KEGG PATHWAY: aag03008

PATHWAY: aag03008

Entry

aag03008 Pathway

Name

Ribosome biogenesis in eukaryotes - Aedes aegypti (yellow fever mosquito)

Description

Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.

Class

Genetic Information Processing; Translation

Pathway map

aag03008

Ribosome biogenesis in eukaryotes

Module

aag_M00425

H/ACA ribonucleoprotein complex [PATH:aag03008]

Organism

Aedes aegypti (yellow fever mosquito) [GN:aag]

Gene

AaeL_AAEL012094	casein kinase ii; K03097 casein kinase II subunit alpha [EC:2.7.11.1] [KO:K03097] [EC:2.7.11.1]
AaeL_AAEL004368	nucleolar RNA-associated protein; K14544 U3 small nucleolar RNA-associated protein 22 [KO:K14544]
AaeL_AAEL015658	hypothetical protein; K14545 ribosomal RNA-processing protein 7 [KO:K14545]
AaeL_AAEL000115	hypothetical protein; K14545 ribosomal RNA-processing protein 7 [KO:K14545]
AaeL_AAEL003949	hypothetical protein; K14546 U3 small nucleolar RNA-associated protein 5 [KO:K14546]
AaeL_AAEL006549	hypothetical protein; K14548 U3 small nucleolar RNA-associated protein 4 [KO:K14548]
AaeL_AAEL000422	U3 small nucleolar RNA-associated protein; K14549 U3 small nucleolar RNA-associated protein 15 [KO:K14549]
AaeL_AAEL001238	bap28; K14550 U3 small nucleolar RNA-associated protein 10 [KO:K14550]
AaeL_AAEL006610	hypothetical protein; K14552 NET1-associated nuclear protein 1 (U3 small nucleolar RNA-associated protein 17) [KO:K14552]
AaeL_AAEL007573	hypothetical protein; K14553 U3 small nucleolar RNA-associated protein 18 [KO:K14553]
AaeL_AAEL009308	wd-repeat protein; K14554 U3 small nucleolar RNA-associated protein 21 [KO:K14554]
AaeL_AAEL004526	hypothetical protein; K14555 U3 small nucleolar RNA-associated protein 13 [KO:K14555]
AaeL_AAEL004364	hypothetical protein; K14556 U3 small nucleolar RNA-associated protein 12 [KO:K14556]
AaeL_AAEL006972	hepatocellular carcinoma-associated antigen; K14557 U3 small nucleolar RNA-associated protein 6 [KO:K14557]
AaeL_AAEL003975	wd-repeat protein; K14558 periodic tryptophan protein 2 [KO:K14558]
AaeL_AAEL000300	wd-repeat protein; K14558 periodic tryptophan protein 2 [KO:K14558]
AaeL_AAEL001506	U3 small nucleolar ribonucleoprotein protein mpp10; K14559 U3 small nucleolar RNA-associated protein MPP10 [KO:K14559]
AaeL_AAEL005263	U3 small nucleolar ribonucleoprotein protein IMP3 (U3 snoRNP protein IMP3); K14560 U3 small nucleolar ribonucleoprotein protein IMP3 [KO:K14560]
AaeL_AAEL006063	U3 small nucleolar ribonucleoprotein protein imp4; K14561 U3 small nucleolar ribonucleoprotein protein IMP4 [KO:K14561]
AaeL_AAEL010248	fibrillarin; K14563 rRNA 2'-O-methyltransferase fibrillarin [EC:2.1.1.-] [KO:K14563] [EC:2.1.1.-]
AaeL_AAEL003352	ribosomal protein l7ae; K12845 U4/U6 small nuclear ribonucleoprotein SNU13 [KO:K12845]
AaeL_AAEL003514	centromere/microtubule binding protein cbf5; K11131 H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-] [KO:K11131] [EC:5.4.99.-]
AaeL_AAEL003469	NHP2 protein; K11129 H/ACA ribonucleoprotein complex subunit 2 [KO:K11129]
AaeL_AAEL007431	hypothetical protein; K11130 H/ACA ribonucleoprotein complex subunit 3 [KO:K11130]
AaeL_AAEL007697	hypothetical protein; K14566 U3 small nucleolar RNA-associated protein 24 [KO:K14566]
AaeL_AAEL008706	smooth muscle caldesmon; K14567 U3 small nucleolar RNA-associated protein 14 [KO:K14567]
