KEGG   Addendum: CAA60459
Entry
CAA60459          CDS       T10000                                 
Symbol
rapB
Name
(KEGG) rapamycin polyketide synthase B
  KO
K16420  rapamycin polyketide synthase A/B/C
Taxonomy
  Lineage
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group
Organism
Streptomyces rapamycinicus
SSDB
Motif
Pfam: ketoacyl-synt Acyl_transf_1 KR Ketoacyl-synt_C PKS_DH_N PS-DH KAsynt_C_assoc PP-binding adh_short Thiolase_N ADH_zinc_N_2 ADH_zinc_N ACP_syn_III ADH_N Docking
Other DBs
NCBI-ProteinID: CAA60459
GB: X86780
UniProt: Q54296
AA seq 10223 aa
MREDQLLDALRKSVKENARLRKANTSLRAAMDEPLAIVGMACRLPGGVSSPEDLWRLVES
GTDAISGFPADRGWDVENLYDPDPEAAGKSYCVQGGFLDSAGGFDASFFGISPREALAMD
PQQRLVLEASWEAFERAGIEPGSLRGSDTGVFMGAYPGGYGVGADLGGFGATAGAVSVLS
GRVSYFFGLEGPAVTVDTACSSSLVALHQAAYALRQGECSLALVGGVTVMATPQSFVEFS
RQRGLASDGRCKAFADSADGTGWAEGAGVLLVERLSDAQRKGHQVLAVVRGSAVNQDGAS
NGLSAPNGPSQQRVIRAALSNAGLSTAEVDVVEAHGTGTTLGDPIEAQALLATYGQDREQ
PLLLGSVKSNLGHTQAAAGVSGVIKMVMALQHVLVPRTLHVDEPSRHVDWTDGAVALVTE
NQPWPDMGRPRRAGVSSFGISGTNAHVILESAPPTQAVDDVPPAEAPVVASELVPLVISA
RTLPALVEYEDRLRAYLAASPGVDVRGVASTLAVTRSVFEHRAVLLGDDTVTGTTVSDPR
VVFVFPGQGSQRAGMGEELAAAFPVFARIHQQVWGLLDVPDLEVNETGYAQPALFALQVA
LFGLLESWGVRPDAVVGHSVGELAAGYVSGLWSLEDACTLVSARARLMQALPPGGVMVAV
PVSEDEARAVLGEGVEIAAVNGPSSVVLSGDETAVLQAAAALGKSTRLATSHAFHSARME
PMLEEFRTVAERLTYQTPRLAMAAGDRVTTAEYWVRQVRDTVRFGEQVASYEDAVFIELG
ADRSLARLVDGVAMLHTDHEAQAAISALAHLYVNGVTVDWTALLGDAPATRVLDLPTYAF
QHQRYWLEGADRAAAGGHPLLGPAVGLAEASGVLFTSQVSRSGDLWLQDQTVLPATAFAE
MALAAADETGCGLVEELTVEALLLLPDDGAVQVQTWVSEPDDAGRRQLSIHARYSDDELW
TRLATATLATTTGRVSGWQAGEAWPPAGAVPVEARVPSLRGVWRRGSEVFAEVALDDTHD
ATRFLLHPGLMTAAFAAVGEETPAAWQGLTLHARNAAELRVRLTSQDDETLSVEAVDSTG
LPVLTARSLALDAVPVNEPATSATDLLTLTWAGIATRQQQTGLTVGAFEDLAADGDAPVP
DVVVFTALPGNDDPLAQTRILTAQVLRTVQEWIGGERFSDSTLVVRTGTGLAAAAVSGLM
RSAQSEHPGRFILVESDDDALTPDQLAATVGLDEPRLRISDGRYEVPRLTRAHADEPEPE
RAWDPDGTVLITGGSGVLAGIVARHLVAERGVRHLLLLSRGTPDRALLSELAELGAAVDT
