KEGG   Ailuropoda melanoleuca (giant panda): 100463930
Entry
100463930         CDS       T01329                                 
Symbol
TOP2A
Name
(RefSeq) DNA topoisomerase 2-alpha isoform X1
  KO
K03164  DNA topoisomerase II [EC:5.6.2.2]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
aml01524  Platinum drug resistance
Brite
KEGG Orthology (KO) [BR:aml00001]
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    100463930 (TOP2A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:aml03032]
    100463930 (TOP2A)
   03036 Chromosome and associated proteins [BR:aml03036]
    100463930 (TOP2A)
Enzymes [BR:aml01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.2  DNA topoisomerase (ATP-hydrolysing)
     100463930 (TOP2A)
DNA replication proteins [BR:aml03032]
 Eukaryotic type
  DNA Topoisomerases
   100463930 (TOP2A)
Chromosome and associated proteins [BR:aml03036]
 Eukaryotic type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    100463930 (TOP2A)
  Centrosome formation proteins
   Centriole proteins
    100463930 (TOP2A)
SSDB
Motif
Pfam: DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT HATPase_c Toprim
Other DBs
NCBI-GeneID: 100463930
NCBI-ProteinID: XP_002924981
Ensembl: ENSAMEG00000007989
UniProt: G1LN78
Position
13:complement(24693558..24721621)
AA seq 1533 aa
MEVSPLQPVNENMQISKTKKNEDAKKGLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQ
MWVYDEDIGINYREVTFVPGLYKIFDEILVNAADNKQRDPNMSCIRVTIDPENNLISIWN
NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKVDETGNPLKIIHEQVNPRWEVC
LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
WIFVNALIENPTFDSQTKENMTLQVKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSNECTLILTEGDSAKTLAVSGLGVVGRDK
YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
RKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLKFLYDDNQRVEPEW
YIPIIPMVLINGAEGIGTGWSCKIPNFDIREVVNNIRRLMDGEEPLPMLPSYKNFKGTIE
ELAPNQYVISGEVAILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
GYDSDPVKAWKEAQQKVPDEEENEESDNENEAEKSDSVRDSGPTFNYLLDMPLWYLTKEK
KDELCKLRNEKEQELETLKRKSPSDLWKEDLAAFIEELEAVETKEKQEEQIGLPGKGGKA
KGKKTQMAEVLPSPCGKRVIPRVTIEMKAEAEKKIKKKIKNENTEGSPPEDGIELEGLKQ
RLEKKQKREAGTKTKKQTTLPFKPIKKGKKRNPWSDSESDMSSNESNFDVPPRETEPRRA
ATKTKFTVDLDSDDDFSDFDEKTQDKDFVPSDGSPLKTKASPKQTTKELKPQKSATSVMD
LDADETKDSVPLPPGSPAADFSAETEIINPVSKKKVAVKKIAAKSQSSTATTGAKKRAAP
KGSKKDPGLNSDVPQKPDPPKTKTRRKRKPSTSDDSDSNFEKMISKTVTNKKSKGESEDF
HLDLDSAVAPRAKSGRAKKPIKYLEESDEDDLF
NT seq 4602 nt   +upstreamnt  +downstreamnt
atggaggtgtcaccattgcagcctgtaaatgaaaatatgcaaatcagcaaaacaaagaaa
aatgaagatgctaagaaaggactgtctattgaaagaatctatcaaaagaaaacccaactg
gaacatatcttgctccgcccagacacctacattggctctgtggaactagtgacccagcaa
atgtgggtttatgatgaagatattggcattaactatagggaagtcacctttgtccctggg
ttgtacaaaatctttgatgagattctagtcaatgctgcagacaataaacaaagggaccca
aatatgtcttgtattagagtcacaattgacccggagaacaatttaattagcatatggaat
aatgggaaaggtattcctgttgttgaacacaaagttgagaagatgtatgtcccagctctc
atctttggacagctcctaacttctagtaactatgatgatgatgaaaagaaagtaacaggt
ggtcgaaatggctatggggccaaattgtgtaacatattcagtaccaaatttactgtggaa
acagcaagtagagaatacaagaaaatgttcaaacagacatggatggataacatggggaga
gctggtgagatggaactcaagccctttaatggggaagattatacatgcattactttccag
cctgacttgtccaagtttaaaatgcaaagcctagataaagatatcgttgcactgatggtt
agaagagcttatgatattgctggatccactaaagatgtcaaagtctttctcaatggaaat
aagctgccagtaaaaggattccgtagctatgtagatatgtatttgaaggataaggtagat
gaaactggcaatccactgaaaattatccatgaacaagtaaaccccaggtgggaagtatgt
ctaacaatgagtgaaaaaggctttcagcaaattagcttcgtcaacagcatcgctacttcc
aagggtggcagacatgttgattatgtagctgatcagattgtgactaaacttgttgatgtt
gtgaagaagaagaacaagggtggtgttgcagtaaaagcacatcaggtgaaaaatcacatg
tggatttttgtgaatgccttaattgaaaacccaacctttgactctcagacaaaagaaaac
