KEGG   PATHWAY: aag03008Help
Entry
aag03008                    Pathway                                

Name
Ribosome biogenesis in eukaryotes - Aedes aegypti (yellow fever mosquito)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is  assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Ribosome biogenesis in eukaryotes
aag03008

All organismsOrtholog table
Organism
Aedes aegypti (yellow fever mosquito) [GN:aag]
Gene
casein kinase ii; K03097 casein kinase II subunit alpha [EC:2.7.11.1] [KO:K03097] [EC:2.7.11.1]
nucleolar RNA-associated protein; K14544 U3 small nucleolar RNA-associated protein 22 [KO:K14544]
hypothetical protein; K14545 ribosomal RNA-processing protein 7 [KO:K14545]
hypothetical protein; K14545 ribosomal RNA-processing protein 7 [KO:K14545]
hypothetical protein; K14546 U3 small nucleolar RNA-associated protein 5 [KO:K14546]
hypothetical protein; K14548 U3 small nucleolar RNA-associated protein 4 [KO:K14548]
U3 small nucleolar RNA-associated protein; K14549 U3 small nucleolar RNA-associated protein 15 [KO:K14549]
bap28; K14550 U3 small nucleolar RNA-associated protein 10 [KO:K14550]
hypothetical protein; K14552 NET1-associated nuclear protein 1 (U3 small nucleolar RNA-associated protein 17) [KO:K14552]
hypothetical protein; K14553 U3 small nucleolar RNA-associated protein 18 [KO:K14553]
wd-repeat protein; K14554 U3 small nucleolar RNA-associated protein 21 [KO:K14554]
hypothetical protein; K14555 U3 small nucleolar RNA-associated protein 13 [KO:K14555]
hypothetical protein; K14556 U3 small nucleolar RNA-associated protein 12 [KO:K14556]
hepatocellular carcinoma-associated antigen; K14557 U3 small nucleolar RNA-associated protein 6 [KO:K14557]
wd-repeat protein; K14558 periodic tryptophan protein 2 [KO:K14558]
wd-repeat protein; K14558 periodic tryptophan protein 2 [KO:K14558]
U3 small nucleolar ribonucleoprotein protein mpp10; K14559 U3 small nucleolar RNA-associated protein MPP10 [KO:K14559]
U3 small nucleolar ribonucleoprotein protein IMP3 (U3 snoRNP protein IMP3); K14560 U3 small nucleolar ribonucleoprotein protein IMP3 [KO:K14560]
U3 small nucleolar ribonucleoprotein protein imp4; K14561 U3 small nucleolar ribonucleoprotein protein IMP4 [KO:K14561]
fibrillarin; K14563 rRNA 2'-O-methyltransferase fibrillarin [EC:2.1.1.-] [KO:K14563] [EC:2.1.1.-]
ribosomal protein l7ae; K12845 U4/U6 small nuclear ribonucleoprotein SNU13 [KO:K12845]
centromere/microtubule binding protein cbf5; K11131 H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-] [KO:K11131] [EC:5.4.99.-]
NHP2 protein; K11129 H/ACA ribonucleoprotein complex subunit 2 [KO:K11129]
hypothetical protein; K11130 H/ACA ribonucleoprotein complex subunit 3 [KO:K11130]
hypothetical protein; K14566 U3 small nucleolar RNA-associated protein 24 [KO:K14566]
smooth muscle caldesmon; K14567 U3 small nucleolar RNA-associated protein 14 [KO:K14567]
ribonuclease iii; K03685 ribonuclease III [EC:3.1.26.3] [KO:K03685] [EC:3.1.26.3]
nucleolar essential protein 1 (nep1); K14568 rRNA small subunit pseudouridine methyltransferase Nep1 [EC:2.1.1.260] [KO:K14568] [EC:2.1.1.260]
ribosome biogenesis protein; K14569 ribosome biogenesis protein BMS1 [KO:K14569]
hypothetical protein; K14521 N-acetyltransferase 10 [EC:2.3.1.-] [KO:K14521] [EC:2.3.1.-]
RNA 3' terminal phosphate cyclase; K11108 RNA 3'-terminal phosphate cyclase-like protein [KO:K11108]
hypothetical protein; K01164 ribonuclease P/MRP protein subunit POP1 [EC:3.1.26.5] [KO:K01164] [EC:3.1.26.5]
ribonuclease P; K03538 ribonuclease P protein subunit POP4 [EC:3.1.26.5] [KO:K03538] [EC:3.1.26.5]
Pop5 protein; K03537 ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5] [KO:K03537] [EC:3.1.26.5]
hypothetical protein; K14525 ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5] [KO:K14525] [EC:3.1.26.5]
hypothetical protein; K14527 ribonuclease P/MRP protein subunit RPP20 [EC:3.1.26.5] [KO:K14527] [EC:3.1.26.5]
