KEGG   Ailuropoda melanoleuca (giant panda): 100463775Help
Entry
100463775         CDS       T01329                                 

Gene name
PIK3CB
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:aml00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100463775 (PIK3CB)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100463775 (PIK3CB)
   04015 Rap1 signaling pathway
    100463775 (PIK3CB)
   04012 ErbB signaling pathway
    100463775 (PIK3CB)
   04370 VEGF signaling pathway
    100463775 (PIK3CB)
   04630 Jak-STAT signaling pathway
    100463775 (PIK3CB)
   04668 TNF signaling pathway
    100463775 (PIK3CB)
   04066 HIF-1 signaling pathway
    100463775 (PIK3CB)
   04068 FoxO signaling pathway
    100463775 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    100463775 (PIK3CB)
   04022 cGMP - PKG signaling pathway
    100463775 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    100463775 (PIK3CB)
   04152 AMPK signaling pathway
    100463775 (PIK3CB)
   04150 mTOR signaling pathway
    100463775 (PIK3CB)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100463775 (PIK3CB)
  Cell growth and death
   04210 Apoptosis
    100463775 (PIK3CB)
  Cell communication
   04510 Focal adhesion
    100463775 (PIK3CB)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100463775 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    100463775 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    100463775 (PIK3CB)
   04660 T cell receptor signaling pathway
    100463775 (PIK3CB)
   04662 B cell receptor signaling pathway
    100463775 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    100463775 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    100463775 (PIK3CB)
   04670 Leukocyte transendothelial migration
    100463775 (PIK3CB)
   04062 Chemokine signaling pathway
    100463775 (PIK3CB)
  Endocrine system
   04910 Insulin signaling pathway
    100463775 (PIK3CB)
   04915 Estrogen signaling pathway
    100463775 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    100463775 (PIK3CB)
   04917 Prolactin signaling pathway
    100463775 (PIK3CB)
   04921 Oxytocin signaling pathway
    100463775 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    100463775 (PIK3CB)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100463775 (PIK3CB)
  Digestive system
   04973 Carbohydrate digestion and absorption
    100463775 (PIK3CB)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100463775 (PIK3CB)
  Nervous system
   04725 Cholinergic synapse
    100463775 (PIK3CB)
   04722 Neurotrophin signaling pathway
    100463775 (PIK3CB)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100463775 (PIK3CB)
  Development
   04380 Osteoclast differentiation
    100463775 (PIK3CB)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100463775 (PIK3CB)
   05205 Proteoglycans in cancer
    100463775 (PIK3CB)
   05203 Viral carcinogenesis
    100463775 (PIK3CB)
   05210 Colorectal cancer
    100463775 (PIK3CB)
   05212 Pancreatic cancer
    100463775 (PIK3CB)
   05214 Glioma
    100463775 (PIK3CB)
   05221 Acute myeloid leukemia
    100463775 (PIK3CB)
   05220 Chronic myeloid leukemia
    100463775 (PIK3CB)
   05218 Melanoma
    100463775 (PIK3CB)
   05211 Renal cell carcinoma
    100463775 (PIK3CB)
   05215 Prostate cancer
    100463775 (PIK3CB)
   05213 Endometrial cancer
    100463775 (PIK3CB)
   05222 Small cell lung cancer
    100463775 (PIK3CB)
   05223 Non-small cell lung cancer
    100463775 (PIK3CB)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100463775 (PIK3CB)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100463775 (PIK3CB)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    100463775 (PIK3CB)
   05166 HTLV-I infection
    100463775 (PIK3CB)
   05162 Measles
    100463775 (PIK3CB)
   05164 Influenza A
    100463775 (PIK3CB)
   05161 Hepatitis B
    100463775 (PIK3CB)
   05160 Hepatitis C
    100463775 (PIK3CB)
   05169 Epstein-Barr virus infection
    100463775 (PIK3CB)
   05146 Amoebiasis
    100463775 (PIK3CB)
   05145 Toxoplasmosis