AACDVSDRAELARVLARVSPEHPLTAVIHTAGVVDDGVVESLSAQRLETVFRPKADGAWH
LHELTRDADLAAFVMYSSAAGVMAGAGQGNYAAANAFLDALAEERRAEGLPALAVAWGLW
EDASGLTAQLTDTDRDRIRRGGLRAISAEHGMRLFDNASRHSEPVLVAAPMEPVRDAEVP
ALLRSLHRPNVRRAALAGGAQWLAALAPEERAKALLKVVRDTAATVLGHADARTIPVTGA
FRDLGIDSLTAVELRNGLAKVTGLRLPATLVFDYPTPAVLAARLGELFTGENPVLVRTAS
VVGQDEPLAIVGMACRLPGGVSSPEDLWRLVESGTDAISGFPADRGWDAESLFDPDPDAV
GKSYCVEGGFLDSAASFDAGFFGISPREALAMDPQQRLIMEVSWEAFERAGIEPGSVRGS
DTGVFMGAYAGGYGAGADLGGFAATASATSVLSGRVSYFFGLEGPAITVDTACSSSLVAL
YQAGYALRQGECSLALVGGVTVMATPQSFVEFSRKSGLDSDGRCKAFADSADGTGWAEGV
GVLLVERLSDAQAKGHQVLAVVRSSAVNQDGASNGLSAPNGPSQQGVIRQALANAGLTTA
EVDVVEAHGTGTTLGDPIEAQAVIATYGQDRERPLLLGSLKSNIGHAQAASGVSGVIKMV
MALQHNTVPRTLHVDEPSRHVDWAAGAVELVRENQPWPGTDRPRRAGVSSFGVSGTNAHV
ILESAPPAQPAEEAQPVETPVVASDVLPLVISAKTQPALTEHEDRLRAYLAASPGVDTRA
VASTLAVTRSVFEHRAVLLGDDTVTGTAVSDPRVVFVFPGQGWQWLGMGSALRDSSIVFA
ERMAECAPALREFVDWDLFTVLDDPAVVDRVDVVQPASWRMMVSLAAVWQAAGVRPDAVI
GHSQGEIAAACVAGAVSMRDAARIVTLRSEAIARGLAGRGAMASVALPAQDVELVDGAWI
AAHNGPASTVIAGTPEAVDHVLTAHEARGVRVRRITVDYASHTPHVELIRDELLDITSDS
SSQAPVVPWLSTVDGSWVDSPLDVEYWYRNLREPVGFHPAVGQLQAEGDTVFVEVSASPV
LLQAMDDDVVTVATLRRDDGDATRMLTALAQAYVHGVTVDWPAILGTATTRVLDLPTYAF
QHQRYWLRSVDRAAADGHPLLGTVVDLPASDGVVLTGRVSLATHTWLADHAVRGSVLLPG
TAFVDLVVRAADEVESDVVDELVIETPLLLPQTGGVQLSVSVGGADESGHRAVMVFSQAD
NTDTWTRHVTATVSTSDSTVSLPEFASWPPAQARPVSVADFYDRLAAAGTEYGPAFQGLQ
AAWRDGDTVYAEVVLAEEQAQEAARFAVHPALLDAAMHASVLHTPDTDQQSVRMPFSWNH
VQIRATDTAMLRVAATPTTDGWSVRVADDTGRPVATIGSLVTRPVTADTLGSAADDLLTL
VWTEIPTPQQSSLSVGRYEDLADGDVPVPDVAVYTARPEADGSPDPLVQTRTLTAQVLQT
AQAWLGGERFTDSTLVVRTGTGLAAAAVSGLMRSAQSEHPGRFVLVESDDDSLTLHQLAA
TVGLDEPRLRVNDGRFEVPRLARVNAAEPESETVWDPHGTVLITGGSGVLAGALARHLVT
ERGVRHLLLLSRTTADEGLLNELGELGARVETADCDVSDRAGLARVLAGVSPEHPLTAVI
QTAGALDDGVLETLTAQRLDTVLRPKADGAWHLHELTRNTGLAAFVMYSSAAGVMGNPGQ
GNLAAATAFLDALADQRRAEGLPALALAWGSSEETSDLIGLRTISAERGMRLFDSASHRG