hypothetical protein; K03539 ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5] [KO:K03539] [EC:3.1.26.5]
hypothetical protein; K14530 ribonucleases P/MRP protein subunit RPP40 [EC:3.1.26.5] [KO:K14530] [EC:3.1.26.5]
exonuclease nef-sp; K14570 RNA exonuclease 1 [EC:3.1.-.-] [KO:K14570] [EC:3.1.-.-]
rnase h (70); K14570 RNA exonuclease 1 [EC:3.1.-.-] [KO:K14570] [EC:3.1.-.-]
rnase h (70); K14570 RNA exonuclease 1 [EC:3.1.-.-] [KO:K14570] [EC:3.1.-.-]
oligoribonuclease; K13288 oligoribonuclease [EC:3.1.-.-] [KO:K13288] [EC:3.1.-.-]
5'-3' exoribonuclease; K12618 5'-3' exoribonuclease 1 [EC:3.1.13.-] [KO:K12618] [EC:3.1.13.-]
5'-3' exoribonuclease; K12619 5'-3' exoribonuclease 2 [EC:3.1.13.-] [KO:K12619] [EC:3.1.13.-]
5'-3' exoribonuclease; K12619 5'-3' exoribonuclease 2 [EC:3.1.13.-] [KO:K12619] [EC:3.1.13.-]
nucleolar GTP-binding protein; K06943 nucleolar GTP-binding protein [KO:K06943]
GTP-binding protein; K14537 nuclear GTP-binding protein [KO:K14537]
GTP-binding protein-invertebrate; K14538 nuclear GTP-binding protein [KO:K14538]
peroxisome assembly factor-2 (peroxisomal-type atpase 1); K14571 ribosome biogenesis ATPase [KO:K14571]
hypothetical protein; K14572 midasin [KO:K14572]
RNA-binding protein; K14573 nucleolar protein 4 [KO:K14573]
hypothetical protein; K11883 RNA-binding protein NOB1 [KO:K11883]
ran; K07936 GTP-binding nuclear protein Ran [KO:K07936]
chromosome region maintenance protein 1/exportin; K14290 exportin-1 [KO:K14290]
nonsense-mediated mrna decay protein; K07562 nonsense-mediated mRNA decay protein 3 [KO:K07562]
hypothetical protein; K14284 nuclear RNA export factor 1/2 [KO:K14284]
nuclear RNA export factor 2 (NXF2); K14284 nuclear RNA export factor 1/2 [KO:K14284]
p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
p15-2a protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
hypothetical protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
p15-2a protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
p15-2a protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
p15-2a protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
hypothetical protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
hypothetical protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
p15-2a protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
translation initiation factor; K03264 translation initiation factor 6 [KO:K03264]
hypothetical protein; K14574 ribosome maturation protein SDO1 [KO:K14574]
translation elongation factor; K14536 ribosome assembly protein 1 [EC:3.6.5.-] [KO:K14536] [EC:3.6.5.-]
hypothetical protein; K14539 large subunit GTPase 1 [EC:3.6.1.-] [KO:K14539] [EC:3.6.1.-]
hypothetical protein; K14539 large subunit GTPase 1 [EC:3.6.1.-] [KO:K14539] [EC:3.6.1.-]
spermatogenesis associated factor; K14575 AAA family ATPase [KO:K14575]
coilin-interacting nulcear ATPase protein; K14535 transcription initiation factor TFIID subunit 9 / adenylate kinase [EC:2.7.4.3] [KO:K14535] [EC:2.7.4.3]
coilin-interacting nulcear ATPase protein; K14535 transcription initiation factor TFIID subunit 9 / adenylate kinase [EC:2.7.4.3] [KO:K14535] [EC:2.7.4.3]
serine/threonine-protein kinase rio1 (rio kinase 1); K07178 RIO kinase 1 [EC:2.7.11.1] [KO:K07178] [EC:2.7.11.1]
serine/threonine-protein kinase rio2 (rio kinase 2); K07179 RIO kinase 2 [EC:2.7.11.1] [KO:K07179] [EC:2.7.11.1]
s-rRNA  
s-rRNA; K01979 small subunit ribosomal RNA [KO:K01979]
l-rRNA  
l-rRNA; K01982 large subunit ribosomal RNA [KO:K01982]
Reference
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
Reference
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
Reference
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
Reference
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
Reference
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
KO pathway
 

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