isoform X1 [KO:K03537] [EC:3.1.26.5]
ribonuclease P protein subunit p25-like protein [KO:K14525] [EC:3.1.26.5]
ribonuclease P protein subunit p30 [KO:K03539] [EC:3.1.26.5]
ribonuclease P protein subunit p40 isoform X2 [KO:K14530] [EC:3.1.26.5]
uncharacterized protein LOC110677665 isoform X1 [KO:K14570] [EC:3.1.-.-]
RNA exonuclease 1 [KO:K14570] [EC:3.1.-.-]
probable oligoribonuclease isoform X2 [KO:K13288] [EC:3.1.-.-]
5'-3' exoribonuclease 1 [KO:K12618] [EC:3.1.13.-]
5'-3' exoribonuclease 2 homolog [KO:K12619] [EC:3.1.13.-]
nucleolar GTP-binding protein 1 [KO:K06943]
nucleolar GTP-binding protein 2 [KO:K14537]
guanine nucleotide-binding protein-like 3 homolog [KO:K14538]
nuclear valosin-containing protein-like [KO:K14571]
midasin [KO:K14572]
RNA-binding protein 28 [KO:K14573]
RNA-binding protein NOB1 [KO:K11883]
GTP-binding nuclear protein Ran [KO:K07936]
exportin-1 [KO:K14290]
60S ribosomal export protein NMD3 [KO:K07562]
nuclear RNA export factor 1 [KO:K14284]
nuclear RNA export factor 2 [KO:K14284]
NTF2-related export protein [KO:K14285]
NTF2-related export protein [KO:K14285]
NTF2-related export protein [KO:K14285]
eukaryotic translation initiation factor 6 [KO:K03264]
ribosome maturation protein SBDS [KO:K14574]
elongation factor-like GTPase 1 [KO:K14536] [EC:3.6.5.-]
large subunit GTPase 1 homolog [KO:K14539] [EC:3.6.1.-]
spermatogenesis-associated protein 5 [KO:K14575]
adenylate kinase isoenzyme 6 homolog [KO:K18532] [EC:2.7.4.3]
serine/threonine-protein kinase RIO1 [KO:K07178] [EC:2.7.11.1]
serine/threonine-protein kinase rio2 [KO:K07179] [EC:2.7.11.1]
Reference
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
KO pathway
 

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