AaeL_AAEL008592	ribonuclease iii; K03685 ribonuclease III [EC:3.1.26.3] [KO:K03685] [EC:3.1.26.3]
AaeL_AAEL002108	nucleolar essential protein 1 (nep1); K14568 rRNA small subunit pseudouridine methyltransferase Nep1 [EC:2.1.1.260] [KO:K14568] [EC:2.1.1.260]
AaeL_AAEL003555	ribosome biogenesis protein; K14569 ribosome biogenesis protein BMS1 [KO:K14569]
AaeL_AAEL006469	hypothetical protein; K14521 N-acetyltransferase 10 [EC:2.3.1.-] [KO:K14521] [EC:2.3.1.-]
AaeL_AAEL001080	RNA 3' terminal phosphate cyclase; K11108 RNA 3'-terminal phosphate cyclase-like protein [KO:K11108]
AaeL_AAEL009542	hypothetical protein; K01164 ribonuclease P/MRP protein subunit POP1 [EC:3.1.26.5] [KO:K01164] [EC:3.1.26.5]
AaeL_AAEL000215	ribonuclease P; K03538 ribonuclease P protein subunit POP4 [EC:3.1.26.5] [KO:K03538] [EC:3.1.26.5]
AaeL_AAEL010832	Pop5 protein; K03537 ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5] [KO:K03537] [EC:3.1.26.5]
AaeL_AAEL003455	hypothetical protein; K14525 ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5] [KO:K14525] [EC:3.1.26.5]
AaeL_AAEL002562	hypothetical protein; K14527 ribonuclease P/MRP protein subunit RPP20 [EC:3.1.26.5] [KO:K14527] [EC:3.1.26.5]
AaeL_AAEL002232	hypothetical protein; K03539 ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5] [KO:K03539] [EC:3.1.26.5]
AaeL_AAEL002157	hypothetical protein; K14530 ribonucleases P/MRP protein subunit RPP40 [EC:3.1.26.5] [KO:K14530] [EC:3.1.26.5]
AaeL_AAEL006744	exonuclease nef-sp; K14570 RNA exonuclease 1 [EC:3.1.-.-] [KO:K14570] [EC:3.1.-.-]
AaeL_AAEL003572	rnase h (70); K14570 RNA exonuclease 1 [EC:3.1.-.-] [KO:K14570] [EC:3.1.-.-]
AaeL_AAEL010932	rnase h (70); K14570 RNA exonuclease 1 [EC:3.1.-.-] [KO:K14570] [EC:3.1.-.-]
AaeL_AAEL008865	oligoribonuclease; K13288 oligoribonuclease [EC:3.1.-.-] [KO:K13288] [EC:3.1.-.-]
AaeL_AAEL008814	5'-3' exoribonuclease; K12618 5'-3' exoribonuclease 1 [EC:3.1.13.-] [KO:K12618] [EC:3.1.13.-]
AaeL_AAEL015316	5'-3' exoribonuclease; K12619 5'-3' exoribonuclease 2 [EC:3.1.13.-] [KO:K12619] [EC:3.1.13.-]
AaeL_AAEL003800	5'-3' exoribonuclease; K12619 5'-3' exoribonuclease 2 [EC:3.1.13.-] [KO:K12619] [EC:3.1.13.-]
AaeL_AAEL009859	nucleolar GTP-binding protein; K06943 nucleolar GTP-binding protein [KO:K06943]
AaeL_AAEL003293	GTP-binding protein; K14537 nuclear GTP-binding protein [KO:K14537]
AaeL_AAEL011255	GTP-binding protein-invertebrate; K14538 nuclear GTP-binding protein [KO:K14538]
AaeL_AAEL000081	peroxisome assembly factor-2 (peroxisomal-type atpase 1); K14571 ribosome biogenesis ATPase [KO:K14571]
AaeL_AAEL014506	hypothetical protein; K14572 midasin [KO:K14572]
AaeL_AAEL008572	RNA-binding protein; K14573 nucleolar protein 4 [KO:K14573]
AaeL_AAEL005628	hypothetical protein; K11883 RNA-binding protein NOB1 [KO:K11883]
AaeL_AAEL009287	ran; K07936 GTP-binding nuclear protein Ran [KO:K07936]
AaeL_AAEL001484	chromosome region maintenance protein 1/exportin; K14290 exportin-1 [KO:K14290]
AaeL_AAEL003039	nonsense-mediated mrna decay protein; K07562 nonsense-mediated mRNA decay protein 3 [KO:K07562]
AaeL_AAEL001007	hypothetical protein; K14284 nuclear RNA export factor 1/2 [KO:K14284]
AaeL_AAEL006050	nuclear RNA export factor 2 (NXF2); K14284 nuclear RNA export factor 1/2 [KO:K14284]
