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aag03008                    Pathway                                

Ribosome biogenesis in eukaryotes - Aedes aegypti (yellow fever mosquito)
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is  assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Genetic Information Processing; Translation
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Ribosome biogenesis in eukaryotes

All organismsOrtholog table
Aedes aegypti (yellow fever mosquito) [GN:aag]
casein kinase II subunit alpha [KO:K03097] [EC:]
WD repeat-containing protein 43 [KO:K14546]
U3 small nucleolar RNA-associated protein 4 homolog [KO:K14548]
U3 small nucleolar RNA-associated protein 15 homolog [KO:K14549]
U3 small nucleolar RNA-associated protein 18 homolog [KO:K14553]
U3 small nucleolar RNA-associated protein 6 homolog [KO:K14557]
U3 small nucleolar ribonucleoprotein protein IMP4 [KO:K14561]
nucleolar protein 56 [KO:K14564]
NHP2-like protein 1 homolog [KO:K12845]
H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129]
H/ACA ribonucleoprotein complex subunit 3 [KO:K11130]
ribonuclease 3 [KO:K03685] [EC:]
ribosomal RNA small subunit methyltransferase NEP1 [KO:K14568] [EC:]
RNA cytidine acetyltransferase [KO:K14521] [EC:2.3.1.-]
uncharacterized protein LOC5574003 isoform X1 [KO:K03537] [EC:]
ribonuclease P protein subunit p30 [KO:K03539] [EC:]
ribonuclease P protein subunit p40 isoform X2 [KO:K14530] [EC:]
probable oligoribonuclease isoform X2 [KO:K13288] [EC:3.1.-.-]
guanine nucleotide-binding protein-like 3 homolog [KO:K14538]
GTP-binding nuclear protein Ran [KO:K07936]
exportin-1 [KO:K14290]
60S ribosomal export protein NMD3 [KO:K07562]
nuclear RNA export factor 1 [KO:K14284]
nuclear RNA export factor 2 [KO:K14284]
NTF2-related export protein [KO:K14285]
NTF2-related export protein [KO:K14285]
NTF2-related export protein [KO:K14285]
eukaryotic translation initiation factor 6 [KO:K03264]
ribosome maturation protein SBDS [KO:K14574]
adenylate kinase isoenzyme 6 homolog [KO:K18532] [EC:]
serine/threonine-protein kinase RIO1 [KO:K07178] [EC:]
serine/threonine-protein kinase rio2 [KO:K07179] [EC:]
Freed EF, Bleichert F, Dutca LM, Baserga SJ
When ribosomes go bad: diseases of ribosome biogenesis.
Mol Biosyst 6:481-93 (2010)
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
Mol Cell Biol 27:5414-29 (2007)
Strunk BS, Karbstein K
Powering through ribosome assembly.
RNA 15:2083-104 (2009)
Granneman S, Baserga SJ
Ribosome biogenesis: of knobs and RNA processing.
Exp Cell Res 296:43-50 (2004)
Kressler D, Hurt E, Bassler J
Driving ribosome assembly.
Biochim Biophys Acta 1803:673-83 (2010)
KO pathway

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