KEGG   PATHWAY: aag03008Help
Entry
aag03008                    Pathway                                

Name
Ribosome biogenesis in eukaryotes - Aedes aegypti (yellow fever mosquito)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is  assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Ribosome biogenesis in eukaryotes
aag03008

All organismsOrtholog table
Organism
Aedes aegypti (yellow fever mosquito) [GN:aag]
Gene
AAEL012094-PA; K03097 casein kinase II subunit alpha [EC:2.7.11.1] [KO:K03097] [EC:2.7.11.1]
AAEL004368-PA; K14544 U3 small nucleolar RNA-associated protein 22 [KO:K14544]
AAEL015658-PA; K14545 ribosomal RNA-processing protein 7 [KO:K14545]
AAEL000115-PA; K14545 ribosomal RNA-processing protein 7 [KO:K14545]
AAEL003949-PA; K14546 U3 small nucleolar RNA-associated protein 5 [KO:K14546]
AAEL006549-PA; K14548 U3 small nucleolar RNA-associated protein 4 [KO:K14548]
AAEL000422-PA; K14549 U3 small nucleolar RNA-associated protein 15 [KO:K14549]
AAEL001238-PA; K14550 U3 small nucleolar RNA-associated protein 10 [KO:K14550]
AAEL006610-PA; K14552 NET1-associated nuclear protein 1 (U3 small nucleolar RNA-associated protein 17) [KO:K14552]
AAEL007573-PA; K14553 U3 small nucleolar RNA-associated protein 18 [KO:K14553]
AAEL009308-PA; K14554 U3 small nucleolar RNA-associated protein 21 [KO:K14554]
AAEL004526-PA; K14555 U3 small nucleolar RNA-associated protein 13 [KO:K14555]
AAEL004364-PA; K14556 U3 small nucleolar RNA-associated protein 12 [KO:K14556]
AAEL006972-PA; K14557 U3 small nucleolar RNA-associated protein 6 [KO:K14557]
AAEL003975-PA; K14558 periodic tryptophan protein 2 [KO:K14558]
AAEL000300-PA; K14558 periodic tryptophan protein 2 [KO:K14558]
AAEL001506-PA; K14559 U3 small nucleolar RNA-associated protein MPP10 [KO:K14559]
AAEL005263-PA; K14560 U3 small nucleolar ribonucleoprotein protein IMP3 [KO:K14560]
AAEL006063-PA; K14561 U3 small nucleolar ribonucleoprotein protein IMP4 [KO:K14561]
AAEL010248-PA; K14563 rRNA 2'-O-methyltransferase fibrillarin [EC:2.1.1.-] [KO:K14563] [EC:2.1.1.-]
AAEL003352-PA; K12845 U4/U6 small nuclear ribonucleoprotein SNU13 [KO:K12845]
AAEL003514-PA; K11131 H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-] [KO:K11131] [EC:5.4.99.-]
AAEL003469-PA; K11129 H/ACA ribonucleoprotein complex subunit 2 [KO:K11129]
AAEL007431-PA; K11130 H/ACA ribonucleoprotein complex subunit 3 [KO:K11130]
AAEL007697-PA; K14566 U3 small nucleolar RNA-associated protein 24 [KO:K14566]
AAEL008706-PA; K14567 U3 small nucleolar RNA-associated protein 14 [KO:K14567]
AAEL008592-PA; K03685 ribonuclease III [EC:3.1.26.3] [KO:K03685] [EC:3.1.26.3]
AAEL002108-PA; K14568 rRNA small subunit pseudouridine methyltransferase Nep1 [EC:2.1.1.260] [KO:K14568] [EC:2.1.1.260]
AAEL003555-PA; K14569 ribosome biogenesis protein BMS1 [KO:K14569]
AAEL006469-PA; K14521 N-acetyltransferase 10 [EC:2.3.1.-] [KO:K14521] [EC:2.3.1.-]
AAEL001080-PA; K11108 RNA 3'-terminal phosphate cyclase-like protein [KO:K11108]
AAEL009542-PA; K01164 ribonuclease P/MRP protein subunit POP1 [EC:3.1.26.5] [KO:K01164] [EC:3.1.26.5]
AAEL000215-PA; K03538 ribonuclease P protein subunit POP4 [EC:3.1.26.5] [KO:K03538] [EC:3.1.26.5]
AAEL010832-PA; K03537 ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5] [KO:K03537] [EC:3.1.26.5]
AAEL003455-PA; K14525 ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5] [KO:K14525] [EC:3.1.26.5]
AAEL002562-PA; K14527 ribonuclease P/MRP protein subunit RPP20 [EC:3.1.26.5] [KO:K14527] [EC:3.1.26.5]
AAEL002232-PA; K03539 ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5] [KO:K03539] [EC:3.1.26.5]