EPLLMAASLDPARAAEVPALLRSLRRPVARRAASADGGVQWLAALAPAEREKALLKVVCD
SAAVVLGHADARTIPVTGAFKDLGVDSLTAVELRNSLVKATGLRLPATMVFDYPTPTALA
ARLDELFTGENPAPVREPVPAVAQDEPLAIVGMACRLPGGVSSPEDLWRLVESGTDAVSG
FPTDRGWDVEGLFDPDPDAAGKSYRAEGGFLDTAAGFDAGFFGISPREALAMDPQQRLLL
EVSWEAFERAGIEPGSVRGSDTGVFIGAFPVGYGAGAAREGYGATAAPNVLSGRLSYFFG
LEGPAITMDTACSSSLVALHLAAQALRNGECSMALAGGVTVMATPEVFTEFARQRGLASD
GRCKAFADSADGAGFSEGAGLLLVERLSDARRNGHQVLAVVRGSAVNQDGASNGFTAPNG
PAQQRVIRQALANAGLTTAEVDVVEAHGTGTTLGDPIEAQAVIATYGQDREQPLLLGTLK
SNVGHTQAAAGVSGVIKMVMALQHSTVPRTLHVNEPSRHVDWSAGAVELVTENQSWPVTG
RPRRAGVSAFGVSGTNAHVVLESAPPAQSVNNAQPVATPVVASELVPLVISAKTLPALTE
HEDRLRAYLAASPGADMRAVGSTLALTRSVFEHRAVLLGHDTVTVTGTGTAVSNPRVVFV
FPGQGWQWLGMGSALRGSSVVFAERMAECAAALSEFVDWDLFAVLDDPAVVDRVDVVQPA
SWAVMVSLAAVWQADGVRPDAVIGHSQGEIAAACVAGAVSLRDAARSVTLRSQAIARGLA
GRGAMASVALPAHEIELVDGAWIAAHNGPASTVVAGAPEAVDRVLAVHEARGVRVRRIAV
DYASHTPHVELIRDELLDITAGIGSQAPVVPWLSTVDGTWVEGPLDVEYWYRNLREPVGF
DSAVGQLRAEGDTVFVEVSASPVLLQAMDDDVVTVATLRRDDGDATRMLTALAQAFVEGV
TVDWPAILGTATTRVPDLPTYAFQHQRFWAEGADRSVAGGHPLLGVAVELPESDGVLLTG
RVSLATHAWLADHAVRGSVLLPGTGFVELVVRAADEVGCDVVDELVIETPLLLPSSASVH
LSVSVGEADESGRRGVTVFSRADGADAWTRHVSATIGVSGAALSLPELAAWPPAQAQPVG
LGDFYDRLTGAGYEYGPAFQGLQAAWRDGDTVFAEVALAEEQAEEAARFAVHPALLDAAL
DAGILNTLDNAEQGVRLPFSWNGVQVRATGSATLRVADNPTSDGWSVRVADDSGRPVATV
DSLVTRPVTADTLGSAADDLLTVVWTEIPTPQQTGLSVGRFEDLADGDVPVPEVVVCTAL
PDSSENPLAPLDPPDPLVQTRTLTTQVLQAVQAWLAGERFTDSTLVVRTGTGLATAGVSG
LMRSAQSEHPGRFVLVECDDNLTLQQLAATVGLDEPRLRVCDGRFEVPRLARANTPESSP
LTIPGDRAWLLEQSHSGTLRDLALVPAETAERPLQSGEVRVDVRAAGLNFRDVLIALGTY
PGEAVIGAEAAGVVLEVGPEVQDLAPGDRVFGLVGGGFGAVAIADRRMLGVIPDGWSFTT
AASVPVVFATAYYGLVDLAGLSAGESVLIHAAAGGVGMAATQIARHLGARIYATASTGKQ
HVLREAGLEDARIGDSRTTGFREMVLDTTDSRGVDVVLNSLSGDFVDASLDLLPRGGRFV
EMGKTDIRDPHQVTADRPGTSYQAFDLMDAGPDRLREIIADLLALFAQGVLLPLPVRAWD
IRQAREAFSWMSRARHIGKIVLTVPQQLDANGTVLVTGGSGVLAGIAARHLVAEQGVRHL
LLLSRSTPDDALINELGELGARVDTAICDVSDRAGLARILAGVSPEHPLTAVIHTAGALD