atgaccttacaagtcaagagctttggatcaacatgccaattaagtgaaaaattcatcaaa
gctgcaattggctgtggtattgtggaaagcatactaaactgggtgaagtttaaggcccaa
gtccaattaaataaaaagtgttcagctgtaaaacataacagaatcaagggaattcccaaa
ctcgatgatgccaatgatgcagggggtcgaaactccaatgagtgtacactcatcctgact
gaaggagactcagctaaaactttggctgtttcaggccttggtgtggttgggagagacaaa
tacggtgttttcccacttagaggaaaaatactcaatgttcgagaagcttctcataaacag
atcatggaaaatgccgaaattaacaatatcatcaagattgtgggtcttcagtacaagaaa
aactatgaagatgaagattcattgaagactcttcgttatggaaagataatgattatgaca
gatcaggaccaagatggttcccatatcaaaggcctgctgattaattttatccatcacaac
tggccctctcttctacggcatcgttttctggaagagtttatcactcccattgtaaaggtg
tctaaaaacaaacaagaaatggcattctatagccttcctgaatttgaagaatggaagagt
tctactccaaatcataaaaaatggaaagtcaagtactacaaaggtttgggcaccagcaca
tcaaaagaagctaaagaatactttgcagatatgaaaagacatcgtattcaattcaaatat
tctggtcctgaagatgatgctgccatcagcctggcctttagcaagaaacagatagatgat
cgaaaggaatggttaactcatttcatggaggatagaaggcaacggaagttacttggcctt
cctgaggattacttgtatgggcaaactaccacatacctgacatataatgacttcataaat
aaggaacttatcctgttctcaaattctgataatgagagatctatcccatctatggtggat
ggtttgaaaccaggtcaaagaaaggttttgtttacctgtttcaaacggaatgataagcga
gaggtgaaggttgcccagttagctgggtcagtggctgagatgtcctcttatcatcatggt
gagatgtcactaatgatgaccattatcaatttggctcagaattttgtgggtagcaataat
ctgaacctcttgcagcccattggtcagtttggtactaggctgcatggtggcaaggattct
gctagtcctcgatacatcttcacaatgctcagccctttggctcggttgttatttccacca
aaagatgatcacacattaaagtttttatatgatgacaatcaacgtgttgaacctgaatgg
tacattcctattatacccatggtgctgataaatggtgctgaaggaatcggtactgggtgg
tcctgcaaaatccccaactttgatattcgtgaagttgtaaataatatcaggcgtttgatg
gatggagaagaacctttgccaatgcttccaagttacaagaacttcaagggtactattgaa
gagctggctccaaatcaatatgtgataagtggtgaagtggctattcttaattccacaacc
attgaaatctcagagcttcctatcagaacatggacccagacatataaagaacaggttcta
gagcccatgttgaacggaactgagaagacaccacctctcataacagattatagggaatac
catacagacaccactgtgaagtttgttgtgaaaatgactgaagagaaactggcagaggca
gagagagtgggactacacaaagtcttcaaactccaaactagccttacatgcaactctatg
gtgctttttgaccatgtaggatgtttaaagaaatatgacacagtgttggatattctaaga
gacttctttgaactcaggcttaaatattatggattaagaaaagaatggcttctaggaatg
cttggtgctgaatctgctaaactgaacaaccaggctcgctttatcttagagaaaatagat
ggcaaaataatcattgaaaataagcctaagaaagaattaattaaagttctgattcagagg
ggatatgattcagatcccgtgaaggcttggaaagaagcccagcaaaaggtaccagatgaa
gaagagaatgaagagagtgacaatgaaaatgaagctgaaaagagtgactctgtaagagat
tctggaccaaccttcaactaccttcttgatatgcctctttggtatctcaccaaggagaag
aaagatgaactgtgcaaactgagaaatgaaaaagagcaagagctagaaacattaaagaga
aagagtccatcagatttgtggaaagaagacttggctgcttttattgaagagctggaggct
gttgaaacaaaggaaaaacaagaagaacaaataggacttcctgggaaaggcgggaaagca
aaggggaaaaaaacacaaatggctgaagttttgccttctccatgcgggaaaagagtcatc
ccccgagtgaccatagagatgaaagcagaggcggaaaagaaaattaaaaagaaaattaag
aatgaaaacactgaagggagccctccagaagacggtatcgaactagaaggtctgaaacaa
aggttggagaaaaaacagaaaagagaagcaggtaccaagacaaagaagcaaactacattg
ccatttaaaccaatcaaaaaaggaaagaagagaaacccctggtctgattcagaatcagat
atgagcagtaacgaaagtaactttgatgtccctcctcgagagacagagccacggagagca
gcaacaaaaaccaaattcacggtggatttggattcagatgacgatttctcagattttgat
gaaaaaactcaagataaggattttgtcccatcagatggtagtcctcttaagaccaaagct
tccccaaaacagactactaaagaactgaagccacagaaaagtgccacgtcagtaatggac
cttgatgctgatgagaccaaggacagtgtgccacttcctccaggttcccctgctgctgat
ttctcagctgaaactgaaattataaaccctgtttctaaaaagaaggtggcggtgaagaag
atagcagcaaaaagtcagtcttccaccgccactacaggtgccaaaaaaagggcggcacca
aaaggaagcaaaaaggatccaggcttgaattctgatgtgcctcaaaagcctgatcctccc
aaaaccaaaactcgccgcaaaaggaagccatccacttctgatgattctgactctaatttt
gagaaaatgatttctaaaacagtcacaaacaagaaatccaagggggagagtgaggacttc
catctggacttagactcagctgtggctcctcgggccaaatctggacgggcaaagaaacct
ataaagtacctcgaagaatcagatgaagatgatctgttctaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (6)   
   Pfam (6)   
All databases (35)   

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