    100463775 (PIK3CB)
   05142 Chagas disease (American trypanosomiasis)
    100463775 (PIK3CB)
Enzymes [BR:aml01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100463775 (PIK3CB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Position
Un
AA seq 1070 aa AA seqDB search
MCFNFIMPPAMADILDIWAVDSQLASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRIKMRKFSEEKIQSLVGLSWMDWLKQTYPPEH
EPSVLENLEDKLYGGKLIVAVHFENCQDVFSFQISPNMNPIKINELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFMLVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKMRIISHVWENNNPFQIVLVKGNKLNTEESVKVHVRAGLFHG
TELLCKTIVSSEISGKNDHIWNEPLEFDINTCDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPETKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAMKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt NT seq  +upstreamnt  +downstreamnt
atgtgcttcaatttcataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagttagcgtctgatggctccatacctgtggatttccttttgcccactgggatt
tatattcagttggaggttcctcgggaagctaccatttcctatattaaacagatgttatgg
aagcaagttcacaattacccaatgtttaacctccttatggaaattgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggagcttgaagatgaaacaagaagactctgt
gatgtcagaccctttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctgcatgaatttgatgcactg
aaggatcctgaagtgaatgaattccgaataaaaatgcgcaaattcagtgaggaaaagatc
cagtcgcttgtgggattgtcttggatggattggctaaagcagacgtatccaccagaacat
gaaccatcagtccttgaaaacttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggatgtatttagctttcaaatatctcctaatatgaatcct
atcaaaataaatgaactggcaatccagaaacgtttgactattcatgggaaagaagatgaa
gttagtccctatgactatgtgttgcaagtcagtgggagagtagaatatgtgtttggtgat
cacccactcattcagttccagtatatccggaactgtgtaatgaacaggaccttgccccat
tttatgcttgtggaatgttgcaagatcaagaagatgtatgaacaggaaatgattgccata
gaggctgccataaatcgaaattcatcaaaccttcctcttcctttaccaccaaagaaaatg
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtgttggttaaggga
aataaacttaacacagaagaaagtgtaaaagttcatgtcagggctggcctttttcatggt
actgaactcctctgtaaaaccatcgtaagctcagagatatcagggaaaaatgatcacatt
tggaatgaaccactggaatttgatataaatacttgtgacctgccacgaatggctcgatta
tgttttgctgtttatgcagttttggataaagtgaaaacgaaaaagtcgactaaaactatt
aatccctctaaatatcagaccatccggaaatctgggaaagtgcattatcctgtagcatgg
gtaaatacgatggtttttgactttaaaggacagttgagatccggagacataatattgcac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatatcaaattcccagagactaaaaaa
caaccttactattatcctcccttcgataagataatcgagaaggcagctgagattgcaagc
agtgacagtgctaatgtatccagtcgaggtggaaaaaagtttcttgctgtactgaaagaa
atcttggacagggatcccttgtctcagttgtgtgagaatgaaatggatcttatttggact
ttgcgacaagattgcagagagaatttcccacagtcactgccaaaattactgctgtcaatc
aagtggaataaacttgaggatgttgctcagcttcaggcactacttcagatttggcctaaa
ctgcccccccgggaggccttagagcttctagatttcaactatccagatcagtacgtgcga
gaatatgctgtgggctgcctgcgacagatgagtgatgaagaactctctcaatatctttta
caactggtgcaagttttaaaatatgagccttttcttgattgtgccctctctagattccta
ttagaaagagcactggctaatcggaggatagggcaatttctattttggcaccttaggtca
gaagtgcatattcctgctgtctcagtacagtttggtgtcatccttgaagcatactgccgg
ggaagtgtagggcacatgaaagtgctttctaagcaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgcaatgaagctaaacagagccaaagggaaggag
gccatgcatacttgtttaaaacagaacgcttaccgggaagccctctctgacctgcagtcg
cctctgaatccatgtgttatcctctcagaactctatgttgaaaagtgtaaatacatggat
tccaaaatgaagcctttgtggctcgtgtacaataacaaagtgttcggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaagatatgttgacactccaaatgctg
cgcttgatggatttactttggaaagaagctggtctggatcttcggatgctgccttatggc
tgtttagcaacaggagaccgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaacgtggctgctgcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctagaccgagccattgaggag
tttaccttgtcctgtgccggctactgtgtagcttcttatgtccttgggattggtgataga
catagtgacaacatcatggtcaaaaaaaccggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggaacgggtgccttttattctt
acctatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagagaagtttggc
cgcttccgccagtgttgtgaggatgcatatctgattctacgacggcacgggaatctcttc
atcactctttttgcactgatgctgactgcagggcttcctgagctcacatcagtcaaggat
atacagtatcttaaggactctcttgccttagggaagagtgaagaagaagcactcaagcag
tttaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtaaactggatg
gcccacacagttcggaaagactacagatcttaa

DBGET integrated database retrieval system