DGVVESLTAQQLETVLRPKADGAWHLHELTRDADLAAFVMYSSAAGVLGSGGQGNYAAAN
AFLDALAEQRRGEGLPALAVAWGLWEDASGLTAEMTDTDRDRIRRGGLRAISAGHGMGLL
DAASRHGEPVLLAAAMEPVREAEVPALLRLLHRPVARRAASTGGSSVQWLARLAPVEREK
ALLKLVCDGAATVLGHADASTIPATAAFKDLGIDSLTAVELRNSLTKATGLRLPATLVFD
YPTPTALAARLGEWFVGETPVPVRTSVSVVAQDEPLAIVGMACRLPGGVSSPEDLWRLLE
SGTDAVSGFPTDRGWDVENLFGPAAGDSYRLQGGFLDAAAGFDASFFGISPREALAMDPQ
QRLVLEVSWEAFERAGIEPGSVRGTDTGVFMGAYPGGYGIGADLGGFGATASAVSVLSGR
VSYFFGLEGPAITVDTACSSSLVALHQAGYALRQGECSLALVGGVTVMATPQTFVEFARQ
GGLAGDGRSKAFADSADGAGFSEGVGVLLVERLSDAQAKGHQVLAMLRSSAVNQDGASNG
LTAPNGPSQQRVIQAALSNAGLAAHEVDVVEAHGTGTTLGDPIEAQALLATYGQDREQPL
LLGSVKSNLGHTQAAAGVSGVIKMVMALQRGFVPRTLHVDEPSRHVDWSAGAVALVTENQ
PWPDMGRARRAGVSSFGISGTNAHVILESAPPTQPADNAVIERAPEWLPMVISARTQSAL
TEHEGRLRAYLAASPGVDMRAVASTLAITRSVFEHRAVLLGDDTVTGTAATDPRVVFVFP
GQGSQRAGMGEELAAAFPVFARIHQQVWDLLDVPDLEVNETGYAQPALFALQVALFGLLE
SWGVRPDAVVGHSVGELAAGYVSGLWSLEDACTLVSARARLMQALPAGGVMVAVPVSEDE
ARAVLGEGVEIAAVNGPSSVVLSGDEAAVLQAAEGLGKWTRLATSHAFHSARMEPMLEEF
RAVAEGLTYRTPQVSMAAGDQLTTTEYWVRQVRDTVRFGEQVASYEDAVFVELGADRSLA
RLVDGVAMLHGDHEAQAAVSALAHLYVNGVTVDWPALLGDAPATRVLDLPTYAFQHQRYW
LEGTDRMAAGGHPLLGEAVAVPGSDGVLLTGRVSLATHPWLADHAVRGSVLLPGTGFVEL
VVRAADEVGCDVIDELVIETPLLLPQTGGVQLSVAVAESDDSGRRAVTVFSRADNVDTWT
RHATVTVSNSDTTLSLPDLSAWPPAQAQPVNVADFYDQLTVVAYEYGPAFQGLQAAWRDG
DTVHAEVALAEEQAQDAARNAVHPALLDAALHAGILNTPDTEQGVRLPFSWNQVQVHAVG
SAMLRVAVTQAADGWSVRVADDTGRPVATIGSLVTRPVTADTLGSTTDDLLALTWTEIPA
PQETSLTIGRFEDLADADVPVPEVVVFTARPDSSENPLAQTRTLTAQVLQKIQAWLAEER
FTDSTLIVRIGTGLAAAAVSGLMRSGQSEHPGRFVLVESDDDTLAPDQLAATVELDEPRL
RISDGRFEVPRLTRTHAAEPESEKVWDPDGTVLITGGSGVLAGIAARHLVAERGVRHLLL
LSRSAPDGALISELGELGAQVATAVCDVSDRPGLVRVLADVSPEHPLTAVIHTAGVVDDG
VVESLTAQRLDTVLRPKADGAWHLHELTRDADLAAFVMYSSAAGVFGSAGQGNYAVANAF
LDALAEQRRAEGLPALALAWGLWEGTSGLTANLTDTDHDRIRRSGMRAISAEHGMRLFDG
ASRRRDPVLVAAAMEPVREAEVPAMLRSLHRPVARRAASGGAVRCLAALAPEERAKALVK
VVCDSAATVLGHADVDSIPVTAAFRDLGVDSLTAVELRNSLTKATGLRLPATLVFDYPTP