AaeL_AAEL008114	p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL002266	p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL010233	p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL001023	p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL004037	p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL001706	p15-2a protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL010849	hypothetical protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL005420	p15-2a protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL008900	p15-2a protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL013497	p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL001714	p15-2a protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL001125	p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL011503	p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL007580	hypothetical protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL011628	hypothetical protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL014575	p15-2a protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL007223	p15-2b protein; K14285 NTF2-related export protein 1/2 [KO:K14285]
AaeL_AAEL003661	translation initiation factor; K03264 translation initiation factor 6 [KO:K03264]
AaeL_AAEL006625	hypothetical protein; K14574 ribosome maturation protein SDO1 [KO:K14574]
AaeL_AAEL001019	translation elongation factor; K14536 ribosome assembly protein 1 [EC:3.6.5.-] [KO:K14536] [EC:3.6.5.-]
AaeL_AAEL006031	hypothetical protein; K14539 large subunit GTPase 1 [EC:3.6.1.-] [KO:K14539] [EC:3.6.1.-]
AaeL_AAEL014908	hypothetical protein; K14539 large subunit GTPase 1 [EC:3.6.1.-] [KO:K14539] [EC:3.6.1.-]
AaeL_AAEL007899	spermatogenesis associated factor; K14575 AAA family ATPase [KO:K14575]
AaeL_AAEL013679	coilin-interacting nulcear ATPase protein; K14535 transcription initiation factor TFIID subunit 9 / adenylate kinase [EC:2.7.4.3] [KO:K14535] [EC:2.7.4.3]
AaeL_AAEL014722	coilin-interacting nulcear ATPase protein; K14535 transcription initiation factor TFIID subunit 9 / adenylate kinase [EC:2.7.4.3] [KO:K14535] [EC:2.7.4.3]
AaeL_AAEL011857	serine/threonine-protein kinase rio1 (rio kinase 1); K07178 RIO kinase 1 [EC:2.7.11.1] [KO:K07178] [EC:2.7.11.1]
AaeL_AAEL011114	serine/threonine-protein kinase rio2 (rio kinase 2); K07179 RIO kinase 2 [EC:2.7.11.1] [KO:K07179] [EC:2.7.11.1]
s-rRNA	s-rRNA; K01979 small subunit ribosomal RNA [KO:K01979]
l-rRNA	l-rRNA; K01982 large subunit ribosomal RNA [KO:K01982]

Reference

PMID:20174677

Authors

Freed EF, Bleichert F, Dutca LM, Baserga SJ

Title

When ribosomes go bad: diseases of ribosome biogenesis.

Journal

Mol Biosyst 6:481-93 (2010)

Reference

PMID:17515605

Authors

Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M

Title

The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.

Journal

Mol Cell Biol 27:5414-29 (2007)

Reference

PMID:19850913

Authors

Strunk BS, Karbstein K

Title

Powering through ribosome assembly.

Journal

RNA 15:2083-104 (2009)

Reference

PMID:15120992

Authors

Granneman S, Baserga SJ

Title

Ribosome biogenesis: of knobs and RNA processing.

Journal

Exp Cell Res 296:43-50 (2004)

Reference

PMID:19879902

Authors

Kressler D, Hurt E, Bassler J

Title

Driving ribosome assembly.

Journal

Biochim Biophys Acta 1803:673-83 (2010)

KO pathway

ko03008

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (86)   
   KEGG GENES (86)   
All databases (88)   

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