AAEL002157-PA; K14530 ribonucleases P/MRP protein subunit RPP40 [EC:3.1.26.5] [KO:K14530] [EC:3.1.26.5]
AAEL006744-PA; K14570 RNA exonuclease 1 [EC:3.1.-.-] [KO:K14570] [EC:3.1.-.-]
AAEL003572-PA; K14570 RNA exonuclease 1 [EC:3.1.-.-] [KO:K14570] [EC:3.1.-.-]
AAEL010932-PA; K14570 RNA exonuclease 1 [EC:3.1.-.-] [KO:K14570] [EC:3.1.-.-]
AAEL008865-PA; K13288 oligoribonuclease [EC:3.1.-.-] [KO:K13288] [EC:3.1.-.-]
AAEL008814-PA; K12618 5'-3' exoribonuclease 1 [EC:3.1.13.-] [KO:K12618] [EC:3.1.13.-]
AAEL015316-PA; K12619 5'-3' exoribonuclease 2 [EC:3.1.13.-] [KO:K12619] [EC:3.1.13.-]
AAEL003800-PA; K12619 5'-3' exoribonuclease 2 [EC:3.1.13.-] [KO:K12619] [EC:3.1.13.-]
AAEL009859-PA; K06943 nucleolar GTP-binding protein [KO:K06943]
AAEL003293-PA; K14537 nuclear GTP-binding protein [KO:K14537]
AAEL011255-PA; K14538 nuclear GTP-binding protein [KO:K14538]
AAEL000081-PA; K14571 ribosome biogenesis ATPase [KO:K14571]
AAEL014506-PA; K14572 midasin [KO:K14572]
AAEL008572-PA; K14573 nucleolar protein 4 [KO:K14573]
AAEL005628-PA; K11883 RNA-binding protein NOB1 [KO:K11883]
AAEL009287-PA; K07936 GTP-binding nuclear protein Ran [KO:K07936]
AAEL001484-PA; K14290 exportin-1 [KO:K14290]
AAEL003039-PA; K07562 nonsense-mediated mRNA decay protein 3 [KO:K07562]
AAEL001007-PA; K14284 nuclear RNA export factor [KO:K14284]
AAEL006050-PA; K14284 nuclear RNA export factor [KO:K14284]
AAEL008114-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL002266-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL010233-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL001023-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL004037-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL001706-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL010849-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL005420-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL008900-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL013497-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL801239; AAEL001714-PA [KO:K14285]
AAEL001125-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL011503-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL007580-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL011628-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL014575-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL007223-PA; K14285 NTF2-related export protein 1/2 [KO:K14285]
AAEL003661-PA; K03264 translation initiation factor 6 [KO:K03264]
AAEL006625-PA; K14574 ribosome maturation protein SDO1 [KO:K14574]
AAEL001019-PA; K14536 ribosome assembly protein 1 [EC:3.6.5.-] [KO:K14536] [EC:3.6.5.-]
AAEL006031-PA; K14539 large subunit GTPase 1 [EC:3.6.1.-] [KO:K14539] [EC:3.6.1.-]
AAEL014908-PA; K14539 large subunit GTPase 1 [EC:3.6.1.-] [KO:K14539] [EC:3.6.1.-]
AAEL007899-PA; K14575 AAA family ATPase [KO:K14575]
AAEL013679-PA; K18532 adenylate kinase [EC:2.7.4.3] [KO:K18532] [EC:2.7.4.3]
AAEL014722-PA; K18532 adenylate kinase [EC:2.7.4.3] [KO:K18532] [EC:2.7.4.3]
AAEL011857-PA; K07178 RIO kinase 1 [EC:2.7.11.1] [KO:K07178] [EC:2.7.11.1]
AAEL011114-PA; K07179 RIO kinase 2 [EC:2.7.11.1] [KO:K07179] [EC:2.7.11.1]
s-rRNA  
s-rRNA; K01979 small subunit ribosomal RNA [KO:K01979]
l-rRNA  
l-rRNA; K01982 large subunit ribosomal RNA [KO:K01982]
Reference
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
Reference
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
Reference
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
Reference
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
Reference
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
KO pathway
 

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