GALAARLEELFTGENPVQVRTPVSAVGQDEPLAIVGMACRLPGGVSSPEDLWRLVESGTD
AISGFPTDRGWDVENLFDSDPDAAGKSYCVEGGFLATAANFDASFFGISPREALAMDPQQ
RLVLEVSWEAFERAGIEPGSVRGSDTGVFMGAFPGGYGIGADLEGYGATAGLNVLSGRLS
YFFGLEGPAVTVDTACSSSLVALHQAGYALRQGECSLALIGGVTVMATPHTFVEFSRQRG
LASDGRCKAFADSADGTGWSEGVGVLLVERLSDAQAKGHQVLAVVRSSAVNQDGASNGLS
APNGPSQQRVIRQALANAGLTTAEVDVVEAHGTGTTLGDPIEAQAVIATYGQDRDQPVLL
GSVKSNVGHTQAAAGVSGVIKMVMALQHGLVPRTLHVDEPSRHVDWTDGAVELVTENQSW
PEAGRPRRAGVSSFGVSGTNAHVILESAPPTQAVDDVRPADAPVVASVMASELVPLVISA
KTQSALAEYEGRLRAYLAASPGVDMRAVASTLAMTRSVFEHRAVIVGDDTVSGTAATDPR
VVFVFPGQGSQRAGMGAELAAAFPVFARIHQQVWDLLDVPDLEVNETGYAQPALFALQVA
LFGLLESWGVRPDAVIGHSVGELAAAYVSGLWSLEDACTLVSARARLMQALPAGGVMVAV
PVSEDEARAVLGEGVEIAAVNGPSSVVLSGDEAAVLQAAEGLGKWTRLATSHAFHSARME
PMLEEFRAVAQGLTYHAPGVVMAAGDRVMTAEYWVRQVRDTVRFGEQVASYEDAVFVELG
ADRSLARLVDGVAMLHGDHETQAAIGALAHLYVNGVTVDWTALLGDVPVTRVLDLPTYAF
QQQRYWAEVGRSADVSGAGLDAVGHPLLGAVVALPGSDGVLLTGRVSLATHAWLADHAVR
GSVLLPGTGFVELVVRAADEVGCDVVDELIVEAPLLLPQTGGVQVSVSVGEADESGHRVV
TIFSRADNADTWVRHVSAVISTSDSTVSLSEFASWPPAQAQPVDVTGFYDPLMAEGYEYG
PAFQGLQAAWRYGDTVFAEVALAEEQVREAARYPSVHPALLDAALHACTLECADAEVGVG
LPFSWDGVRVHAGGSAMLRVAVTQAADGWSVRVADEIGRPVANVGSLVTRPVTADALGSA
ADDLLALTWAEIPAPEGTGLTVGRFEELVSDGDVPVPEVAVFTALPDNDDDPLEQTRKLT
GQVLQAVQEWLGGERFSDSTLVVRTGTGLAAAGVSGLMRSAQSEHPGRFVLVESDDDALA
LDQLAAAVGLDEPRLRISDGRFEAPRLTRTHAAEPESEKVWDPDGTVLITGGSGVLAGIA
VRHLVTERGVRHLLLLSRSAPDEALINQLGELGARVETAACDVSDRAALAQVLAGVSPEH
PLTAVIHTAGVLDDGVVESLTAQRLDAVLRPKADGAWNLHELTRDADLAAFVMYSSAAGV
LGSGGQGNYAAANAFLDALAEQRHAEGLPALAVAWGLWEDASGLTAQLTDTDRDRIRRGG
LRAISAEHGMGLFDSASRHSEPVLVAAPMEPVRDAEVPALLRSLHRPVARRAAAAGGARW
LAALAPAEREKALLKLVSDGAATVLGHADTSTIPATTAFKDLGIDSLTAVELRNSLAKAT
ELRLPATLVFDYPTPTALAARLDELFTGENPAPVRGPVSAVAQDEPLAIVGMACRLPGGV
SSPEDLWRLVESGTDAISGFPTDRGWDVENLYDPDPDAPGKSYSVQGGFLDAAAGFDASF
FGISPREALAMDPQQRLMLEVSWEAFERAGIEPGSVRGSDTGVFIGAYPGGYGIGADLGG
FGTTAGAASVLSGRVSYFFGLEGPAFTVDTACSSSLVALHQAGYALRQGECSLALVGGVT
VMPTPQTFVEFSRQRGLSADGRCKAFADAADGTGWAEGVGVLLVERLSDAQANGHQILAV
VRSSAVNQDGASNGLSAPNGPSQQRVIRAALSNAGLAPHEVDVVEAHGTGTTLGDPIEAQ
AVIATYGQGRGEPLLLGSLKSNVGHTQAAAGVSGVIKMVMALQHSMVPRTLHVDEPSRHV
DWSAGAVELVAENQPWPETGRPRRAGVSSFGISGTNAHVILESAPAQSVGDTAGSTPVLV
SELVPLVISAKTQPALTEHEDRLRAYLAASPGVDIRAVASTLAVTRSVFEHRAVLLGDET
VTGTAVSDPRIVFVFPGQGWQWLGMGSALRDSSVVFAERMAECAAALSEFVDWDLFAVLD
DPAVVDRVDVVQPASWAVMVSLAAVWQAAGVRPDAVIGHSQGEIAAACVAGAVSMRDAAR
IVTLRSQAIARGLAGRGAMASVALPAQDVELVDGAWIAAHNGPASTVIAGTPEAVDHVLT
ALRQRGAGAADHVDYASHTPHVELIRDELLDITSDSSSQDPLVPWLSTVDGTWVDSPLDG
EYWYRNLREPVGFHPAVSQLQAQGDTVFVEVSASPVLMQAMDDDVVTVATLRRDDGDATR
MLTALAQAYVHGVTVDWRAVLGDVPATRVLDLPTYAFQHQRYWAEAGRSADVSAAGLDAV
GHPLLGAVLAMPGSDGVMLTGRVSLATHAWLADHAVRGSVLLPGTGFVELVVRAADEVAC
DVVDELIVEAPLLLPQTGGVQLSVSVGEADESGHRAVTVFSRADSADAWVRHVSATVSVS
DTTVPTSDLTAWPPAQAKPVDVAGFYDQLTRAGYEYGPAFQGLQAAWRDGDTVFAEVALA
EEQTQDAARFAVHPAVLDAALHAGILNTPDADRDTVRLPFSWNHVQVHVTGSATLRVAMT
RVADGWGVRVADDIGRPVATIGSLVTRPVAADALGSAVDDLFALTWTEIPVSQQVGVTVG
KFEDLADGEVPMPDVVVFTALPDSGDPLAQTRRLTAEVLQAVQVWLAGERFTDSTLVVRT
GTGLAAAAVSGLMRSAQSEHPGRFVLVESDDDTLTPDQLAATVGLDEPRLRVIDGRYEAP
RLTRTGVAEPEPEGVWDPDGTVLITGGSGVLAGIAARHLVAERGVRHLLLLSRSAPDEAL
ISELAELGAAVVDTAVCDVSDRAGLARVLAGVSPDHPLTAVIHTAGVLDDGVVESLTARR
LDTVLRPKADGAWNLHELTRDIDLAAFVMYSSAAGVLGSAGQGNYAVANAFVDALAEQRR
AEGLPALALAWGLWEDASGLTAKLTGTDHDRIRRSGLRTITAERGMRLFDIASRQGEPVL
VATPMEPVREVEVPALLRLLHRPVARRAASTGDSSAQWLVGLAPEERAKALLKVVRDSAA
TVLGHADARSIPATGAFKDLGVDSLTAVELRNSLTKATGLRLPATMVFDYPTPADLAARL
GDLMNPRVQSTTLLAEIDRIEKMFTSVTFDDRQASAIKDRLSSVLNKWQRISSPEEVSTT
ALSSASASEILDFIDREFGDPTA
Reference
PMID:7644502
  Authors
Schwecke T, Aparicio JF, Molnar I, Konig A, Khaw LE, Haydock SF, Oliynyk M, Caffrey P, Cortes J, Lester JB, et al.
  Title
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.
  Journal
Proc Natl Acad Sci U S A 92:7839-43 (1995)
DOI:10.1073/pnas.92.17.7839

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